Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen

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Identification

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Name
Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen
Accession Number
DB10293
Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Conjugate
Description

Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 1 individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Synonyms
  • Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Prevnar 13Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2010-03-12Not applicableUs
Prevnar 13Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings Llc, a Subsidiary of Pfizer Inc.2010-03-12Not applicableUs
Categories
UNII
54EC0SE5PZ
CAS number
Not Available

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Contraindications

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347910479

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingPreventionAging / HIV Lipodystrophy1
0SuspendedTreatmentMultiple Myeloma (MM)1
1Active Not RecruitingPreventionInfections, Pneumococcal1
1, 2CompletedPreventionInfections, Pneumococcal1
1, 2SuspendedTreatmentAggressive Non-Hodgkin Lymphoma / Indolent Non-Hodgkin's Lymphomas / Recurrent Adult Non-Hodgkin Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mediastinal (Thymic) Large B-Cell Cell Lymphoma / Recurrent T-Cell Non-Hodgkin Lymphoma / Small Lymphocytic Lymphoma (SLL)1
2Active Not RecruitingPreventionInfections, Pneumococcal1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Small Lymphocytic Lymphoma (SLL)1
2Active Not RecruitingTreatmentMonoclonal B-Cell Lymphocytosis / Stage 0 Chronic Lymphocytic Leukemia / Stage I Chronic Lymphocytic Leukemia / Stage I Small Lymphocytic Lymphoma1
2CompletedPreventionInfections, Pneumococcal2
2CompletedPreventionStreptococcal Infections2
2Not Yet RecruitingPreventionSystemic Vasculitis1
2RecruitingPreventionInfections, Pneumococcal1
2Unknown StatusPreventionInfectious Diseases1
2, 3RecruitingPreventionInfections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
3Active Not RecruitingPreventionInfections, Pneumococcal3
3Active Not RecruitingPreventionPneumonia1
3CompletedPreventionBacterial Infections / Virus Diseases2
3CompletedPreventionHaemophilus Influenzae Type B1
3CompletedPreventionHaemophilus Influenzae Type B / Neisseria Meningitidis1
3CompletedPreventionInfections, Pneumococcal1
3CompletedPreventionMeasles; Mumps; Rubella1
3CompletedPreventionMumps / Rubella / Rubeola1
3RecruitingPreventionInfections, Pneumococcal3
4CompletedDiagnosticImmune Response / Pneumonia / Streptococcus Pneumoniae1
4CompletedPreventionDiphtheria / Meningococcal / Pertussis Diseases / Streptococcal / Tetanus1
4Not Yet RecruitingPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
4RecruitingPreventionChronic Kidney Disease (CKD)1
Not AvailableActive Not RecruitingBasic ScienceAging / Pneumonia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Injection, suspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Drug created on December 01, 2015 13:03 / Updated on June 04, 2019 07:13