Corynebacterium diphtheriae

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Corynebacterium diphtheriae
Accession Number
DB09877
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Other vaccines
Description

Corynebacterium diphtheriae toxin is extracted from the pathogenic actinobacterium C. diphtheriae that causes diphtheria. The bacteria culture is grown in a medium and through purification, diphtheria toxin is detoxified with formaldehyde and diafiltered. The vaccine is intramuscularly administered to provide active immunization against diphtheria in infants and children.

Synonyms
Not Available
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Prevnar 13Corynebacterium diphtheriae (34 mcg/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 mcg/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 mcg/0.5mL)SuspensionIntramuscularPfizer Canada Ulc2010-03-01Not applicableCanada
Tetanus and Diphtheria Toxoids AdsorbedCorynebacterium diphtheriae (2.0 1/0.5mL) + Clostridium tetani (2.0 1/0.5mL)InjectionIntramuscularRebel Distributors1967-10-13Not applicableUs
Categories
Not Available
UNII
3U7E3O07S8
CAS number
Not Available

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347910466
Wikipedia
Corynebacterium_diphtheriae

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingTreatmentSubstance Use Disorder (SUD)1
0CompletedPreventionInfections, Pneumococcal1
0RecruitingPreventionAging / HIV Lipodystrophy1
0RecruitingTreatmentMultiple Myeloma (MM)1
0RecruitingTreatmentStage III Hepatocellular Carcinoma AJCC v8 / Stage III Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IIIA Hepatocellular Carcinoma AJCC v8 / Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IIIB Hepatocellular Carcinoma AJCC v8 / Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IV Hepatocellular Carcinoma AJCC v8 / Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IVA Hepatocellular Carcinoma AJCC v8 / Stage IVB Hepatocellular Carcinoma AJCC v8 / Unresectable Hepatocellular Carcinoma / Unresectable Intrahepatic Cholangiocarcinoma1
1Active Not RecruitingPreventionInfections, Pneumococcal1
1CompletedPreventionInfections, Pneumococcal1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1TerminatedTreatmentMultiple Myeloma (MM)1
1, 2CompletedPreventionInfections, Pneumococcal1
1, 2CompletedPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae1
1, 2RecruitingOtherHealthy Volunteers1
1, 2RecruitingPreventionHealthy Volunteers / Pneumococcal Diseases1
1, 2RecruitingTreatmentAggressive Non-Hodgkin Lymphoma / Indolent Non-Hodgkin's Lymphomas / Recurrent Adult Non-Hodgkin Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mediastinal (Thymic) Large B-Cell Cell Lymphoma / Recurrent T-Cell Non-Hodgkin Lymphoma / Small Lymphocytic Lymphoma1
2Active Not RecruitingPreventionClostridium Difficile Immunisation / Diphtheria / Diphtheria Immunisation / Pertussis / Tetanus / Tetanus Immunisation1
2Active Not RecruitingPreventionInfections, Pneumococcal1
2Active Not RecruitingTreatmentChildhood Cancers / Multiple Diseases1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Small Lymphocytic Lymphoma1
2CompletedPreventionDiphtheria / Pertussis / Poliomyelitis / Tetanus / Viral Hepatitis B1
2CompletedPreventionInfections, Pneumococcal6
2CompletedPreventionStreptococcal Infections2
2CompletedTreatmentMonoclonal B-Cell Lymphocytosis / Stage 0 Chronic Lymphocytic Leukemia / Stage I Chronic Lymphocytic Leukemia / Stage I Small Lymphocytic Lymphoma1
2CompletedTreatmentMultiple Myeloma (MM)1
2Not Yet RecruitingPreventionSystemic Vasculitis1
2TerminatedBasic ScienceTransplant-Related Cancer1
2Unknown StatusPreventionInfectious Diseases1
2, 3Active Not RecruitingPreventionVaccines, Pneumococcal1
2, 3RecruitingPreventionInfections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
3Active Not RecruitingPreventionInfections, Pneumococcal7
3Active Not RecruitingPreventionInfections, Pneumococcal / Vaccines, Pneumococcal1
3Active Not RecruitingPreventionPneumonia1
3CompletedPreventionBacterial Infections / Neisseria Meningitidis / Virus Diseases1
3CompletedPreventionBacterial Infections / Virus Diseases2
3CompletedPreventionHaemophilus Influenzae Type B1
3CompletedPreventionHaemophilus Influenzae Type B / Neisseria Meningitidis1
3CompletedPreventionInfections, Pneumococcal2
3CompletedPreventionMeasles; Mumps; Rubella1
3CompletedPreventionMeningococcal Disease1
3CompletedPreventionMumps / Rubella / Rubeola2
3RecruitingPreventionInfections, Pneumococcal4
3RecruitingTreatmentInfections, Pneumococcal1
4CompletedDiagnosticImmune Response / Pneumonia / Streptococcus Pneumoniae1
4CompletedPreventionDiphtheria / Meningococcal / Pertussis Diseases / Streptococcal / Tetanus1
4CompletedPreventionDiphtheria / Pertussis / Tetanus1
4CompletedPreventionDiphtheria / Tetanus1
4CompletedTreatmentEnd Stage Renal Disease (ESRD)1
4RecruitingBasic ScienceHIV-1-infection / Human Immunodeficiency Virus (HIV) / Human Immunodeficiency Virus (HIV) Infections / Human Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS)1
4RecruitingPreventionChronic Kidney Disease (CKD)1
4RecruitingPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
4RecruitingTreatmentPlasma Cell Neoplasms1
4Unknown StatusPreventionPertussis1
Not AvailableActive Not RecruitingBasic ScienceAging / Pneumonia1
Not AvailableCompletedNot AvailableInflammatory Bowel Diseases (IBD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SuspensionIntramuscular
InjectionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 14:23 / Updated on December 02, 2019 08:46