Indium In-111 chloride

Identification

Name
Indium In-111 chloride
Accession Number
DB09490
Type
Small Molecule
Groups
Approved
Description

Indium In-111 Chloride is a diagnosticradiopharmaceutical intended for radiolabeling OncoScint(satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. It is supplied as a sterile, pyrogen-free solution of Indium ("'In) Chloride in O.04M HCI.

Structure
Thumb
Synonyms
  • 111indium trichloride
  • Indium chloride (111incl3)
  • Indium chloride In-111
  • Indium In 111 chloride
  • Indium In 111m chloride
  • Indium In-111m chloride
  • Indium-111 chloride
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IndiclorSolution5 mCi/.5mLIntravenousMedi Physics Inc.1992-12-29Not applicableUs
Indium In 111 ChlorideSolution10 mCi/mLIntravenousMallinckrodt2007-12-072017-07-01Us
Indium In 111 ChlorideSolution10 mCi/mLIntravenousMallinckrodt Nuclear Medicine Llc2007-12-07Not applicableUs
Categories
Not Available
UNII
58TD96H03I
CAS number
50800-85-6
Weight
Average: 217.26
Monoisotopic: 215.8116688
Chemical Formula
Cl3In
InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K
InChI
InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
IUPAC Name
trichloro(¹¹¹In)indigane
SMILES
Cl[111In](Cl)Cl

Pharmacology

Indication

Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure

Structured Indications
Not Available
Pharmacodynamics

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone

Mechanism of action

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone

Absorption

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone

Volume of distribution

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone

Protein binding

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its protein binding is related to the final product and not specific to Indium In-111 Chloride alone

Metabolism

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone

Route of elimination

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone

Half life

2.8 days

Clearance

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone

Toxicity

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its toxicity is related to the final product and not specific to Indium In-111 Chloride alone

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. FDA label [Link]
External Links
PubChem Compound
49800058
PubChem Substance
347827862
ChemSpider
4954694

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionIntravenous5 mCi/.5mL
SolutionIntravenous10 mCi/mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility27.4 mg/mLALOGPS
logP1.69ALOGPS
logP1.9ChemAxon
logS-0.91ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity18.41 m3·mol-1ChemAxon
Polarizability9.87 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on December 01, 2017 16:16