Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen

Identification

Brand Names

Prevnar 13, Prevnar 20, Vaxneuvance

Generic Name

Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen

DrugBank Accession Number

DB10293

Background

Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 1 individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Type

Biotech

Groups

Approved

Biologic Classification

Vaccines
Conjugate

Synonyms

• Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine

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Pharmacology

Indication

Not Available

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Used in combination to prevent	Invasive streptococcal infection	Combination Product in combination with: Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10297)	••••••••••••			•••••••••• ••••••••••
Used in combination to prevent	Otitis media (om) caused by streptococcus pneumoniae	Combination Product in combination with: Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10297)	••••••••••••			•••••••••• ••••••••••
Prevention of	Invasive infection caused by streptococcus pneumoniae serotype 1		••••••••••••
Used in combination to prevent	Pneumonia caused by streptococcus pneumoniae	Combination Product in combination with: Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (DB10297)	••••••••••••			•••••••••• ••••••••••

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

Products

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
PREVENAR 13	Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2017-01-10	Not applicable
PREVENAR 13	Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2014-07-08	Not applicable
PREVENAR 13	Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2014-07-08	Not applicable
PREVENAR 13	Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2017-01-10	Not applicable
PREVENAR 13	Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)	Injection, suspension	Intramuscular	Pfizer Europe Ma Eeig	2017-01-10	Not applicable

Categories

Drug Categories

• Actively Acquired Immunity
• Inactivated Pneumococcal Vaccine

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

54EC0SE5PZ

CAS number

Not Available

References

General References

Not Available

External Links

PubChem Substance

347910479

RxNav

901620

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Recruiting	Basic Science	Coronavirus Disease 2019 (COVID‑19) / Lymphoma	1
3	Active Not Recruiting	Prevention	Acute Otitis Media (AOM)	1
3	Active Not Recruiting	Prevention	Meningococcal Infections	1
3	Active Not Recruiting	Prevention	Respiratory Syncytial Virus (RSV) Infection	1
3	Completed	Prevention	Coronavirus Disease 2019 (COVID‑19) / Pneumococcal Infection	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection, suspension	Intramuscular
Suspension	Intramuscular

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

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Drug created at December 01, 2015 20:03 / Updated at August 13, 2021 20:47