Sodium acetate

Identification

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Name
Sodium acetate
Accession Number
DB09395  (DB09470)
Type
Small Molecule
Groups
Approved, Investigational
Description

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct sodium levels in hyponatremic patients. It can be used also in metabolic acidosis and for urine alkalinization.

Structure
Thumb
Synonyms
  • Acetato de sodio
  • acetic acid, sodium salt
  • Acetic acid, sodium salt (1:1)
  • anhydrous sodium acetate
  • Natriumazetat
  • Sodio acetato
  • Sodium acetate anhydrous
  • Sodium acetate, anhydrous
  • Sodium acetate,anhydrous
External IDs
Fema no. 3024
Product Ingredients
IngredientUNIICASInChI Key
Sodium acetate trihydrate4550K0SC9B6131-90-4AYRVGWHSXIMRAB-UHFFFAOYSA-M
Active Moieties
NameKindUNIICASInChI Key
Acetic acidprodrugQ40Q9N063P64-19-7QTBSBXVTEAMEQO-UHFFFAOYSA-N
Acetateionic569DQM74SC71-50-1QTBSBXVTEAMEQO-UHFFFAOYSA-M
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
16.4% Sodium Acetate Injection, USPSolution16.4 %IntravenousBaxter Laboratories2003-02-132011-05-10Canada
Sodium AcetateInjection, solution, concentrate164 mg/1mLIntravenousHospira, Inc.2005-04-30Not applicableUs
Sodium AcetateInjection, solution, concentrate3.28 g/20mLIntravenousHospira, Inc.2005-03-31Not applicableUs
Sodium Acetate Inj 328mg/ml USPLiquid328 mgIntravenousSabex Inc1988-12-312008-08-07Canada
Sodium Acetate Inj 328mg/ml USPLiquid328 mgIntravenousLyphomed, Division Of Fujisawa Canada Inc.1984-12-311996-09-10Canada
Sodium Acetate Injection, USPSolution328 mgIntravenousFresenius Kabi1996-08-14Not applicableCanada
Sodium Acetate-omegaLiquid328 mgIntravenousOmega Laboratories Ltd1999-05-28Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium AcetateInjection, solution, concentrate4 meq/100mLIntravenousFresenius Kabi USA, LLC2017-10-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
2.5% Travasol Amino Acid Injection With Electrolytes In 10% DextroseSodium acetate (170 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (130.5 mg) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + L-Alanine (520 mg) + L-Arginine (290 mg) + L-Leucine (182.5 mg) + L-Lysine (145 mg) + L-Phenylalanine (140 mg) + L-Threonine (105 mg) + L-Tryptophan (45 mg) + L-Valine (145 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Proline (170 mg) + Serine (125 mg) + Sodium chloride (29.3 mg) + Tyrosine (10 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose ClinimixSodium acetate (170 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (130.5 mg) + Glycine (520 mg) + Histidine (110 mg) + Isoleucine (120 mg) + L-Alanine (520 mg) + L-Arginine (260 mg) + L-Leucine hydrochloride (155 mg) + L-Lysine hydrochloride (145 mg) + Phenylalanine hydrochloride (155 mg) + L-Threonine (105 mg) + L-Tryptophan (45 mg) + L-Valine (115 mg) + Magnesium chloride (25.5 mg) + Methionine (145 mg) + Proline (105 mg) + Sodium chloride (29.3 mg) + Tyrosine (10 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312015-08-05Canada
2.5%travasol Amino Acid InJ.W.eleC.W.25%dexSodium acetate (170 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (130.5 mg) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + L-Alanine (520 mg) + L-Arginine (290 mg) + L-Leucine (182.5 mg) + L-Lysine (145 mg) + L-Phenylalanine (140 mg) + L-Threonine (105 mg) + L-Tryptophan (45 mg) + L-Valine (145 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Proline (170 mg) + Serine (125 mg) + Sodium chloride (29.3 mg) + Tyrosine (10 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada
2.75% Travas. Amino Acid InJ.W.elecw.25%dexSodium acetate (215.5 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (261 mg) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + L-Alanine (570 mg) + L-Arginine (316 mg) + L-Leucine (201 mg) + L-Lysine (159.5 mg) + L-Phenylalanine (154 mg) + L-Threonine (115.5 mg) + L-Tryptophan (49.5 mg) + L-Valine (159.5 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Proline (187 mg) + Serine (137.5 mg) + Sodium chloride (112 mg) + Tyrosine (11 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose QuickmixSodium acetate (215.5 mg) + Dextrose, unspecified form (25 g) + Dipotassium phosphate (261 mg) + Glycine (570 mg) + Histidine (120.5 mg) + Isoleucine (131.5 mg) + L-Alanine (570 mg) + L-Arginine (285 mg) + L-Leucine hydrochloride (170 mg) + L-Lysine hydrochloride (159 mg) + Phenylalanine hydrochloride (170 mg) + L-Threonine (115 mg) + L-Tryptophan (49.5 mg) + L-Valine (126 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Proline (115 mg) + Sodium chloride (112 mg) + Tyrosine (11 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-02-022007-08-02Canada
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose QuickmixSodium acetate (256 mg) + Dextrose, unspecified form (5 g) + Dipotassium phosphate (215.5 mg) + Glycine (570 mg) + Histidine (120.5 mg) + Isoleucine (131.5 mg) + L-Alanine (570 mg) + L-Arginine (285 mg) + L-Leucine hydrochloride (170 mg) + L-Lysine hydrochloride (159 mg) + Phenylalanine hydrochloride (170 mg) + L-Threonine (115 mg) + L-Tryptophan (49.5 mg) + L-Valine (126 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Proline (115 mg) + Sodium chloride (112 mg) + Tyrosine (11 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312007-08-02Canada
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.Sodium acetate (215 mg) + Dextrose, unspecified form (5 g) + Dipotassium phosphate (261 mg) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + L-Alanine (570 mg) + L-Arginine (316 mg) + L-Leucine (201 mg) + L-Lysine (159.5 mg) + L-Phenylalanine (154 mg) + L-Threonine (115.5 mg) + L-Tryptophan (49.5 mg) + L-Valine (159.5 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Proline (187 mg) + Serine (137.5 mg) + Sodium chloride (112 mg) + Tyrosine (11 mg)LiquidIntravenousClintec Nutrition Company1996-12-311999-08-10Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 10% DextroseSodium acetate (297 mg) + Dextrose, unspecified form (10 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Alanine (880 mg) + L-Arginine (489 mg) + L-Leucine (310 mg) + L-Lysine hydrochloride (246.5 mg) + L-Phenylalanine (238 mg) + L-Threonine (178.5 mg) + L-Tryptophan (76.5 mg) + L-Valine (246.5 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Proline (289 mg) + Serine (212.5 mg) + Sodium chloride (77 mg) + Tyrosine (17 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 20% DextroseSodium acetate (297 mg) + Dextrose, unspecified form (20 g) + Dipotassium phosphate (261 mg) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + L-Alanine (880 mg) + L-Arginine (489 mg) + L-Leucine (310 mg) + L-Lysine hydrochloride (246.5 mg) + L-Phenylalanine (238 mg) + L-Threonine (178.5 mg) + L-Tryptophan (76.5 mg) + L-Valine (246.5 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Proline (289 mg) + Serine (212.5 mg) + Sodium chloride (77 mg) + Tyrosine (17 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312007-08-02Canada
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose QuickmixSodium acetate (297 mg) + Dextrose, unspecified form (20 g) + Dipotassium phosphate (261 mg) + Glycine (880 mg) + Histidine (186 mg) + Isoleucine (203 mg) + L-Alanine (880 mg) + L-Arginine (440 mg) + L-Leucine hydrochloride (263 mg) + L-Lysine hydrochloride (246 mg) + Phenylalanine hydrochloride (263 mg) + L-Threonine (178 mg) + L-Tryptophan (76 mg) + L-Valine (195 mg) + Magnesium chloride (51 mg) + Methionine (246 mg) + Proline (178 mg) + Sodium chloride (77 mg) + Tyrosine (17 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1995-12-312007-08-02Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Cytosol Ophthalmics - Balanced Salt SolutionSodium acetate trihydrate (3.90 mg/1mL) + Calcium chloride dihydrate (48 mg/1mL) + Magnesium chloride hexahydrate (30 mg/1mL) + Potassium chloride (75 mg/1mL) + Sodium citrate dihydrate (1.70 mg/1mL) + Sodium chloride (6.40 mg/1mL)SolutionIrrigationBiomet Biologics2010-01-012010-09-04Us
Hyperlyte CRSodium acetate trihydrate (0.68 g/20mL) + Calcium chloride dihydrate (0.37 g/20mL) + Magnesium chloride hexahydrate (0.51 g/20mL) + Potassium acetate (1.96 g/20mL) + Sodium chloride (1.17 g/20mL)Injection, solution, concentrateIntravenousB. Braun Medical Inc.2012-04-12Not applicableUs
NutrilyteSodium acetate trihydrate (135 mg/1mL) + Calcium acetate (22 mg/1mL) + Sodium gluconate (55 mg/1mL) + Magnesium acetate (43 mg/1mL) + Potassium acetate (34.5 mg/1mL) + Potassium chloride (125 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-09-302013-05-08Us
Nutrilyte IISodium acetate trihydrate (64.6 mg/1mL) + Calcium chloride dihydrate (16.55 mg/1mL) + Magnesium chloride hexahydrate (25.5 mg/1mL) + Potassium acetate (98 mg/1mL) + Sodium chloride (74.5 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-10-012014-01-01Us
Nutrilyte IISodium acetate trihydrate (64.6 mg/1mL) + Calcium chloride dihydrate (16.55 mg/1mL) + Magnesium chloride hexahydrate (25.5 mg/1mL) + Potassium acetate (98 mg/1mL) + Sodium chloride (74.5 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-10-012014-01-01Us
Prenatal PlusSodium acetate trihydrate (2000 [iU]/1) + Ascorbic acid (120 mg/1) + Beta carotene (2000 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (22 mg/1) + Ferrous fumarate (27 mg/1) + Folic Acid (1 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (1.84 mg/1) + Zinc oxide (25 mg/1)TabletOralSeton Pharmaceuticals2014-03-072017-01-26Us
Sodium AcetateSodium acetate (164 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-09-302013-03-01Us
Sodum AcetateSodium acetate (328 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-09-30Not applicableUs
Categories
UNII
NVG71ZZ7P0
CAS number
127-09-3
Weight
Average: 82.0338
Monoisotopic: 82.003074015
Chemical Formula
C2H3NaO2
InChI Key
VMHLLURERBWHNL-UHFFFAOYSA-M
InChI
InChI=1S/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
IUPAC Name
sodium acetate
SMILES
[Na+].CC([O-])=O

Pharmacology

Indication

Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Sodium acetate and other bicarbonate precursors are alkalinising agents, and can be used to correct metabolic acidosis, or for alkalinisation of the urine.

Associated Conditions
Associated Therapies
Pharmacodynamics

Sodium is the principal cation of extracellular fluid. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. The sodium ion exerts a primary role in controlling total body water and its distribution. Acetate ions acts as hydrogen ion acceptor which is alternative to bicarbonate.

Mechanism of action

It works as a source of sodium ions especially in cases of hyponatremic patients. Sodium has a primary role in regulating extracellular fluid volume. It controls water distribution, fluid and electrolyte balance and the osmotic pressure of body fluids. Sodium is also involved in nerve conduction, muscle contraction, acid-base balance and cell nutrient uptake.

Absorption

It is readily available in the circulation after IV administration.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

In liver, sodium acetate is being metabolized into bicarbonate. To form bicarbonate, acetate is slowly hydrolyzed to carbon dioxide and water, which are then converted to bicarbonate by the addition of a hydrogen ion.

Route of elimination

Both the sodium and bicarbonate ions are excreted mainly in the urine. Some sodium is excreted in the feces, and small amounts may also be excreted in saliva, sweat, bile and pancreatic secretions.

Half life
Not Available
Clearance
Not Available
Toxicity

LD50: 25956 mg/kg (Rat.)

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcarboseAcarbose may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Sodium acetate which could result in a lower serum level and potentially a reduction in efficacy.
AclidiniumAclidinium may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AcrivastineSodium acetate may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfaSodium acetate may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
AldesleukinAldesleukin may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AllopurinolAllopurinol may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
AllylestrenolAllylestrenol may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
Food Interactions
Not Available

References

General References
  1. wikipedia [Link]
  2. rxlist [Link]
  3. monograph [Link]
External Links
PubChem Compound
517045
PubChem Substance
347827840
ChemSpider
29105
ChEBI
32954
ChEMBL
CHEMBL1354
PharmGKB
PA451369
Wikipedia
Sodium_acetate
ATC Codes
B05XA08 — Sodium acetate
AHFS Codes
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDiagnosticHuman Immunodeficiency Virus (HIV) Infections1
1, 2CompletedOtherGlaucoma1
1, 2RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS)1
2Active Not RecruitingTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
2CompletedPreventionAcute Kidney Injury (AKI)1
2CompletedTreatmentCataracts1
2CompletedTreatmentNeoplasms, Brain1
2CompletedTreatmentRespiratory Distress Syndrome, Adult1
2CompletedTreatmentSymptomatic Focal Vitreomacular Adhesion1
2RecruitingTreatmentAnterior Wall Myocardial Infarction1
2RecruitingTreatmentCancer, Breast1
2RecruitingTreatmentCancer, Breast / Estrogen Receptor Positive Tumor / Her2-Positive Breast Cancer1
2, 3CompletedTreatmentGlaucoma1
3CompletedTreatmentAcidosis, Metabolic / Critical Illness1
3CompletedTreatmentAnaesthesia therapy1
3CompletedTreatmentParents2
3RecruitingTreatmentDelayed Graft Function / End Stage Kidney Disease / Kidney Transplant; Complications1
3RecruitingTreatmentGeneral Surgery / Parenteral Feeding1
3RecruitingTreatmentGeneral Surgery / Parenteral Nutrition1
4CompletedPreventionInflammatory Reaction1
4CompletedTreatmentGlaucoma / Intraocular Pressure1
4RecruitingSupportive CareMalnutrition1
4RecruitingTreatmentHypovolaemia1
4WithdrawnTreatmentClostridium Difficile Infection (CDI)1
Not AvailableCompletedTreatmentCataracts1
Not AvailableRecruitingTreatmentShock / Shock, Septic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionIntravenous16.4 %
SolutionIntraocular
SolutionIrrigation
SolutionOphthalmic
LiquidHemodialysis
SolutionHemodialysis
Injection, solution, concentrateIntravenous
LiquidIntraocular
Injection, emulsionIntravenous
LiquidIntravenous
EmulsionIntravenous
IrrigantIrrigation
Injection, solutionIntravenous
SolutionIntravenous
TabletOral
Injection, solution, concentrateIntravenous164 mg/1mL
Injection, solution, concentrateIntravenous3.28 g/20mL
Injection, solution, concentrateIntravenous4 meq/100mL
SolutionIntravenous328 mg
LiquidIntravenous328 mg
Injection, solution, concentrateIntravenous328 mg/1mL
InjectionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility429.0 mg/mLALOGPS
logP-0.2ALOGPS
logP-0.22ChemAxon
logS0.72ALOGPS
pKa (Strongest Acidic)4.54ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.13 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity23.48 m3·mol-1ChemAxon
Polarizability4.96 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as acetate salts. These are organic compounds containing acetic acid as its acid component.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Acetate salts
Alternative Parents
Monocarboxylic acids and derivatives / Carboxylic acids / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Acetate salt / Organic alkali metal salt / Monocarboxylic acid or derivatives / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic sodium salt / Organic salt / Organooxygen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organic sodium salt (CHEBI:32954)

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Atp binding
Specific Function
Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name
ACSS2
Uniprot ID
Q9NR19
Uniprot Name
Acetyl-coenzyme A synthetase, cytoplasmic
Molecular Weight
78579.11 Da
References
  1. article [Link]

Drug created on November 30, 2015 12:10 / Updated on April 18, 2019 06:15