Diiodohydroxyquinoline

Identification

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Name
Diiodohydroxyquinoline
Accession Number
DB09115
Type
Small Molecule
Groups
Approved
Description

Diiodohydroxyquinoline, also known as uidoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products.

Structure
Thumb
Synonyms
  • Diiodohydroxyquin
  • Diiodohydroxyquinoline
  • Iodoquinol
  • Ioquin
External IDs
NSC-8704 / SS-578
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Diodoquin Tab 210mgTabletOralGlenwood Inc.1992-12-312015-06-18Canada
Diodoquin Tab 650mgTabletOralGlenwood Inc.1992-12-312014-07-30Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Ovoquinol ConesDiiodohydroxyquinoline (75 mg) + Sulfadiazine (400 mg) + Undecylenic acid (50 mg)SuppositoryVaginalLab Nadeau LtÉe, Division Of Technilab Inc.1963-12-311999-09-28Canada
Ovoquinol Crm VaginaleDiiodohydroxyquinoline (2 %) + Sulfadiazine (8 %) + Undecylenic acid (1 %)CreamVaginalLab Nadeau LtÉe, Division Of Technilab Inc.1980-12-311999-09-28Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AlcortinDiiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2 g/100g)GelTopicalPrimus Pharmaceuticals2003-07-25Not applicableUs
Alcortin ADiiodohydroxyquinoline (10 mg/1g) + Aloe Vera Leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalNovum Pharma, Llc2015-03-01Not applicableUs
Alcortin ADiiodohydroxyquinoline (10 mg/1g) + Aloe Vera Leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalPrimus Pharmaceuticals2010-01-01Not applicableUs
AloquinDiiodohydroxyquinoline (12.5 mg/1g) + Aloe Vera Leaf (10 mg/1g)GelTopicalNovum Pharma, Llc2015-03-01Not applicableUs
AloquinDiiodohydroxyquinoline (12.5 mg/1g) + Aloe Vera Leaf (10 mg/1g)GelTopicalPrimus Pharmaceuticals2009-07-06Not applicableUs
DermazeneDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g)CreamTopicalStratus Pharmaceuticals2001-06-11Not applicableUs
Hydro-IodoquinolDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalSeton Pharmaceuticals2010-06-102010-10-02Us
Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2%Diiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2.5 g/100g) + Ketoconazole (2 g/100g)CreamTopicalSincerus Florida, LLC2019-05-17Not applicableUs
Hydrocortisone Acetate, IodoquinolDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (19 mg/1g)CreamTopicalBowyn Labs, Llc2011-07-29Not applicableUs
hydrocortisone IodoquinolDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g)CreamTopicalPerrigo New York Inc2008-07-14Not applicableUs
Categories
UNII
63W7IE88K8
CAS number
83-73-8
Weight
Average: 396.954
Monoisotopic: 396.84605
Chemical Formula
C9H5I2NO
InChI Key
UXZFQZANDVDGMM-UHFFFAOYSA-N
InChI
InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
IUPAC Name
5,7-diiodoquinolin-8-ol
SMILES
OC1=C2N=CC=CC2=C(I)C=C1I

Pharmacology

Indication

Used in the treatment of amoebiasis.

Pharmacodynamics
Not Available
Mechanism of action

Unknown.

Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D00581
KEGG Compound
C07636
PubChem Compound
3728
PubChem Substance
310265032
ChemSpider
3597
BindingDB
66035
ChEBI
5950
ChEMBL
CHEMBL86754
Drugs.com
Drugs.com Drug Page
Wikipedia
Diiodohydroxyquinoline
ATC Codes
G01AC01 — Diiodohydroxyquinoline

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GelTopical
TabletOral
CreamTopical
SuppositoryVaginal
CreamVaginal
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0815 mg/mLALOGPS
logP3.93ALOGPS
logP3.69ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)7.39ChemAxon
pKa (Strongest Basic)3.34ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area33.12 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity68.69 m3·mol-1ChemAxon
Polarizability25.9 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as haloquinolines. These are compounds containing a quinoline moiety, which is substituted at one or more ring positions by n halogen atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Quinolines and derivatives
Sub Class
Haloquinolines
Direct Parent
Haloquinolines
Alternative Parents
8-hydroxyquinolines / P-iodophenols / O-iodophenols / Pyridines and derivatives / Aryl iodides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds
show 2 more
Substituents
Haloquinoline / 8-hydroxyquinoline / 2-iodophenol / 4-iodophenol / Aryl halide / Aryl iodide / Pyridine / Benzenoid / Heteroaromatic compound / Azacycle
show 9 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
quinolines (CHEBI:5950)

Drug created on September 22, 2015 11:14 / Updated on December 02, 2019 08:37