You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.

This drug entry is a stub and has not been fully annotated. It was added on October 29, 2015 and is scheduled to be annotated soon.

NameActivated charcoal
Accession NumberDB09278  (DB05269)
TypeSmall Molecule
DescriptionActivated charcoal, or activated carbon, is used as a medication to treat poisonings following excessive oral ingestion of certain medications or poisons. Side effects may include aspiration into the lungs. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
Activated carbon
Carbo activates
Carbo activatus
Carbo vegetabilis
Carbon, Activated
Carbon, decolorizing
Charcoal activated
Charcoal, Activated
Medicinal carbon
External IDs AST 120 / AST-120 / GC BM-3
Product Ingredients Not Available
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ActidoseSuspension208 mg/mLOralPaddock Laboratories, Inc.1983-10-01Not applicableUs
Actidose AquaSuspension208 mg/mLOralPaddock Laboratories, Inc.1984-01-01Not applicableUs
Activated CharcoalCapsule225 mgOralJamp Pharma CorporationNot applicableNot applicableCanada
Activated CharcoalCapsule225 mgOralLeo Desilets Maitre Herboriste Inc1998-10-07Not applicableCanada
Activated Charcoal 260mgCapsule260 mgOralValeant Canada Lp Valeant Canada S.E.C.1998-12-07Not applicableCanada
Activated Charcoal Cap 280mgCapsule280 mgOralNutrition Professionals Inc.1988-12-311997-02-27Canada
Activated Charcoal Cap 280mgCapsule280 mgOralNature's Way Of Canada Ltd.1984-12-312010-07-27Canada
Activated Charcoal PowderPowder, for solution1 gOralLeo Desilets Maitre Herboriste Inc1999-04-082013-06-18Canada
Activated Charcoal USPPowder100 %OralLifeforce Nutri Blends Canada Inc.2002-06-172012-07-05Canada
Adrien Gagnon Charbon Activé/activated Charcoal CapsulesCapsule170 mgOralSantÉ Naturelle (Ag) LtÉe2009-12-212014-06-09Canada
Biochala Charbon Activé/activated CharcoalCapsule225 mgOralImportations Biochala Inc.Not applicableNot applicableCanada
Char-flo Aqueous Base - Sus Orl 208mg/mlSuspension208 mgOralBallard Medical Products1997-08-202004-08-04Canada
Charac-25Suspension222 mgOralOmega Laboratories Ltd1985-12-31Not applicableCanada
Charac-50Suspension50 gOralOmega Laboratories Ltd1985-12-31Not applicableCanada
Charactol-25Suspension200 mgOralOmega Laboratories Ltd1985-12-31Not applicableCanada
Charactol-50Suspension50 gOralOmega Laboratories Ltd1985-12-31Not applicableCanada
Charbon ActifTablet230 mgOralNatural World Distribution IncNot applicableNot applicableCanada
Charbon Active 260mgCapsule260 mgOralGamme Nature2002-08-012008-07-31Canada
Charco CapsCapsule260 mgOralDse Healthcare Solutions, Llc.2016-01-15Not applicableCanada
CharcoalCapsule162 mgOralLaboratoires ArkopharmaNot applicableNot applicableCanada
Charcodote Tfs Sus 200mg/mlSuspension200 mgOralPharmascience Inc1990-12-311997-09-26Canada
Charcodote Tfs Sus 200mg/mlSuspension200 mgOralPharmascience Inc1997-08-06Not applicableCanada
Charcodote-aqueous Sus 200mg/mlSuspension200 mgOralPharmascience Inc1997-03-17Not applicableCanada
Ez CharPellet25 g/25gOralPaddock Laboratories, Inc.2002-01-14Not applicableUs
Humco Charcoal ActivatedPowder1000 mg/gOralHumco Holding Group. Inc.2008-01-01Not applicableUs
Insta Char Adult 50gm/250mlLiquid50 gOralFrank W. Kerr Chemical Company1983-12-311996-09-09Canada
Insta Char Pediatric 15gm/120mlLiquid15 gOralFrank W. Kerr Chemical Company1983-12-311996-09-09Canada
Insta-char AqueousSuspension50 g/240mLOralVista Pharm, Inc.2006-10-03Not applicableUs
Insta-char Aqueous CherrySuspension50 g/240mLOralVista Pharm, Inc.2007-12-11Not applicableUs
Insta-char SorbitolSuspension50 g/240mLOralVista Pharm, Inc.2008-03-28Not applicableUs
Jamp-activated CharcoalSuspension200 mgOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-activated Charcoal PlusSuspension200 mgOralJamp Pharma CorporationNot applicableNot applicableCanada
NoricolCapsule280 mgOralViva Pharmaceutical Inc.Not applicableNot applicableCanada
Premium Activated Charcoal USPCapsule260 mgOralSource of Life Products, Division of Chemimex Ent2008-02-04Not applicableCanada
W Lab Sebum Out Peel Off PackGel2 g/100mLTopicalWow Ventures2016-08-01Not applicableUs
Wampole Activated CharcoalCapsule225 mgOralJamp Pharma Corporation2013-03-19Not applicableCanada
International BrandsNot Available
Brand mixtures
CarbosylaneLaboratoires Grimberg
Char-flo With Sorbitol - SusBallard Medical Products
Flat-eezeSeaford Pharmaceuticals Inc
CategoriesNot Available
CAS number64365-11-3
WeightAverage: 12.011
Monoisotopic: 12.0
Chemical FormulaC
IndicationUsed as a medication to treat poisonings following excessive oral ingestion of certain medications or poisons.
PharmacodynamicsNot yet annotated
Mechanism of actionActive charcoal acts by binding to the poison to prevent stomach and intestinal absorption. As binding is reversible, a cathartic such as sorbitol may be added as well. Additionally, it interrupts the enterohepatic and enteroenteric circulation of some drugs/toxins and their metabolites.
TargetKindPharmacological actionActionsOrganismUniProt ID
Lipoprotein lipaseProteinunknownNot AvailableHumanP06858 details
Related Articles
Drug Interactions
DrugInteractionDrug group
LeflunomideThe serum concentration of the active metabolites of Leflunomide can be reduced when Leflunomide is used in combination with Activated charcoal resulting in a loss in efficacy.Approved, Investigational
TeriflunomideThe serum concentration of Teriflunomide can be decreased when it is combined with Activated charcoal.Approved
Food InteractionsNot Available
Synthesis ReferenceNot Available
General References
  1. Shimoishi K, Anraku M, Kitamura K, Tasaki Y, Taguchi K, Hashimoto M, Fukunaga E, Maruyama T, Otagiri M: An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharm Res. 2007 Jul;24(7):1283-9. Epub 2007 Mar 27. [PubMed:17387602 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials
1CompletedNot AvailableAsthma2
1CompletedNot AvailableHealthy Volunteers3
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentMajor Depressive Disorder (MDD)1
1CompletedTreatmentPulmonary Disease, Chronic Obstructive1
2CompletedTreatmentHepatic Encephalopathy1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2CompletedTreatmentMalaria / Severe Malaria1
2CompletedTreatmentMild Hepatic Encephalopathy1
2TerminatedTreatmentGastroesophageal Reflux Disease (GERD)1
3CompletedTreatmentAnal Incontinence1
3CompletedTreatmentChronic Kidney Disease (CKD)2
3CompletedTreatmentInflammatory Bowel Diseases (IBD) / Intestinal Fistula1
3CompletedTreatmentMultiple Sclerosis (MS)1
4CompletedTreatmentAST-120 / Chronic Kidney Disease (CKD)1
4CompletedTreatmentChronic Kidney Disease (CKD)1
4CompletedTreatmentLoss of Solute Clearance1
4Not Yet RecruitingTreatmentAnticoagulants; Circulating, Hemorrhagic Disorder1
Not AvailableCompletedTreatmentPhenytoin Toxicity1
Experimental PropertiesNot Available
Predicted Properties
Water Solubility0.0 mg/mLALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.11 m3·mol-1ChemAxon
Polarizability1.51 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET featuresNot Available
Mass Spec (NIST)Not Available
SpectraNot Available
DescriptionThis compound belongs to the class of organic compounds known as organic compounds. These are compounds that contain at least one carbon atom, excluding isocyanide/cyanide and their non-hydrocarbyl derivatives, thiophosgene, carbon diselenide, carbon monosulfide, carbon disulfide, carbon subsulfide, carbon monoxide, carbon trioxide, carbon suboxide, and dicarbon monoxide.
KingdomOrganic compounds
Super ClassNot Available
ClassNot Available
Sub ClassNot Available
Direct ParentOrganic compounds
Alternative ParentsNot Available
  • Organic compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors


Pharmacological action
General Function:
Triglyceride lipase activity
Specific Function:
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
Gene Name:
Uniprot ID:
Molecular Weight:
53162.07 Da
comments powered by Disqus
Drug created on October 29, 2015 08:53 / Updated on December 21, 2016 09:34