Dimetotiazine

Identification

Name
Dimetotiazine
Accession Number
DB08967
Type
Small Molecule
Groups
Approved
Description

Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.

Structure
Thumb
Synonyms
Not Available
External IDs
8599 R.P. / IL-6302
Product Ingredients
IngredientUNIICASInChI Key
Fonazine mesylateB28V86NGNK13115-40-7JGKVKXPDDVRUKC-UHFFFAOYSA-N
Categories
UNII
1FTA475ZDB
CAS number
7456-24-8
Weight
Average: 391.55
Monoisotopic: 391.138819405
Chemical Formula
C19H25N3O2S2
InChI Key
VWNWVCJGUMZDIU-UHFFFAOYSA-N
InChI
InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
IUPAC Name
10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
SMILES
CC(CN1C2=CC=CC=C2SC2=C1C=C(C=C2)S(=O)(=O)N(C)C)N(C)C

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Dimetotiazine.Experimental, Illicit
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Dimetotiazine.Experimental
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Dimetotiazine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Dimetotiazine.Experimental, Illicit
AmphetamineAmphetamine may decrease the sedative activities of Dimetotiazine.Approved, Illicit, Investigational
BenzphetamineBenzphetamine may decrease the sedative activities of Dimetotiazine.Approved, Illicit
Benzylpenicilloyl PolylysineDimetotiazine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Dimetotiazine.Approved, Investigational
ChlorphentermineChlorphentermine may decrease the sedative activities of Dimetotiazine.Illicit, Withdrawn
DextroamphetamineDextroamphetamine may decrease the sedative activities of Dimetotiazine.Approved, Illicit
DiethylpropionDiethylpropion may decrease the sedative activities of Dimetotiazine.Approved, Illicit
GepefrineGepefrine may decrease the sedative activities of Dimetotiazine.Experimental
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Dimetotiazine.Approved, Investigational
HydroxyamphetamineHydroxyamphetamine may decrease the sedative activities of Dimetotiazine.Approved
Iofetamine I-123Iofetamine I-123 may decrease the sedative activities of Dimetotiazine.Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Dimetotiazine.Approved, Investigational
MephedroneMephedrone may decrease the sedative activities of Dimetotiazine.Investigational
MephentermineMephentermine may decrease the sedative activities of Dimetotiazine.Approved
MethamphetamineMethamphetamine may decrease the sedative activities of Dimetotiazine.Approved, Illicit
MethoxyphenamineMethoxyphenamine may decrease the sedative activities of Dimetotiazine.Experimental
MidomafetamineMidomafetamine may decrease the sedative activities of Dimetotiazine.Experimental, Illicit, Investigational
MMDAMMDA may decrease the sedative activities of Dimetotiazine.Experimental, Illicit
PhenterminePhentermine may decrease the sedative activities of Dimetotiazine.Approved, Illicit
PseudoephedrinePseudoephedrine may decrease the sedative activities of Dimetotiazine.Approved
RitobegronRitobegron may decrease the sedative activities of Dimetotiazine.Investigational
Food Interactions
Not Available

References

Synthesis Reference

British Patent 814,512.

General References
Not Available
External Links
PubChem Compound
3089
PubChem Substance
310264930
ChemSpider
2979
ChEBI
135616
ChEMBL
CHEMBL346977
Wikipedia
Dimetotiazine
ATC Codes
N02CX05 — Dimetotiazine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0647 mg/mLALOGPS
logP3.47ALOGPS
logP3.34ChemAxon
logS-3.8ALOGPS
pKa (Strongest Basic)8.99ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area43.86 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity110.46 m3·mol-1ChemAxon
Polarizability41.79 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazines
Sub Class
Phenothiazines
Direct Parent
Phenothiazines
Alternative Parents
Alkyldiarylamines / Diarylthioethers / Organosulfonamides / Benzenoids / 1,4-thiazines / Aminosulfonyl compounds / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Organic oxides
show 1 more
Substituents
Phenothiazine / Alkyldiarylamine / Diarylthioether / Aryl thioether / Tertiary aliphatic/aromatic amine / Para-thiazine / Organosulfonic acid amide / Benzenoid / Organic sulfonic acid or derivatives / Organosulfonic acid or derivatives
show 15 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 09, 2014 09:37 / Updated on May 02, 2018 01:43