Identification
- Summary
Sodium iodide is a supplement used in total parenteral nutrition.
- Brand Names
- Sclerodine
- Generic Name
- Sodium iodide
- DrugBank Accession Number
- DB11119
- Background
Sodium iodide is a water-soluble ionic compound with a crystal lattice. Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition 2 but is more commonly used in veterinary medicine. Radiolabelled compound, Iodide I-131, is used as a diagnostic tool to evaluate thyroid function and morphology.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Sodium iodide (DB11119)
- Weight
- Average: 149.8942
Monoisotopic: 149.89424 - Chemical Formula
- INa
- Synonyms
- Sodium iodide
Pharmacology
- Indication
Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN) 2.
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Abscesses Combination Product in combination with: Iodine (DB05382) ••• ••• •••••••• Used in combination to treat Bleeding of the vitreal body Combination Product in combination with: Chlorhexidine (DB00878), Potassium Iodide (DB06715) ••• ••• •••••••• • ••••• Used in combination to treat Clouding of the lenses Combination Product in combination with: Potassium Iodide (DB06715), Chlorhexidine (DB00878) ••• ••• •••••••• • ••••• Used in combination to treat Vitreous opacities Combination Product in combination with: Potassium Iodide (DB06715), Chlorhexidine (DB00878) ••• ••• •••••••• • ••••• Used in combination to treat Wounds Combination Product in combination with: Iodine (DB05382) ••• ••• •••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
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When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms 2.
- Mechanism of action
- Not Available
- Absorption
Iodide salts are readily absorbed in the gastrointestinal tract 1.
- Volume of distribution
Iodides are distributed widely throughout extracellular fluid of thyroid gland 1.
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Iodides are expected to be renal excreted 1.
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Acute oral LD50 is 4340 mg/kg in rat and 1000 mg/kg in mouse MSDS. Chronic iodide overdoses may result in iodism, which is commonly characterized by salivation, coryza, sneezing, conjunctivitis, headache, fever, laryngitis, bronchitis, stomatitis, parotitis and oedema of the glottis 1. Up to 10g of sodium iodide has been administered intravenously without any signs of toxicity 1.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Iodide ionic 09G4I6V86Q 20461-54-5 XMBWDFGMSWQBCA-UHFFFAOYSA-M Sodium cation ionic LYR4M0NH37 17341-25-2 FKNQFGJONOIPTF-UHFFFAOYSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Iodopen Sodium Iodide Injection, solution 118 ug/1mL Intravenous Fresenius Kabi USA, LLC 2001-07-18 2015-09-30 US 
Micro I Liquid 100 mcg / mL Intravenous Sandoz Canada Incorporated 1993-12-31 Not applicable Canada 
Sodium Iodide Inj 100mg/ml Liquid 100 mg / mL Intravenous Sabex Inc 1988-12-31 1999-08-12 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image CVS Iodine Sodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL) Liquid Topical CVS PHARMACY 2008-01-01 Not applicable US DDM Iodine Tincture Mild Sodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL) Liquid Topical Discount Drug Mart 1979-01-01 Not applicable US De La Cruz Tincture of Iodine Sodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL) Liquid Topical DLC Laboratories, Inc. 1979-01-01 Not applicable US GNP Idoinde Tincture 2% Mild Sodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL) Liquid Topical Amerisource Bergen 2008-01-01 Not applicable US Harris Teeter Iodine Tincture Mild Sodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL) Liquid Topical Harris Teeter, LLC 1979-01-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Iodopen Sodium Iodide Sodium iodide (118 ug/1mL) Injection, solution Intravenous Fresenius Kabi USA, LLC 2001-07-18 2015-09-30 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal salts
- Sub Class
- Alkali metal iodides
- Direct Parent
- Alkali metal iodides
- Alternative Parents
- Inorganic sodium salts
- Substituents
- Alkali metal iodide / Inorganic salt / Inorganic sodium salt
- Molecular Framework
- Not Available
- External Descriptors
- inorganic sodium salt, iodide salt (CHEBI:33167)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- F5WR8N145C
- CAS number
- 7681-82-5
- InChI Key
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M
- InChI
- InChI=1S/HI.Na/h1H;/q;+1/p-1
- IUPAC Name
- sodium iodide
- SMILES
- [Na+].[I-]
References
- General References
- External Links
- KEGG Compound
- C14042
- PubChem Compound
- 5238
- PubChem Substance
- 347827903
- ChemSpider
- 5048
- BindingDB
- 50098561
- 9884
- ChEBI
- 33167
- ChEMBL
- CHEMBL1644695
- Wikipedia
- Sodium_iodide
- MSDS
- Download (47.4 KB)
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Topical Spray Topical Tincture Topical Injection, solution Intravenous 118 ug/1mL Liquid Intravenous 100 mcg / mL Solution Intravenous Capsule, coated Oral 7400 MBq Tablet Oral Liquid Topical Liquid Intravenous Liquid Intravenous 100 mg / mL Injection, solution Intravenous 37 MBq/mL Capsule, coated Oral 37 MBq Solution / drops Ophthalmic Solution Intravenous; Oral 740 MBq - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 651 MSDS boiling point (°C) Decomposes MSDS water solubility Soluble MSDS - Predicted Properties
Property Value Source logP 1.02 Chemaxon pKa (Strongest Acidic) -9 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 13.95 m3·mol-1 Chemaxon Polarizability 5.07 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 113.77963 predictedDeepCCS 1.0 (2019) [M+H]+ 115.67505 predictedDeepCCS 1.0 (2019) [M+Na]+ 123.3359 predictedDeepCCS 1.0 (2019)
Drug created at December 03, 2015 16:51 / Updated at April 18, 2024 09:15