Zinc citrate
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Zinc citrate is an ingredient found in a variety of supplements and vitamins.
- Generic Name
- Zinc citrate
- DrugBank Accession Number
- DB11154
- Background
Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration 1.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 574.34
Monoisotopic: 569.794481 - Chemical Formula
- C12H10O14Zn3
- Synonyms
- Citric acid, zinc salt
- Trizinc dicitrate
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareCarbamazepine Zinc citrate can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy. Ceftibuten Zinc citrate can cause a decrease in the absorption of Ceftibuten resulting in a reduced serum concentration and potentially a decrease in efficacy. Cephalexin Zinc citrate can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy. Cinoxacin Zinc citrate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy. Ciprofloxacin Zinc citrate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy. - Food Interactions
- Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
- Do not take with bran and high fiber foods. For optimal absorption, take zinc citrate at least 2 hours before or after eating high-fiber foods.
- Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Zinc citrate trihydrate GNM26GAX7R 178326-57-3 VSJRDSLPNMGNFG-UHFFFAOYSA-H - Active Moieties
Name Kind UNII CAS InChI Key Zinc unknown J41CSQ7QDS 7440-66-6 HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc cation ionic 13S1S8SF37 23713-49-7 PTFCDOFLOPIGGS-UHFFFAOYSA-N Citric acid unknown XF417D3PSL 77-92-9 KRKNYBCHXYNGOX-UHFFFAOYSA-N - Product Images
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Zinc 50 mg Tablet 50 mg Oral Preferred Nutrition Inc. 2004-05-12 2005-08-04 Canada Zinc Citrate - Cap 30mg Capsule 30 mg Oral Sisu Inc. 1996-07-30 2006-07-31 Canada Zinc Citrate Chelate Tab 50mg Tablet 50 mg Oral Gahler Enterprises Ltd. 1979-12-31 2008-07-17 Canada Zinc Citrate Tab 15mg Tablet 15 mg Oral Gahler Enterprises Ltd. 1990-12-31 2008-07-17 Canada Zinc Lozenges With Non-medicinal Echinacea Lozenge 5 mg / loz Oral Holista Health (Canada) Inc. 1997-08-26 2001-08-01 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Berocca Film Coated Tablets Zinc citrate trihydrate (10 mg) + Ascorbic acid (500 mg) + Biotin (150 mcg) + Calcium carbonate (100 mg) + Cyanocobalamin (10 mcg) + Folic acid (400 mcg) + Magnesium carbonate (100 mg) + Nicotinamide (50 mg) + Pantothenic acid (23 mg) + Pyridoxine hydrochloride (10 mg) + Riboflavin (15 mg) + Thiamine hydrochloride (15 mg) Tablet, film coated Oral BAYER CO. (MALAYSIA) SDN. BHD. 2020-09-08 2022-03-03 Malaysia Berocca Plus Zink - Brausetabletten Zinc citrate trihydrate (32 mg) + Ascorbic acid (500 mg) + Biotin (0.15 mg) + Calcium carbonate (244 mg) + Cyanocobalamin (0.01 mg) + Riboflavin-5'-phosphate sodium salt dihydrate (15 mg) + Folic acid (0.4 mg) + Magnesium carbonate (195 mg) + Magnesium sulfate dihydrate (328 mg) + Nicotinamide (50 mg) + Calcium pantothenate (25 mg) + Pyridoxine hydrochloride (10 mg) + Thiamine hydrochloride (15 mg) Tablet, effervescent Oral Bayer Austria Ges.M.B.H. 2003-06-13 Not applicable Austria Berocca plus Zink - Filmtabletten Zinc citrate trihydrate (32 mg) + Ascorbic acid (500 mg) + Biotin (0.15 mg) + Calcium carbonate (244 mg) + Cyanocobalamin (0.01 mg) + Folic acid (0.4 mg) + Magnesium carbonate (122 mg) + Magnesium oxide (115 mg) + Nicotinamide (50 mg) + Calcium pantothenate (25 mg) + Pyridoxine hydrochloride (10 mg) + Riboflavin (15 mg) + Thiamine mononitrate (15 mg) Tablet, film coated Oral Bayer Austria Ges.M.B.H. 2003-06-13 Not applicable Austria Bio-b12 Zinc citrate (15.0 mg) + Cyanocobalamin (1000.0 mcg) + Folic acid (0.8 mg) Capsule Oral Thorne Research Inc. 1997-09-09 2006-08-04 Canada C-force Zinc citrate (5 mg / cap) + Ascorbic acid (133.33 mg / cap) + Cyanocobalamin (35 mcg / cap) + Pyridoxine hydrochloride (10 mg / cap) + Thiamine (10 mg / cap) Capsule Oral Prairie Naturals 1997-04-01 2002-06-21 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dialyvite 3000 Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2004-02-01 Not applicable US Dialyvite 5000 Zinc citrate (25 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2008-05-01 Not applicable US Dialyvite Supreme D Zinc citrate (15 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2010-09-08 Not applicable US Dialyvite with Zinc Zinc citrate (50 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2002-10-01 Not applicable US LiquiCal with Magnesium Zinc citrate (1.4 mg/1mL) + Calcium citrate tetrahydrate (168 mg/1mL) + Cholecalciferol (66 [iU]/1mL) + Magnesium citrate (48 mg/1mL) Liquid Oral PureTek Corporation 2023-12-27 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Tricarboxylic acids and derivatives
- Direct Parent
- Tricarboxylic acids and derivatives
- Alternative Parents
- Tertiary alcohols / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organic transition metal salt
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- K72I3DEX9B
- CAS number
- 546-46-3
- InChI Key
- WGIWBXUNRXCYRA-UHFFFAOYSA-H
- InChI
- InChI=1S/2C6H8O7.3Zn/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6
- IUPAC Name
- trizinc(2+) ion bis(2-hydroxypropane-1,2,3-tricarboxylate)
- SMILES
- [Zn++].[Zn++].[Zn++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
References
- General References
- Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. [Article]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Unknown Status Treatment Antioxidants / Men Infertility / Semen Quality 1 1 Completed Basic Science Healthy Volunteers (HV) 1 1 Not Yet Recruiting Treatment Tuberculosis (TB) 1 Not Available Completed Treatment Male Pattern of Hair Loss, Androgenic Alopecia 1 Not Available Recruiting Not Available COVID-19, Long Haul / Long Haul COVID / Post-Acute COVID-19 / Post-acute COVID-19 (PACS), or "Long COVID" Syndrome 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral Tablet, effervescent Oral Liquid Oral Capsule Oral Paste, dentifrice Dental Tablet, coated Oral Wafer Oral Tablet Oral Lozenge Oral Capsule Oral 30 mg Tablet Oral 50 mg Tablet Oral 15 mg Lozenge Oral 5 mg / loz - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 6.11 mg/mL ALOGPS logP 0.04 ALOGPS logP -1.3 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 3.05 Chemaxon pKa (Strongest Basic) -4.2 Chemaxon Physiological Charge -3 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 140.62 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 68.14 m3·mol-1 Chemaxon Polarizability 14.23 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53