Nitrogen

Identification

Name
Nitrogen
Accession Number
DB09152
Type
Small Molecule
Groups
Approved, Vet approved
Description

Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office. Also, nitrogen is very famous component in fertilizers and energy-stores.

Structure
Thumb
Synonyms
Not Available
External IDs
E-941 / INS NO.941 / INS-941
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Gaseous Nitrogen 99.0%Gas99.0 %Respiratory (inhalation)Air Products Canada Ltd/LtÉe.1983-12-31Not applicableCanada
Liquid NitrogenLiquid99.5 %TopicalNorthside Development Corporation2012-10-23Not applicableCanada
Liquid NitrogenLiquid100 %TopicalN Two Medical Inc2011-09-13Not applicableCanada
Liquid Nitrogen NfLiquid100 %TopicalVitalaire Canada Inc2008-01-21Not applicableCanada
Liquid Nitrogen NfLiquid100 %TopicalCryogen Nitrogen Deliveries Limited2015-10-20Not applicableCanada
NitrogenGas99 L/100LRespiratory (inhalation)Central-McGowan, Inc.2014-02-01Not applicableUs
NitrogenGas990 mL/1LRespiratory (inhalation)A Ox Welding Supply Company Inc.2012-01-09Not applicableUs
NitrogenGas99 L/100LRespiratory (inhalation)Prest-O-Sales & Service Inc2010-01-01Not applicableUs
NitrogenGas99 L/100LRespiratory (inhalation)Nlr Welding Supply, Inc.1986-01-01Not applicableUs
NitrogenGas999 mL/1LRespiratory (inhalation)General Welding Supply Corp.1984-01-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Air USPNitrogen (80.5 %) + Oxygen (19.5 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada
Carbon Dioxide MixtureNitrogen (65 %) + Carbon dioxide (12 %) + Oxygen (23 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Monox, Helium, Oxygen, Nitrogen L.D.M.Nitrogen (67.7 %) + Carbon monoxide (0.3 %) + Helium (10.5 %) + Oxygen (21.5 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada
Co-HE-O2-N2 MixtureNitrogen (68.7 %) + Carbon monoxide (0.3 %) + Helium (10.0 %) + Oxygen (21.0 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Co-NE-O2-N2 MixtureNitrogen (78.2 %) + Carbon monoxide (0.3 %) + Neon (0.5 %) + Oxygen (21.0 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Helium Oxygen Nitrogen mixtureNitrogen (300 mL/1L) + Helium (200 mL/1L) + Oxygen (500 mL/1L)GasRespiratory (inhalation)Praxair Distribution, Inc.2005-10-01Not applicableUs
Lung Diffusion Test Mix No Ne CoNitrogen (78.2 %) + Carbon monoxide (0.3 %) + Neon (0.5 %) + Oxygen (21 %)GasRespiratory (inhalation)Praxair, Inc.1968-12-31Not applicableCanada
Lung Diffusion Test Mix NohcoNitrogen (68.7 %) + Carbon monoxide (.3 %) + Helium (10 %) + Oxygen (21 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1968-12-311998-06-09Canada
Lung Diffusion Test MixtureNitrogen (68.7 %) + Carbon dioxide (.3 %) + Helium (10 %) + Oxygen (21 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1961-12-311997-12-24Canada
Lung Diffusion Test MixtureNitrogen (74 %) + Carbon monoxide (.5 %) + Helium (15 %) + Oxygen (23 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1982-12-311997-12-24Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AirNitrogen (77 L/100L) + Oxygen (23 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-01Not applicableUs
AirNitrogen (99 L/100L) + Oxygen (99 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-012010-06-15Us
Compressed Gas N.O.S.Nitrogen (75.05 mL/1L) + Carbon dioxide (5 mL/1L) + Oxygen (19.95 mL/1L)GasRespiratory (inhalation)Medical-Technical Gases, Inc.2012-05-29Not applicableUs
Helium Oxygen Nitrogen mixtureNitrogen (300 mL/1L) + Helium (200 mL/1L) + Oxygen (500 mL/1L)GasRespiratory (inhalation)Praxair Distribution Southest Llc2005-10-01Not applicableUs
Hyperbaric Chamber MixNitrogen (500 mL/1L) + Oxygen (500 mL/1L)GasRespiratory (inhalation)Spec Connection International Inc2013-01-01Not applicableUs
Medical Air CompressedNitrogen (790 mL/1L) + Oxygen (210 mL/1L)GasRespiratory (inhalation)Monroe Welding Supply, Inc.2010-08-22Not applicableUs
Nitric Oxide Nitrogen MixNitrogen (955 mL/1L) + Nitric Oxide (5 mL/1L)GasRespiratory (inhalation)Airgas Specialty Gases2010-05-01Not applicableUs
NitrogenNitrogen (99 L/100L)GasRespiratory (inhalation)Linde Gas North America LLC1986-08-01Not applicableUs
NitrogenNitrogen (99 L/100L)GasRespiratory (inhalation)Specialty Gases Of America2010-08-01Not applicableUs
NitrogenNitrogen (99 L/100L)GasRespiratory (inhalation)Line Pressure2013-02-11Not applicableUs
Categories
UNII
N762921K75
CAS number
7727-37-9
Weight
Average: 28.0134
Monoisotopic: 28.00614801
Chemical Formula
N2
InChI Key
IJGRMHOSHXDMSA-UHFFFAOYSA-N
InChI
InChI=1S/N2/c1-2
IUPAC Name
diazyne
SMILES
N#N

Pharmacology

Indication

Liquid nitrogen is used mainly as a cryogenic agent for the treatment of various benign and malignant skin lesions.

Pharmacodynamics
Not Available
Mechanism of action

In cryotherapy, mechanism of action could be classified into three stages: 1. heat transfer, 2. cell injury and 3. inflammation. Boiling point of liquid nitrogen is -196°C, which is the responsible for creating the initial stage which is heat transfer. The second stage is cell injury which is induced during thawing conditions of the cells. The last step in the cryotherapy is the inflammation stage which is characterized by edema and erythema. Inflammation occurs as a result of cellular death and it helps in local cell destruction.

Absorption

For local use only, no systemic absorption.

Volume of distribution

For local use only.

Protein binding

for local use only, not bound to protein.

Metabolism

For local use only.

Route of elimination

For local use only.

Half life

For local use only.

Clearance

For local use only.

Toxicity

Liquid nitrogen: Serious adverse effects include hemorrhage, infection, and excessive granulation tissue formation. Alopecia, atrophy, keloids, scarring, hypopigmentation, and ectropion formation are among permanent complications of cryotherapy.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Patient info [Link]
  2. Product info [Link]
External Links
Human Metabolome Database
HMDB0001371
KEGG Drug
D00083
KEGG Compound
C00697
PubChem Compound
947
PubChem Substance
310265065
ChemSpider
922
ChEBI
17997
ChEMBL
CHEMBL142438
HET
HDZ
Wikipedia
Nitrogen
ATC Codes
V03AN04 — Nitrogen
AHFS Codes
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
PDB Entries
1mae / 1maf / 2nnc / 2z18 / 3qc5 / 3qc6 / 3wa3

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0WithdrawnTreatmentSymptomatic Osteoarthritis of the Knee1
1, 2CompletedTreatmentCystic Fibrosis (CF)1
2CompletedPreventionChronic Lung Disease of Prematurity1
2CompletedSupportive CarePulmonary Fibrosis1
2CompletedTreatmentAnginal Pain1
2CompletedTreatmentCongestive Heart Failure (CHF)1
2CompletedTreatmentCystic Fibrosis (CF)1
2CompletedTreatmentTinea infections1
2CompletedTreatmentNeurocostal neuralgia1
2Not Yet RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Large B-cell Lymphoma / Refractory CD19+ B-cell Pediatric ALL / Refractory Diffuse Large B Cell Lymphoma / Refractory Large B-cell Lymphoma / Relapsed CD19+ B-cell Pediatric ALL / Relapsed Large B-cell Lymphoma1
2RecruitingTreatmentHeart Arrest, Out-Of-Hospital1
2, 3TerminatedTreatmentPain, Acute1
3CompletedPreventionColorectal Cancers1
3CompletedTreatmentChronic Lung Disease of Prematurity / Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction) / Surfactant Dysfunction1
3CompletedTreatmentChronic Lung Diseases1
3CompletedTreatmentParents1
3CompletedTreatmentPregnancy termination therapy1
3TerminatedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
3WithdrawnTreatmentHypoxic Respiratory Failure With Pulmonary Hypertension1
4CompletedPreventionPain NOS1
4CompletedTreatmentAnaesthesia therapy2
4CompletedTreatmentLiver Biopsy1
4CompletedTreatmentPain, Acute1
4TerminatedTreatmentPlantar Warts1
4Unknown StatusPreventionChronic Lung Disease of Prematurity / Respiratory Distress Syndrome (RDS)1
Not AvailableCompletedPreventionPharyngitis1
Not AvailableCompletedTreatmentChronic Obstructive Pulmonary Disease (COPD) / Endurance Shuttle Walking Test (Exercise at 85% of Maximal Shuttle Walking Test) / Exercise1
Not AvailableCompletedTreatmentHand Injuries/Disease Requiring Surgery to the Hand1
Not AvailableCompletedTreatmentPeriodontitis1
Not AvailableCompletedTreatmentVerruca Vulgaris1
Not AvailableEnrolling by InvitationTreatmentAirway Obstruction1
Not AvailableNot Yet RecruitingTreatmentAnal abscess / Anal Fistulas1
Not AvailableUnknown StatusBasic SciencePain NOS1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)
GasRespiratory (inhalation)99.0 %
LiquidTopical99.5 %
LiquidTopical100 %
GasCutaneous; Respiratory (inhalation)99 L/100L
GasEndosinusial995 mL/1L
GasRespiratory (inhalation)90 L/100L
GasRespiratory (inhalation)900 mL/1L
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)99 mL/100mL
GasRespiratory (inhalation)99 L/1L
GasRespiratory (inhalation)99 mL/1L
GasRespiratory (inhalation)99.1 L/1L
GasRespiratory (inhalation)99.5 L/100L
GasRespiratory (inhalation)99.5 L/1L
GasRespiratory (inhalation)99.9 L/100L
GasRespiratory (inhalation)99.9 L/1L
GasRespiratory (inhalation)990 L/1L
GasRespiratory (inhalation)990 mL/1L
GasRespiratory (inhalation)992 mL/1L
GasRespiratory (inhalation)992 L/1000L
GasRespiratory (inhalation)995 mL/1L
GasRespiratory (inhalation)999 L/1000L
GasRespiratory (inhalation)999 mL/1L
LiquidRespiratory (inhalation)99 L/100L
LiquidRespiratory (inhalation)990 L/1L
LiquidRespiratory (inhalation)997 mL/1L
LiquidTopical99 L/100L
GasRespiratory (inhalation)100 %
LiquidRespiratory (inhalation)999 L/1000L
LiquidTopical99 %
GasRespiratory (inhalation)99 %
GasRespiratory (inhalation)99.5 %
LiquidCutaneous992 mL/1L
LiquidRespiratory (inhalation)1 L/1L
EmulsionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.31ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area47.58 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity26.23 m3·mol-1ChemAxon
Polarizability1.77 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-004i-9000000000-6369f2c7b3a3b0e3772c
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-096cae140ae566643e88
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-096cae140ae566643e88
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-096cae140ae566643e88
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-6d8e7ecefdead45cc87d
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-6d8e7ecefdead45cc87d
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-6d8e7ecefdead45cc87d

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal nitrides. These are inorganic compounds of nitrogen where nitrogen has a formal oxidation state of -3, and the heaviest atom bonded to it belongs to the class of 'other non-metals'.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal nitrides
Direct Parent
Other non-metal nitrides
Alternative Parents
Inorganic nitrides
Substituents
Other non-metal nitride / Inorganic nitride
Molecular Framework
Not Available
External Descriptors
diatomic nitrogen, elemental molecule (CHEBI:17997) / a non-metabolic compound (NITROGEN-MOLECULE)

Drug created on October 01, 2015 13:51 / Updated on November 17, 2018 04:48