Clocapramine

Identification

Generic Name
Clocapramine
DrugBank Accession Number
DB09003
Background

Clocapramine is an atypical antipsychotic of the imidobenzyl class which was introduced in Japan in 1974 for the treatment of schizophrenia. In addition to psychosis, clocapramine has also been used to augment antidepressants in the treatment of anxiety and panic. Clocapramine has been implicated in at least one strange death, including a suicide.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 481.073
Monoisotopic: 480.265589533
Chemical Formula
C28H37ClN4O
Synonyms
  • Clocapramina
  • Clocapramine
  • Clocapraminum

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Clocapramine hydrochloride9NLU6H3LRD60789-62-0SWCNPPOGIXOVAZ-UHFFFAOYSA-N

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as dibenzazepines. These are compounds with two benzene rings connected by an azepine ring. Azepine is an unsaturated seven-member heterocycle with one nitrogen atom replacing a carbon atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzazepines
Sub Class
Dibenzazepines
Direct Parent
Dibenzazepines
Alternative Parents
Alkyldiarylamines / Piperidinecarboxamides / Azepines / Aminopiperidines / Benzenoids / Aryl chlorides / Trialkylamines / Carboximidic acids / Azacyclic compounds / Organopnictogen compounds
show 3 more
Substituents
4-aminopiperidine / Alkyldiarylamine / Amine / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide / Azacycle / Azepine / Benzenoid / Carboximidic acid
show 15 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
6EEL1GB72K
CAS number
47739-98-0
InChI Key
QAZKXHSIKKNOHH-UHFFFAOYSA-N
InChI
InChI=1S/C28H37ClN4O/c29-24-12-11-23-10-9-22-7-2-3-8-25(22)33(26(23)21-24)18-6-15-31-19-13-28(14-20-31,27(30)34)32-16-4-1-5-17-32/h2-3,7-8,11-12,21H,1,4-6,9-10,13-20H2,(H2,30,34)
IUPAC Name
1'-(3-{14-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}propyl)-[1,4'-bipiperidine]-4'-carboximidic acid
SMILES
OC(=N)C1(CCN(CCCN2C3=CC=CC=C3CCC3=C2C=C(Cl)C=C3)CC1)N1CCCCC1

References

Synthesis Reference

U.S. Patent 3,668,210.

General References
Not Available
KEGG Drug
D07718
PubChem Compound
2793
PubChem Substance
310264963
ChemSpider
2691
ChEBI
135778
ChEMBL
CHEMBL2104103
ZINC
ZINC000000608266
Drugs.com
Drugs.com Drug Page
Wikipedia
Clocapramine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)181-183U.S. Patent 3,668,210.
Predicted Properties
PropertyValueSource
Water Solubility0.0055 mg/mLALOGPS
logP4.69ALOGPS
logP2.83Chemaxon
logS-4.9ALOGPS
pKa (Strongest Acidic)-4Chemaxon
pKa (Strongest Basic)13.07Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area53.8 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity151.89 m3·mol-1Chemaxon
Polarizability55.32 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0001900000-db028d2667749428d70e
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0000900000-2b7a86ef0276d8bbde2f
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0229400000-ddee6d2f1f1a3e547467
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0059-4000900000-01a9193c9f62d6cd1dc6
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0319300000-a0985a5ee516514340e8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9004700000-84743fcfa376650ea15a
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-216.75046
predicted
DeepCCS 1.0 (2019)
[M+H]+219.10847
predicted
DeepCCS 1.0 (2019)
[M+Na]+225.75941
predicted
DeepCCS 1.0 (2019)

Drug created at June 17, 2014 18:42 / Updated at February 21, 2021 18:52