Benzalkonium

Identification

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Name
Benzalkonium
Accession Number
DB11105
Type
Small Molecule
Groups
Approved, Investigational
Description

Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase transfer agent Label. Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride Label. This salt is used in a great variety of international pharmaceutical products such as eye, ear, and nasal drops or sprays as an excipient ingredient serving as an antimicrobial preservative Label. When used as an ingredient in antiseptic and disinfectant products however, it is an active antimicrobial agent 2.

Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Benzalkonium bromide151T1GQ42D91080-29-4Not applicable
Benzalkonium chlorideF5UM2KM3W78001-54-5Not applicable
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EUDERMIS RxGel0.0887 g/88.7mLTopicalBlaine Labs Inc.2019-04-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2XL Mega Rolls Sanitizing WipesSwab0.13 g/100gTopical2xl Corporation2017-03-16Not applicableUs
3 Pack Scented Hand SanitizerGel0.1 g/100gTopicalFoshan Jinxiong Technology Co ., Ltd.2017-01-03Not applicableUs
4 SURE Plus E3 Instant Foam Hand SanitizerLiquid1 mg/1mLTopicalDevMar Products LLC2013-01-10Not applicableUs
4158 First Aid KitKit1.3 mg/1mLTopicalHoneywell Safety Products USA, Inc.2018-10-13Not applicableUs
4161 First Aid KitKit1.3 mg/1mLTopicalHoneywell Safety Products USA, Inc.2018-10-13Not applicableUs
4174 First Aid KitKit1.3 mg/1mLTopicalHoneywell Safety Products USA, Inc.2018-10-13Not applicableUs
4175 First Aid KitKit1.3 mg/1mLTopicalHoneywell Safety Products USA, Inc2017-12-22Not applicableUs
4176 First Aid KitKit1.3 mg/1mLTopicalHoneywell Safety Products USA, Inc.2018-10-13Not applicableUs
4178 First Aid KitKit1.3 mg/1mLTopicalHoneywell Safety Products USA, Inc.2018-10-13Not applicableUs
5247OP Hand SanitizerSpray0.1 g/100mLTopicalInnovation Specialties2018-01-24Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
10 Person ANSIBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ibuprofen (200 mg/1) + Lidocaine (0.5 1/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralGenuine First Aid2010-04-24Not applicableUs
10 Person ANSIBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ibuprofen (200 mg/1) + Lidocaine (0.5 1/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOralGenuine First Aid2010-04-24Not applicableUs
25 Person ANSIBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ethanol (62 g/100g) + Ibuprofen (200 mg/1) + Isopropyl alcohol (70 mL/100mL) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitTopicalGenuine First Aid2010-04-25Not applicableUs
25 Person ANSIBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ethanol (62 g/100g) + Ibuprofen (200 mg/1) + Isopropyl alcohol (70 mL/100mL) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitTopicalGenuine First Aid2010-04-25Not applicableUs
3 Step First Aid KitBenzalkonium chloride (1 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL)LiquidTopicalSwabplus Inc.2003-03-012013-01-30Us
3-Step First Aid KitBenzalkonium chloride (11 mg/10mL) + Lidocaine hydrochloride (100 mg/10mL) + Povidone-iodine (100 mg/10mL)KitTopicalSwabplus Inc.2003-03-01Not applicableUs
4017 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4017 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4022 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4022 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
4017 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4017 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4022 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4022 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Acetaminophen (325 mg/1) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmicHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4032 First Aid KitBenzalkonium chloride (1.3 mg/1mL) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitTopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUs
4042 First Aid KitBenzalkonium chloride (0.13 g/100g) + Bacitracin zinc (400 [iU]/1g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUs
4044 First Aid KitBenzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Povidone-iodine (10 mg/1mL)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUs
4045 First Aid KitBenzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Povidone-iodine (10 mg/1mL)KitTopicalHoneywell Safety Products USA, Inc2018-11-21Not applicableUs
4049 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-29Not applicableUs
4049 First Aid KitBenzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)KitTopicalHoneywell Safety Products USA, Inc2018-11-29Not applicableUs
Categories
UNII
7N6JUD5X6Y
CAS number
Not Available

Pharmacology

Indication

When used as an active ingredient in products like antibacterial, antiseptic, or disinfectant soaps, topical sanitizers, or cleaning agents, benzalkonium is primarily implemented in its salt form, benzalkonium chloride, where it may often be the only active ingredient present and indicated for the primary purpose of topical washing to decrease bacteria on skin 2.

Conversely, when implemented as an excipient ingredient in a variety of multidose aqueous nose, eye, or ear products, benzalkonium chloride is being used as the antimicrobial preservative of choice to facilitate effective bactericidal and fungicidal actions to help minimize the growth of unwanted organisms in the multidose containers Label.

Pharmacodynamics

Benzalkonium chloride solutions are generally categorized as biocidal agents with relative long durations of action. Their spectrum of activity has been demonstrated against bacteria, to some viruses, fungi, and protozoa 3, although bacterial spores are treated as being resistant to the agent. Additionally, the agent generally shows more activity against gram-positive than gram-negative bacteria 3. Finally, solutions of benzalkonium chloride are bacteriostatic or bactericidal based on their concentration. Bacteriostatic agents act to prevent further growth of bacterial organisms that are present while bactericidal agents function to kill bacteria that are present 1. In general, the activity of the agent is not largely affected by pH, but such activity does increase substantially at higher temperatures and prolonged exposure times.

Mechanism of action

Although not entirely elucidated, the bactericidal action of benzalkonium chloride is believed to be due to the disruption of intermolecular interactions. Such disruption can cause the dissociation of cellular membrane lipid bilayers of bacteria, resulting in compromised cellular permeability control and the leakage of important cellular contents. Additionally, other important molecular complexes like enzymes which control the maintenance of a great range of respiratory and metabolic cellular activities, are also susceptible to such deactivation. Consequently, a variety of critical intermolecular interactions and tertiary structures in very highly specific biochemical systems that allow bacterial agents to function normally can be readily disrupted or deactivated by cationic surfactants like benzalkonium chloride. 3.

Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Percutaneous absorption is considered to be insignificant 3.

In one study, benzalkonium chloride absorption was evaluated in women using tampons containing the agent. Venous blood samples were drawn 15 minutes before the tampon application and then again at 15 min, 1 h, 3 h, and 24 h after application. Benzalkonium chloride was not detected in any of the blood samples at any time tested. 3

Similarly, in another study, benzalkonium chloride absorption was tested in women using tampons containing the agent. Venous blood and breast milk samples were taken 15 minutes before application and 3 h and 24 h after tampon administration. Benzalkonium chloride was not found in any of the subjects' samples. 3.

Moreover, in a study where benzalkonium chloride solution was placed on the corneal surface of rabbit subjects, at various intervals after administration, the rabbits' eyes would be washed with 1 mL saline and the following tissues and fluids were removed: bulbar and palpebral conjunctiva, aqueous humour, corneal epithelium, endothelium and stroma, iris-ciliary body, lens, vitreous, retina, and choroid. Plasma samples were obtained with direct cardiac punctures. After administration of one drop, benzalkonium chloride was found in the corneal epithelium, endothelium, and stroma, and in the bulbar and palpebral conjunctivae. Benzalkonium chloride loss from ocular tissues was such that about one-third to two thirds of its concentration (depending on the tissue) at 30 min remained after 24 hr; measurable values existed for as long as 120 hr. The administration of multiple drops led to continued accumulation of benzalkonium chloride. 3.

Volume of distribution

When applied as a topical antibacterial, antiseptic, disinfectant, or sanitizer it is believed that molecules of benzalkonium chloride are poorly absorbed (perhaps due to their large, positively charged nature 5), especially considering expectations for such topical applications to keep their biocidal agents available for action at the topical level and to not be absorbed significantly beyond it.

When benzalkonium chloride is implemented as an excipient preservative ingredient in various eye, nose, and ear aqueous products, such products will always have other active pharmacological agents whose volume of distribution will be of greater importance. In these cases the excipients will only ever be present at the minimal levels necessary to maintain the integrity of the product substance.

Moreover, Benzalkonium chloride is currently listed as a Category III ingredient by the United States Food and Drug Administration 6. Ingredients are listed in the FDA Category III when the data available about them are insufficient to classify as safe and effective, requiring further testing to determine more formal details about elements like human pharmacokinetic studies, and studies on the ingredients' absorption, distribution, metabolism, and excretion.

Protein binding
Not Available
Metabolism

Since benzalkonium chloride is structurally a large, positively charged molecule it is likely poorly absorbed and eliminated largely in faeces, similar to other quaternary ammonium compounds 5.

Route of elimination

Administered benzalkonium chloride is likely eliminated largely in faeces, similar to other quaternary ammonium compounds 5.

Half life
Not Available
Clearance
Not Available
Toxicity

An oral dose of 100-400 mg/kg or a parenteral dose of 5-15 mg/kg is believed to be fatal in humans 5.

A potential concern for larger concentrations of benzalkonium chloride to possibly cause corneal damage when implemented as an excipient ingredient in aqueous eye products is an issue that should be discussed between potential patents and their health care providers 5. Since decreased regular blinking and tear generation in patients experiencing dry eyes due to any number of eye conditions can result in reduced dilution of applied eye drops containing the benzalkonium chloride preservative 5, alternative options including benzalkonium chloride-free products should be considered.

Additionally, benzalkonium chloride has been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy. In addition, benzalkonium chloride may cause eye irritation and is known to discolour soft contact lenses 5. There may also be the possibility of benzalkonium chloride containing eye drops to cause some stinging and pain 5.

There is the possibility of ototoxicity occurring when benzalkonium chloride containing ear drops are applied to the ear 5.

Benzalkonium chloride used as a preservative in nebulised solutions of anti-asthma drugs has been reported to cause dose-related bronchoconstriction especially in asthmatic patients and has been associated with the precipitation of respiratory arrest 5.

Despite the fairly widespread cutaneous use of benzalkonium chloride, only limited human evidence of sensitization in relatively small populations of individuals have been reported 5. Nevertheless, the main adverse effect for topical formulations of benzalkonium chloride is usually the warning 'may cause local irritation' 5.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. Pankey GA, Sabath LD: Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections. Clin Infect Dis. 2004 Mar 15;38(6):864-70. doi: 10.1086/381972. Epub 2004 Mar 1. [PubMed:14999632]
  2. DailyMed: Benzalkonium Chloride - antibacterial hand soap refill liquid Monograph [Link]
  3. NIH Toxnet Benzalkonium Chloride Compounds [Link]
  4. The National Institute for Occupational Safety and Health (NIOSH) Benzalkonium Chloride Chemical Safety Card [Link]
  5. European Medicines Agency: Benzalkonium chloride used as an excipient [Link]
  6. Food and Drug Administration: Safety and Effecrtiveness for Health Care Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use; Proposed Amendment of the Tentative Final Monograph; Reopening of Administrative Record [Link]
External Links
PubChem Substance
347911117
Wikipedia
Benzalkonium
ATC Codes
R02AA16 — BenzalkoniumD08AJ01 — BenzalkoniumD09AA11 — Benzalkonium
AHFS Codes
  • 84:04.92 — Miscellaneous Local Anti-infectives
FDA label
Download (121 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceAlcohol Dependence / Alcohol Related Disorders1
1Unknown StatusTreatmentEye Diseases1
2CompletedPreventionHealthy Volunteers1
2CompletedTreatmentGlaucoma / Ocular Hypertension1
3CompletedTreatmentAnterior Uveitis (AU)1
4Active Not RecruitingTreatmentContraception1
4CompletedTreatmentEndocrine ophthalmopathy1
4CompletedTreatmentGlaucoma, Primary Open Angle (POAG)1
4CompletedTreatmentIntraocular Pressure1
4CompletedTreatmentPharyngitis1
4Enrolling by InvitationNot AvailableHealthy Volunteers1
4RecruitingTreatmentWound Infections1
4Unknown StatusTreatmentChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedNot AvailableHealthy Volunteers / High Blood Pressure (Hypertension)1
Not AvailableCompletedTreatmentWound Healing1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
KitIrrigation
LiquidTopical78 mg/60mL
CreamTopical.005 g/2g
KitTopical
SoapTopical25.0 mg/1mL
LiquidTopical1.29 mg/1mL
SoapTopical1 mg/1mL
LiquidTopical1.30 mL/100mL
SolutionTopical.13 g/100mL
SwabTopical0.40 g/100g
Aerosol, foamTopical.1 g/10mL
LiquidTopical.13 g/10mL
Aerosol, foamTopical0.13 mL/100mL
Aerosol, foamTopical1.2 mL/1000mL
GelTopical.13 mL/100mL
GelTopical1 mg/1mL
DressingTopical0.28 mg/3.125cm2
LiquidTopical1.2 g/1000mL
SoapTopical25 mg/1mL
SoapTopical1.3 g/1000mL
ClothTopical0.155 1/1001
LiquidTopical1.3 mg/1000mL
PatchTopical0.12 g/100g
SwabTopical0.12 g/100g
SwabTopical1 g/100g
DressingTopical0.12 g/100g
LotionTopical1.313 mg/1mL
SolutionTopical0.325 mL/295.74mL
SolutionTopical0.055 mL/50.275mL
GelTopical1.0 mg/1mL
LotionTopical.13 mL/100mL
GelTopical0.25 g/100g
LiquidTopical0.12 g/100g
SprayTopical0.4 g/100g
LiquidTopical1.313 mg/1mL
ClothTopical1.3 mg/1
LiquidTopical13 kg/100kg
SwabTopical1 mg/1mL
ClothTopical3.3 mg/1
LiquidTopical0.3 g/100g
SwabTopical0.1 g/100g
SwabTopical0.115 mg/100mg
SwabTopical0.115 g/100g
SwabTopical0.3 g/100g
SwabTopical0.115 mL/100mL
LiquidTopical0.115 g/100g
LiquidTopical1.3 ug/1mg
SoapTopical0.3 g/100mL
ClothTopical0.01417 g/1
LiquidTopical1.2478 g/1L
LiquidTopical1.30 mL/1L
SwabTopical1.3 mg/1g
SwabTopical1.3 mg/1mL
DressingTopical0.042 mg/1
DressingTopical0.1 mg/100mg
ClothTopical1.3 mg/1g
GelTopical0.12 %
GelTopical0.15 %
LotionTopical
CreamTopical0.12 g/100mL
LiquidTopical1.1 mg/1.4mL
SwabTopical0.13 g/100g
SwabTopical1 mg/1
ClothTopical1.3 mg/1mL
ClothTopical0.133 g/100g
LiquidTopical1000 mg/1.3mg
LiquidTopical100 mg/100mL
KitOral
LozengeOral
LiquidTopical1.3 mg/100mL
PatchTopical0.1 mg/100mg
SoapTopical25 mL/1000mL
SprayTopical0.3 g/100mL
GelTopical1 g/1000mL
SprayOral
GelVaginal100 mg/100mL
DoucheVaginal0.1 mL/100mL
GelTopical1.3 mg/1mL
GelTopical1.3 mg/100mL
LiquidTopical0.1 mL/100mL
SprayTopical0.13 g/100mL
Aerosol, foamTopical100 g/100L
LiquidTopical0.05 g/50mL
LiquidTopical0.5 g/500mL
LiquidTopical0.03 g/30mL
LiquidTopical0.2 g/200mL
LiquidTopical0.1713 g/100mL
AerosolTopical
SwabTopical0.0012 mg/1mg
LiquidTopical.13 g/1mL
LiquidTopical1 g/13mg
SwabTopical0.0013 g/1mL
SwabTopical
SwabTopical0.0013 mg/1
SwabTopical0.004 mL/1
GelTopical0.06 mg/59mg
LiquidDental
LiquidTopical0.12 g/100mL
GelTopical0.1 g/100g
SoapCutaneous0.1 g/100g
LiquidTopical.1 mg/1mL
Aerosol, foamTopical1 mg/1000mL
LiquidTopical0.0013 g/1g
SwabTopical1 mg/1g
SwabTopical1.33 mg/1mL
SwabTopical0.10 g/100g
SwabTopical0.13 mg/100mg
SwabTopical1 g/750g
SwabTopical1 mL/750mL
SolutionTopical0.4 g/100mL
SolutionTopical0.13 g/100g
SolutionTopical.0013 mL/1
SolutionTopical0.0013 mL/1mL
SwabTopical0.00133 mL/1.0mL
ClothTopical0.133 %
SolutionEpidural; Topical.0013 mL/1
SwabTopical0.001 mL/1.4mL
SwabTopical0.00186 mL/1.4mL
SoapTopical1.0 mg/1mL
LiquidTopical20 g/1L
ClothTopical0.05 g/1g
SwabTopical0.133 g/100g
LiquidTopical1.2 g/1L
SwabTopical0.1 1/1
GelTopical0.13 mL/100mL
SoapTopical0.13 g/100mL
SwabTopical0.13 mg/1
SoapTopical.12 g/100mL
SolutionTopical0.13 mg/100mL
ShampooTopical0.19 g/191.64g
TinctureTopical0.13 mL/1mL
CreamTopical
SwabTopical0.12 mg/100mg
SolutionTopical0.115 g/1
SprayTopical.0013 mL/1mL
GelTopical.0013 mL/1mL
LotionTopical0.59 mL/59mL
GelTopical0.13 g/100g
SwabTopical1.3 mg/1
SwabTopical
GelTopical0.13 g/100mL
RinseTopical
KitTopical1.3 mg/1mL
SprayTopical
Gel, dentifriceDental
ClothTopical0.12 g/100mL
GelTopical1.3 g/1mL
LiquidTopical.13 mg/1mL
LiquidTopical1.3 g/1L
SprayTopical1 mg/1mL
PowderTopical
SoapTopical0.113 g/113g
SoapTopical0.115 g/100g
GelTopical1 mg/100mg
LiquidTopical0.1 g/100g
PatchTopical0.1 g/100g
GelTopical1 g/59mL
LiquidTopical2.5 mg/250mL
SoapTopical2.5 g/100g
LiquidTopical.10 g/100g
LiquidTopical1 g/1000mL
LiquidTopical0.13 %
SolutionTopical0.1 mg/100mL
SolutionTopical1 mg/1mL
SolutionTopical19.8 mg/1mL
SolutionTopical4.7 mg/1mL
SolutionTopical5.5 mg/1mL
SolutionTopical8.9 mg/1mL
SwabTopical.12 1/1
SwabTopical0.12 1/1
LiquidTopical13 mg/1mL
SolutionTopical0.1 g/100g
Kit
SolutionTopical0.998 g/1mL
LiquidTopical0.1 %
SoapTopical0.1 mg/1mL
SolutionTopical1 g/1mL
LiquidTopical.13 g/100mL
GelDental
LiquidTopical2.5 g/100mL
GelTopical0.0887 g/88.7mL
LotionTopical1.1 mg/1mL
CreamTopical1.3 mg/1g
SwabTopical0.11 g/100g
SolutionTopical1.3 g/1000mL
Liquid; sprayTopical
SprayTopical0.13 g/100g
CreamTopical
SwabTopical0.13 mg/100mL
SwabTopical0.00182 mL/1.4mL
SoapTopical0.13 mL/100mL
GelTopical1 mg/1g
GelTopical0.029 mL/29.57mL
LiquidTopical2 g/100g
SoapTopical0.013 mg/1mL
LiquidTopical0.1 mg/1mL
LiquidTopical0.15 %
LotionTopical1.3 mg/1mL
LiquidTopical0.1000 mL/100mL
SoapTopical0.003 mg/1mL
SolutionTopical0.115 mL/100mL
LiquidTopical0.001 g/1mL
LotionTopical.0013 g/1mL
SprayTopical0.001 g/1mL
LotionTopical.364 g/280mL
GelTopical0.01 g/59g
LiquidTopical
SolutionTopical0.0026 g/2mL
PatchTopical0.133 g/100g
SprayTopical1.3 mg/1mL
LotionTopical0.0013 g/1mL
SprayTopical0.0013 g/1mL
LiquidTopical10 mg/100mL
ClothTopical.0013 mg/100mg
SolutionTopical1.3 g/100mL
SwabTopical1.15 mg/1mL
Aerosol, foamTopical0.0013 g/1g
GelTopical0.0013 g/1g
SprayTopical0.0013 g/1g
SoapTopical0.13 1/1mL
GelTopical
ClothTopical3.480 g/34.8g
SolutionTopical.001 g/1g
SolutionTopical0.001 g/1g
FilmTopical0.115 g/1001
PillVaginal0.003 g/1
LotionTopical0.1 g/100mL
DoucheVaginal1 mg/1mL
LiquidTopical1200 ug/1mL
LiquidTopical1.3 mg/1g
Aerosol, foamTopical.27 mL/207mL
GelTopical0.13 g/1mL
LiquidTopical0.0039 mg/1mL
LiquidTopical1.00 mg/1L
LiquidTopical1.3 g/1000g
LiquidTopical7.49 g/1L
LotionTopical1.3 g/1000g
SolutionTopical1.3 g/1mL
SprayTopical0.0294 g/30mL
SprayTopical0.13 %
LiquidTopical0.13 kg/100kg
GelTopical0.13 g/1001
ClothTopical0.0067275 g/1
ClothTopical0.12 %
LiquidTopical.999 mg/1mL
LiquidTopical1.3091 mg/1mL
LiquidTopical0.222 g/222mL
ClothTopical1.3 g/1mL
SoapTopical1.3 mg/1mL
SprayTopical
SoapTopical
KitTopical0.1 g/100g
OintmentTopical
GelTopical0.059 g/59mL
LiquidTopical0.13 L/100L
Solution / dropsAuricular (otic)
Aerosol, foamTopical1 mg/1mL
LiquidCutaneous; Infiltration
LiquidTopical0.0013 g/1mL
LiquidTopical130 mg/100mL
SoapTopical2.5 mg/1L
SoapTopical0.0026 mg/100mL
GelTopical0.095 mg/100mL
SolutionTopical1.2 mg/1mL
LiquidTopical1.2 mg/1mL
LiquidTopical0.13 g/100g
Liquid; swabTopical
LiquidTopical0.13 g/1mL
LiquidTopical0.5 mg/100mL
LiquidTopical0.7 mg/100mL
LiquidTopical0.44 g/354mL
SolutionTopical1.3 g/1L
SolutionTopical0.013 mg/1L
SolutionTopical0.1 %
SolutionTopical1.3 mg/1000mL
SolutionTopical0.001 g/1mL
ClothTopical0.13 mg/100mL
SoapTopical1.3 g/1L
SoapTopical1.0 g/1L
SolutionTopical0.1 g/100mL
LiquidTopical1.3 mg/1.7mL
LiquidTopical3 mg/100mL
ShampooTopical
AerosolTopical
LiquidTopical0.13 mg/100mg
SprayTopical1.3 g/1L
KitOphthalmic
ClothTopical0.12 mg/100mL
ClothTopical0.133 g/1
LotionTopical.596 g/298g
SolutionTopical5 mg/1mL
PatchTopical0.12 mg/100mg
CreamTopical0.13 g/100g
GelTopical1 g/59g
LotionTopical.1 g/100g
SoapTopical1.3 g/1mL
LotionTopical0.1 mL/100mL
LiquidTopical0.005 mg/1mL
LotionTopical0.13 mg/1mL
GelTopical1 g/22mL
TabletVaginal
SoapTopical.27 mL/236mL
SoapTopical4.3 mL/3.75L
GelTopical0.1 mL/100mL
KitRespiratory (inhalation)
KitTopical1.33 mg/1mL
SwabTopical.0021 mL/1.4mL
PatchTopical1.33 mg/1g
SolutionTopical.004 mL/1
ClothTopical0.04 mg/100mL
LiquidTopical10 g/1000mL
ClothTopical0.05 mg/1
SwabTopical0.05 mg/1
LiquidTopical2.6 g/1L
SolutionTopical1 g/1000mL
GelTopical
GelDental; Topical
SolutionTopical.26 g/100mL
SolutionCutaneous1.3 mg/1mL
SolutionCutaneous2.6 mg/2mL
ClothTopical0.13 mL/1mL
ClothTopical0.1 g/100g
SoapTopical0.13 g/100g
LiquidTopical0.0002218 mg/221.8mL
ClothTopical0.1 g/1
ClothTopical0.0155 g/1
SoapTopical120 mg/100mL
Spray1.3 mg/1mL
LiquidTopical28.39 mg/100mL
LiquidTopical12 mL/100mL
ClothTopical0.13 g/100g
LotionTopical
SprayTopical0.13 mL/100mL
Aerosol, foamTopical1.3 mg/1mL
LiquidTopical1.3 g/1mL
LiquidTopical0.0013 mg/1mL
ClothTopical0.00013 mg/1mL
LiquidTopical0.00013 1/1
ClothTopical0.0013 mg/1mL
ClothTopical0.13 %
SwabTopical0.0013 1/1
LiquidTopical0.00115 1/1
LiquidTopical0.0013 mL/1mL
SprayTopical10 mg/100mL
ClothTopical0.10 g/1
Cloth
SoapTopical0.0013 g/1mL
ClothTopical
ClothTopical0.12 g/100g
KitTopical0.13 g/100g
SoapTopical0.13 g/1L
LiquidTopical1.3 mg/1mL
SolutionTopical120 mg/100mL
GelTopical170 mg/89mL
Gel, dentifriceOral
LiquidTopical4.918 g/100mL
LiquidCutaneous1.3 mg/1mL
GelCutaneous1.3 mg/1mL
LiquidTopical0.13 g/100mL
LiquidTopical0.12 mg/100mL
ClothCutaneous1 mg/1
ClothTopical0.13 mg/1mL
ClothTopical0.24 mg/1mL
LiquidCutaneous1.0 mg/1mL
GelCutaneous1 mg/1mL
SwabTopical0.26 g/100g
LiquidTopical1.3 mg/1.4g
PatchTopical0.13 g/100g
SolutionTopical1 mg/1000mL
SolutionTopical0.13 %
SolutionTopical1.3 mg/1mL
SolutionTopical0.13 g/100mL
SolutionTopical
ClothTopical0.00097 g/1mL
ClothTopical
ClothTopical0.13 g/1
LiquidTopical1.25 mg/1mL
LiquidTopical1.5 mg/1mL
ClothTopical.13 g/1g
SprayTopical13 mg/1mL
LiquidTopical1.33 mg/1mL
LiquidTopical1.0 mL/1L
LotionTopical.13 g/100g
LotionTopical.56 g/293g
LotionTopical.13 mg/100mL
LiquidTopical1 mg/13mL
LiquidTopical0.237 g/237mL
SoapTopical1.00 mg/1mL
LiquidTopical0.24 mL/100mL
SolutionTopical0.12 g/100mL
LotionTopical0.13 g/100g
ClothTopical0.0062 g/1
ClothTopical0.13 mg/100mg
SoapTopical0.1 mg/1L
LiquidTopical1.3 uL/1mL
LiquidTopical1.3 mL/1mL
TinctureTopical1.3 mg/1mL
SolutionTopical0.13 g/1mL
SoapTopical13 mg/10mL
SoapTopical2.34 mg/1.8mL
LiquidTopical1.25 mL/1000mL
LiquidTopical0.1 g/100mL
IrrigantTopical1.3 mg/1mL
ClothTopical0.115 g/1
SoapTopical0.12 g/100mL
Aerosol, sprayTopical0.13 g/100g
LiquidTopical0.1 mg/1L
ClothCutaneous1.3 mg/1
SprayTopical0.1 g/100mL
SoapTopical0.1 g/100g
LiquidTopical1 mg/1mL
SoapTopical0.1 g/100mL
GelTopical1 g/30mL
GelTopical0.1 g/100mL
LiquidTopical0.13 mL/100mL
SprayTopical1.2 mg/1mL
LiquidTopical
SwabTopical0.0013 mL/1mL
SwabTopical0.13 mg/1mL
ClothTopical0.09 g/1
SwabTopical0.1 g/1
SoapTopical13 mg/1.0mL
SwabTopical0.0062 g/1
Aerosol, sprayTopical1.3 mg/1mL
SwabTopical.0013 g/1g
LiquidTopical268575.42 mg/208198 mL
LotionTopical99468.4 g/100L
SolutionTopical
SoapTopical0.5 g/444g
LiquidTopical0.5 g/444g
SoapTopical0.2 g/221g
GelTopical3 g/207g
Spray, meteredTopical
LiquidTopical0.13 mg/1mL
LiquidTopical0.1 mg/0.001L
SoapTopical0.13 mg/1mL
LiquidTopical0.013 g/10mL
LiquidTopical.013 g/10mL
LotionTopical296 mg/1000mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on September 19, 2019 03:16