Rubidium chloride Rb-82

Identification

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Name
Rubidium Rb-82
Commonly known or available as Rubidium chloride Rb-82
Accession Number
DB09479
Type
Small Molecule
Groups
Approved, Investigational
Description

Rubidium chloride Rb-82 injection is a sterile nonpyrogenic solutions of rubidium Rb 82 chloride. It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.

Structure
Thumb
Synonyms
  • Rubidium (82Rb) cation
  • Rubidium cation Rb-82
  • Rubidium Rb-82 cation
Product Ingredients
IngredientUNIICASInChI Key
Rubidium chloride Rb-82F0Z746KRKQ132486-03-4FGDZQCVHDSGLHJ-RYDPDVNUSA-M
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CardioGen-82Injection, solution150 mCi/1IntravenousBracco Diagnostics Inc1989-12-30Not applicableUs
Ruby-fillInjection, solution100 mCi/1IntravenousJubilant Draximage Inc.2016-09-30Not applicableUs
Ruby-fillInjection, solution100 mCi/1IntravenousJubilant Draximage Inc.2016-09-30Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Categories
UNII
550Z839889
CAS number
Not Available
Weight
Average: 81.9177
Monoisotopic: 81.917659111
Chemical Formula
Rb
InChI Key
NCCSSGKUIKYAJD-OIOBTWANSA-N
InChI
InChI=1S/Rb/q+1/i1-3
IUPAC Name
(82Rb)rubidium(1+) ion
SMILES
[82Rb+]

Pharmacology

Indication

Rubidium Rb 82 chloride injection is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.

Associated Conditions
Pharmacodynamics

In human studies, myocardial activity was noted within the first minute after peripheral intravenous injection of Rb-82. When areas of infarction or ischemia are present in the myocardium, they are visualized within 2-7 minutes after injection as photon-deficient, or “cold”, areas on the myocardial scan. In patients with reduced cardiac function, transit of the injected dose from the peripheral infusion site to the myocardium may be delayed Blood flow brings Rb-82 to all areas of the body during the first pass of circulation. Accordingly, visible uptake is also observed in other highly vascularized organs, such as the kidneys, liver, spleen and lungs.

Mechanism of action

Rb-82 is analogous to potassium ion (K+) in its biochemical behavior and is rapidly extracted by the myocardium proportional to the blood flow. Rb+ participates in the sodium-potassium (Na+/K+) ion exchange pumps that are present in cell membranes. The intracellular uptake of Rb-82 requires maintenance of ionic gradient across cell membranes. Rb-82 radioactivity is increased in viable myocardium reflecting intracellular retention, while the tracer is cleared rapidly from necrotic or infarcted tissue.

Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Rubidium is rapidly extracted from the blood and is taken up by the myocardium in relation to myocardial perfusion, which requires energy for myocardial uptake through Na+/K+-ATPase

Route of elimination

It is rapidly extracted by the myocardium proportional to blood flow.

Half life

1.27 minutes

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Hasbak P, Enevoldsen LH, Fosbol MO, Skovgaard D, Knigge UP, Kjaer A: Rubidium-82 uptake in metastases from neuroendocrine tumors: No flow response to adenosine. J Nucl Cardiol. 2016 Aug;23(4):840-2. doi: 10.1007/s12350-015-0251-z. Epub 2015 Sep 10. [PubMed:26358083]
  2. LOVE WD, BURCH GE: A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro. J Lab Clin Med. 1953 Mar;41(3):351-62. [PubMed:13035272]
  3. Drug Information [Link]
  4. Daily med [Link]
External Links
PubChem Compound
71357
PubChem Substance
347827860
ChemSpider
8351588
ChEMBL
CHEMBL1200727

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedDiagnosticCoronary Artery Disease1
Not AvailableCompletedNot AvailableNuclear radiation emergency2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Injection, solutionIntravenous150 mCi/1
Injection, solutionIntravenous100 mCi/1
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Carriers

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Transporter activity
Specific Function
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Gene Name
FXYD2
Uniprot ID
P54710
Uniprot Name
Sodium/potassium-transporting ATPase subunit gamma
Molecular Weight
7283.265 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Sodium:potassium-exchanging atpase activity
Specific Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulat...
Gene Name
ATP1B1
Uniprot ID
P05026
Uniprot Name
Sodium/potassium-transporting ATPase subunit beta-1
Molecular Weight
35061.07 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Sodium:potassium-exchanging atpase activity
Specific Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of th...
Gene Name
ATP1B2
Uniprot ID
P14415
Uniprot Name
Sodium/potassium-transporting ATPase subunit beta-2
Molecular Weight
33366.925 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Sodium:potassium-exchanging atpase activity
Specific Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of th...
Gene Name
ATP1B3
Uniprot ID
P54709
Uniprot Name
Sodium/potassium-transporting ATPase subunit beta-3
Molecular Weight
31512.34 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Sodium:potassium-exchanging atpase activity
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A4
Uniprot ID
Q13733
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-4
Molecular Weight
114165.44 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A2
Uniprot ID
P50993
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-2
Molecular Weight
112264.385 Da
References
  1. Drug Information [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A3
Uniprot ID
P13637
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-3
Molecular Weight
111747.51 Da
References
  1. Drug Information [Link]

Drug created on November 30, 2015 12:10 / Updated on August 02, 2019 08:44