Borage oil

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates
Name
Borage oil
Accession Number
DB11238
Type
Small Molecule
Groups
Approved, Investigational
Description

Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurodermatitis as well as other inflammatory, cardiovascular and endocrine disorders, although its clinical efficacy and long-term effects are not fully elucidated yet. GLA, which accounts for approximately 24% of the oil, is converted to dihomo-γ-linolenic acid (DGLA) which acts as a precursor to anti-inflammatory mediators such as 1-series prostaglandins and the 3-series leukotrienes. Borage oil may be found in foods or in skin care products.

Synonyms
  • Borago officinalis
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Borage Oil CapsulesBorage oil (500 mg) + Gamolenic acid (125 mg) + Linoleic acid (220 mg)CapsuleOralBioforce Canada Inc.1994-12-311999-10-14Canada
Cheon Shim Bo HwaBorage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1)CapsuleOralSaimdang Cosmetics Co., Ltd2011-04-06Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Cheon Shim Bo HwaBorage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1)CapsuleOralSaimdang Cosmetics Co., Ltd2011-04-06Not applicableUs
Categories
UNII
F8XAG1755S
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

Learn more
Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

Learn more
Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

Learn more
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
7-NitroindazoleThe therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Borage oil.
AcetazolamideThe therapeutic efficacy of Acetazolamide can be decreased when used in combination with Borage oil.
AmifampridineThe risk or severity of seizure can be increased when Borage oil is combined with Amifampridine.
AmobarbitalThe therapeutic efficacy of Amobarbital can be decreased when used in combination with Borage oil.
BarbexacloneThe therapeutic efficacy of Barbexaclone can be decreased when used in combination with Borage oil.
BarbitalThe therapeutic efficacy of Barbital can be decreased when used in combination with Borage oil.
BeclamideThe therapeutic efficacy of Beclamide can be decreased when used in combination with Borage oil.
BrexanoloneThe therapeutic efficacy of Brexanolone can be decreased when used in combination with Borage oil.
BrivaracetamThe therapeutic efficacy of Brivaracetam can be decreased when used in combination with Borage oil.
BupropionThe risk or severity of seizure can be increased when Bupropion is combined with Borage oil.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

    Learn more
  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

    Learn more
  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

    Learn more
  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

    Learn more
Food Interactions
Not Available

References

General References
  1. Tocher DR, Bell JG, Farndale BM, Sargent JR: Effects of dietary gamma-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in delta5 fatty acyl desaturase. Prostaglandins Leukot Essent Fatty Acids. 1997 Aug;57(2):125-34. [PubMed:9250695]
  2. Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D: Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8. [PubMed:10233322]
  3. Chung S, Kong S, Seong K, Cho Y: Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J Nutr. 2002 Oct;132(10):3090-7. [PubMed:12368400]
  4. Foster RH, Hardy G, Alany RG: Borage oil in the treatment of atopic dermatitis. Nutrition. 2010 Jul-Aug;26(7-8):708-18. doi: 10.1016/j.nut.2009.10.014. [PubMed:20579590]
External Links
PubChem Substance
347911161
Wikipedia
Borage_oil

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedTreatmentAsthma1
2CompletedBasic ScienceDiabetes / Metabolic Syndromes1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on February 06, 2020 13:06