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Identification
NameTartaric acid
Accession NumberDB09459
TypeSmall Molecule
GroupsApproved
DescriptionTartaric acid is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes.Tartaric is an alpha-hydroxy-carboxylic acid, is diprotic and aldaric in acid characteristics, and is a dihydroxyl derivative of succinic acid.
Structure
Thumb
SynonymsNot Available
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Baros Effervescent GranulesTyco Healthcare
BicaruvasProsana Distribuciones, S.A. De C.V.
Brioschi Childrens Effervescent AntacidBrioschi, Inc.
Brioschi Effervescent AntacidBrioschi, Inc.
E-Z-gas 2 GranulesTherapex Division De E Z Em Canada Inc
Gingera Effervescent AntacidBrioschi, Inc.
Unik Zoru PwrTherapex Division De E Z Em Canada Inc
Unik Zoru TabTherapex Division De E Z Em Canada Inc
Urasal GranulesAxxess Pharma Inc.
Categories
UNIIW4888I119H
CAS numberNot Available
WeightNot Available
Chemical FormulaNot Available
InChI KeyNot Available
InChINot Available
IUPAC NameNot Available
SMILESNot Available
Pharmacology
IndicationTartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic.
Structured Indications
Pharmacodynamics Tartaric acid is used to generate carbon dioxide through interaction with sodium bicarbonate following oral administration. Carbon dioxide extends the stomach and provides a negative contrast medium during double contrast radiography. In high doses, this agent acts as a muscle toxin by inhibiting the production of malic acid, which could cause paralysis and maybe death.
Mechanism of actionNot Available
Related Articles
AbsorptionOral or parenteral doses of monosodium 14C-L(+)-tartrate (400 mg/kg) are rapidly excreted by rats and a proportion completely metabolized to CO2. The oral dose was well-absorbed.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Most tartarate that is consumed by humans is metabolized by bacteria in the gastrointestinal tract , primarily in the large instestine.

Route of eliminationOnly about 15-20% of consumed tartaric acid is secreted in the urine unchanged.
Half lifeNot Available
ClearanceNot Available
ToxicityRoutes of Entry: Inhalation. Ingestion. Toxicity to Animals: Lowest Published Lethal Dose: LDL [Rat - Route: oral; Dose: 7500 mg/kg LDL [Rabbit] - Route: Oral; Dose: 5000 mg/kg LDL [Dog] - Rout: Oral; Dose: 5000 mg/kg Lethal Dose/Conc 50% kill: LD50 [Mouse] - Route: Intravenous; Dose: 485 mg/kg Other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation Eyes: Causes eye irritation Inhalation: Causes respiratory tract irritation Ingestion: Causes gastrointestinal tract irritation with nausea, vomiting and diarrhea. May affect kidneys (kidney damage), blood, and behavior (convulsions, somnolence), and respiration. Chronic Potential Health Effects: Ingestion: Repeated or prolonged ingestion may cause lesions of the mouth, gastric ulcers, gastrointestinal hyperacidity, and symptoms similar to those of metal fume fever - flu-like condition with fever, chills, sweats, nausea, vomiting, muscle aches, pains, and weakness. Skin: Repeated or prolonged skin contact may cause skin ulcerations or lesions.
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Chasseaud LF, Down WH, Kirkpatrick D: Absorption and biotransformation of L(+)-tartaric acid in rats. Experientia. 1977 Aug 15;33(8):998-9. [PubMed:891842 ]
  2. Pubchem [Link]
  3. Wikipedia [Link]
External LinksNot Available
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials Not Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Powder, for solutionOral
Granule, effervescentOral
PowderOral
TabletOral
PricesNot Available
PatentsNot Available
Properties
StateNot Available
Experimental PropertiesNot Available
Predicted PropertiesNot Available
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Taxonomy
ClassificationNot classified

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
catalytic activity
General Function:
Udp-galactose:beta-n-acetylglucosamine beta-1,3-galactosyltransferase activity
Specific Function:
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activit...
Gene Name:
B3GAT1
Uniprot ID:
Q9P2W7
Molecular Weight:
38255.675 Da
References
  1. UniProt [Link]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
catalytic activity
General Function:
Zinc ion binding
Specific Function:
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specif...
Gene Name:
HIF1AN
Uniprot ID:
Q9NWT6
Molecular Weight:
40285.25 Da
References
  1. UniProt [Link]
  2. HMDB [Link]
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Drug created on November 30, 2015 12:10 / Updated on March 13, 2017 20:50