Chromium picolinate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Chromium picolinate
Accession Number
DB11255
Type
Small Molecule
Groups
Approved
Description

Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate insulin by promoting glucose utilization and increasing the sensitivity of the insulin receptor [1].

Structure
Thumb
Synonyms
  • Chromium(III) picolinate
Active Moieties
NameKindUNIICASInChI Key
Chromiumunknown0R0008Q3JB7440-47-3VYZAMTAEIAYCRO-UHFFFAOYSA-N
Chromic cationionicX1N4508KF116065-83-1BFGKITSFLPAWGI-UHFFFAOYSA-N
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
DivistaChromium picolinate (1000 ug/1) + Biotin (2 mg/1) + Cyanocobalamin (15 ug/1) + Folic Acid (1 mg/1) + Omega-3-acid ethyl esters (300 mg/1) + Pyridoxine (25 mg/1)CapsuleOralUs Pharmaceutical Corporation2010-07-10Not applicableUs
Medi-10Chromium picolinate (1 mg/1) + Acetylcysteine (200 mg/1) + Cholecalciferol (1000 [iU]/1) + Levomefolate calcium (2.5 mg/1) + Lipoic Acid (200 mg/1) + Methylcobalamin (2.5 mg/1) + Nicotinamide (10 mg/1) + Pyridoxal Phosphate (20 mg/1) + Resveratrol (83 mg/1) + Ubidecarenone (16 mg/1)CapsuleOralMedicap Laboratories Inc.2015-05-012016-01-12Us
RE FAC-xChromium picolinate (200 ug/1) + Ascorbic acid (200 mg/1) + Biotin (200 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (2.5 mg/1) + Cyanocobalamin (2500 ug/1) + Folic Acid (2800 ug/1) + Lutein (500 ug/1) + Lycopene (500 ug/1) + Magnesium (100 mg/1) + Manganese sulfate (2.5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (100 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A (5000 [iU]/1) + Vitamin E (100 [iU]/1) + Zinc (15 mg/1)TabletOralRiver’s Edge Pharmaceuticals, LLC2007-07-012011-01-13Us
Vita-Rx Diabetic VitaminChromium picolinate (0.465 mg/1) + Ascorbic acid (120 mg/1) + Biotin (2.5 mg/1) + Cholecalciferol (0.0625 mg/1) + Folic Acid (0.8 mg/1) + Lipoic Acid (150 mg/1) + Methylcobalamin (0.0025 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxal Phosphate (12.5 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Ubidecarenone (50 mg/1) + alpha-Tocopherol acetate (10 mg/1)Capsule, gelatin coatedOralMas Management Group Inc.2015-08-11Not applicableUs
Vita-Rx Diabetic VitaminChromium picolinate (0.465 mg/1) + Ascorbic acid (120 mg/1) + Biotin (2.5 mg/1) + Cholecalciferol (0.0625 mg/1) + Folic Acid (0.8 mg/1) + Lipoic Acid (150 mg/1) + Methylcobalamin (0.0025 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxal Phosphate (12.5 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Ubidecarenone (50 mg/1) + alpha-Tocopherol acetate (10 mg/1)Capsule, gelatin coatedOralPure Source, Llc2015-08-11Not applicableUs
Categories
UNII
S71T8B8Z6P
CAS number
14639-25-9
Weight
Average: 418.3005
Monoisotopic: 418.013122035
Chemical Formula
C18H12CrN3O6
InChI Key
CBDQOLKNTOMMTL-UHFFFAOYSA-K
InChI
InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3
IUPAC Name
bis(pyridine-2-carbonyloxy)chromio pyridine-2-carboxylate
SMILES
O=C(O[Cr](OC(=O)C1=CC=CC=N1)OC(=O)C1=CC=CC=N1)C1=CC=CC=N1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Broadhurst CL, Domenico P: Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review. Diabetes Technol Ther. 2006 Dec;8(6):677-87. [PubMed:17109600]
External Links
PubChem Compound
625469
PubChem Substance
347827953
ChemSpider
133913
ChEBI
50369
Wikipedia
Chromium(III)_picolinate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1TerminatedTreatmentType 2 Diabetes Mellitus1
4CompletedTreatmentType 2 Diabetes Mellitus1
Not AvailableCompletedPreventionAtypical Depression / BMI >30 kg/m21
Not AvailableCompletedTreatmentBMI >30 kg/m2 / Insulin Resistance / Metabolic Diseases / Metabolic Syndromes / Prediabetic State1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral
TabletOral
Capsule, gelatin coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0312 mg/mLALOGPS
logP2.9ALOGPS
logP1.53ChemAxon
logS-4.1ALOGPS
pKa (Strongest Basic)2.85ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area117.57 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity89.57 m3·mol-1ChemAxon
Polarizability35.52 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Pyridinecarboxylic acids and derivatives
Direct Parent
Pyridinecarboxylic acids
Alternative Parents
Heteroaromatic compounds / Carboxylic acid salts / Monocarboxylic acids and derivatives / Carboxylic acids / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic zwitterions / Organic oxides
show 2 more
Substituents
Pyridine carboxylic acid / Heteroaromatic compound / Carboxylic acid salt / Carboxylic acid derivative / Carboxylic acid / Monocarboxylic acid or derivatives / Organic transition metal salt / Azacycle / Organic nitrogen compound / Hydrocarbon derivative
show 9 more
Molecular Framework
Not Available
External Descriptors
chromium coordination entity (CHEBI:50369)

Drug created on December 03, 2015 09:51 / Updated on November 02, 2018 07:08