Talc

Identification

Name
Talc
Accession Number
DB09511
Type
Small Molecule
Groups
Approved
Description

Talc is a mineral composed primarily of magnesium, silicon and oxygen. It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders. Talc helps absorb moisture, freshen materials, and reduce friction to prevent rashes.

Although talc has been widely used for decades, lawsuits that have come to the surface claim serious health complications linked to its use. In fact, recent studies have reported that talc increases the risk of ovarian and endometrial cancers by approximately 30 percent.

Synonyms
  • Talco
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SclerosolAerosol, powder4 g/25.0gIntrapleuralBryan Corporation2013-06-30Not applicableUs
Sterile TalcPowder5 g/100mLIntrapleuralBryan Corporation2003-12-15Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BabyPowder100 g/100gTopicalWalgreen2014-07-17Not applicableUs
Budpak BabyPowder0.9 g/1gTopicalBudpak Inc.2014-07-072015-12-18Us
Dusting PowderPowder99 g/100gTopicalViny Health and Beauty Products Inc2012-02-012017-10-26Us
Health Smart BabyPowder1 g/1gTopicalHome Smart Products2012-12-19Not applicableUs
Natures Choice BabyPowder99 g/100gTopicalUnipack2016-06-07Not applicableUs
Pan Aromas BabyPowder1 g/1gTopicalPan Aromas Llc2012-12-19Not applicableUs
Sof Skin Baby PowderPowder1 g/1gTopicalViny Health and Beauty Products Inc2007-03-272017-10-17Us
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AHC Premium Intense Contour BalmTalc (2.05 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Titanium dioxide (3.96 g/50mL) + Zinc oxide (0.96 g/50mL)CreamTopicalCarver Korea Co.,Ltd.2014-01-152017-11-22Us
CaldeseneTalc (57.51 g/71g) + Zinc oxide (10.65 g/71g)PowderTopicalInsight Pharmaceuticals2009-07-092017-08-31Us
Careline Perfect Care BBTalc (2.5 g/100g) + Allantoin (0.2 g/100g) + Caffeine (0.2 g/100g) + Octinoxate (4 g/100g) + Titanium dioxide (2.5 g/100g)CreamTopicalCosmopharm Ltd.2015-09-172019-09-01Us
Careline Perfect Care BBTalc (2.5 g/100g) + Allantoin (0.2 g/100g) + Caffeine (0.2 g/100g) + Octinoxate (4 g/100g) + Titanium dioxide (5 g/100g)CreamTopicalCosmopharm Ltd.2015-09-172019-09-01Us
Face It Hd Perfect Bb Spf30 Pa 01Talc (0.684 mL/100mL) + Glycine betaine (2 mL/100mL) + Octinoxate (6 mL/100mL) + Titanium dioxide (6.36 mL/100mL) + Zinc oxide (2.88 mL/100mL)CreamTopicalThefaceshop Co., Ltd.2011-08-23Not applicableUs
Face It Hd Perfect Bb Spf30 Pa 02Talc (0.684 mL/100mL) + Glycine betaine (2 mL/100mL) + Octinoxate (6 mL/100mL) + Titanium dioxide (6.36 mL/100mL) + Zinc oxide (2.88 mL/100mL)CreamTopicalThefaceshop Co., Ltd.2011-08-23Not applicableUs
Foot and Body PowderTalc (90.8 kg) + Zinc undecylenate (908 g)PowderTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada
Foot Spray With PowderTalc (18 %) + Undecylenic acid (.35 %)AerosolTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada
Fresh Scent Protective PowderTalc (115 g/142g) + Zinc oxide (21.3 g/142g)PowderTopicalCVS Health2017-01-11Not applicableUs
Fresh Scent Protective PowderTalc (115 g/142g) + Zinc oxide (21.3 g/142g)PowderTopicalDavion, Inc.2016-09-01Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AHC Premium Intense Contour BalmTalc (2.05 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Titanium dioxide (3.96 g/50mL) + Zinc oxide (0.96 g/50mL)CreamTopicalCarver Korea Co.,Ltd.2014-01-152017-11-22Us
Categories
UNII
7SEV7J4R1U
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Indicated to prevent recurrence of malignant pleural effusions in symptomatic patients during thoracoscopy or open thoracotomy.

Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action

It has very good absorptive properties.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Intended for local use only.

Volume of distribution

Intended for local use only.

Protein binding

Intended for local use only.

Metabolism

Intended for local use only.

Route of elimination

Intended for local use only.

Half life

Intended for local use only.

Clearance

Intended for local use only.

Toxicity

LC50: Not available.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1alpha-Hydroxyvitamin D5The serum concentration of Talc can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2The serum concentration of Talc can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
AlfacalcidolThe serum concentration of Talc can be increased when it is combined with Alfacalcidol.
BecocalcidiolThe serum concentration of Talc can be increased when it is combined with Becocalcidiol.
CalcifediolThe serum concentration of Talc can be increased when it is combined with Calcifediol.
CalcitriolThe serum concentration of Talc can be increased when it is combined with Calcitriol.
CholecalciferolThe serum concentration of Talc can be increased when it is combined with Cholecalciferol.
CinoxacinTalc can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
CiprofloxacinTalc can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
DeferiproneTalc can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
  1. MSDS [Link]
  2. product info [Link]
External Links
PubChem Substance
347910456
RxNav
10323
Wikipedia
Talc

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Enrolling by InvitationTreatmentSecondary Pneumothorax1
2Unknown StatusTreatmentKnee Osteoarthritis (Knee OA) / Osteoarthritis, Hip1
3CompletedSupportive CareMetastatic Cancers1
3CompletedTreatmentMalignant Pleural Effusions1
Not AvailableCompletedNot AvailablePleuritis1
Not AvailableRecruitingTreatmentMalignant Pleural Effusions / Pleural Diseases / Pleural Effusions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
PowderTopical100 g/100g
PowderTopical0.9 g/1g
CreamTopical
AerosolTopical
PowderTopical1 g/1g
PowderTopical99 g/100g
PowderTopical
Aerosol, powderIntrapleural4 g/25.0g
PowderIntrapleural5 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on March 01, 2020 20:37

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