Showing BioInteractions for Tegafur-uracil (DB09327)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Dihydropyrimidine dehydrogenase [NADP(+)] antagonist
1	Dihydropyrimidine dehydrogenase [NADP(+)] substrates	Capecitabine, Fluorouracil, Tegafur-uracil
2	Dihydropyrimidine dehydrogenase [NADP(+)] inhibitors	Gimeracil

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Thymidylate synthase antagonist
1	Thymidylate synthase inhibitors	Capecitabine, Gemcitabine, Methotrexate, Pemetrexed, Pralatrexate, Raltitrexed, Tegafur, Trifluridine
2	Thymidylate synthase substrates	Fluorouracil, Methotrexate

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Cytochrome P450 2A6 substrate
1	Cytochrome P450 2A6 substrates	Acetaminophen, Antipyrine, Apremilast, Arformoterol, Artesunate, Asunaprevir, Azelastine, Cenobamate, Chlorzoxazone, Cinnarizine, Cisapride, Clomethiazole, Clozapine, Cyclophosphamide, Dapagliflozin, Flunarizine, Flunitrazepam, Fluorouracil, Flurazepam, Formoterol, Halothane, Ifosfamide, Letrozole, Lidocaine, Lonafarnib, Lorcaserin, Methoxyflurane, Metronidazole, Montelukast, Nevirapine, Nicotine, Nifedipine, Norethisterone, Phenacetin, Phenytoin, Plitidepsin, Selegiline, Sevoflurane, Tamoxifen, Tegafur, Tretinoin, Valproic acid, Vortioxetine, Zidovudine
2	Cytochrome P450 2A6 inhibitors	Amiodarone, Amphetamine, Azelastine, Clotrimazole, Fenofibrate, Fomepizole, Isoniazid, Ketoconazole, Letrozole, Memantine, Menadione, Methimazole, Methoxsalen, Metyrapone, Miconazole, Nicotine, Nilvadipine, Pilocarpine, Rosiglitazone, Selegiline, Seratrodast, Tranylcypromine, Triclabendazole
3	Cytochrome P450 2A6 inducers	Betamethasone, Budesonide, Dexamethasone, Dexamethasone acetate, Eletriptan, Hydrocortisone, Methylprednisolone, Pentobarbital, Phenobarbital, Prednisolone phosphate, Prednisone, Progesterone, Rifampicin, Valproic acid

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Dihydropyrimidine dehydrogenase [NADP(+)] substrate
1	Dihydropyrimidine dehydrogenase [NADP(+)] substrates	Capecitabine, Fluorouracil
2	Dihydropyrimidine dehydrogenase [NADP(+)] inhibitors	Gimeracil
3	Dihydropyrimidine dehydrogenase [NADP(+)] antagonists	Tegafur-uracil

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Solute carrier family 22 member 7 substrate
1	Solute carrier family 22 member 7 inhibitors	Bumetanide, Cefalotin, Cefamandole, Cefoperazone, Cefotaxime, Cholic Acid, Cimetidine, Clarithromycin, Dinoprostone, Enalapril, Ganciclovir, Glyburide, Ketoprofen, Minocycline, Oxtriphylline, Oxytetracycline, Probenecid, Rifampicin, Testosterone, Tetracycline, Theophylline
2	Solute carrier family 22 member 7 substrates	Allopurinol, Aminohippuric acid, Cimetidine, Cyclic adenosine monophosphate, Dinoprostone, Docetaxel, Fluorouracil, Glutaric Acid, Indomethacin, Methotrexate, Oxytetracycline, Pravastatin, Salicylic acid, Valproic acid, Zalcitabine
3	Solute carrier family 22 member 7 inducers	Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Equilibrative nucleoside transporter 1 substrate
1	Equilibrative nucleoside transporter 1 inhibitors	Cannabidiol, Fostamatinib, Medical Cannabis, Nabiximols, Troglitazone
2	Equilibrative nucleoside transporter 1 substrates	Cytarabine, Fludarabine, Fluorouracil, Gemcitabine, Mercaptopurine, Ribavirin, Trifluridine
3	Equilibrative nucleoside transporter 1 inducers	Pemetrexed

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Equilibrative nucleoside transporter 2 substrate
1	Equilibrative nucleoside transporter 2 substrates	Azathioprine, Mercaptopurine, Trifluridine

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Sodium/nucleoside cotransporter 1 substrate
1	Sodium/nucleoside cotransporter 1 substrates	Decitabine, Trifluridine

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Sodium/nucleoside cotransporter 2 substrate
1	Sodium/nucleoside cotransporter 2 substrates	Mercaptopurine

	Interacting Group	Interacting Drugs
	Tegafur-uracil is a Solute carrier family 28 member 3 substrate
1	Solute carrier family 28 member 3 substrates	Azathioprine, Gemcitabine, Mercaptopurine, Ribavirin