Brilliant green

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Brilliant green is an ingredient used in topical medications to prevent infections of the umbilical cord.

Generic Name
Brilliant green cation
Commonly known or available as Brilliant green
DrugBank Accession Number
DB11279
Background

Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Weight
Average: 385.574
Monoisotopic: 385.263825491
Chemical Formula
C27H33N2
Synonyms
  • Brilliant green ion
  • Brilliant green, free form
  • Brilliant green(1+)
External IDs
  • NSC-5011

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatHansen's diseaseCombination Product in combination with: Ethanol (DB00898), Gentian violet cation (DB00406)••••••••••••••••••••
Used in combination to preventInfection of the umbilical cord areaCombination Product in combination with: Acriflavine (DB13373), Gentian violet cation (DB00406)••• •••••••••••
Used in combination to preventInfection of the umbilical cord areaCombination Product in combination with: Proflavine (DB01123), Gentian violet cation (DB00406)••• •••••••••••• ••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Brilliant greenG0L543D370633-03-4NNBFNNNWANBMTI-UHFFFAOYSA-M
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Kerr 100 Triple Dye Dispos-ABrilliant green (2.29 mg/1mL) + Gentian violet (2.2 mg/1mL) + Proflavine hemisulfate (1.14 mg/1mL)SwabTopicalVistaPharm, LLC2004-05-01Not applicableUS flag
Perineze Triple DyeBrilliant green (2.29 mg/0.61mL) + Gentian violet (2.29 mg/0.61mL) + Proflavine hemisulfate (1.14 mg/0.61mL)SolutionTopicalPeace Medical Inc.2011-09-28Not applicableUS flag
Triple DyeBrilliant green (2.29 mg / mL) + Gentian violet (2.29 mg / mL) + Proflavine hemisulfate (1.14 mg / mL)LiquidTopicalFrank W. Kerr Chemical Company1983-12-312004-10-27Canada flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
S85JD8CLBH
CAS number
18198-35-1
InChI Key
HXCILVUBKWANLN-UHFFFAOYSA-N
InChI
InChI=1S/C27H33N2/c1-5-28(6-2)25-18-14-23(15-19-25)27(22-12-10-9-11-13-22)24-16-20-26(21-17-24)29(7-3)8-4/h9-21H,5-8H2,1-4H3/q+1
IUPAC Name
4-{[4-(diethylamino)phenyl](phenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium
SMILES
CCN(CC)C1=CC=C(C=C1)C(C1=CC=CC=C1)=C1C=CC(C=C1)=[N+](CC)CC

References

General References
Not Available
PubChem Compound
12449
PubChem Substance
347827961
ChemSpider
11942
BindingDB
81263
RxNav
1546367
ChEBI
88176
ChEMBL
CHEMBL1589793
ZINC
ZINC000004235575
Wikipedia
Brilliant_Green

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SwabTopical
SolutionTopical
LiquidTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0003 mg/mLALOGPS
logP2.47ALOGPS
logP2.71Chemaxon
logS-6.2ALOGPS
pKa (Strongest Basic)5.36Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area6.25 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity150.57 m3·mol-1Chemaxon
Polarizability47.39 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-229.3384492
predicted
DarkChem Lite v0.1.0
[M+H]+229.7536492
predicted
DarkChem Lite v0.1.0
[M+Na]+228.7235492
predicted
DarkChem Lite v0.1.0

Drug created at December 03, 2015 16:52 / Updated at June 12, 2020 16:53