Showing BioInteractions for Tibolone (DB09070)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 2
Enzyme Mediated Interactions 4

	Interacting Group	Interacting Drugs
	Tibolone is a Estrogen receptor alpha antagonist
1	Estrogen receptor alpha agonists	Allylestrenol, Bazedoxifene, Chlorotrianisene, Clomifene, Conjugated estrogens, Danazol, Desogestrel, Dienestrol, Diethylstilbestrol, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estriol, Estrone, Estrone sulfate, Ethinylestradiol, Ethynodiol diacetate, Gestrinone, Lasofoxifene, Medroxyprogesterone acetate, Mestranol, Norgestimate, Ospemifene, Phenolphthalein, Polyestradiol phosphate, Progesterone, Quinestrol, Raloxifene, Tamoxifen
2	Estrogen receptor alpha modulators	Quinestrol, Toremifene
3	Estrogen receptor alpha antagonists	Bazedoxifene, Clomifene, Fluoxymesterone, Fulvestrant, Gestrinone, Lasofoxifene, Melatonin, Naloxone, Ospemifene, Tamoxifen
4	Estrogen receptor alpha inhibitors	Progesterone, Testosterone
5	Estrogen receptor alpha negative modulators	Lasofoxifene
6	Estrogen receptor alpha binders	Fluoroestradiol F-18, Prasterone, Zinc chloride, Zinc sulfate, unspecified form
7	Estrogen receptor alpha ligands	Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B
8	Estrogen receptor alpha cofactors	Zinc

	Interacting Group	Interacting Drugs
	Tibolone is a Estrogen receptor alpha agonist
1	Estrogen receptor alpha agonists	Allylestrenol, Bazedoxifene, Chlorotrianisene, Clomifene, Conjugated estrogens, Danazol, Desogestrel, Dienestrol, Diethylstilbestrol, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estriol, Estrone, Estrone sulfate, Ethinylestradiol, Ethynodiol diacetate, Gestrinone, Lasofoxifene, Medroxyprogesterone acetate, Mestranol, Norgestimate, Ospemifene, Phenolphthalein, Polyestradiol phosphate, Progesterone, Quinestrol, Raloxifene, Tamoxifen
2	Estrogen receptor alpha modulators	Quinestrol, Toremifene
3	Estrogen receptor alpha antagonists	Bazedoxifene, Clomifene, Fluoxymesterone, Fulvestrant, Gestrinone, Lasofoxifene, Melatonin, Naloxone, Ospemifene, Tamoxifen
4	Estrogen receptor alpha inhibitors	Progesterone, Testosterone
5	Estrogen receptor alpha negative modulators	Lasofoxifene
6	Estrogen receptor alpha binders	Fluoroestradiol F-18, Prasterone, Zinc chloride, Zinc sulfate, unspecified form
7	Estrogen receptor alpha ligands	Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B
8	Estrogen receptor alpha cofactors	Zinc

	Interacting Group	Interacting Drugs
	Tibolone is a Steryl-sulfatase inhibitor
1	Steryl-sulfatase inhibitors	Irosustat, Norelgestromin

	Interacting Group	Interacting Drugs
	Tibolone is a 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 substrate
1	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 inhibitors	Trilostane
2	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 positive allosteric modulators	Androstenedione
3	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 substrates	Prasterone

	Interacting Group	Interacting Drugs
	Tibolone is a 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 substrate
1	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 inhibitors	Medroxyprogesterone acetate, Trilostane
2	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 inducers	Corticotropin
3	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 substrates	Norethisterone

	Interacting Group	Interacting Drugs
	Tibolone is a Sulfotransferase 1A1 substrate
1	Sulfotransferase 1A1 substrates	Acetaminophen, Apomorphine, Polyethylene glycol 400, Propacetamol, Tamoxifen, Thyroid, porcine