Zinc citrate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Zinc citrate
Accession Number
DB11154
Type
Small Molecule
Groups
Investigational
Description

Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration 1.

Structure
Thumb
Synonyms
  • Citric acid, zinc salt
  • Trizinc dicitrate
Product Ingredients
IngredientUNIICASInChI Key
Zinc citrate trihydrateGNM26GAX7R178326-57-3VSJRDSLPNMGNFG-UHFFFAOYSA-H
Active Moieties
NameKindUNIICASInChI Key
ZincunknownJ41CSQ7QDS7440-66-6HCHKCACWOHOZIP-UHFFFAOYSA-N
Citric acidunknownXF417D3PSL77-92-9KRKNYBCHXYNGOX-UHFFFAOYSA-N
Zinc cationionic13S1S8SF3723713-49-7PTFCDOFLOPIGGS-UHFFFAOYSA-N
Product Images
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Colgate Total Zx Pro-Shield Plus SensitiveZinc citrate trihydrate (20 mg/1g) + Potassium nitrate (50 mg/1g) + Sodium fluorophosphate (2 mg/1g)Paste, dentifriceDentalColgate-Palmolive2013-02-012013-09-01Us
Palm Springs Multvit and Min TabZinc citrate (1.25 mg) + Ascorbic acid (10 mg) + Biotin (50 mcg) + Calcium carbonate (133.4 mg) + Cholecalciferol (33.4 unit) + Chromic chloride (8.4 mcg) + Cyanocobalamin (1 mcg) + DL-alpha tocopheryl acetate (5 unit) + Ferrous fumarate (1.5 mg) + Folic acid (.0667 mg) + Nicotinamide (3.4 mg) + Calcium pantothenate (1.7 mg) + Potassium Iodide (8.3 mcg) + Pyridoxine hydrochloride (.34 mg) + Riboflavin (.29 mg) + Thiamine mononitrate (.25 mg) + Vitamin A acetate (417 unit)TabletOralL & S Research Corporation1993-12-311996-09-09Canada
Prenatal Chelated MineralZinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1)TabletOralUsana Health Sciences, Inc.2012-04-11Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Dialyvite 3000Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2004-02-01Not applicableUs
Dialyvite 5000Zinc citrate (25 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2008-05-01Not applicableUs
Dialyvite Supreme DZinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2010-09-08Not applicableUs
Dialyvite with ZincZinc citrate (50 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2002-10-01Not applicableUs10542 01220180618 22549 l4id3e
Prenatal Chelated MineralZinc citrate (5 mg/1) + Calcium carbonate (30 mg/1) + Calcium citrate tetrahydrate (32.5 mg/1) + Copper gluconate (0.5 mg/1) + Ferrous fumarate (7 mg/1) + Magnesium citrate (75 mg/1) + Potassium Iodide (75 ug/1)TabletOralUsana Health Sciences, Inc.2012-04-11Not applicableUs
Categories
UNII
K72I3DEX9B
CAS number
546-46-3
Weight
Average: 574.34
Monoisotopic: 569.794481
Chemical Formula
C12H10O14Zn3
InChI Key
WGIWBXUNRXCYRA-UHFFFAOYSA-H
InChI
InChI=1S/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
IUPAC Name
trizinc(2+) ion bis(2-hydroxypropane-1,2,3-tricarboxylate)
SMILES
[Zn++].[Zn++].[Zn++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(1,2,6,7-3H)Testosterone(1,2,6,7-3H)Testosterone may increase the anticoagulant activities of Zinc citrate.
(R)-warfarinThe risk or severity of bleeding can be increased when (R)-warfarin is combined with Zinc citrate.
(S)-WarfarinThe risk or severity of bleeding can be increased when (S)-Warfarin is combined with Zinc citrate.
1-Testosterone1-Testosterone may increase the anticoagulant activities of Zinc citrate.
18-methyl-19-nortestosterone18-methyl-19-nortestosterone may increase the anticoagulant activities of Zinc citrate.
3,5-Diiodotyrosine3,5-Diiodotyrosine may increase the anticoagulant activities of Zinc citrate.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when 4-hydroxycoumarin is combined with Zinc citrate.
4-Hydroxytestosterone4-Hydroxytestosterone may increase the anticoagulant activities of Zinc citrate.
5beta-dihydrotestosterone5beta-dihydrotestosterone may increase the anticoagulant activities of Zinc citrate.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of bleeding and hemorrhage can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Zinc citrate.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
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  • Action
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Food Interactions
Not Available

References

General References
  1. Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. [PubMed:24259556]
External Links
PubChem Compound
11023
PubChem Substance
347827923
ChemSpider
10557
RxNav
236911

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral
Paste, dentifriceDental
Tablet, coatedOral
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility6.11 mg/mLALOGPS
logP0.04ALOGPS
logP-1.3ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)3.05ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area140.62 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity68.14 m3·mol-1ChemAxon
Polarizability14.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Tricarboxylic acids and derivatives
Direct Parent
Tricarboxylic acids and derivatives
Alternative Parents
Tertiary alcohols / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Tricarboxylic acid or derivatives / Tertiary alcohol / Carboxylic acid salt / Organic transition metal salt / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organooxygen compound
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on December 03, 2015 09:51 / Updated on March 04, 2020 19:16

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