Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen

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Identification

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Name
Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen
Accession Number
DB10286
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Conjugate
Description

Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 4 individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197) . It is contained in the vaccine under the market name Prevnar that contains the saccharides for serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F for intramuscular injection. The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Synonyms
  • Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
PrevnarStreptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings Llc, a Subsidiary of Pfizer Inc.2000-03-012011-02-28Us
Prevnar 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2010-03-12Not applicableUs
Prevnar 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings Llc, a Subsidiary of Pfizer Inc.2010-03-12Not applicableUs
Categories
UNII
TGJ6YZC4W7
CAS number
Not Available

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347910472

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionInfections, Pneumococcal / Vaccines, Pneumococcal1
1RecruitingPreventionInfections, Pneumococcal1
1, 2Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
1, 2CompletedOtherPneumonia1
1, 2CompletedPreventionInfections, Pneumococcal1
1, 2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
2CompletedPreventionDiseases Caused by Measles, Mumps, Rubella and Varicella Viruses / Measles-Mumps-Rubella-Varicella Vaccine / Mumps / Rubella / Rubeola / Varicella1
2CompletedPreventionHaemophilus Influenzae Type B / Neisseria Meningitidis1
2CompletedPreventionInfections, Pneumococcal1
2CompletedPreventionInfections, Rotavirus / Rotavirus Gastroenteritis1
2CompletedPreventionMeningitis / Meningococcal Infections1
2CompletedPreventionMumps / Rubella / Rubeola1
2CompletedPreventionPlasmodium Infections1
2CompletedPreventionPrevention of Meningococcal Disease1
2CompletedPreventionTuberculosis Infection1
2CompletedTreatmentLeukemias1
3CompletedPreventionChronic Obstructive Pulmonary Disease (COPD)1
3CompletedPreventionDiphtheria / Haemophilus Infections / Pertussis / Poliomyelitis / Tetanus1
3CompletedPreventionDiphtheria / Haemophilus Influenzae Type B / Pertussis / Poliomyelitis / Viral Hepatitis B1
3CompletedPreventionHaemophilus Influenza b Infections / Haemophilus Influenzae Type B / Meningococcal Infections / Neisseria Meningitidis / Neisseria Meningitidis-Haemophilus Influenzae Type b Vaccine1
3CompletedPreventionHaemophilus Influenzae Type B / Haemophilus Influenzae Type B Infection / Meningococcal Infections / Neisseria Meningitidis1
3CompletedPreventionInflammation, Brain1
3CompletedPreventionMeningococcal Meningitis1
3CompletedPreventionMumps / Rubella / Rubeola / Varicella1
3CompletedPreventionStreptococcus Pneumoniae1
3RecruitingPreventionInfections, Pneumococcal1
3Unknown StatusTreatmentImmunosuppression / Solid Organ Transplant1
4CompletedNot AvailableInfections, Pneumococcal1
4CompletedPreventionAsthma Bronchial1
4CompletedPreventionHepatitis A Virus1
4CompletedPreventionHuman Immunodeficiency Virus (HIV) / Invasive Pneumococcal Disease (IPD) / Meningitis / Pneumonia1
4CompletedPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae / Pneumonia1
4CompletedTreatmentPain NOS1
4Not Yet RecruitingPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
Not AvailableActive Not RecruitingPreventionHuman Immunodeficiency Virus (HIV) / Infections, Pneumococcal / Vaccines, Pneumococcal1
Not AvailableCompletedNot AvailableInvasive Pneumococcal Disease (IPD)1
Not AvailableCompletedNot AvailableMultiple Myeloma (MM)1
Not AvailableCompletedTreatmentMalignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Small Intestine Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Injection, suspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Drug created on December 01, 2015 13:03 / Updated on June 04, 2019 07:13