Panthenol

Identification

Name
Panthenol
Accession Number
DB11204
Type
Small Molecule
Groups
Approved
Description

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol). While pantothenic acid is optically active, only the dextrorotatory form (Dexpanthenol) is biologically active.

Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium [1].

Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties [2].

Synonyms
  • DL-panthenol
  • DL-Pantothenol
  • Pantenol
  • Panthenol
  • Panthenolum
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ahc Hydra B5 SootherLiquid0.5 g/50mLTopicalCarver Korea Co.,Ltd.2017-05-12Not applicableUs
Ahc Hydra B5 Soother (red)Liquid0.5 g/50mLTopicalCarver Korea Co.,Ltd.2017-05-12Not applicableUs
Ahc Premium Hydra Soother Cellulose MaskPatch0.081 g/27mLTopicalCarver Korea Co.,Ltd.2017-05-18Not applicableUs
BABOR Baborganic Calm and RelaxCream0.04875 g/50mLTopicalBabor Cosmetics America, Corp.2008-11-012017-02-12Us
BABOR BODY LINE THERMAL Firming BodyLotion1.5 g/200mLTopicalBabor Cosmetics America, Corp.2006-04-152017-02-12Us
Babor Body Line Thermal Smooth Effect BodyLotion1.8 mL/200mLTopicalBabor Cosmetics America, Corp.2010-04-102017-02-16Us
BABOR CLEANSING Mild CleanserLiquid0.75 mL/200mLTopicalBabor Cosmetics America, Corp.2004-04-152017-02-15Us
BABOR HSR Lifting Decollete MaskGel1.5 mL/100mLTopicalBabor Cosmetics America, Corp.2009-11-012017-02-16Us
BABOR HSR Lifting Decollete Mask CPGel1.5 mL/100mLTopicalBabor Cosmetics America, Corp.2009-11-012017-02-16Us
BABOR Selection Ultimate CareCream0.4875 mL/50mLTopicalBabor Cosmetics America, Corp.2008-11-152017-02-16Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Add More HairPanthenol (0.5 g/100mL) + Pyrithione zinc (0.29 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2017-03-012018-09-05Us
Add More HairPanthenol (0.5 g/100mL) + Pyrithione zinc (0.28 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2018-06-092018-09-05Us
Ahc Radiance Gommage PeelingPanthenol (1 g/100mL) + Allantoin (1 g/100mL)GelTopicalCarver Korea Co.,Ltd.2017-05-10Not applicableUs
All New TSPanthenol (0.5 g/100mL) + Nicotinamide (0.3 g/100mL)ShampooTopicalTalmocom Co., Ltd2016-07-012018-05-03Us
Atomy Hair TreatmentPanthenol (0.40 mg/200mL) + Levomenthol (0.60 mg/200mL) + Salicylic acid (0.38 mg/200mL)LiquidTopicalAtomy Co., Ltd.2015-02-01Not applicableUs
BABOR Baborganic Age Preventing Body CreamPanthenol (1.8 mg/200mL) + Glycerin (2 mg/200mL)CreamTopicalBabor Cosmetics America, Corp.2008-11-012017-02-12Us
bdr Re-charge contour push up serum high-potential moisturizerPanthenol (0.75 g/50mL) + Nicotinamide (0.005 g/50mL)LiquidTopicalHanaim International Llc2016-11-15Not applicableUs
bdr Re-lax 3 multiple level serum highly-potential youthPanthenol (0.33 g/30mL) + Allantoin (0.15 g/30mL)ElixirTopicalHanaim International Llc2016-11-16Not applicableUs
Bonnoir Hair MediPanthenol (1.75 mL/350mL) + Biotin (0.21 mL/350mL) + Nicotinamide (1.05 mL/350mL) + Pyrithione zinc (7.35 mL/350mL)ShampooTopicalCellinbio Co Ltd2011-07-27Not applicableUs
Bonogen hair care shampooPanthenol (0.5 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Pyrithione zinc (2.1 g/100g)ShampooTopicalBonogen Co., Ltd2010-03-01Not applicableUs
Categories
Not Available
UNII
WV9CM0O67Z
CAS number
16485-10-2
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Panthenol (containing a racemic mixture of dexpanthenol and levopanthenol) is not currently available in any FDA-approved products and therefore does not have an indication.

Please see Dexpanthenol for FDA-approved uses of the dextrorotatory form of Panthenol.

Associated Conditions
Pharmacodynamics

Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.

Mechanism of action

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium [1].

Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties [2].

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Proksch E, de Bony R, Trapp S, Boudon S: Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080/09546634.2017.1325310. Epub 2017 May 14. [PubMed:28503966]
  2. Biro K, Thaci D, Ochsendorf FR, Kaufmann R, Boehncke WH: Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 2003 Aug;49(2):80-4. [PubMed:14641355]
External Links
KEGG Drug
D03726
ChEBI
27373
ChEMBL
CHEMBL1371937
Wikipedia
Panthenol

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidTopical0.5 g/50mL
PatchTopical0.081 g/27mL
GelTopical
CreamTopical0.04875 g/50mL
LotionTopical1.5 g/200mL
LotionTopical1.8 mL/200mL
LiquidTopical0.75 mL/200mL
GelTopical1.5 mL/100mL
CreamTopical0.4875 mL/50mL
CreamTopical1.5 mL/200mL
LiquidTopical0.075 mL/10mL
LiquidTopical0.45 g/30mL
LotionTopical0.09 g/12mL
ElixirTopical
LiquidTopical0.003 g/5mL
LotionTopical0.375 g/50mL
LiquidTopical0.375 1/50mL
LiquidTopical0.002 mg/1mL
ShampooTopical
LotionTopical
LiquidTransdermal
LiquidTopical
GelTopical0.01 mL/100mL
LiquidTopical0.018 mL/2mL
Kit
CreamTopical0.47 g/479.39g
LiquidTopical3.75 g/750mL
CreamTopical
ShampooTopical0.02 mL/1mL
LiquidTopical0.002 mL/1mL
LiquidIntravenous
SprayTopical
SolutionIntravenous
PatchTopical
SolutionTopical
CreamTopical0.45 mL/50mL
CreamTopical1.8 mL/200mL
LiquidTopical0.3 g/30mL
ShampooTopical1.2 mg/240mL
LiquidTopical0.5 mg/100mL
ShampooTopical0.002 mL/1mL
ShampooTopical0.95 g/958.50g
GelTopical0.95 g/958.50g
EmulsionTopical
LiquidTopical0.5 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on December 16, 2018 06:58