This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Borage oil
- DrugBank Accession Number
- DB11238
- Background
Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurodermatitis as well as other inflammatory, cardiovascular and endocrine disorders, although its clinical efficacy and long-term effects are not fully elucidated yet. GLA, which accounts for approximately 24% of the oil, is converted to dihomo-γ-linolenic acid (DGLA) which acts as a precursor to anti-inflammatory mediators such as 1-series prostaglandins and the 3-series leukotrienes. Borage oil may be found in foods or in skin care products.
- Type
- Biotech
- Groups
- Approved, Investigational
- Synonyms
- Borago officinalis
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Borage oil. Amifampridine The risk or severity of seizure can be increased when Borage oil is combined with Amifampridine. Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Borage oil. Brexanolone The therapeutic efficacy of Brexanolone can be decreased when used in combination with Borage oil. Brivaracetam The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Borage oil. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Borage Oil Capsules Borage oil (500 mg) + Gamolenic acid (125 mg) + Linoleic acid (220 mg) Capsule Oral Bioforce Canada Inc. 1994-12-31 1999-10-14 Canada 
Cheon Shim Bo Hwa Borage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1) Capsule Oral Saimdang Cosmetics Co., Ltd 2011-04-06 Not applicable US 
Efficas Care Borage oil (4.4 g/15ml) + Fish oil (3.1 g/15ml) Emulsion Oral Thrustant Consulting Sdn Bhd 2020-09-08 2022-04-03 Malaysia 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Cheon Shim Bo Hwa Borage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1) Capsule Oral Saimdang Cosmetics Co., Ltd 2011-04-06 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- F8XAG1755S
- CAS number
- Not Available
References
- General References
- Tocher DR, Bell JG, Farndale BM, Sargent JR: Effects of dietary gamma-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in delta5 fatty acyl desaturase. Prostaglandins Leukot Essent Fatty Acids. 1997 Aug;57(2):125-34. [Article]
- Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D: Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8. [Article]
- Chung S, Kong S, Seong K, Cho Y: Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J Nutr. 2002 Oct;132(10):3090-7. [Article]
- Foster RH, Hardy G, Alany RG: Borage oil in the treatment of atopic dermatitis. Nutrition. 2010 Jul-Aug;26(7-8):708-18. doi: 10.1016/j.nut.2009.10.014. [Article]
- External Links
- PubChem Substance
- 347911161
- 68905
- Wikipedia
- Borage_seed_oil
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Basic Science Diabetes / Syndrome, Metabolic 1 1, 2 Completed Treatment Asthma 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Emulsion Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at December 03, 2015 16:51 / Updated at April 01, 2021 12:32