NAV

Meglumine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Meglumine is an amino sugar found in iodinated contrast media.

Generic Name
Meglumine
DrugBank Accession Number
DB09415
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
3D
Similar Structures
Weight
Average: 195.215
Monoisotopic: 195.110672651
Chemical Formula
C7H17NO5
Synonyms
  • 1-deoxy-1-methylaminosorbitol
  • Iosulamide
  • Meglumina
  • Méglumine
  • Meglumine
  • Megluminum
  • N-methyl-D-glucamine
External IDs
  • NSC-52907
  • NSC-7391
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Methylglucamine hydrochloride2IG86HL9XM35564-86-4PKPZZAVJXDZHDW-LJTMIZJLSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
UROGRAFIN %76 ENJEKSIYON VE INFUZYON ICIN COZELTI, 100 MLMeglumine (660 mg/ml) + Diatrizoate sodium (100 mg/ml)SolutionIntravascularBAYER TÜRK KİMYA SAN. LTD. ŞTİ.1994-03-29Not applicableTurkey flag
UROGRAFIN %76 ENJEKSIYON VE INFUZYON ICIN COZELTI, 50 MLMeglumine (660 mg/ml) + Diatrizoate sodium (100 mg/ml)SolutionIntravascularBAYER TÜRK KİMYA SAN. LTD. ŞTİ.1994-03-29Not applicableTurkey flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Hexoses
Alternative Parents
1,3-aminoalcohols / Secondary alcohols / 1,2-aminoalcohols / Polyols / Dialkylamines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
1,2-aminoalcohol / 1,3-aminoalcohol / Alcohol / Aliphatic acyclic compound / Amine / Hexose monosaccharide / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
secondary amino compound, hexosamine (CHEBI:59732)
Affected organisms
Not Available

Chemical Identifiers

UNII
6HG8UB2MUY
CAS number
6284-40-8
InChI Key
MBBZMMPHUWSWHV-BDVNFPICSA-N
InChI
InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
IUPAC Name
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

References

General References
Not Available
Human Metabolome Database
HMDB0240291
KEGG Drug
D01796
ChemSpider
8249
RxNav
6704
ChEBI
59732
ChEMBL
CHEMBL1200570
ZINC
ZINC000002020259
Wikipedia
Meglumine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedBasic SciencePharmacokinetics1
4CompletedDiagnosticAllergic Reaction1
4CompletedTreatmentIschemic Stroke2
4RecruitingSupportive CareNephrogenic Fibrosing Dermopathy1
3CompletedTreatmentCognitive Dysfunctions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionParenteral
SolutionIntravascular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility240.0 mg/mLALOGPS
logP-2.4ALOGPS
logP-3.4Chemaxon
logS0.09ALOGPS
pKa (Strongest Acidic)12.65Chemaxon
pKa (Strongest Basic)9.11Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count6Chemaxon
Polar Surface Area113.18 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity44.84 m3·mol-1Chemaxon
Polarizability19.66 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9100000000-e892e9e9fcffcbf59eaa
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-03g0-4900000000-ce94dacb039b69990abf
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0ab9-9600000000-f47beba53b552efec686
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-9000000000-f6c793f8db7fab4f7d50
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-377cce2f4ba5ed769dc9
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-052f-9000000000-fd0c48f177bc73593ec3
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-4b8c380a2c659c824335
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-146.6372385
predicted
DarkChem Lite v0.1.0
[M-H]-146.8297385
predicted
DarkChem Lite v0.1.0
[M-H]-146.7461385
predicted
DarkChem Lite v0.1.0
[M-H]-149.42961
predicted
DeepCCS 1.0 (2019)
[M+H]+146.9549385
predicted
DarkChem Lite v0.1.0
[M+H]+147.3735385
predicted
DarkChem Lite v0.1.0
[M+H]+147.0454385
predicted
DarkChem Lite v0.1.0
[M+H]+151.82518
predicted
DeepCCS 1.0 (2019)
[M+Na]+146.6261385
predicted
DarkChem Lite v0.1.0
[M+Na]+147.0320385
predicted
DarkChem Lite v0.1.0
[M+Na]+146.5143385
predicted
DarkChem Lite v0.1.0
[M+Na]+157.7377
predicted
DeepCCS 1.0 (2019)

Drug created at November 30, 2015 19:10 / Updated at May 21, 2021 10:21