Identification

Name
Lanolin
Accession Number
DB11112
Type
Small Molecule
Groups
Approved
Description

Lanolin is a yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid [6]. The US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointments [9].

Lanolin is the purified, secreted product of the sheep sebaceous glands [10]. Lanolin primarily consists of long-chain waxy esters, or sterol esters, that lack glycerides. For this reason, it is also called wool wax or wool grease. Lanolin is used in the protection, treatment, and cosmetic enhancement of human skin. Its hydrophobic properties can help protect skin against infections or skin irritation, as it helps seal in moisture that is already present in the skin [13].

Lanolin is used as an active ingredient in over the counter topical products such as ointments, lubricants, lotions and facial cosmetics. Lanolin is also frequently used in protective baby skin treatment and for sore nipples in breastfeeding mothers [9], [1].

Synonyms
  • Anhydrous lanolin
  • Fats, lanolin
  • Lanolin oil
  • Lanolin, anhydrous
  • Wool fat
  • Wool grease
  • Wool oil
  • Wool wax, lanolin
  • Wool wax, refined
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
3ce Drawing Lip ChillingLipstick0.02 g/1.1gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
4sport Skincare Anti ChafingLotion40 g/100mLTopical4sport d.o.o.2018-01-07Not applicableUs
AmeriDerm DermaFixOintment22 g/100gTopicalShield Line LLC2015-02-01Not applicableUs
Lana1263Ointment50 g/100gTopicalBlossom Pharmaceuticals2014-10-23Not applicableUs
LanashieldOintment50 g/100gTopicalDynarex Corporation2014-10-12Not applicableUs
LanodermOintment0.3 g/100gTopicalDermarite Industries LLC2012-04-16Not applicableUs
LanoGuard Daily Care Skin ProtectantOintment300 mg/1gTopicalSummit Industries2013-03-21Not applicableUs
LanoGuard Dry Skin TherapyCream370 mg/1gTopicalSummit Industries2009-12-30Not applicableUs
LanolinOintment50 g/100gTopicalSion Biotext Medical Ltd.2012-07-09Not applicableUs
LanolinOintment50 g/100gTopicalDynarex Corporation2010-05-12Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A and D Diaper Rash and Skin ProtectantLanolin (0.15 mg/1g) + Petrolatum (0.53 mg/1g)CreamTopicalNatureplex, LLC2014-11-12Not applicableUs
A and D First AidLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalFamar Montreal Inc2003-06-04Not applicableUs
A and D First AidLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalBayer2003-06-04Not applicableUs
A and D OriginalLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalBayer Healthcare Llc.2003-06-04Not applicableUs
A and D OriginalLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalFamar Montreal Inc2003-06-04Not applicableUs
A D and L Original Diaper Rash SkinLanolin (15.5 g/100g) + Petrolatum (53.4 g/100g)OintmentTopicalHarmon Stores2014-09-01Not applicableUs
A+d Diaper Rash OintmentLanolin (15.5 %) + Petrolatum (53.4 %)OintmentTopicalSchering Plough1998-07-082014-07-31Canada
Alpha KeriLanolin (3 %) + Mineral oil (91.7 %)LiquidTopicalBristol Myers Squibb1958-12-311999-08-09Canada
Baby ButzLanolin (8.8 g/57g) + Starch, corn (14.3 g/57g) + Zinc oxide (17.1 g/57g)CreamTopicalOlen Cosmetics Corporation2012-07-172013-07-08Us
Baby Care Vitamins A and DLanolin (15.5 g/100g) + Petrolatum (53.4 g/100g)OintmentTopicalRite Aid2014-03-05Not applicableUs
Categories
UNII
7EV65EAW6H
CAS number
8006-54-0
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Used as a skin protectant, and to relieve dryness and irritation of the skin [12], [7]. Helps prevent and treat diaper dermatitis [5].

Pharmacodynamics

Lanolin treats cracked, dry, irritated skin and minor burns. It prevents and treats sore nipples during breastfeeding [4], [15]. Protects chafed skin or minor skin irritations due to various causes [5], [7].

Mechanism of action

Lanolin is an emollient. Emollients soften the skin by forming an occlusive oil film on the stratum corneum layer of the epithelium, thus decreasing the transepidermal water loss [7].

TargetActionsOrganism
ASkin epithelial cells
coating agent
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

Studies have shown a positive association between atopic dermatitis and lanolin contact allergy [14]. The prevalence of lanolin allergy is low (1.8%-2.5%) [1]. Patch testing with lanolin is helpful in patients with dermatitis and suspected cosmetic allergy [14].

The acute dermal LD50 of lanolin oil was > 10 mL/kg for rabbits [16].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Miest RY, Yiannias JA, Chang YH, Singh N: Diagnosis and prevalence of lanolin allergy. Dermatitis. 2013 May-Jun;24(3):119-23. doi: 10.1097/DER.0b013e3182937aa4. [PubMed:23665833]
  2. Hon KL, Kung JSC, Ng WGG, Leung TF: Emollient treatment of atopic dermatitis: latest evidence and clinical considerations. Drugs Context. 2018 Apr 17;7:212530. doi: 10.7573/dic.212530. eCollection 2018. [PubMed:29692852]
  3. Code of federal regulations [Link]
  4. NIH: Lanolin on the skin [Link]
  5. Lanolin Ointment [Link]
  6. Lanolin MeSH [Link]
  7. Lanolin synthesis reference [Link]
  8. Lanolin, Drugs.com [Link]
  9. NIH Toxnet Lanolin [Link]
  10. Final Report of the Safety Assessment for PEG-75 Lanolin, PEG-20 Lanolin, PEG-27 Lanolin, PEG-30 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-60 Lanolin, and PEG-85 Lanolin [Link]
  11. LipidBank Wax [Link]
  12. Lanolin Monograph, Epocrates [Link]
  13. Lanolin, Web MD [Link]
  14. Contact allergy to lanolin: temporal changes in prevalence and association with atopic dermatitis [Link]
  15. An evaluation of the effect ov lanolin in healing nipple injuries [Link]
  16. Safety Assessment of Polyether Lanolins as Used in Cosmetics [File]
External Links
PubChem Substance
347911120
Wikipedia
Lanolin
AHFS Codes
  • 84:24.12 — Basic Ointments and Protectants
MSDS
Download (66.8 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LipstickTopical0.02 g/1.1g
OintmentTopical
PasteTopical
Kit
CreamTopical
OintmentTopical0.3 g/100g
CreamTopical370 mg/1g
OintmentTopical50 g/100g
OintmentTopical70 g
OintmentTopical72 %
CreamTopical300 mg/1g
CreamTopical500 mg/1g
OintmentTopical22 g/100g
OintmentTopical300 mg/1g
OintmentTopical5 g/10g
CreamTopical50 g/100g
LotionTopical40 g/100mL
CreamTopical1 mg/50mg
OintmentTopical500 mg/1g
OintmentOphthalmic
LiquidTopical
LotionTopical
LiquidTopical12.5 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)38-44MSDS
water solubilityinsoluble MSDS
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

1. Skin epithelial cells
Kind
Group
Organism
Human
Pharmacological action
Yes
Actions
Coating agent
References
  1. Lanolin synthesis reference [Link]

Drug created on December 03, 2015 09:51 / Updated on December 18, 2018 05:46