Ferrous bisglycinate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Ferrous bisglycinate
Accession Number
DB11210
Type
Small Molecule
Groups
Approved
Description

Ferrous bisglycinate is a chelate that is used as a source of dietary iron. Forming a ring structure when reacting with glycine, ferrous bisglycinate acts as both a chelate and a nutritionally functional 2. It is found in foods for food enrichment or in supplements for the treatment of iron deficiency or iron deficiency anemia.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Ferrous bisglycinate hydrochlorideIW3QLZ8MRC67972-33-2JTLXXRNVKWTJHD-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
IronunknownE1UOL152H77439-89-6XEEYBQQBJWHFJM-UHFFFAOYSA-N
Ferrous cationionicGW89581OWR15438-31-0CWYNVVGOOAEACU-UHFFFAOYSA-N
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
FeRivaFerrous bisglycinate (75 mg/1) + Ascorbic acid (175 mg/1) + Biotin (300 ug/1) + Cyanocobalamin (120 ug/1) + Folic acid (1 mg/1)CapsuleOralAvion Pharmaceuticals, Llc2012-12-302014-11-30Us
FeRiva FAFerrous bisglycinate (36.7 mg/1) + Ascorbic acid (175 mg/1) + Biotin (300 ug/1) + Cupric oxide (1.5 mg/1) + Cyanocobalamin (12 ug/1) + Docusate sodium (50 mg/1) + Ferrous asparto glycinate (36.7 mg/1) + Ferrous fumarate (36.7 mg/1) + Folic acid (1 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2015-01-20Not applicableUs
FeRivaFAFerrous bisglycinate (110 mg/1) + Ascorbic acid (175 mg/1) + Biotin (300 ug/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (12 ug/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-01-022015-12-31Us
Folet DHAFerrous bisglycinate (38 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2700 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (18 [iU]/1) + Doconexent (350 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (40 mg/1) + Riboflavin (3.4 mg/1) + Selenium (65 ug/1) + Thiamine hydrochloride (3 mg/1) + Zinc glycinate (10 mg/1)KitPronova Corporation2014-08-28Not applicableUs
healthy mamaBE WELL ROUNDED BE WELL ROUNDEDFerrous bisglycinate (28 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (4000 [iU]/1) + Biotin (30 ug/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Folic acid (800 ug/1) + Magnesium oxide (30 mg/1) + Methylcobalamin (8 ug/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2.6 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.8 mg/1) + Zinc oxide (25 mg/1)Tablet, film coatedOralMATERNAL SCIENCE, LLC2013-07-09Not applicableUs
Irospan 24/6Ferrous bisglycinate (65 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium Carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)KitWOMENS CHOICE PHARMACEUTICALS LLC2011-04-15Not applicableUs
NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPAFerrous bisglycinate (32 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + Doconexent (230 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Tocopherylquinone (30 [iU]/1) + Vitamin E (2 [iU]/1) + Zinc oxide (10 mg/1)KitWOMENS CHOICE PHARMACEUTICALS LLC2011-02-01Not applicableUs
NESTABS Prenatal Multi-vitamin/Mineral SupplementFerrous bisglycinate (32 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)Tablet, film coatedOralWomens Choice Pharmaceuticals, Llc2011-02-01Not applicableUs
Nutri-Tab OBFerrous bisglycinate (32 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Folic acid (1000 ug/1) + Calcium formate (155 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)TabletOralWh Nutritionals, Llc2012-05-03Not applicableUs
Nutri-Tab OB plus DHAFerrous bisglycinate (32 mg/1) + Calcium Carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (230 mg/1) + Folic acid (1000 ug/1) + Calcium formate (155 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)KitWh Nutritionals, Llc2012-05-03Not applicableUs
Categories
UNII
SFW1D987QV
CAS number
20150-34-9
Weight
Average: 203.963
Monoisotopic: 203.983343
Chemical Formula
C4H8FeN2O4
InChI Key
GIPOFCXYHMWROH-UHFFFAOYSA-L
InChI
InChI=1S/2C2H5NO2.Fe/c2*3-1-2(4)5;/h2*1,3H2,(H,4,5);/q;;+2/p-2
IUPAC Name
lambda2-iron(2+) ion bis(2-aminoacetate)
SMILES
[Fe++].NCC([O-])=O.NCC([O-])=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
3-Aza-2,3-Dihydrogeranyl DiphosphateFerrous bisglycinate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alendronic acidFerrous bisglycinate can cause a decrease in the absorption of Alendronic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
AlmasilateAlmasilate can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
AloglutamolAloglutamol can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
AluminiumAluminium can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium acetoacetateAluminium acetoacetate can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium glycinateAluminium glycinate can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphateAluminium phosphate can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
AsenapineAsenapine can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
  1. Milman N, Jonsson L, Dyre P, Pedersen PL, Larsen LG: Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial. J Perinat Med. 2014 Mar;42(2):197-206. doi: 10.1515/jpm-2013-0153. [PubMed:24152889]
  2. Ashmead SD: The chemistry of ferrous bis-glycinate chelate. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):7-12. [PubMed:11688084]
External Links
PubChem Compound
9837124
PubChem Substance
347827942
ChemSpider
8012845

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAnemias1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral
Capsule, gelatin coatedOral
Tablet, film coatedOral
TabletOral
Kit
KitOral
Tablet, coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility211.0 mg/mLALOGPS
logP-1.5ALOGPS
logP-3.4ChemAxon
logS0.02ALOGPS
pKa (Strongest Acidic)2.31ChemAxon
pKa (Strongest Basic)9.24ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area66.15 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity26.84 m3·mol-1ChemAxon
Polarizability6.25 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acids
Alternative Parents
Carboxylic acid salts / Amino acids / Organic transition metal salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alpha-amino acid / Carboxylic acid salt / Amino acid / Carboxylic acid / Monocarboxylic acid or derivatives / Organic transition metal salt / Organic salt / Organic zwitterion / Primary amine / Organooxygen compound
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on December 03, 2015 09:51 / Updated on June 04, 2019 07:17