Povidone

Identification

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Name
Povidone
Accession Number
DB11061
Type
Small Molecule
Groups
Approved
Description

Providone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone that is used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in complex with iodine, Povidone-iodine displays antiseptic properties where the iodine, a bactericidal component, mainly contributes to this effect and povidone acts as a carrier 1. Povidone-iodine can be found in over-the-counter topical solutions, ointment, pessaries, liquid soaps and surgical scrubs. The clinical effectiveness of Povidone-iodine on wound healing remains somewhat controversial, as it was demonstrated in few clinical studies that application of the compound in wounds was associated with impaired wound healing, reduced wound strength, or infection in open wounds 1.

Synonyms
  • 1-ethenyl-2-pyrrolidinone homopolymer
  • 1-vinyl-2-pyrrolidinone polymer
  • Polividone
  • Povidona
  • Povidone
  • Povidone, unspecified
  • Povidonum
External IDs
E-1201 / Ins no.1201 / INS-1201
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Soothe HydrationSolution12 mg/1mLOphthalmicBauch & Lomb Incorporated2011-05-02Not applicableUs
Soothe Hydration TherapySolution / drops2 %OphthalmicBausch & Lomb IncNot applicableNot applicableCanada
Soothe Long LastingSolution20 mg/1mLOphthalmicBauch & Lomb Incorporated2013-06-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Advance Relief Eye DropsPovidone (1000 mg/100mL) + Dextran 70 (100 mg/100mL) + Polyethylene glycol 400 (1000 mg/100mL) + Tetrahydrozoline hydrochloride (50 mg/100mL)Solution / dropsOphthalmicWinCo Foods, LLC2015-01-09Not applicableUs
Advanced reliefPovidone (10 mg/1mL) + Dextran 70 (1 mg/1mL) + Polyethylene glycol 400 (10 mg/1mL) + Tetrahydrozoline hydrochloride (0.5 mg/1mL)LiquidOphthalmicAmerican Sales Company2011-09-07Not applicableUs
Advanced reliefPovidone (10 mg/1mL) + Dextran 70 (1 mg/1mL) + Polyethylene glycol 400 (10 mg/1mL) + Tetrahydrozoline hydrochloride (0.5 mg/1mL)LiquidOphthalmicSamchundang Pharm. Co., Ltd.2010-08-29Not applicableUs
Advanced ReliefPovidone (10 mg/1mL) + Dextran 70 (1 mg/1mL) + Polyethylene glycol 400 (10 mg/1mL) + Tetrahydrozoline hydrochloride (0.5 mg/1mL)LiquidOphthalmicKareway Product, Inc.2018-05-30Not applicableUs
Advanced Relief Eye DropsPovidone (1 %) + Dextran 70 (0.1 %) + Polyethylene glycol 400 (1 %) + Tetrahydrozoline hydrochloride (0.05 %)SolutionOphthalmicKc Pharmaceuticals, Inc.Not applicableNot applicableCanada
Advanced Relief Eye DropsPovidone (1 %) + Dextran 70 (0.1 %) + Polyethylene glycol 400 (1 %) + Tetrahydrozoline hydrochloride (0.05 %)SolutionOphthalmicTeva2010-08-30Not applicableCanada
Artifical TearsPovidone (0.06 g/1mL) + Polyvinyl alcohol (0.05 g/1mL)Solution / dropsOphthalmicmedsource pharmaceuticals2016-04-04Not applicableUs
Artificial TearsPovidone (6 mg/1mL) + Polyvinyl alcohol (5 mg/1mL)Solution / dropsOphthalmicMc Kesson2012-03-01Not applicableUs
Artificial TearsPovidone (6 mg/1mL) + Polyvinyl alcohol (5 mg/1mL)Solution / dropsOphthalmicKc Pharmaceuticals, Inc.2003-11-25Not applicableUs
Artificial Tears ExtraPovidone (0.6 %) + Polyvinyl alcohol (1.4 %)SolutionOphthalmicPharmascience Inc1997-05-162016-10-31Canada
International/Other Brands
Vinisil
Categories
UNII
FZ989GH94E
CAS number
9003-39-8

Pharmacology

Indication

When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

Pharmacodynamics

Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties 2. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application 1.

Mechanism of action

Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen 1. Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

This pharmacokinetic data does not apply to povidone.

Volume of distribution

This pharmacokinetic data does not apply to povidone.

Protein binding

This pharmacokinetic data does not apply to povidone.

Metabolism

This pharmacokinetic data does not apply to povidone.

Route of elimination

This pharmacokinetic data does not apply to povidone.

Half life

This pharmacokinetic data does not apply to povidone.

Clearance

This pharmacokinetic data does not apply to povidone.

Toxicity

Oral LD50 in mouse, rat, and rabbit are >40 mg/kg, 100 mg/kg, and 1040 mg/kg, respectively MSDS. No cases of overdose in humans have been reported.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Kramer SA: Effect of povidone-iodine on wound healing: a review. J Vasc Nurs. 1999 Mar;17(1):17-23. [PubMed:10362983]
  2. Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23. [PubMed:28648795]
External Links
KEGG Drug
D02295
KEGG Compound
C19509
PubChem Substance
347911100
Wikipedia
Povidone
AHFS Codes
  • 52:13.00* — Artificial Tears
MSDS
Download (211 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentConjunctivitis, Seasonal Allergic1
2CompletedTreatmentBacterial blepharitis1
3CompletedTreatmentConjunctivitis, Viral1
3CompletedTreatmentEye Dryness1
3Unknown StatusTreatmentAdenovirus / Conjunctivitis1
4CompletedPreventionOcular Hypertension / Posterior Capsule Opacification1
4CompletedTreatmentConjunctivitis, Seasonal Allergic1
4CompletedTreatmentDry Eye Syndromes / Eye Dryness1
4CompletedTreatmentHealthy Volunteers1
4Unknown StatusDiagnosticEye Dryness1
4WithdrawnTreatmentDry Eye Syndrome (DES)1
Not AvailableCompletedPreventionEye Dryness1
Not AvailableCompletedTreatmentDry Eye Syndrome (DES)1
Not AvailableCompletedTreatmentEye Dryness1
Not AvailableCompletedTreatmentIntraocular Pressure1
Not AvailableRecruitingTreatmentAdenoviral Conjunctivitis / Conjunctivitis1
Not AvailableTerminatedTreatmentMigraine1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Solution / dropsIntraocular
SolutionOphthalmic
LiquidOphthalmic
SolutionOphthalmic12 mg/1mL
Solution / dropsOphthalmic2 %
SolutionOphthalmic20 mg/1mL
Solution / dropsOphthalmic
Kit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)100MSDS
water solubilitySolubleMSDS
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on July 16, 2019 06:23