Talc

Identification

Name
Talc
Accession Number
DB09511
Type
Small Molecule
Groups
Approved
Description

Talc is a mineral composed primarily of magnesium, silicon and oxygen. It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders. Talc helps absorb moisture, freshen materials, and reduce friction to prevent rashes.

Although talc has been widely used for decades, lawsuits that have come to the surface claim serious health complications linked to its use. In fact, recent studies have reported that talc increases the risk of ovarian and endometrial cancers by approximately 30 percent.

Synonyms
Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SclerosolAerosol, powder4 g/25.0gIntrapleuralBryan Corporation2013-06-30Not applicableUs
Sterile TalcPowder5 g/100mLIntrapleuralBryan Corporation2003-12-15Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BabyPowder100 g/100gTopicalWalgreen2014-07-17Not applicableUs
Budpak BabyPowder0.9 g/1gTopicalBudpak Inc.2014-07-072015-12-18Us
Dusting PowderPowder99 g/100gTopicalViny Health and Beauty Products Inc2012-02-012017-10-26Us
Health Smart BabyPowder1 g/1gTopicalHome Smart Products2012-12-19Not applicableUs
Natures Choice BabyPowder99 g/100gTopicalUnipack2016-06-07Not applicableUs
Pan Aromas BabyPowder1 g/1gTopicalPan Aromas Llc2012-12-19Not applicableUs
Sof Skin Baby PowderPowder1 g/1gTopicalViny Health and Beauty Products Inc2007-03-272017-10-17Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CaldeseneTalc (57.51 g/71g) + Zinc oxide (10.65 g/71g)PowderTopicalInsight Pharmaceuticals2009-07-092017-08-31Us
Careline Perfect Care BBTalc (2.5 g/100g) + Allantoin (0.2 g/100g) + Caffeine (0.2 g/100g) + Octinoxate (4 g/100g) + Titanium dioxide (5 g/100g)CreamTopicalCosmopharm Ltd.2015-09-17Not applicableUs
Careline Perfect Care BBTalc (2.5 g/100g) + Allantoin (0.2 g/100g) + Caffeine (0.2 g/100g) + Octinoxate (4 g/100g) + Titanium dioxide (2.5 g/100g)CreamTopicalCosmopharm Ltd.2015-09-17Not applicableUs
Face It Hd Perfect Bb Spf30 Pa 01Talc (0.684 mL/100mL) + Glycine betaine (2 mL/100mL) + Octinoxate (6 mL/100mL) + Titanium dioxide (6.36 mL/100mL) + Zinc oxide (2.88 mL/100mL)CreamTopicalThefaceshop Co., Ltd.2011-08-23Not applicableUs
Face It Hd Perfect Bb Spf30 Pa 02Talc (0.684 mL/100mL) + Glycine betaine (2 mL/100mL) + Octinoxate (6 mL/100mL) + Titanium dioxide (6.36 mL/100mL) + Zinc oxide (2.88 mL/100mL)CreamTopicalThefaceshop Co., Ltd.2011-08-23Not applicableUs
Foot and Body PowderTalc (90.8 kg) + Zinc undecylenate (908 g)PowderTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada
Foot Spray With PowderTalc (18 %) + Undecylenic acid (.35 %)AerosolTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada
Fresh Scent Protective PowderTalc (115 g/142g) + Zinc oxide (21.3 g/142g)PowderTopicalCVS Health2017-01-11Not applicableUs
Fresh Scent Protective PowderTalc (115 g/142g) + Zinc oxide (21.3 g/142g)PowderTopicalDavion, Inc.2016-09-01Not applicableUs
OHUI Sun Science Sun Block EX plus BeigeTalc (55.493 g/100g) + Arbutin (2 g/100g) + Atractylodes lancea root oil (0.1 g/100g) + Octinoxate (7.2 g/100g) + Titanium dioxide (2.59956 g/100g) + Zinc oxide (5.76 g/100g)PowderTopicalLg Household & Health Care Ltd.2011-05-25Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AHC Premium Intense Contour BalmTalc (2.05 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 cst) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Titanium dioxide (3.96 g/50mL) + Zinc oxide (0.96 g/50mL)CreamTopicalCarver Korea Co.,Ltd.2014-01-152017-11-22Us
Categories
UNII
7SEV7J4R1U
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Preventing diaper rashes, Eliminating body odors, Preventing skin from chafing due to friction, Various cosmetics such as eyeshadow and lipstick Absorbing excess oil in hair, Freshening clothes and other materials.

Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action

It has very good absorptive properties.

Absorption

Intended for local use only.

Volume of distribution

Intended for local use only.

Protein binding

Intended for local use only.

Metabolism

Intended for local use only.

Route of elimination

Intended for local use only.

Half life

Intended for local use only.

Clearance

Intended for local use only.

Toxicity

LC50: Not available.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AmlodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Amlodipine is combined with Talc.
CalcidiolThe serum concentration of Talc can be increased when it is combined with Calcidiol.
CalcipotriolThe serum concentration of Talc can be increased when it is combined with Calcipotriol.
CalcitriolThe serum concentration of Talc can be increased when it is combined with Calcitriol.
CholecalciferolThe serum concentration of Talc can be increased when it is combined with Cholecalciferol.
Clodronic AcidTalc can cause a decrease in the absorption of Clodronic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
DiltiazemThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Talc.
DoxycyclineTalc can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
ErgocalciferolThe serum concentration of Talc can be increased when it is combined with Ergocalciferol.
FelodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Felodipine is combined with Talc.
Food Interactions
Not Available

References

General References
  1. MSDS [Link]
  2. product info [Link]
External Links
PubChem Substance
347910456
Wikipedia
Talc

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedSupportive CareMetastatic Cancers1
3RecruitingTreatmentMalignant Pleural Effusions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
PowderTopical100 g/100g
PowderTopical0.9 g/1g
PowderTopical
AerosolTopical
PowderTopical1 g/1g
PowderTopical99 g/100g
CreamTopical
Aerosol, powderIntrapleural4 g/25.0g
PowderIntrapleural5 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on August 02, 2018 06:18