Indium In-111 chloride

Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates
Name
Indium In-111 chloride
Accession Number
DB09490
Type
Small Molecule
Groups
Approved
Description

Indium In-111 Chloride is a diagnostic radiopharmaceutical agent intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. It is supplied as a sterile, pyrogen-free solution of Indium ("'In) Chloride in O.04M HCI.

Structure
Thumb
Synonyms
  • 111indium trichloride
  • Indium chloride (111incl3)
  • Indium chloride In-111
  • Indium In 111 chloride
  • Indium In 111m chloride
  • Indium In-111m chloride
  • Indium-111 chloride
Active Moieties
NameKindUNIICASInChI Key
Indium cation In-111ionicWJZ06C0H8L131391-70-3RJMMFJHMVBOLGY-AHCXROLUSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IndiclorSolution5 mCi/0.5mLIntravenousMedi Physics Inc.1992-12-29Not applicableUs
Indium In 111 ChlorideSolution10 mCi/1mLIntravenousMallinckrodt2007-12-072017-07-01Us
Indium In 111 ChlorideSolution10 mCi/1mLIntravenousCurium US LLC2007-12-07Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
OctreoscanIndium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL)IntravenousCurium US LLC2015-10-14Not applicableUs
OctreoscanIndium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL)KitIntravenousMallinckrodt2007-05-012017-07-01Us
Categories
UNII
58TD96H03I
CAS number
50800-85-6
Weight
Average: 217.26
Monoisotopic: 215.8116688
Chemical Formula
Cl3In
InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K
InChI
InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
IUPAC Name
trichloro(¹¹¹In)indigane
SMILES
Cl[111In](Cl)Cl

Pharmacology

Indication

Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure

Pharmacodynamics

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone

Mechanism of action

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

Learn more
Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

Learn more
Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

Learn more
Absorption

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone

Volume of distribution

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone

Protein binding

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its protein binding is related to the final product and not specific to Indium In-111 Chloride alone

Metabolism

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone

Route of elimination

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone

Half life

2.8 days

Clearance

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone

Toxicity

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its toxicity is related to the final product and not specific to Indium In-111 Chloride alone

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. FDA label [Link]
External Links
PubChem Compound
49800058
PubChem Substance
347827862
ChemSpider
4954694
RxNav
42987

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2TerminatedDiagnosticGastroenteropancreatic Neuroendocrine Tumors1
4TerminatedDiagnosticTumors, Solid1
Not AvailableCompletedDiagnosticSarcoidosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionIntravenous5 mCi/0.5mL
SolutionIntravenous10 mCi/1mL
KitIntravenous
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6123916No2000-09-262017-09-26Us
US5776894No1998-07-072015-07-07Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility27.4 mg/mLALOGPS
logP1.69ALOGPS
logP1.9ChemAxon
logS-0.91ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity18.41 m3·mol-1ChemAxon
Polarizability9.87 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on February 06, 2020 13:01