Nitrogen

Identification

Name
Nitrogen
Accession Number
DB09152
Type
Small Molecule
Groups
Approved, Vet approved
Description

Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office. Also, nitrogen is very famous component in fertilizers and energy-stores.

Structure
Thumb
Synonyms
Not Available
External IDs
E-941 / INS NO.941 / INS-941
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Gaseous Nitrogen 99.0%GasRespiratory (inhalation)Air Products Canada Ltd/LtÉe.1983-12-31Not applicableCanada
Liquid NitrogenLiquidTopicalNorthside Development Corporation2012-10-23Not applicableCanada
Liquid NitrogenLiquidTopicalN Two Medical Inc2011-09-13Not applicableCanada
Liquid Nitrogen NfLiquidTopicalCryogen Nitrogen Deliveries Limited2015-10-20Not applicableCanada
Liquid Nitrogen NfLiquidTopicalVitalaire Canada Inc2008-01-21Not applicableCanada
NitrogenGas990 mL/1LRespiratory (inhalation)Fullerton Welding Supply2018-08-30Not applicableUs
NitrogenGas900 mL/1LRespiratory (inhalation)Tech Air Of California, Inc.2018-04-11Not applicableUs
NitrogenGas99 L/100LRespiratory (inhalation)American Welding & Gas2009-05-01Not applicableUs
NitrogenGas990 mL/1LRespiratory (inhalation)Hartman Brothers, Inc.1977-07-01Not applicableUs
NitrogenGas991 mL/1LRespiratory (inhalation)Tulsa Gas & Gear, Llc2017-10-26Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Air USPNitrogen (80.5 %) + Oxygen (19.5 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada
Carbon Dioxide MixtureNitrogen (65 %) + Carbon dioxide (12 %) + Oxygen (23 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.Nitrogen (67.7 %) + Carbon monoxide (0.3 %) + Helium (10.5 %) + Oxygen (21.5 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada
Co-HE-O2-N2 MixtureNitrogen (68.7 %) + Carbon monoxide (0.3 %) + Helium (10.0 %) + Oxygen (21.0 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Co-NE-O2-N2 MixtureNitrogen (78.2 %) + Carbon monoxide (0.3 %) + Neon (0.5 %) + Oxygen (21.0 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Helium Oxygen Nitrogen mixtureNitrogen (300 mL/1L) + Helium (200 mL/1L) + Oxygen (500 mL/1L)GasRespiratory (inhalation)Praxair Distribution, Inc.2005-10-01Not applicableUs
Lung Diffusion Test Mix No Ne CoNitrogen (78.2 %) + Carbon monoxide (0.3 %) + Neon (0.5 %) + Oxygen (21 %)GasRespiratory (inhalation)Praxair, Inc.1968-12-31Not applicableCanada
Lung Diffusion Test Mix NohcoNitrogen (68.7 %) + Carbon monoxide (.3 %) + Helium (10 %) + Oxygen (21 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1968-12-311998-06-09Canada
Lung Diffusion Test MixtureNitrogen (68.7 %) + Carbon dioxide (.3 %) + Helium (10 %) + Oxygen (21 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1961-12-311997-12-24Canada
Lung Diffusion Test MixtureNitrogen (74 %) + Carbon monoxide (.5 %) + Helium (15 %) + Oxygen (23 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1982-12-311997-12-24Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AirNitrogen (99 L/100L) + Oxygen (99 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-012010-06-15Us
AirNitrogen (77 L/100L) + Oxygen (23 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-01Not applicableUs
Compressed Gas N.O.S.Nitrogen (75.05 mL/1L) + Carbon dioxide (5 mL/1L) + Oxygen (19.95 mL/1L)GasRespiratory (inhalation)Medical-Technical Gases, Inc.2012-05-29Not applicableUs
Helium Oxygen Nitrogen mixtureNitrogen (300 mL/1L) + Helium (200 mL/1L) + Oxygen (500 mL/1L)GasRespiratory (inhalation)Praxair Distribution Southest Llc2005-10-01Not applicableUs
Hyperbaric Chamber MixNitrogen (500 mL/1L) + Oxygen (500 mL/1L)GasRespiratory (inhalation)Spec Connection International Inc2013-01-01Not applicableUs
Medical Air CompressedNitrogen (790 mL/1L) + Oxygen (210 mL/1L)GasRespiratory (inhalation)Monroe Welding Supply, Inc.2010-08-22Not applicableUs
Nitric Oxide Nitrogen MixNitrogen (955 mL/1L) + Nitric Oxide (5 mL/1L)GasRespiratory (inhalation)Airgas Specialty Gases2010-05-01Not applicableUs
NitrogenNitrogen (99 L/100L)GasRespiratory (inhalation)American Welding & Gas2009-05-01Not applicableUs
NitrogenNitrogen (990 mL/1L)GasRespiratory (inhalation)Praxair Distribution Mid-atlantic, Llc2007-10-01Not applicableUs
NitrogenNitrogen (990 mL/1L)GasRespiratory (inhalation)Melo's Gas And Gear, Inc.2012-05-01Not applicableUs
Categories
UNII
N762921K75
CAS number
7727-37-9
Weight
Average: 28.0134
Monoisotopic: 28.00614801
Chemical Formula
N2
InChI Key
IJGRMHOSHXDMSA-UHFFFAOYSA-N
InChI
InChI=1S/N2/c1-2
IUPAC Name
diazyne
SMILES
N#N

Pharmacology

Indication

Liquid nitrogen is used mainly as a cryogenic agent for the treatment of various benign and malignant skin lesions.

Pharmacodynamics
Not Available
Mechanism of action

In cryotherapy, mechanism of action could be classified into three stages: 1. heat transfer, 2. cell injury and 3. inflammation. Boiling point of liquid nitrogen is -196°C, which is the responsible for creating the initial stage which is heat transfer. The second stage is cell injury which is induced during thawing conditions of the cells. The last step in the cryotherapy is the inflammation stage which is characterized by edema and erythema. Inflammation occurs as a result of cellular death and it helps in local cell destruction.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

For local use only, no systemic absorption.

Volume of distribution

For local use only.

Protein binding

for local use only, not bound to protein.

Metabolism

For local use only.

Route of elimination

For local use only.

Half life

For local use only.

Clearance

For local use only.

Toxicity

Liquid nitrogen: Serious adverse effects include hemorrhage, infection, and excessive granulation tissue formation. Alopecia, atrophy, keloids, scarring, hypopigmentation, and ectropion formation are among permanent complications of cryotherapy.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. Patient info [Link]
  2. Product info [Link]
External Links
Human Metabolome Database
HMDB0001371
KEGG Drug
D00083
KEGG Compound
C00697
PubChem Compound
947
PubChem Substance
310265065
ChemSpider
922
RxNav
7456
ChEBI
17997
ChEMBL
CHEMBL142438
PDBe Ligand
HDZ
Wikipedia
Nitrogen
ATC Codes
V03AN04 — Nitrogen
AHFS Codes
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
PDB Entries
1mae / 1maf / 2nnc / 2z18 / 3qc5 / 3qc6 / 3wa3

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentDepression, Bipolar / Major Depressive Disorder (MDD)1
1, 2CompletedTreatmentCystic Fibrosis (CF)1
2Active Not RecruitingTreatmentNon-Tuberculous Mycobacterial / Non-Tuberculous Mycobacterial Pneumonia1
2CompletedTreatmentCongestive Heart Failure1
2CompletedTreatmentDepression / Major Depressive Disorder (MDD)1
2CompletedTreatmentMalaria, Cerebral1
2CompletedTreatmentNeuralgia1
2CompletedTreatmentTinea infections1
2Not Yet RecruitingTreatmentHigh Blood Pressure (Hypertension) / Metabolic Syndromes1
2Not Yet RecruitingTreatmentObsessive Compulsive Disorder (OCD)1
2RecruitingBasic ScienceCardiovascular Heart Disease / Endothelial Dysfunction / Oxidative Stress1
2RecruitingTreatmentHeart Arrest, Out-Of-Hospital1
2TerminatedTreatmentAcute Myocardial Infarction (AMI) / ST Elevation MI / ST Elevation Myocardial Infarction (STEMI)1
2TerminatedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
2TerminatedTreatmentRight Ventricular Infarction1
2, 3CompletedTreatmentLiver Injury / Reperfusion Injury1
2, 3TerminatedPreventionChronic Lung Disease of Prematurity1
3CompletedPreventionColorectal Cancers1
3CompletedTreatmentActinic Keratosis (AK)1
3CompletedTreatmentChronic Lung Disease of Prematurity1
3CompletedTreatmentChronic Lung Diseases1
3CompletedTreatmentParents1
3RecruitingTreatmentGeneral Surgery / Parenteral Nutrition1
3TerminatedTreatmentAnoxemia / Respiratory Insufficiency1
3WithdrawnTreatmentHypoxic Respiratory Failure With Pulmonary Hypertension1
3WithdrawnTreatmentMinor burns1
4CompletedDiagnosticMalignancies / Pain1
4CompletedTreatmentLiver Biopsy1
4CompletedTreatmentNeoplasms, Gastrointestinal / Postoperative Complications1
4RecruitingSupportive CareIllness, Critical1
4TerminatedSupportive CareCancer-related Malnutrition1
4TerminatedTreatmentPlantar Warts1
4WithdrawnTreatmentHypertension, Pulmonary, of Newborn, Persistent / Persistent Fetal Circulation Syndrome / Persistent Pulmonary Hypertension of Newborn (PPHN)1
Not AvailableCompletedTreatmentVerruca Vulgaris1
Not AvailableEnrolling by InvitationTreatmentAirway Obstruction1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)
GasRespiratory (inhalation)
LiquidTopical
GasCutaneous; Respiratory (inhalation)99 L/100L
GasEndosinusial995 mL/1L
GasRespiratory (inhalation)90 L/100L
GasRespiratory (inhalation)900 mL/1L
GasRespiratory (inhalation)99 mL/1L
GasRespiratory (inhalation)99 mL/100mL
GasRespiratory (inhalation)99 L/1L
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)99.1 L/1L
GasRespiratory (inhalation)99.5 L/100L
GasRespiratory (inhalation)99.5 L/1L
GasRespiratory (inhalation)99.9 L/100L
GasRespiratory (inhalation)99.9 L/1L
GasRespiratory (inhalation)990 mL/1L
GasRespiratory (inhalation)990 L/1L
GasRespiratory (inhalation)991 mL/1L
GasRespiratory (inhalation)992 L/1000L
GasRespiratory (inhalation)992 mL/1L
GasRespiratory (inhalation)995 mL/1L
GasRespiratory (inhalation)999 L/1000L
GasRespiratory (inhalation)999 mL/1L
LiquidRespiratory (inhalation)99 L/100L
LiquidRespiratory (inhalation)990 L/1L
LiquidRespiratory (inhalation)990 mL/1L
LiquidRespiratory (inhalation)997 mL/1L
LiquidTopical99 L/100L
LiquidRespiratory (inhalation)999 L/1000L
Gas
GasRespiratory (inhalation)99 %
GasRespiratory (inhalation)99.5 %
LiquidCutaneous992 mL/1L
LiquidRespiratory (inhalation)1 L/1L
EmulsionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.31ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area47.58 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity26.23 m3·mol-1ChemAxon
Polarizability1.77 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-004i-9000000000-6369f2c7b3a3b0e3772c
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-096cae140ae566643e88
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-096cae140ae566643e88
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-096cae140ae566643e88
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-6d8e7ecefdead45cc87d
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-6d8e7ecefdead45cc87d
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-6d8e7ecefdead45cc87d

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal nitrides. These are inorganic compounds of nitrogen where nitrogen has a formal oxidation state of -3, and the heaviest atom bonded to it belongs to the class of 'other non-metals'.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal nitrides
Direct Parent
Other non-metal nitrides
Alternative Parents
Inorganic nitrides
Substituents
Other non-metal nitride / Inorganic nitride
Molecular Framework
Not Available
External Descriptors
diatomic nitrogen, elemental molecule (CHEBI:17997) / a non-metabolic compound (NITROGEN-MOLECULE)

Drug created on October 01, 2015 13:51 / Updated on March 29, 2020 16:20

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