Octocrylene

Identification

Name
Octocrylene
Accession Number
DB09535
Type
Small Molecule
Groups
Approved, Investigational
Description

Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics.

Synonyms
Not Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Scarsystem Scar GelGel3.8 %TopicalSystem Biologie AgNot applicableNot applicableCanada
UV Defense Pocket Sun Block Tissues (Broad Spectrum, SPF30)Liquid9.5 g/100gTopicalC&tech Corporation2018-03-012018-03-25Us
UV Defense Pocket Sun Pad (Broad Spectrum, SPF30)Liquid9.5 g/100gTopicalC&tech Corporation2018-03-012018-03-25Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
100 SPF CreamOctocrylene (10 %) + Avobenzone (3 %) + Homosalate (15 %) + Octisalate (5 %) + Oxybenzone (6 %)CreamTopicalVital Science A Div. Of/Une Div. De Valeant Canada Ltd/Ltee2010-06-032014-08-27Canada
1000 Roses Daily Shade Facial SPF 18Octocrylene (50 mg/1mL) + Avobenzone (25 mg/1mL) + Octisalate (50 mg/1mL)LotionTopicalAndalou Naturals2014-03-01Not applicableUs
14-day Skin Rescue SPF 30Octocrylene (2.35 %) + Avobenzone (3 %) + Homosalate (4 %) + Octisalate (5 %) + Oxybenzone (6 %)CreamTopicalJohnson & Johnson2009-02-162013-07-31Canada
15 Continuous Spray Sunscreen With Instant BronzerOctocrylene (1.85 %) + Avobenzone (2 %) + Octisalate (5 %)SprayTopicalPrime Enterprises, Inc.2018-04-09Not applicableCanada
15 SPF Fps Premium SunscreenOctocrylene (10.0 %) + Avobenzone (3.0 %) + Ensulizole (2.0 %) + Oxybenzone (2.0 %)LotionTopicalEmpack Spraytech Inc.2005-05-04Not applicableCanada
15 SPF Fps Sunscreen Lotion écran SolaireOctocrylene (3.0 %) + Avobenzone (0.9 %) + Oxybenzone (3.0 %)LotionTopicalEnergizer Canada Inc2007-03-012011-07-29Canada
15 SPF Sunscreen Uva/uvb Protection Oil-free Milky SprayOctocrylene (2.0 %) + Avobenzone (3.0 %) + Octinoxate (5.0 %) + Octisalate (3.0 %) + Oxybenzone (2.0 %)EmulsionTopicalCoty Canada Inc.2009-02-232013-07-24Canada
15 SPF Sunscreen Uva/uvb Protection Vitalizing Age-defying CreamOctocrylene (2.0 %) + Avobenzone (3.0 %) + Octinoxate (7.5 %) + Octisalate (5.0 %) + Oxybenzone (3.0 %)CreamTopicalCoty Canada Inc.2009-02-232013-07-24Canada
15 Spray Gel Sunscreen With Instant BronzerOctocrylene (1.85 %) + Avobenzone (2 %) + Octisalate (5 %) + Oxybenzone (0.5 %)GelTopicalPrime Enterprises, Inc.2018-04-09Not applicableCanada
15 Tanning CVSOctocrylene (5 g/100mL) + Avobenzone (2 g/100mL) + Homosalate (10 g/100mL) + Octisalate (5 g/100mL)LotionTopicalProduct Quest Mff, Llc2014-11-062016-04-20Us
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Abalone Crystaldouble EX BbOctocrylene (3 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Octinoxate (2 g/100mL) + Titanium dioxide (9.9 g/100mL)CreamTopicalC&bcosmetic Co.,ltd.2017-03-10Not applicableUs
BEYOND THE SHAVE For MenOctocrylene (2.7 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Dimethicone (2.9 g/100mL) + Homosalate (2.5 g/100mL) + Octasulfur (3.0 g/100mL) + Octisalate (5 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
D-one By Tamdoan Bb LightOctocrylene (1 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octisalate (5 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-232016-09-05Us
D-one By Tamdoan Bb MediumOctocrylene (1 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octisalate (5 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-23Not applicableUs
D-one By Tamdoan Sunscreen 50Octocrylene (1 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octisalate (5 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-23Not applicableUs
Dr.althea Aurora Cover Cushion 21Octocrylene (2 g/100g) + Adenosine (0.04 g/100g) + Nicotinamide (2 g/100g) + Octinoxate (7 g/100g) + Octisalate (4.8 g/100g) + Titanium dioxide (9.00552 g/100g) + Zinc oxide (2 g/100g)LiquidTopicalDr. Althea2017-04-03Not applicableUs
Glytone Clarifying SunVanish with SunscreenOctocrylene (18.6 mg/1g) + Avobenzone (20 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) + Oxybenzone (50 mg/1g)CreamTopicalGenesis2012-06-13Not applicableUs
Glytone SunVanish Skin LighteningOctocrylene (18.6 mg/1g) + Avobenzone (20 mg/1g) + Hydroquinone (40 mg/1g) + Octinoxate (75 mg/1g) + Oxybenzone (50 mg/1g)CreamTopicalGenesis2012-06-13Not applicableUs
MediSpa SunSpray sunblockOctocrylene (0.01 mL/1mL) + Enzacamene (0.05 mL/1mL) + Octinoxate (0.075 mL/1mL)SprayTopicalUniversal Cosmetic Co., Ltd2010-08-06Not applicableUs
Preventage Firming Defense Normal/Oily Broad Spectrum SPF 15 Merle NormanOctocrylene (5.264 g/56g) + Avobenzone (1.064 g/56g)CreamTopicalMerle Norman Cosmetics2012-08-152013-05-06Us
Categories
UNII
5A68WGF6WM
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

In the US, Octocrylene has been evaluated by the FDA and is considered safe for use up to 10% in the formula. Similarly, the EU allows its use up to 10% in a formula while Health Canada allows a maximum use level of 12%.

Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action

Octocrylene is an effective oil soluble liquid UV‐B filter. It has excellent dissolving properties for crystalline UV filters. Due to its outstanding photostability it is used as photostabilizer. The extended conjugation of the acrylate portion of the molecule absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths from 280 to 320 nm, protecting the skin from direct DNA damage. The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water resistant) properties.

TargetActionsOrganism
UEstrogen receptor alphaNot AvailableHuman
UEstrogen receptor betaNot AvailableHuman
Absorption

Ecamsule is used topically, it not absorbed or metabolized.

Volume of distribution

Ecamsule is only used topically, it not absorbed.

Protein binding

Ecamsule is only used topically, it not absorbed.

Metabolism

Ecamsule is used topically, it not absorbed.

Route of elimination

Ecamsule is used topically, it not absorbed.

Half life

Ecamsule is only used topically, it does not have half life

Clearance

Ecamsule is used topically, it not absorbed or metabolized.

Toxicity

Octocrylene is one of those ingredients that can be absorbed into the skin and some studies have shown that it may promote generation of potentially harmful free radicals when exposed to light. Since free radicals can damage DNA, there is concern that this ingredient might have contributed to an increased incidence of melanoma in sunscreen-users compared to non-users.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Hanson KM, Gratton E, Bardeen CJ: Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med. 2006 Oct 15;41(8):1205-12. Epub 2006 Jul 6. [PubMed:17015167]
  2. Wikipedia [Link]
  3. Drug Information [Link]
  4. Skin care research [Link]
External Links
PubChem Substance
347910458
Wikipedia
Octocrylene
AHFS Codes
  • 84:80.00 — Sunscreen Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedOtherMelasma1
1Not Yet RecruitingPreventionActinic Keratosis (AK) / Therapy, Photodynamic1
1RecruitingOtherSystemic Exposure to Sunscreen Ingredients1
2CompletedSupportive CareAdvanced Malignant Neoplasm / Dermatologic Complication / Dermatologic Complications / Neoplasms, Malignant1
2CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
2Unknown StatusPreventionAtopic Dermatitis (AD)1
2, 3CompletedTreatmentFemale Genital Diseases1
2, 3RecruitingTreatmentProstate Cancer1
3CompletedSupportive CareDermatologic Complications / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedTreatmentActinic Keratosis (AK)1
3CompletedTreatmentMenstrual Irregularities1
3RecruitingTreatmentAcute Lymphoblastic Leukemia, Pediatric1
3RecruitingTreatmentFollicular Lymphoma (FL)1
4CompletedTreatmentHypermenorrhea1
4CompletedTreatmentHyperpigmentation1
4CompletedTreatmentHypertrophic Cicatrix / Hypertrophic Scars / Keloid Scars1
4CompletedTreatmentMelasma1
4CompletedTreatmentPruritis1
4Not Yet RecruitingTreatmentPostoperative pain / Rotator Cuff Syndrome1
4RecruitingDiagnosticCancer, Breast / Sentinel Lymph Node Biopsy1
4RecruitingTreatmentColon Cancer Stage1
4TerminatedNot AvailableSkin Aging1
Not AvailableCompletedNot AvailableLaryngospasm1
Not AvailableCompletedDiagnosticDermatitis, Photocontact1
Not AvailableCompletedTreatmentFoot Dryness in Patients With NIDDM / Foot Transepidermal Water Loss in Patients in NIDDM1
Not AvailableCompletedTreatmentRadiation Induced Fibrosis to the Head and Neck1
Not AvailableCompletedTreatmentStrokes1
Not AvailableUnknown StatusPreventionDermatitis, Eczematous1
Not AvailableUnknown StatusTreatmentPrepubertal Labial Adhesions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical
GelCutaneous
LotionTopical20 mg/1mL
PasteTopical
Cream, augmentedTopical
SalveTopical
LotionTopical
Kit
Aerosol, foamTopical
PowderTopical
Gel; kit; lotionTopical
Kit; stickTopical
OintmentTopical
EmulsionTopical
KitTopical
SoapTopical
LipstickTopical
GelTopical
SuspensionTopical
AerosolTopical
Aerosol, sprayTopical
LiquidTopical
Kit; lotionTopical
Cream; kitTopical
GelTopical3.8 %
SolutionTopical
SprayOral
SprayTopical
StickTopical
OilTopical
LotionOral
LiquidTopical9.5 g/100g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [PubMed:16079615]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent m...
Gene Name
ESR2
Uniprot ID
Q92731
Uniprot Name
Estrogen receptor beta
Molecular Weight
59215.765 Da
References
  1. Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [PubMed:16079615]

Drug created on November 30, 2015 12:10 / Updated on September 25, 2018 03:20