Sodium fluorophosphate

Identification

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Name
Sodium fluorophosphate
Accession Number
DB09484
Type
Small Molecule
Groups
Approved
Description

Sodium monofluorophosphate is used in OTC dental preparations to help protect against cavities.

Structure
Thumb
Synonyms
  • Disodium phosphorofluoridate
  • Phosphorofluoridic acid, disodium salt
  • Sodium monofluorophosphate
Active Moieties
NameKindUNIICASInChI Key
Monofluorophosphate ionionic4964UZ79MI15181-43-8DWYMPOCYEZONEA-UHFFFAOYSA-L
Fluoride ionionicQ80VPU408O16984-48-8KRHYYFGTRYWZRS-UHFFFAOYSA-M
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
10g Colgate plus Toothbrush Kit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUs
10g Colgate plus Toothbrush plus Floss Kit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUs
365 Everyday Value Cavity Fighting and WhiteningPaste, dentifrice0.76 g/100gDentalWhole Foods Market, Inc.2019-03-06Not applicableUs
365 Everyday Value Kids FlouridePaste, dentifrice0.76 g/100gDentalWhole Foods Market, Inc.2019-03-06Not applicableUs
5g Colgate plus Toothbrush KitKit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUs
5g Colgate plus Toothbrush plus Floss Kit7.6 mg/1gDentalColgate-Palmolive (Thailand) Limited - Branch2018-06-07Not applicableUs
AdoptaPlatoonPaste0.76 g/100gDentalHUAIAN ZONGHENG BIO-TECH CO., LTD2016-07-10Not applicableUs
Advanced Fluoride AnticavityPaste, dentifrice0.76 g/100gDentalPersonal Care Products2011-01-24Not applicableUs
Advanced Fluoride AnticavityPaste, dentifrice1000 mg/181gDentalPersonal Care Products2017-07-24Not applicableUs
Advanced Whitening Anticavity FluoridePaste, dentifrice0.76 g/100gDentalPersonal Care Products2011-01-24Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
28tak Clair ToothSodium fluorophosphate (0.13 g/60g) + Silicon dioxide (4.8 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUs
ATOMY PROPOLIS 200gSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.20 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2015-02-01Not applicableUs
ATOMY PROPOLIS 50gSodium fluorophosphate (0.08 g/41) + Sodium fluoride (0.05 g/41)Paste, dentifriceOralAtomy Co., Ltd.2015-02-01Not applicableUs
Atomy Propolis Toothpas Te 200gSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.2 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2019-11-25Not applicableUs
ATOMY PROPOLIS TOOTHPAS TE 200gSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.20 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2016-08-01Not applicableUs
Atomy Propolis Toothpas Te 50gSodium fluorophosphate (0.08 g/50g) + Sodium fluoride (0.05 g/50g)Paste, dentifriceOralAtomy Co., Ltd.2019-12-01Not applicableUs
ATOMY PROPOLIS TOOTHPAS TE 50gSodium fluorophosphate (0.08 g/50g) + Sodium fluoride (0.05 g/50g)Paste, dentifriceOralAtomy Co., Ltd.2016-08-01Not applicableUs
Atomy ToothpasteSodium fluorophosphate (0.32 g/200g) + Sodium fluoride (0.2 g/200g)Paste, dentifriceDentalAtomy Co., Ltd.2010-05-25Not applicableUs
BIOTENE SensitiveSodium fluorophosphate (1 mg/1g) + Potassium nitrate (19.3 mg/1g)PasteDentalGlaxo Smith Kline Consumer Heathcare Lp2011-04-152013-01-31Us
BlanX Advanced WhiteningSodium fluorophosphate (0.4 g/100g) + Sodium fluoride (0.08 g/100g)PasteOralCoswell Spa2017-04-26Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
28tak Clair ToothSodium fluorophosphate (0.13 g/60g) + Silicon dioxide (4.8 g/60g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUs
Black Is WhiteSodium fluorophosphate (.095 mg/1mg)Gel, dentifriceDentalCuraden Ag2017-01-29Not applicableUs
Chunzam Silk Amino Acid ToothSodium fluorophosphate (0.33 g/100g) + Silicon dioxide (4 g/100g) + alpha-Tocopherol acetate (0.1 g/100g)Paste, dentifriceDentalChunzam Bio Co Ltd2016-11-11Not applicableUs
Colgate Cavity Protection Great Regular FlavorSodium fluorophosphate (11.4 mg/1g)PasteDentalColgate Oral Pharmaceuticals2012-02-03Not applicableUs
Dr.EL BERRYGOOD TOOTHSodium fluorophosphate (0.38 g/100g) + Silicic acid (10 g/100g) + Silicon dioxide (5 g/100g) + alpha-Tocopherol acetate (0.09 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUs
Dr.EL CHARCOR PARTY TOOTHSodium fluorophosphate (0.38 g/100g) + Silicic acid (10 g/100g) + Silicon dioxide (5 g/100g) + alpha-Tocopherol acetate (0.09 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUs
Dr.EL CLAIR TOOTHSodium fluorophosphate (0.22 g/100g) + Silicon dioxide (8 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUs
Dr.EL ORTHO CARE TOOTHSodium fluorophosphate (0.5 g/100g) + Silicon dioxide (15 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUs
DR.EL Very Good ToothSodium fluorophosphate (0.38 g/100g) + Silicic acid (10 g/100g) + Silicon dioxide (5 g/100g) + alpha-Tocopherol acetate (0.09 g/100g)Paste, dentifriceDentalDr. EL CO., LTD.2019-08-01Not applicableUs
K-MOM Kids ToothSodium fluorophosphate (0.35 g/100g) + Silicon dioxide (2 g/100g)Paste, dentifriceDentalMOTHER-K CO.,LTD2019-10-01Not applicableUs
Categories
UNII
C810JCZ56Q
CAS number
10163-15-2
Weight
Average: 143.949
Monoisotopic: 143.93644758
Chemical Formula
FNa2O3P
InChI Key
BFDWBSRJQZPEEB-UHFFFAOYSA-L
InChI
InChI=1S/FH2O3P.2Na/c1-5(2,3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
IUPAC Name
disodium phosphorofluoridate
SMILES
[Na+].[Na+].[O-]P([O-])(F)=O

Pharmacology

Indication

Sodium monofluorophosphate is indicated for the treatment of cavities

Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

LD50 Oral: rat-502 -638 mg/kg LC50 Inhalation: rat-male and female-4 h-> 2,1 mg/l

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium fluorophosphate.
AclidiniumThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium fluorophosphate is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Almasilate.
AloglutamolThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Aloglutamol.
AlphacetylmethadolThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Alphaprodine.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

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Food Interactions
Not Available

References

General References
  1. Safety Data Sheet [Link]
  2. Drug information [Link]
External Links
KEGG Drug
D05864
PubChem Substance
347910454
ChemSpider
22686
ChEBI
86431
ChEMBL
CHEMBL1908359
Wikipedia
Sodium_monofluorophosphate
ATC Codes
A12CD02 — Sodium monofluorophosphateA01AA02 — Sodium monofluorophosphate
AHFS Codes
  • 34:00.00 — Dental Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedPreventionVentilator-Associated Pneumonia (VAP)1
0Not Yet RecruitingTreatmentDementias / Swallowing Disorders1
2CompletedTreatmentDentinal Hypersensitivity1
2CompletedTreatmentDentine Hypersensitivity1
3CompletedTreatmentCaries1
3CompletedTreatmentDental Plaque1
3CompletedTreatmentDental Plaque / Gingival Inflammation1
3CompletedTreatmentDentin Sensitivity1
3CompletedTreatmentDentine Hypersensitivity5
3CompletedTreatmentGingival Diseases1
3CompletedTreatmentGingival Inflammation1
3CompletedTreatmentSalivary Bacteria Levels1
3RecruitingTreatmentDentin Sensitivity1
3TerminatedPreventionOral Mucositis1
4CompletedPreventionDental Prophylaxis and Implant Surgery1
4CompletedTreatmentGingival Inflammation2
4CompletedTreatmentNeoplasms, Head and Neck1
4Not Yet RecruitingTreatmentCompliance / Dry Mouth / Urinary Bladder, Overactive1
Not AvailableCompletedTreatmentDentinal Sensitivity / Hypersensitivity1
Not AvailableCompletedTreatmentGingival Inflammation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Paste, dentifriceDental1000 mg/181g
Paste, dentifriceOral0.98 g/130g
Paste, dentifriceDental0.76 g/100g
PasteTopical0.22 g/100g
Paste, dentifriceOral1 mg/1g
PowderDental0.76 g/100g
Powder, dentifriceOral0.4332 g/57g
PasteDental0.76 g/1g
PowderDental0.1 g/100g
KitDental7.6 mg/1g
Paste, dentifriceOral0.016 g/160g
Paste, dentifriceDental1460 mg/200g
PasteDental8.6 mg/1g
Paste, dentifriceDental1380 mg/200g
PasteDental1.10 mg/1g
PasteDental1.5 mg/1g
Paste, dentifriceTopical
Paste, dentifriceOral0.1 g/100g
PasteOral
Paste, dentifriceOral
Paste, dentifriceDental
Paste, dentifriceOral100 mg/100g
Paste, dentifriceDental0.15 g/100g
PasteOral0.76 mg/1g
PasteOral1.4 mg/1g
GelOral0.76 mg/1g
Gel, dentifriceDental.095 mg/1mg
PasteOral0.82 g/100g
PasteOral0.4 g/100g
Paste, dentifriceOral0.066 g/100g
Paste, dentifriceDental0.0076 g/1g
Paste, dentifriceOral0.13 g/100g
PasteDental11.4 mg/1g
Paste; paste, dentifriceDental
Paste, dentifriceDental1 mg/1g
Paste, dentifriceDental1.5 mg/1g
Paste, dentifriceDental1.1 mg/1g
Paste, dentifriceDental11.4 mg/1g
Gel, dentifriceDental1 mg/1g
Paste, dentifriceDental1.0 mg/1g
Paste, dentifriceDental7.6 mg/1g
Paste, dentifriceDental60 mg/120g
SpongeOral0.05 g/100mL
PasteDental0.76 g/3g
Paste, dentifriceDental0.76 %
Paste, dentifriceDental0.76 mL/100mL
PasteDental0.208 g/160g
PasteDental0.156 g/120g
Paste, dentifriceDental172 mg/25g
Kit7.6 mg/1g
Paste, dentifriceDental8 mg/1g
Paste, dentifriceOral
PasteDental0.15 g/100g
Paste, dentifriceDental076 g/100g
Paste, dentifriceDental0.379 g/100g
Paste, dentifriceDental0.7581 g/100g
Paste, dentifriceDental0.758 g/100g
Paste, dentifriceDental0.5 g/100g
Paste, dentifriceDental1.2 g/200g
PasteOral0.912 g/120g
PasteDental1.4 g/200g
Paste, dentifriceOral0.91 g/120g
Paste, dentifriceOral0.76 g/100g
Paste, dentifriceTopical0.76 g/100g
Paste, dentifriceTopical1.02 g/135g
PasteDental0.76 g/100g
PasteTopical0.75 g/1g
Paste, dentifriceDental0.8 g/100g
Paste, dentifriceDental0.85 mg/1g
PasteDental76 mg/1g
Paste, dentifriceDental0.84 g/100g
Paste, dentifriceOral.76 g/100g
Paste, dentifriceDental0.6 g/100g
Gel, dentifriceDental0.14 g/100g
PasteDental0.1 g/100g
GelOral0.76 g/100g
Gel, dentifriceDental0.76 g/100g
GelDental
PasteDental76 g/100g
Paste, dentifriceOral1.3 mg/1g
Gel, dentifriceOral1.3 mg/1g
Gel, dentifriceOral7.6 mg/1g
Paste, dentifriceDental.0076 g/1g
Gel, dentifriceOral0.88 g/100g
PasteDental0.88 g/100g
PasteDental
Paste, dentifriceBuccal
Paste, dentifriceDental2.43 mg/1g
Paste, dentifriceDental0.10 g/100g
KitDental
Gel, dentifriceDental8.4 mg/1g
Paste, dentifriceDental0.45 g/100g
PasteOral1 mg/1g
PasteOral7.6 mg/1g
PasteOral76 mg/1g
Paste, dentifriceDental0.83 g/100g
PasteOral
PasteDental8.4 mg/1g
PasteDental0.228 g/120g
GelDental0.4 g/30g
Paste, dentifriceDental0.15 g/150g
Paste, dentifriceDental1452 mg/220g
Kit
Paste, dentifriceDental0.18 g/180g
PasteDental0.36 g/60g
GelDental0.36 g/60g
PasteDental1.4 mg/1g
PasteDental0.4 g/100g
PasteDental0.8 g/100g
PasteTopical0.74 g/100g
Paste, dentifriceDental
SuspensionDental
PasteDental
Paste, dentifriceDental1.3 mg/1mL
Gel, dentifriceOral0.83 g/100g
Paste, dentifriceOral1.14 g/100g
Paste, dentifriceOral0.83 g/100g
PasteOral0.884 g/100g
PasteDental0.884 g/100g
Paste, dentifriceTopical0.29 g/40g
Paste, dentifriceTopical0.31 g/90g
Paste, dentifriceOral0.31 g/90g
Gel, dentifriceDental0.88 g/100g
PasteDental7.6 mg/1g
Paste, dentifriceOral88.4 mg/1g
Paste, dentifriceOral1.5 mg/1g
KitTopical
Paste, dentifriceDental1.026 g/133g
Paste, dentifriceDental1.079 g/133g
Paste, dentifriceDental10.21 g/96.4g
Paste, dentifriceDental64 mg/8g
Paste, dentifriceDental0.1 g/100g
Paste, dentifriceTopical7.6 mg/1g
Paste, dentifriceDental; Oral1.4 mg/1g
LiquidDental0.4 g/100g
Paste, dentifriceDental1.4 mg/1g
Paste, dentifriceDental0.4 g/100g
Paste, dentifriceDental0.833 mg/1g
Kit0.13 g/100g
Paste, dentifriceOral0.74 g/100g
Paste, dentifriceDental1.125 g/150g
CreamDental76 mg/181g
Paste, dentifriceDental0.0014 g/1g
Paste, dentifriceDental0.00243 g/1g
Paste, dentifriceDental11.5 mg/1g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.54ChemAxon
pKa (Strongest Acidic)0.1ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.35 m3·mol-1ChemAxon
Polarizability4.59 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on December 12, 2019 07:27