Showing BioInteractions for DB09330 (Osimertinib)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Osimertinib is a Cytochrome P450 3A4 inducer
1Cytochrome P450 3A4 substratesAbemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Albendazole, Alclometasone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, Alprazolam, Ambrisentan, Ambroxol, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Antipyrine, Apixaban, Apremilast, Aprepitant, Argatroban, Aripiprazole, Artemether, Asenapine, Astemizole, Atazanavir, Atorvastatin, Avanafil, Axitinib, Azelastine, Azithromycin, Banoxantrone, Bedaquiline, Benzphetamine, Benzyl alcohol, Bexarotene, Bezafibrate, Bicalutamide, Bisoprolol, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Carbamazepine, Carbinoxamine, Cariprazine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilostazol, Cinacalcet, Cisapride, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Cortisone acetate, Crizotinib, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delavirdine, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexchlorpheniramine maleate, Dexlansoprazole, Dextromethorphan, Dextropropoxyphene, Diazepam, Diclofenac, Dienogest, Digitoxin, Digoxin, Dihydrocodeine, Dihydroergotamine, Diltiazem, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Dutasteride, Efavirenz, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Enalapril, Enasidenib, Enzalutamide, Epinastine, Eplerenone, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinyl Estradiol, Ethosuximide, Ethylmorphine, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Flibanserin, Flunisolide, Flunitrazepam, Fluorometholone, Fluoxetine, Flurazepam, Flutamide, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fulvestrant, Galantamine, Gefitinib, Gemfibrozil, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halofantrine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydromorphone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipratropium bromide, Irinotecan, Isavuconazonium, Isosorbide Dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Levobupivacaine, Levocetirizine, Levomethadyl Acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lisuride, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Losartan, Lovastatin, Lumefantrine, Lurasidone, Macitentan, Maraviroc, Mebendazole, Medroxyprogesterone acetate, Mefloquine, Meloxicam, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Montelukast, Morphine, Mycophenolate mofetil, Naloxegol, Naloxone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Nilotinib, Nilvadipine, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Norethisterone, Norgestrel, Nortriptyline, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Orphenadrine, Ospemifene, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pioglitazone, Pipotiazine, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednisolone, Prednisone, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propoxyphene napsylate, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rilpivirine, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Theophylline, Thiotepa, Tiagabine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tofacitinib, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinorelbine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone
2Cytochrome P450 3A4 inhibitorsAcetaminophen, Acetazolamide, Aldesleukin, Alprazolam, Ambroxol, Amiodarone, Amlodipine, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, Atorvastatin, Azelastine, Azithromycin, Betamethasone, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brentuximab vedotin, Bromocriptine, Buprenorphine, Cabergoline, Caffeine, Capsaicin, Caspofungin, Ceritinib, Cerivastatin, Chloramphenicol, Chlorzoxazone, Cilostazol, Cimetidine, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Conivaptan, Cortisone acetate, Crizotinib, Cyclophosphamide, Cyclosporine, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Dexamethasone, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Docetaxel, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Elbasvir, Enasidenib, Epinephrine, Ergoloid mesylate, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Gemfibrozil, Glyburide, Glycerol Phenylbutyrate, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irbesartan, Irinotecan, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Josamycin, Ketazolam, Ketoconazole, Lansoprazole, Lapatinib, Lercanidipine, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Lurasidone, Manidipine, Mefloquine, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mirtazapine, Mitoxantrone, Modafinil, Nefazodone, Nelfinavir, Netupitant, Nevirapine, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Olanzapine, Olaparib, Omeprazole, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Pazopanib, Pergolide, Phenelzine, Pilocarpine, Pimozide, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Repaglinide, Resveratrol, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rolitetracycline, Rosuvastatin, Roxithromycin, Rutin, Salbutamol, Saquinavir, Sarilumab, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Thiopental, Ticagrelor, Ticlopidine, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Troglitazone, Troleandomycin, Valproic Acid, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone, Zucapsaicin
3Cytochrome P450 3A4 inducersAcetaminophen, Alclometasone, Alimemazine, Aminoglutethimide, Armodafinil, Artemether, Atorvastatin, Azatadine, Bexarotene, Bosentan, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clofibrate, Clotrimazole, Clozapine, Colchicine, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desvenlafaxine, Dexamethasone, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Ethanol, Etoposide, Etravirine, Exemestane, Felbamate, Flucloxacillin, Fluorometholone, Fluvastatin, Fosaprepitant, Fosphenytoin, Gemfibrozil, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Idelalisib, Ifosfamide, Isavuconazonium, Lansoprazole, Lopinavir, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nicardipine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifapentine, Rifaximin, Rilpivirine, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, Simvastatin, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Topiramate, Topotecan, Trametinib, Troglitazone, Vemurafenib
Interacting GroupInteracting Drugs
Osimertinib is a Cytochrome P450 1A2 inducer
1Cytochrome P450 1A2 substratesAcenocoumarol, Acetaminophen, Albendazole, Almotriptan, Alosetron, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Anagrelide, Antipyrine, Apixaban, Aprepitant, Asenapine, Axitinib, Azelastine, Bendamustine, Benzyl alcohol, Betaxolol, Bortezomib, Bromazepam, Bupivacaine, Bupropion, Caffeine, Carbamazepine, Carmustine, Carvedilol, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Clenbuterol, Clevidipine, Clomipramine, Clonidine, Clopidogrel, Clozapine, Conjugated estrogens, Cyclobenzaprine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Desipramine, Deutetrabenazine, Dexfenfluramine, Diazepam, Diclofenac, Dinoprostone, Diphenhydramine, Domperidone, Doxepin, Duloxetine, Eltrombopag, Enasidenib, Ergotamine, Erlotinib, Estradiol, Estrone, Estrone sulfate, Ethanol, Etoposide, Etoricoxib, Flunarizine, Flunitrazepam, Fluorouracil, Fluoxetine, Flutamide, Fluvoxamine, Frovatriptan, Genistein, Grepafloxacin, Guanabenz, Haloperidol, Hesperetin, Hexobarbital, Icotinib, Iloperidone, Imatinib, Imipramine, Imiquimod, Ixazomib, Leflunomide, Levobupivacaine, Lidocaine, Lomefloxacin, Lorcaserin, Lumiracoxib, Malathion, Maprotiline, Melatonin, Menadione, Mephenytoin, Methadone, Methoxyflurane, Mexiletine, Mianserin, Mirtazapine, Nabumetone, Naproxen, Nicotine, Nifedipine, Nitric Oxide, Nortriptyline, Olanzapine, Omeprazole, Ondansetron, Oxaliplatin, Oxtriphylline, Palonosetron, Pantoprazole, Pazopanib, Pentamidine, Pentoxifylline, Perphenazine, Phenacetin, Pimozide, Pipotiazine, Pomalidomide, Praziquantel, Primaquine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propranolol, Pyrazinamide, Quinine, Ramelteon, Ranitidine, Rasagiline, Resveratrol, Rifabutin, Riluzole, Ritonavir, Rizatriptan, Rofecoxib, Ropinirole, Ropivacaine, Rotigotine, Rucaparib, Selegiline, Sertraline, Stiripentol, Tacrine, Tamoxifen, Telithromycin, Temafloxacin, Terbinafine, Thalidomide, Theobromine, Theophylline, Thiabendazole, Thioridazine, Thiothixene, Tizanidine, Toremifene, Triamterene, Trifluoperazine, Ulipristal, Vadimezan, Verapamil, Voxilaprevir, Warfarin, Zileuton, Ziprasidone, Zolmitriptan, Zolpidem
2Cytochrome P450 1A2 inhibitorsAbiraterone, Aciclovir, Agomelatine, Albendazole, Alitretinoin, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Anastrozole, Apomorphine, Atazanavir, Atropine, Azithromycin, Bortezomib, Bromocriptine, Buprenorphine, Caffeine, Carbamazepine, Carbimazole, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clobetasol propionate, Clomifene, Clotrimazole, Clozapine, Conjugated estrogens, Crisaborole, Delavirdine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Diacerein, Diazepam, Diclofenac, Disulfiram, Dopamine, Dosulepin, Edetic Acid, Efavirenz, Eltrombopag, Enasidenib, Enoxacin, Entacapone, Epinephrine, Erythromycin, Estradiol, Etoricoxib, Fluconazole, Fluoxetine, Fluphenazine, Flutamide, Fluvastatin, Fluvoxamine, Gemfibrozil, Glecaprevir, Glycerol Phenylbutyrate, Imipramine, Interferon Alfa-2b, Recombinant, Interferon gamma-1b, Irbesartan, Isoniazid, Ketoconazole, Levofloxacin, Lidocaine, Lobeglitazone, Lomefloxacin, Lopinavir, Losartan, Manidipine, Meclizine, Melatonin, Mestranol, Methimazole, Methotrimeprazine, Methoxsalen, Mexiletine, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirtazapine, Moclobemide, Modafinil, Nefazodone, Nelfinavir, Nevirapine, Niclosamide, Nifedipine, Nilvadipine, Nisoldipine, Nitroprusside, Norepinephrine, Norfloxacin, Obeticholic acid, Ofloxacin, Olanzapine, Omeprazole, Ondansetron, Orphenadrine, Oxymetholone, Paroxetine, Pefloxacin, Peginterferon alfa-2a, Peginterferon alfa-2b, Pentoxifylline, Perphenazine, Phentermine, Phenylbutyric acid, Phenylpropanolamine, Pibrentasvir, Primaquine, Propafenone, Propofol, Propranolol, Quinidine, Quinine, Ranitidine, Resveratrol, Rhein, Rofecoxib, Ropinirole, Rosiglitazone, Rotigotine, Roxithromycin, Selegiline, Sertraline, Simeprevir, Sorafenib, Sulconazole, Sulindac, Synthetic Conjugated Estrogens, A, Tegaserod, Temafloxacin, Tenofovir disoproxil, Theophylline, Thiabendazole, Thioridazine, Ticlopidine, Tioconazole, Tocainide, Topiroxostat, Tranylcypromine, Triamterene, Valaciclovir, Valproic Acid, Vemurafenib, Verapamil, Zafirlukast, Zileuton, Zucapsaicin
3Cytochrome P450 1A2 inducersAlbendazole, Aminoglutethimide, Armodafinil, Belinostat, beta-Naphthoflavone, Capsaicin, Carbamazepine, Danthron, Griseofulvin, Insulin Aspart, Insulin Beef, Insulin Detemir, Insulin Glargine, Insulin Glulisine, Insulin Human, Insulin Lispro, Insulin Pork, Lansoprazole, Menadione, Midostaurin, Modafinil, Nafcillin, Nicotine, Omeprazole, Pantoprazole, Phenobarbital, Phenylephrine, Primaquine, Primidone, Quinine, Rabeprazole, Resveratrol, Rifampicin, Rilpivirine, Ritonavir, Secobarbital, Streptozocin
Interacting GroupInteracting Drugs
Osimertinib is a Multidrug resistance protein 1 substrate
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Apixaban, Arsenic trioxide, Atazanavir, Atenolol, Axitinib, Belinostat, Betamethasone, Bosutinib, Brentuximab vedotin, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carbamazepine, Carfilzomib, Ceritinib, Cerivastatin, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Dihydrotestosterone, Diltiazem, Dipyridamole, Docetaxel, Domperidone, Doxorubicin, Edoxaban, Elbasvir, Eletriptan, Enasidenib, Epinastine, Erlotinib, Estradiol, Estriol, Estrone, Ethinyl Estradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluticasone furoate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ketazolam, Ketoconazole, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Paclitaxel, Panobinostat, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Reserpine, Rifampicin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salicylic acid, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Sorafenib, Sparfloxacin, Sphingosine, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Ulipristal, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Albendazole, Alectinib, Alfentanil, Amantadine, Aminohippuric acid, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Amsacrine, Astemizole, Atazanavir, Atenolol, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Biperiden, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carbamazepine, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorpropamide, Chlorprothixene, Cholesterol, Cilazapril, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Dexamethasone, Dextromethorphan, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Etravirine, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Glycerin, Gramicidin D, Grepafloxacin, Haloperidol, Hydrocortisone, Idelalisib, Imatinib, Imipramine, Indinavir, Indomethacin, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ketamine, Ketoconazole, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomitapide, Loperamide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Maprotiline, Mebendazole, Mefloquine, Megestrol acetate, Meprobamate, Methadone, Metoprolol, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitomycin, Mitoxantrone, Morphine, Naltrexone, Naringenin, Nelfinavir, Neostigmine, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrazepam, Nitrendipine, Omeprazole, P-Nitrophenol, Paclitaxel, Palmitic Acid, Pantoprazole, Paroxetine, Perindopril, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Pravastatin, Prazosin, Prednisone, Probenecid, Progesterone, Promethazine, Propafenone, Propranolol, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Rifampicin, Rilpivirine, Ritonavir, Rolapitant, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Spironolactone, Staurosporine, Sulfinpyrazone, Sumatriptan, Sunitinib, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Trimipramine, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersBetrixaban, Ledipasvir
Interacting GroupInteracting Drugs
Osimertinib is a ATP-binding cassette sub-family G member 2 substrate
1ATP-binding cassette sub-family G member 2 substratesAbemaciclib, Afatinib, Alvocidib, Apixaban, Camptothecin, Carboplatin, Cerivastatin, Cholesterol, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dactinomycin, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Doxorubicin, Enasidenib, Etoposide, Ezetimibe, Fluorouracil, Folic Acid, Gefitinib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Leflunomide, Lenvatinib, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nilotinib, Nitrofurantoin, Ombitasvir, Oxaliplatin, Paclitaxel, Pazopanib, Pibrentasvir, Pitavastatin, Ponatinib, Pravastatin, Prazosin, Riluzole, Riociguat, Rosuvastatin, Safinamide, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sumatriptan, Tamoxifen, Teniposide, Teriflunomide, Testosterone, Topotecan, Velpatasvir, Vemurafenib, Venetoclax, Vincristine, Voxilaprevir, Zidovudine
2ATP-binding cassette sub-family G member 2 inhibitorsAbemaciclib, Afatinib, Alectinib, Buprenorphine, Cabazitaxel, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Daidzin, Dasabuvir, Dasatinib, Dexamethasone, Diethylstilbestrol, Doxorubicin, Dronabinol, Elacridar, Enasidenib, Erlotinib, Estradiol, Estrone, Gefitinib, Genistein, Glecaprevir, Glyburide, Hesperetin, Hydrocortisone, Imatinib, Lansoprazole, Letermovir, Mitoxantrone, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Omeprazole, Pantoprazole, Pibrentasvir, Ponatinib, Pravastatin, Prazosin, Quercetin, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rolapitant, Saquinavir, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Taurocholic Acid, Telmisartan, Topiroxostat, Topotecan, Vandetanib, Velpatasvir, Verapamil, Vismodegib, Voxilaprevir
3ATP-binding cassette sub-family G member 2 Antagonist sZafirlukast
4ATP-binding cassette sub-family G member 2 inducersVenlafaxine
5ATP-binding cassette sub-family G member 2 weak inhibitorsCobimetinib
6ATP-binding cassette sub-family G member 2 transportersLedipasvir