Identification

Name
Selenious acid
Accession Number
DB11127
Type
Small Molecule
Groups
Approved, Investigational
Description

Selenious acid is the acid form of sodium selenite, a form of selenium [8].

Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties. Selenium is a component of glutathione peroxidase enzyme, which protects cell components from oxidative damage due to peroxides produced during cellular metabolism [13].

Selenium (Se) has been demonstrated to prevent cancer in numerous animal models when administered selenium at levels exceeding the nutritional requirements. One study showed efficacy in the prevention of malignancy while utilizing a selenium supplement in humans. The reports from such studies have heightened the interest in additional human selenium supplementation studies to validate the results in larger populations [15].

Interestingly, selenium is being studied as a potential therapy in the prevention or management of atherosclerosis [18].

Structure
Thumb
Synonyms
  • selenige Säure
  • Selenous acid
External IDs
UN 3283 / UN-3283
Product Ingredients
IngredientUNIICASInChI Key
Sodium seleniteHIW548RQ3W10102-18-8BVTBRVFYZUCAKH-UHFFFAOYSA-L
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Micro SeSolution40 mcgIntravenousSandoz Canada Incorporated1993-12-31Not applicableCanada
SelepenSolution40 mcgIntravenousPartners Health Care, Inc.1997-01-162008-02-15Canada
Selepen Inj 40mcg/ml USPLiquid40 mcgIntravenousLyphomed, Division Of Fujisawa Canada Inc.1984-12-311997-01-30Canada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Formula-SETablet30 mcgOralGesar Ag1997-09-262001-07-02Canada
Selenium SupplementCapsule30 mcgOralFor Mor International Inc.2000-03-252004-08-11Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
C. Vit-min FormulaSodium selenite (200 mcg) + Ascorbic acid (100 mg) + Biotin (30 mcg) + Calcium (175 mg) + Cholecalciferol (400 unit) + Choline (30 mg) + Chromium (50 mcg) + Copper (5 mg) + Cyanocobalamin (100 mcg) + Ferrous fumarate (10 mg) + Folic Acid (0.600 mg) + Inositol (30 mg) + Magnesium (80 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (50 mg) + Calcium pantothenate (50 mg) + Potassium (40 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (50 mg) + Racemethionine (3 mg) + Riboflavin (50 mg) + Silicon (0.01 mg) + Thiamine (50 mg) + Vanadium (10 mcg) + Vitamin A (5000 unit) + Zinc (40 mg) + alpha-Tocopherol acetate (100 unit)TabletOralNutramed Laboratories Inc.Not applicableNot applicableCanada
Children's Chewable TabSodium selenite (2.6 mcg) + Ascorbic acid (33.33 mg) + Beta carotene (333.3 unit) + Biotin (33 mcg) + Chromic chloride (2.2 mcg) + Cyanocobalamin (7.33 mcg) + Folic Acid (.1 mg) + Magnesium (23.33 mg) + Manganese sulfate (1.82 mg) + Molybdenum (.7 mcg) + Niacin (.33 mg) + Nicotinamide (2.66 mg) + Calcium pantothenate (5 mg) + Potassium (9.44 mg) + Potassium Iodide (.016 mg) + Pyridoxine hydrochloride (1.66 mg) + Racemethionine (2.66 mg) + Riboflavin (1 mg) + Thiamine mononitrate (1.66 mg) + Vitamin A palmitate (333.3 unit) + Zinc (.95 mg) + alpha-Tocopherol succinate (15 unit)TabletOralNf Formulas Inc.1988-12-312000-06-21Canada
Golf Vitamin and Mineral SupplementSodium selenite (2 mcg) + Ascorbic acid (10 mg) + Cyanocobalamin (5 mcg) + Zinc (5 mg)LiquidOralMuscle Marketing Usa Inc.2001-02-242008-06-27Canada
I-care Multivitamin and Multimineral TabletsSodium selenite (40 mcg) + Ascorbic acid (60 mg) + Beta carotene (5000 unit) + Cupric oxide (2 mg) + Zinc (40 mg) + alpha-Tocopherol acetate (30 unit)TabletOralPharmetics (2011) Inc.2002-05-302009-07-30Canada
M.T.E.-6 ConcentratedSelenious acid (60 mcg) + Chromic chloride (10 mcg) + Copper (1 mg) + Manganese (0.5 mg) + Sodium iodide (75 mcg) + Zinc (5 mg)SolutionIntravenousPartners Health Care, Inc.1996-09-102008-02-15Canada
M.T.E.-6 ConcentratedSelenious acid (60 mcg) + Chromic chloride (10 mcg) + Copper (1 mg) + Manganese (.5 mg) + Potassium Iodide (75 mcg) + Zinc (5 mg)LiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1993-12-311997-08-14Canada
Micro Plus 5 ConcentrateSelenious acid (60 mcg) + Chromic chloride (10 mcg) + Copper (1 mg) + Manganese (0.5 mg) + Zinc (5 mg)LiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 6 (concentrate)Selenious acid (60 mcg) + Chromic chloride (10 mcg) + Copper (1 mg) + Manganese (0.5 mg) + Sodium iodide (75 mcg) + Zinc (5 mg)LiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 6 (pediatric)Selenious acid (20 mcg) + Chromic chloride (4 mcg) + Copper (0.4 mg) + Manganese (0.1 mg) + Sodium iodide (60 mcg) + Zinc (3 mg)LiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 6 (regular)Selenious acid (20 mcg) + Chromic chloride (4 mcg) + Copper (0.4 mg) + Manganese (0.1 mg) + Sodium iodide (25 mcg) + Zinc (1 mg)LiquidIntravenousSandoz Canada Incorporated1996-07-30Not applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Multitrace-5Selenious acid (32.7 ug/1mL) + Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL) + Zinc sulfate heptahydrate (4.39 mg/1mL)Injection, solutionIntravenousAmerican Regent1994-02-17Not applicableUs
Multitrace-5Selenious acid (98 ug/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1993-09-14Not applicableUs
Multitrace-5Selenious acid (98 ug/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1993-12-17Not applicableUs
SeleniumSelenious acid (65.4 ug/1mL)Injection, solutionIntravenousAmerican Regent1990-09-30Not applicableUs
Tricare Prenatal 2-part Daily Prenatal Vitamin SystemSodium selenite (.0325 mg/1) + Ascorbic acid (30 mg/1) + Biotin (.150 mg/1) + Cholecalciferol (400 [iU]/1) + Chromium Cr-51 chloride (.060 mg/1) + Copper gluconate (1 mg/1) + Cyanocobalamin (.125 mg/1) + Doconexent (150 1/1) + Ferric pyrophosphate (4.5 mg/1) + Icosapent (37.5 1/1) + Levomefolic acid (1 mg/1) + Manganese citrate decahydrate (1 mg/1) + Nicotinamide (10 mg/1) + Omega-3 fatty acids (75 1/1) + Calcium pantothenate (5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (.85 mg/1) + Sodium molybdate (.0375 mg/1) + Thiamine mononitrate (1.25 mg/1) + Zinc (7 mg/1) + alpha-Tocopherol succinate (15 [iU]/1)KitMedecor Pharma, Llc2016-05-10Not applicableUs
Categories
UNII
F6A27P4Q4R
CAS number
7783-00-8
Weight
Average: 128.97
Monoisotopic: 129.916915758
Chemical Formula
H2O3Se
InChI Key
MCAHWIHFGHIESP-UHFFFAOYSA-N
InChI
InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)
IUPAC Name
selenous acid
SMILES
O[Se](O)=O

Pharmacology

Indication

Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenious acid in TPN formulas helps to maintain plasma selenium levels and also to maintain endogenous stores to prevent deficiency [19].

Selenium compounds, such as selenium sulfide, are used topically in anti-dandruff shampoos and in cases of seborrhea [13].

For the purpose of brevity, selenite will the focus of discussion, and more information about selenium can be obtained at Selenium.

Pharmacodynamics

Selenium is a component glutathione peroxidase, which protects cells from oxidative damage caused by peroxidases produced during cellular metabolism [8].

Selenium is needed to maintain the circulatory system. It also keeps the heart muscle and skin tissue healthy. It may also help in the prevention of cancer due to its stimulation of antioxidant activity and protection of cell membranes [13], [3].

Selenious acid preserves vitamin E, which improves the cell's antioxidant defense, and plays an important role in the structure of teeth [8].

Prolonged TPN (total parenteral nutrition) support in humans has resulted in selenium deficiency symptoms which include muscle pain and tenderness. The symptoms have been reported to respond to supplementation of TPN solutions with selenium Selenium, [19].

Pediatric conditions, Keshan disease, and Kwashiorkor have been associated with low dietary intake of selenium. The conditions are endemic to geographical areas marked by low selenium content in the soil. Dietary supplementation with selenium salts has been reported to reduce the incidence of the conditions among affected children [19].

Mechanism of action

Sodium selenite likely has the same mechanism of action as Selenium.

The most important physiological role of sodium selenite is associated with its presence as an active component of many enzymes and proteins, in addition to its antioxidative role. Selenium has been shown to activate anticancer agents, prevent heart and vascular diseases, exhibit anti-proliferative and anti-inflammatory properties, and to stimulate the immune system [22].

Its anticancer properties may be explained by the oxidation of free sulfhydryl groups. Tumor cells express free sulfhydryl groups (–SH) on the surface of their cell membranes and contribute to uncontrolled cell division. Only those compounds that can oxidize these groups to disulfides (S–S) may inhibit this process. Some organic forms of selenium, including selenocysteine, methylseleninic acid, and Se-methylselenocysteine have been established to be antioxidants. However, their anticancer mechanism is still not well understood [22].

Selenious acid, during an in vitro study, was found to stimulate hemoglobin synthesis in three different malignant erythroleukemia cell lines (MEL) [8]. It has also been shown to increase the release of interleukin 2 in a dose-dependent manner [6]. Interleukin-2 is made by a type of T lymphocyte (white blood cell). It increases the growth and activity of other T-lymphocytes and B-lymphocytes and this contributes to the development of the immune system [6].

Absorption

The absorption of selenite following oral administration approximately 40-70% of an oral dose, based on studies done in humans [20].

Selenoprotein P, the plasma form of selenium, contains at least 40% of the total selenium in plasma [25]. Deletion of the gene for selenoprotein P in mouse models alters the distribution of selenium in body tissues suggesting that selenoprotein P is necessary for selenium transport [4].

Volume of distribution

Following oral intake and absorption, selenium from sodium selenite is found in the highest concentrations in the liver and kidneys of humans and animals [20].

In one study, tissue samples taken at autopsy from 46 healthy individuals killed in accidents and from 75 corpses of victims of various diseases to analyze selenium levels and distribution [4]. The per-weight-unit basis of selenium levels ng/gm in wet in tissues decreased in the following order: kidney (469) > liver > spleen > pancreas > heart > brain > lung > bone > skeletal muscle. The highest proportion of body selenium was found in skeletal muscles (27.5%) [4], [24]. Significantly less selenium was measured in bones (16%) and blood (10%). In the tissues of cancer corpses, the selenium levels were lower than levels in the control group. The lowest selenium concentrations were measured in alcoholic livers [4].

Protein binding
Not Available
Metabolism

Absorbed selenium, from both inorganic sources such as selenite and organic sources including selenomethionine, is metabolized to hydrogen selenide, and subsequently incorporated into essential selenoproteins [20].

In vivo, selenium compounds are generally metabolized to reduced states. For example, quadrivalent selenium (Se+4) in selenite often undergoes reduction to Se−2, metabolized firstly to H2Se and, finally, being methylated to various excretory forms. Selenious acid to oxidize sulfurous acid: H2SeO3 + 2H2SO3 → Se0 + 2H2SO4 + H2O [10].

Se may also produce reactive oxygen species and, thereby, exert cancer-selective cytotoxicity. Selenodiglutathione (SDG) is a primary Se metabolite conjugated to two glutathione (GSH) moieties. Selenodiglutathione increases intracellular selenium accumulation and is significantly more toxic than selenous acid (H2SeO3). [2].

The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium [10].

Route of elimination

Selenium is eliminated mainly in the urine. However, significant endogenous losses through the feces can also occur [23]. The rate of excretion varies with the chemical form of selenium used in supplementation and the route of administration. Other minor routes of elimination are lungs and skin [19].

Analysis of 72-hour urine sampling from a study of 48 Norwegian women given a 200 μg supplement of selenium in the form of selenite indicated approximately 50% absorption of selenite [20].

Half life

30 days in beagle dogs [8].

Clearance
Not Available
Toxicity

The toxicity of selenium has been consistently well documented. However, some early studies reported that selenium may be a carcinogen. Nelson et al. (1943) showed that rats fed diets containing Se as seleniferous wheat developed hepatic tumors and low-grade carcinomas in 11 out 53 study animals [11].

Selenium at high doses (15-30 mcg/egg) has been reported to have significant adverse embryological effects on developing chickens. There currently no adequate and well-controlled studies in pregnant women. Selenious acid injections should be used during pregnancy only when the potential benefits justify the potential risk to the growing fetus [20].

The presence of selenium in the placenta and the umbilical cord blood has been reported in humans [20].

Overdosage symptoms with selenious acid include:

Acute Brick red–color gastric mucosa, cerebral edema, coma, death, fulminating peripheral vascular collapse, garlic or sour breath odor, gastrointestinal disturbance, hemolysis, hypersalivation, internal vascular congestion, liver necrosis, muscle spasms, pulmonary edema, and restlessness [20].

Chronic Dental defects, dermatitis, garlic odor of breath and/or sweat, gastrointestinal disorders, hair loss, mental depression, metallic taste, nervousness, nausea, vomiting, weak nails [20].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcetaminophenAcetaminophen may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Selenious acid which could result in a higher serum level.
AlprazolamAlprazolam may decrease the excretion rate of Selenious acid which could result in a higher serum level.
AmilorideAmiloride may increase the excretion rate of Selenious acid which could result in a lower serum level and potentially a reduction in efficacy.
AmlodipineAmlodipine may decrease the excretion rate of Selenious acid which could result in a higher serum level.
AmoxicillinAmoxicillin may decrease the excretion rate of Selenious acid which could result in a higher serum level.
AmphetamineAmphetamine may decrease the excretion rate of Selenious acid which could result in a higher serum level.
AmpicillinAmpicillin may decrease the excretion rate of Selenious acid which could result in a higher serum level.
AuranofinAuranofin may decrease the excretion rate of Selenious acid which could result in a higher serum level.
BaclofenBaclofen may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Food Interactions
Not Available

References

General References
  1. Burk RF, Hill KE: Regulation of Selenium Metabolism and Transport. Annu Rev Nutr. 2015;35:109-34. doi: 10.1146/annurev-nutr-071714-034250. Epub 2015 May 13. [PubMed:25974694]
  2. Tobe T, Ueda K, Aoki A, Okamoto Y, Kojima N, Jinno H: Selenium uptake through cystine transporter mediated by glutathione conjugation. J Toxicol Sci. 2017;42(1):85-91. doi: 10.2131/jts.42.85. [PubMed:28070112]
  3. Combs GF Jr, Noguchi T, Scott ML: Mechanisms of action of selenium and vitamin E in protection of biological membranes. Fed Proc. 1975 Oct;34(11):2090-5. [PubMed:1100438]
  4. Zachara BA, Pawluk H, Bloch-Boguslawska E, Sliwka KM, Korenkiewicz J, Skok Z, Ryc K: Tissue level, distribution, and total body selenium content in healthy and diseased humans in Poland. Arch Environ Health. 2001 Sep-Oct;56(5):461-6. doi: 10.1080/00039890109604483. [PubMed:11777029]
  5. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [PubMed:10469608]
  6. Zhuang T, Xu H, Hao S, Ren F, Chen X, Pan C, Huang K: Effects of selenium on proliferation, interleukin-2 production and selenoprotein mRNA expression of normal and dexamethasone-treated porcine splenocytes. Res Vet Sci. 2015 Feb;98:59-65. doi: 10.1016/j.rvsc.2014.11.019. Epub 2014 Dec 4. [PubMed:25499746]
  7. Haratake M, Hongoh M, Ono M, Nakayama M: Thiol-dependent membrane transport of selenium through an integral protein of the red blood cell membrane. Inorg Chem. 2009 Aug 17;48(16):7805-11. doi: 10.1021/ic900988j. [PubMed:19722686]
  8. Selenious Acid PubChem [Link]
  9. Selenium (As selenious acid) [Link]
  10. Selenium overview [Link]
  11. EPA Label, Selenious Acid [Link]
  12. High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study [Link]
  13. Selenium, URMC Rochester encyclopedia [Link]
  14. Absorption, distribution, and retention of inhaled selenious acid and selenium metal aerosols in Beagle dogs [Link]
  15. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase [Link]
  16. Distribution of Selenium in Plasma of French Women: Relation to Age and Selenium Status [Link]
  17. Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk [Link]
  18. Selenium in the prevention of atherosclerosis and its underlying mechanisms [Link]
  19. Selenium Injection [Link]
  20. Selenious acid as a source of selenium added for nutritional purposes to food supplements [Link]
  21. Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study [Link]
  22. Application of Sodium Selenite in the Prevention and Treatment of Cancers [Link]
  23. Selenious Acid Injection [Link]
  24. Selenium Overview [Link]
  25. Selenoprotein P [Link]
External Links
Human Metabolome Database
HMDB0011119
PubChem Compound
1091
PubChem Substance
347827908
ChemSpider
1060
ChEBI
26642
ChEMBL
CHEMBL2009089
Wikipedia
Selenious_acid
ATC Codes
A12CE02 — Sodium selenite
AHFS Codes
  • 88:29.00* — Minerals
  • 40:12.00 — Replacement Preparations
MSDS
Download (132 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Not Yet RecruitingTreatmentStroke, Ischemic1
0Unknown StatusPreventionPrevention of Colorectal Cancer1
1CompletedTreatmentProstate Cancer1
1TerminatedTreatmentLymphatic Malformations1
1, 2Unknown StatusTreatmentHematopoietic Stem Cell Transplantation (HSCT) / Mucositis1
2CompletedSupportive CareEndometriosis1
2CompletedTreatmentProstate Cancer1
2Unknown StatusTreatmentFollicular Lymphoma (FL)1
2, 3Active Not RecruitingPreventionPostoperative Myalgia1
3Active Not RecruitingPreventionAdenomatous Colorectal Polyps / Colorectal Cancers / Precancerous Conditions1
3CompletedPreventionCataracts / Macular Degeneration1
3CompletedPreventionColorectal Cancers / Precancerous Conditions1
3CompletedPreventionPrecancerous/Nonmalignant Condition / Prostate Cancer1
3CompletedPreventionProstate Cancer1
3CompletedTreatmentArsenic Exposure / Arsenic Poisoning / Arsenic Toxicity / Arsenical Cancers / Arsenical Keratosis / Arsenical Melanosis / Arsenicosis1
3CompletedTreatmentMycobacterium Tuberculosis1
3RecruitingTreatmentChagas Disease1
3RecruitingTreatmentHeart Diseases1
3TerminatedPreventionLung Cancers1
3TerminatedPreventionSepsis1
3Unknown StatusPreventionBladder Cancers2
4CompletedPreventionCardiovascular Disease (CVD) / Chronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedNot AvailableAlzheimer's Disease (AD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral30 mcg
LiquidOral
LiquidIntravenous
SolutionIntravenous
SolutionIntravenous40 mcg
Injection, solutionIntravenous
Injection, solution, concentrateIntravenous
CapsuleOral
TabletOral
Injection, solutionIntravenous65.4 ug/1mL
CapsuleOral30 mcg
LiquidIntravenous40 mcg
PowderOral
Kit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)70MSDS
boiling point (°C)684.9MSDS
water solubilitysoluble MSDS
pKa2.46MSDS
Predicted Properties
PropertyValueSource
logP-1.3ChemAxon
pKa (Strongest Acidic)11.93ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity19.69 m3·mol-1ChemAxon
Polarizability5.84 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as non-metal selenites. These are inorganic non-metallic compounds containing a selenite as its largest oxoanion.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Other mixed metal/non-metal oxoanionic compounds
Sub Class
Non-metal selenites
Direct Parent
Non-metal selenites
Alternative Parents
Inorganic oxides
Substituents
Non-metal selenite / Inorganic oxide
Molecular Framework
Not Available
External Descriptors
selenium oxoacid (CHEBI:26642) / an anion (SELENITE)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Activator
General Function
Sh3 domain binding
Specific Function
Protects the hemoglobin in erythrocytes from oxidative breakdown.
Gene Name
GPX1
Uniprot ID
P07203
Uniprot Name
Glutathione peroxidase 1
Molecular Weight
22087.94 Da
References
  1. High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study [Link]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Substrate
General Function
Thioredoxin-disulfide reductase activity
Specific Function
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enha...
Gene Name
TXNRD1
Uniprot ID
Q16881
Uniprot Name
Thioredoxin reductase 1, cytoplasmic
Molecular Weight
70905.58 Da
References
  1. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [PubMed:10469608]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Transporter
General Function
Selenium binding
Specific Function
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and tes...
Gene Name
SEPP1
Uniprot ID
P49908
Uniprot Name
Selenoprotein P
Molecular Weight
43173.37 Da
References
  1. Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk [Link]

Drug created on December 03, 2015 09:51 / Updated on September 17, 2018 21:04