Octocrylene

Identification

Name
Octocrylene
Accession Number
DB09535
Type
Small Molecule
Groups
Approved
Description

Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics.

Structure
Thumb
Synonyms
Not Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Scarsystem Scar GelGel3.8 %TopicalSystem Biologie AgNot applicableNot applicableCanada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
100 SPF CreamOctocrylene (10 %) + Avobenzone (3 %) + Homosalate (15 %) + Octisalate (5 %) + Oxybenzone (6 %)CreamTopicalVital Science A Div. Of/Une Div. De Valeant Canada Ltd/Ltee2010-06-032014-08-27Canada
1000 Roses Daily Shade Facial SPF 18Octocrylene (50 mg/mL) + Avobenzone (25 mg/mL) + Octisalate (50 mg/mL)LotionTopicalAndalou Naturals2014-03-01Not applicableUs
14-day Skin Rescue SPF 30Octocrylene (2.35 %) + Avobenzone (3 %) + Homosalate (4 %) + Octisalate (5 %) + Oxybenzone (6 %)CreamTopicalJohnson & Johnson2009-02-162013-07-31Canada
15 SPF Fps Premium SunscreenOctocrylene (10.0 %) + Avobenzone (3.0 %) + Ensulizole (2.0 %) + Oxybenzone (2.0 %)LotionTopicalEmpack Spraytech Inc.2005-05-04Not applicableCanada
15 SPF Fps Sunscreen Lotion écran SolaireOctocrylene (3.0 %) + Avobenzone (0.9 %) + Oxybenzone (3.0 %)LotionTopicalEnergizer Canada Inc2007-03-012011-07-29Canada
15 SPF Sunscreen Uva/uvb Protection Oil-free Milky SprayOctocrylene (2.0 %) + Avobenzone (3.0 %) + Octinoxate (5.0 %) + Octisalate (3.0 %) + Oxybenzone (2.0 %)EmulsionTopicalCoty Canada Inc.2009-02-232013-07-24Canada
15 SPF Sunscreen Uva/uvb Protection Vitalizing Age-defying CreamOctocrylene (2.0 %) + Avobenzone (3.0 %) + Octinoxate (7.5 %) + Octisalate (5.0 %) + Oxybenzone (3.0 %)CreamTopicalCoty Canada Inc.2009-02-232013-07-24Canada
15 Tanning CVSOctocrylene (5 g/100mL) + Avobenzone (2 g/100mL) + Homosalate (10 g/100mL) + Octisalate (5 g/100mL)LotionTopicalProduct Quest Mff, Llc2014-11-062016-04-05Us
29 by LYDIA MONDAVI Napa Valley BROAD SPECTRUM SPF 30 D VINE DAYOctocrylene (20 mg/mL) + Avobenzone (30 mg/mL) + Homosalate (100 mg/mL) + Octisalate (50 mg/mL) + Oxybenzone (25 mg/mL)CreamTopical29 Luxury Goods, Inc.2013-10-16Not applicableUs
2X Sunblock SPF 50Octocrylene (6 mL/100mL) + Avobenzone (3 mL/100mL) + Homosalate (15 mL/100mL) + Oxybenzone (6 mL/100mL)LiquidTopicalNupur Formulations Inc2011-04-22Not applicableUs
Categories
UNII
5A68WGF6WM
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

In the US, Octocrylene has been evaluated by the FDA and is considered safe for use up to 10% in the formula. Similarly, the EU allows its use up to 10% in a formula while Health Canada allows a maximum use level of 12%.

Structured Indications
Pharmacodynamics
Not Available
Mechanism of action

Octocrylene is an effective oil soluble liquid UV‐B filter. It has excellent dissolving properties for crystalline UV filters. Due to its outstanding photostability it is used as photostabilizer. The extended conjugation of the acrylate portion of the molecule absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths from 280 to 320 nm, protecting the skin from direct DNA damage. The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water resistant) properties.

TargetActionsOrganism
UEstrogen receptor alphaNot AvailableHuman
UEstrogen receptor betaNot AvailableHuman
Absorption

Ecamsule is used topically, it not absorbed or metabolized.

Volume of distribution

Ecamsule is only used topically, it not absorbed.

Protein binding

Ecamsule is only used topically, it not absorbed.

Metabolism

Ecamsule is used topically, it not absorbed.

Route of elimination

Ecamsule is used topically, it not absorbed.

Half life

Ecamsule is only used topically, it does not have half life

Clearance

Ecamsule is used topically, it not absorbed or metabolized.

Toxicity

Octocrylene is one of those ingredients that can be absorbed into the skin and some studies have shown that it may promote generation of potentially harmful free radicals when exposed to light. Since free radicals can damage DNA, there is concern that this ingredient might have contributed to an increased incidence of melanoma in sunscreen-users compared to non-users.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
  1. Hanson KM, Gratton E, Bardeen CJ: Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med. 2006 Oct 15;41(8):1205-12. Epub 2006 Jul 6. [PubMed:17015167]
  2. Wikipedia [Link]
  3. Drug Information [Link]
  4. Skin care research [Link]
External Links
Not Available
ATC Codes
Not Available
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingSupportive CareDermatologic Complications / Neoplasms, Malignant1
2Unknown StatusPreventionAtopic Dermatitis (AD)1
2, 3CompletedTreatmentFemale Genital Diseases1
3CompletedSupportive CareDermatologic Complications / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedTreatmentActinic Keratosis (AK)1
3RecruitingTreatmentFollicular Lymphoma (FL)1
4CompletedTreatmentHyperpigmentation1
4CompletedTreatmentHypertrophic Cicatrix / Hypertrophic Scars / Keloid Scars1
4CompletedTreatmentMelasma1
4TerminatedNot AvailableSkin Aging1
4Unknown StatusTreatmentPruritis1
Not AvailableCompletedNot AvailableLaryngospasm1
Not AvailableCompletedDiagnosticDermatitis, Photocontact1
Not AvailableCompletedTreatmentFoot Dryness in Patients With NIDDM / Foot Transepidermal Water Loss in Patients in NIDDM1
Not AvailableCompletedTreatmentRadiation Induced Fibrosis to the Head and Neck1
Not AvailableCompletedTreatmentStrokes1
Not AvailableUnknown StatusPreventionDermatitis, Eczematous1
Not AvailableUnknown StatusTreatmentPrepubertal Labial Adhesions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GelCutaneous
PasteTopical
OilTopical
Cream, augmentedTopical
Kit
GelTopical
PowderTopical
SalveTopical
LotionTopical
SprayTopical
Gel; kit; lotionTopical
Aerosol, foamTopical
OintmentTopical
Kit; stickTopical
KitTopical
SoapTopical
SolutionTopical
SuspensionTopical
LiquidTopical
Aerosol, sprayTopical
Kit; lotionTopical
Cream; kitTopical
GelTopical3.8 %
EmulsionTopical
AerosolTopical
CreamTopical
StickTopical
SprayOral
LipstickTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [PubMed:16079615]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent m...
Gene Name
ESR2
Uniprot ID
Q92731
Uniprot Name
Estrogen receptor beta
Molecular Weight
59215.765 Da
References
  1. Matsumoto H, Adachi S, Suzuki Y: [Estrogenic activity of ultraviolet absorbers and the related compounds]. Yakugaku Zasshi. 2005 Aug;125(8):643-52. [PubMed:16079615]

Drug created on November 30, 2015 12:10 / Updated on July 06, 2017 16:53