Zinc picolinate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Zinc picolinate
Accession Number
DB11175
Type
Small Molecule
Groups
Approved, Investigational
Description

Zinc picolinate is a zinc salt of picolinic acid. It is available as OTC dietary supplements as a source of zinc to treat and prevent zinc deficiency. The absorption of zinc after oral administration of zinc picolinate is shown to be effective.

Structure
Thumb
Synonyms
Not Available
Active Moieties
NameKindUNIICASInChI Key
Zinc cationionic13S1S8SF3723713-49-7PTFCDOFLOPIGGS-UHFFFAOYSA-N
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
TozalZinc picolinate (40 mg/31) + Ascorbic acid (452 mg/31) + Cholecalciferol (1000 [iU]/31) + Copper (1.6 mg/31) + Cyanocobalamin (100 ug/31) + Folic acid (1 mg/31) + Lutein (15 mg/31) + Omega-3 fatty acids (600 mg/31) + Pyridoxine hydrochloride (20 mg/31) + Taurine (400 mg/31) + Vitamin A palmitate (10000 [iU]/31) + Vitamin E (200 [iU]/31) + Zeaxanthin (3 mg/31)Capsule, gelatin coatedOralFocus Laboratories, Inc.2013-06-012015-07-15Us
Categories
UNII
ALO92O31SE
CAS number
Not Available
Weight
Average: 309.59
Monoisotopic: 307.977549
Chemical Formula
C12H8N2O4Zn
InChI Key
NHVUUBRKFZWXRN-UHFFFAOYSA-L
InChI
InChI=1S/2C6H5NO2.Zn/c2*8-6(9)5-3-1-2-4-7-5;/h2*1-4H,(H,8,9);/q;;+2/p-2
IUPAC Name
zinc(2+) ion bis(pyridine-2-carboxylate)
SMILES
[Zn++].[O-]C(=O)C1=CC=CC=N1.[O-]C(=O)C1=CC=CC=N1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
Bamet-UD2Zinc picolinate can cause a decrease in the absorption of Bamet-UD2 resulting in a reduced serum concentration and potentially a decrease in efficacy.
CarbamazepineZinc picolinate can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy.
CeftibutenZinc picolinate can cause a decrease in the absorption of Ceftibuten resulting in a reduced serum concentration and potentially a decrease in efficacy.
CephalexinZinc picolinate can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chenodeoxycholic acidZinc picolinate can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic AcidZinc picolinate can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
CinoxacinZinc picolinate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
CiprofloxacinZinc picolinate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
ClomocyclineZinc picolinate can cause a decrease in the absorption of Clomocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
DeferasiroxZinc picolinate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
  1. Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC: Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents Actions. 1987 Jun;21(1-2):223-8. [PubMed:3630857]
External Links
PubChem Compound
9904746
PubChem Substance
347827932
ChemSpider
8080400
Wikipedia
Zinc_picolinate
ATC Codes
C05AX04 — Zinc preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedBasic SciencePremature Births1
Not AvailableRecruitingBasic ScienceDNA Damage / Immune System Disorder1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Capsule, gelatin coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility12.2 mg/mLALOGPS
logP1.55ALOGPS
logP-0.65ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)1ChemAxon
pKa (Strongest Basic)5.52ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area53.02 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity41.62 m3·mol-1ChemAxon
Polarizability10.94 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Pyridinecarboxylic acids and derivatives
Direct Parent
Pyridinecarboxylic acids
Alternative Parents
Heteroaromatic compounds / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Azacyclic compounds / Organooxygen compounds / Organonitrogen compounds / Organic zwitterions / Organic oxides / Hydrocarbon derivatives
Substituents
Pyridine carboxylic acid / Heteroaromatic compound / Carboxylic acid salt / Carboxylic acid derivative / Carboxylic acid / Azacycle / Organic transition metal salt / Organic nitrogen compound / Organic salt / Organic zwitterion
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on December 03, 2015 09:51 / Updated on June 04, 2019 07:17