| 1 | Cytochrome P450 3A4 substrates | Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Albendazole, Alclometasone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, Alprazolam, Ambrisentan, Ambroxol, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Antipyrine, Apixaban, Apremilast, Aprepitant, Argatroban, Aripiprazole, Artemether, Asenapine, Astemizole, Atazanavir, Atorvastatin, Avanafil, Axitinib, Azelastine, Azithromycin, Banoxantrone, Bedaquiline, Benzphetamine, Benzyl alcohol, Bexarotene, Bezafibrate, Bicalutamide, Bisoprolol, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brinzolamide, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Carbamazepine, Carbinoxamine, Cariprazine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chloroquine, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilostazol, Cinacalcet, Cisapride, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clofibrate, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Cortisone acetate, Crizotinib, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delavirdine, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexchlorpheniramine maleate, Dextromethorphan, Dextropropoxyphene, Diazepam, Diclofenac, Digitoxin, Digoxin, Dihydrocodeine, Dihydroergotamine, Diltiazem, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Dutasteride, Efavirenz, Eletriptan, Eliglustat, Elvitegravir, Enalapril, Enzalutamide, Epinastine, Eplerenone, Ergocalciferol, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethylmorphine, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Flibanserin, Flunisolide, Flunitrazepam, Fluorometholone, Fluoxetine, Flurazepam, Flutamide, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fulvestrant, Galantamine, Gefitinib, Gemfibrozil, Glipizide, Glyburide, Granisetron, Grepafloxacin, Guanfacine, Halofantrine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydromorphone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipratropium, Irinotecan, Isavuconazonium, Isosorbide dinitrate, Isosorbide mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Levacetylmethadol, Levobupivacaine, Levocetirizine, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lisuride, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Losartan, Lovastatin, Lumefantrine, Lurasidone, Macitentan, Maraviroc, Mebendazole, Medroxyprogesterone acetate, Mefloquine, Meloxicam, Meperidine, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Montelukast, Morphine, Mycophenolate mofetil, Naloxegol, Naloxone, Nateglinide, Nefazodone, Nelfinavir, Nevirapine, Nicardipine, Nicotine, Nifedipine, Nilotinib, Nilvadipine, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Norethisterone, Norgestrel, Nortriptyline, Olaparib, Olopatadine, Omeprazole, Ondansetron, Orphenadrine, Ospemifene, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perphenazine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pioglitazone, Pipotiazine, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednisolone, Prednisone, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rilpivirine, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Selexipag, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Theophylline, Thiotepa, Tiagabine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tofacitinib, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Udenafil, Ulipristal, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinorelbine, Vismodegib, Voriconazole, Vortioxetine, Warfarin, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone |
| 2 | Cytochrome P450 3A4 inhibitors | Acetaminophen, Acetazolamide, Albuterol, Aldesleukin, Alprazolam, Ambroxol, Amiodarone, Amlodipine, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, Atorvastatin, Azelastine, Azithromycin, Betamethasone, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brentuximab vedotin, Bromocriptine, Buprenorphine, Cabergoline, Caffeine, Capsaicin, Caspofungin, Ceritinib, Cerivastatin, Chloramphenicol, Chlorzoxazone, Cilostazol, Cimetidine, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Conivaptan, Cortisone acetate, Crizotinib, Cyclophosphamide, Cyclosporine, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Dexamethasone, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Docetaxel, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Epinephrine, Ergoloid mesylate, Ergometrine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Gemfibrozil, Glyburide, Glycerol phenylbutyrate, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irbesartan, Irinotecan, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Josamycin, Ketazolam, Ketoconazole, Lansoprazole, Lapatinib, Lercanidipine, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Lurasidone, Mefloquine, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mirtazapine, Mitoxantrone, Modafinil, Nefazodone, Nelfinavir, Netupitant, Nevirapine, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Olanzapine, Olaparib, Omeprazole, Oxybutynin, Paclitaxel, Palbociclib, Paramethasone, Pazopanib, Pergolide, Phenelzine, Pilocarpine, Pimozide, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Repaglinide, Resveratrol, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rolitetracycline, Rosuvastatin, Roxithromycin, Rutin, Saquinavir, Sertraline, Sildenafil, Simvastatin, Sirolimus, Sitaxentan, Sorafenib, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Thiopental, Ticagrelor, Ticlopidine, Tioconazole, Tipranavir, Tofisopam, Topotecan, Tramadol, Tranylcypromine, Troglitazone, Valproic acid, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone |
| 3 | Cytochrome P450 3A4 inducers | Acetaminophen, Alclometasone, Alimemazine, Aminoglutethimide, Armodafinil, Artemether, Atorvastatin, Azatadine, Bexarotene, Bosentan, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clofibrate, Clotrimazole, Clozapine, Colchicine, Cyclophosphamide, Dabrafenib, Deferasirox, Desvenlafaxine, Dexamethasone, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enzalutamide, Eslicarbazepine acetate, Estradiol, Ethanol, Etoposide, Etravirine, Exemestane, Felbamate, Flucloxacillin, Fluorometholone, Fluvastatin, Fosaprepitant, Fosphenytoin, Gemfibrozil, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Idelalisib, Ifosfamide, Isavuconazonium, Lansoprazole, Lopinavir, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Metyrapone, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nicardipine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifapentine, Rifaximin, Rilpivirine, Ritonavir, Rofecoxib, Rufinamide, Simvastatin, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Topiramate, Topotecan, Trametinib, Troglitazone, Vemurafenib |