Sodium iodide

Identification

Name
Sodium iodide
Accession Number
DB11119
Type
Small Molecule
Groups
Approved
Description

Sodium iodide is a water-soluble ionic compound with a crystal lattice. Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition [2] but is more commonly used in veterinary medicine. Radiolabelled compound, Iodide I-131, is used as a diagnostic tool to evaluate thyroid function and morphology.

Structure
Thumb
Synonyms
Not Available
Active Moieties
NameKindUNIICASInChI Key
Iodideionic09G4I6V86Q20461-54-5XMBWDFGMSWQBCA-UHFFFAOYSA-M
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Micro ILiquid100 mcgIntravenousSandoz Canada Incorporated1993-12-31Not applicableCanada
Sodium Iodide Inj 100mg/mlLiquid100 mgIntravenousSabex Inc1988-12-311999-08-12Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CVS IodineSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalCVS PHARMACY2008-01-01Not applicableUs
DDM Iodine Tincture MildSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalDiscount Drug Mart1979-01-01Not applicableUs
De La Cruz Tincture of IodineSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalDLC Laboratories, Inc.1979-01-01Not applicableUs
GNP Idoinde Tincture 2% MildSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalAmerisource Bergen2008-01-01Not applicableUs
Harris Teeter Iodine Tincture MildSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalHarris Teeter1979-01-01Not applicableUs
Health Mart Iodine Tincture MildSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalMcKesson2011-01-01Not applicableUs
IodineSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalGeiss, Destin, & Dunn2008-11-08Not applicableUs
IodineSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalVi-Jon2008-11-08Not applicableUs
IodineSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalSUPERVALU INC.2005-02-04Not applicableUs
IodineSodium iodide (20.4 mg/1mL) + Ethanol (470 mg/1mL) + Iodine (20 mg/1mL)LiquidTopicalWalgreen Co2011-03-11Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Iodopen Sodium IodideSodium iodide (118 ug/1mL)Injection, solutionIntravenousAPP Pharmaceuticals, Inc.2001-07-182018-06-14Us
Categories
UNII
F5WR8N145C
CAS number
7681-82-5
Weight
Average: 149.8942
Monoisotopic: 149.89424
Chemical Formula
INa
InChI Key
FVAUCKIRQBBSSJ-UHFFFAOYSA-M
InChI
InChI=1S/HI.Na/h1H;/q;+1/p-1
IUPAC Name
sodium iodide
SMILES
[Na+].[I-]

Pharmacology

Indication

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN) [2].

Pharmacodynamics

When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms [2].

Mechanism of action
Not Available
Absorption

Iodide salts are readily absorbed in the gastrointestinal tract [1].

Volume of distribution

Iodides are distributed widely throughout extracellular fluid of thyroid gland [1].

Protein binding
Not Available
Metabolism
Not Available
Route of elimination

Iodides are expected to be renal excreted [1].

Half life
Not Available
Clearance
Not Available
Toxicity

Acute oral LD50 is 4340 mg/kg in rat and 1000 mg/kg in mouse [MSDS]. Chronic iodide overdoses may result in iodism, which is commonly characterized by salivation, coryza, sneezing, conjunctivitis, headache, fever, laryngitis, bronchitis, stomatitis, parotitis and oedema of the glottis [1]. Up to 10g of sodium iodide has been administered intravenously without any signs of toxicity [1].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium iodide.
AclidiniumThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Alfentanil.
AlmasilateThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Almasilate.
AloglutamolThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Aloglutamol.
AlphacetylmethadolThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Alphaprodine.
AluminiumThe therapeutic efficacy of Sodium iodide can be decreased when used in combination with Aluminium.
Food Interactions
Not Available

References

General References
  1. SODIUM IODIDE - National Library of Medicine HSDB Database - Toxnet [Link]
  2. Dailymed - IODOPEN SODIUM IODIDE- sodium iodide injection, solution [Link]
External Links
KEGG Compound
C14042
PubChem Compound
5238
PubChem Substance
347827903
ChemSpider
5048
BindingDB
50098561
ChEBI
33167
ChEMBL
CHEMBL1644695
Wikipedia
Sodium_iodide
AHFS Codes
  • 40:12.00 — Replacement Preparations
  • 68:36.00 — Thyroid and Antithyroid Agents
MSDS
Download (47.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentCancer, Breast1
3CompletedTreatmentDental Plaque1
4CompletedPreventionTransient Hypothyroxinemia1
4RecruitingPreventionHysterectomy1
4Unknown StatusTreatmentAmputation Wound / Wound Infections1
Not AvailableCompletedPreventionBacteremia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Solution / dropsTopical
SprayTopical
Injection, solutionIntravenous118 ug/1mL
SolutionIntravenous
LiquidIntravenous100 mcg
TabletOral
LiquidTopical
LiquidIntravenous
LiquidIntravenous100 mg
TinctureTopical
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)651MSDS
boiling point (°C)DecomposesMSDS
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
logP1.02ChemAxon
pKa (Strongest Acidic)-9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.95 m3·mol-1ChemAxon
Polarizability5.07 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal salts
Sub Class
Alkali metal iodides
Direct Parent
Alkali metal iodides
Alternative Parents
Inorganic sodium salts
Substituents
Alkali metal iodide / Inorganic sodium salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
inorganic sodium salt, iodide salt (CHEBI:33167)

Drug created on December 03, 2015 09:51 / Updated on December 14, 2018 05:45