Iodine povacrylex

Identification

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Name
Iodine povacrylex
Accession Number
DB09537
Type
Small Molecule
Groups
Approved
Description

Iodine povacrylex (DuraPrep) is a surgical solution, film-forming iodophor complex that provides fast acting, persistent, broad-spectrum antimicrobial activity. DuraPrep solution is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection. It is a broad spectrum antiseptic and can provide almost 99.9% antiseptic conditions. It is intended for local use only. Prolonged skin exposure could cause skin defatting manifested by the following signs/symptoms; localized redness, itching, drying and cracking of skin.

Synonyms
  • Iodine povacrylex
Active Moieties
NameKindUNIICASInChI Key
Iodineunknown9679TC07X47553-56-2PNDPGZBMCMUPRI-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
3M DuraPrep SurgicalIodine povacrylex (6.02 mg/1mL) + Isopropyl alcohol (636.4 mg/1mL)SolutionTopical3 M Pharmaceuticals2006-09-29Not applicableUs
Categories
Not Available
UNII
6E43AWY083
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Antispetic and germicidal agent. It is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection.

Associated Therapies
Pharmacodynamics

Microbial reduction of the skin ideally kills all skin organisms.

Mechanism of action

Killing microorganisms by denaturation of proteins in its fluid state through oxidation after penetration of the cell wall.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

For local use only, no systemic absorption.

Volume of distribution

For local use only, no systemic absorption.

Protein binding

For local use only, no systemic absorption.

Metabolism

For local use only, no systemic absorption.

Route of elimination

For local use only, no systemic absorption.

Half life

For local use only, no systemic absorption.

Clearance

For local use only, no systemic absorption.

Toxicity

No data available; calculated acute toxicity estimate: 2,000 - 5,000 mg/kg.

Affected organisms
  • Fungi
  • Gram negative and gram positive bacteria
  • Various viruses
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. FDA label [Link]
  2. MSDS [Link]
  3. article [Link]
External Links
PubChem Substance
347910459

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingPreventionSurgical Site Infections1
Not AvailableCompletedPreventionSurgery, Colorectal1
Not AvailableCompletedTreatmentArthroplasties, Hip Replacement / Postoperative Wound Infection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on December 02, 2019 08:46