Famphur

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Famphur
DrugBank Accession Number
DB11408
Background

Not Available

Type
Small Molecule
Groups
Vet approved
Structure
Weight
Average: 325.33
Monoisotopic: 325.020751965
Chemical Formula
C10H16NO5PS2
Synonyms
  • Famophos
  • O-[4-(dimethylsulfamoyl)phenyl] O,O-dimethyl thiophosphate
  • Phosphorothioic acid, O-(4-((dimethylamino)sulfonyl)phenyl) O,O-dimethyl ester

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcrivastineThe risk or severity of QTc prolongation can be increased when Acrivastine is combined with Famphur.
AdenosineThe risk or severity of QTc prolongation can be increased when Famphur is combined with Adenosine.
AjmalineThe risk or severity of QTc prolongation can be increased when Ajmaline is combined with Famphur.
AlfuzosinThe risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Famphur.
AlimemazineThe risk or severity of QTc prolongation can be increased when Alimemazine is combined with Famphur.
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenyl thiophosphates. These are organothiophosphorus compounds that contain a thiophosphoric acid O-esterified with a phenyl group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic thiophosphoric acids and derivatives
Sub Class
Thiophosphoric acid esters
Direct Parent
Phenyl thiophosphates
Alternative Parents
Benzenesulfonamides / Benzenesulfonyl compounds / Thiophosphate triesters / Phenoxy compounds / Organosulfonamides / Aminosulfonyl compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides
show 1 more
Substituents
Aminosulfonyl compound / Aromatic homomonocyclic compound / Benzenesulfonamide / Benzenesulfonyl group / Benzenoid / Hydrocarbon derivative / Monocyclic benzene moiety / Organic nitrogen compound / Organic oxide / Organic oxygen compound
show 11 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
organic thiophosphate, organothiophosphate insecticide (CHEBI:38677) / Organophosphorus insecticides (C18658)
Affected organisms
Not Available

Chemical Identifiers

UNII
02UOP4Z0O0
CAS number
52-85-7
InChI Key
JISACBWYRJHSMG-UHFFFAOYSA-N
InChI
InChI=1S/C10H16NO5PS2/c1-11(2)19(12,13)10-7-5-9(6-8-10)16-17(18,14-3)15-4/h5-8H,1-4H3
IUPAC Name
O-4-(dimethylsulfamoyl)phenyl O,O-dimethyl phosphorothioate
SMILES
COP(=S)(OC)OC1=CC=C(C=C1)S(=O)(=O)N(C)C

References

General References
  1. Franson JC, Kolbe EJ, Carpenter JW: Famphur toxicosis in a bald eagle. J Wildl Dis. 1985 Jul;21(3):318-20. [Article]
  2. Cummins LJ: Cow fertility after lice treatment with famphur. Aust Vet J. 1977 Apr;53(4):200. [Article]
  3. Cummins LJ: Cow fertility after lice treatment with famphur. Aust Vet J. 1977 Aug;53(8):406-7. [Article]
  4. Johnson WP, Alford BT, Drain JJ: Safety of famphur to young Brahman heifers, bulls and steers. Vet Med Small Anim Clin. 1972 Jun;67(6):686. [Article]
  5. Erne K, Nordkvist M: The disappearance rate in reindeer of famphur an organophosphorus parasiticide. Acta Vet Scand. 1970;11(2):209-18. [Article]
  6. Randell WF, Bradley RE: Effects of injectable famphur on young Brahman and Angus cattle. Am J Vet Res. 1980 Sep;41(9):1423-6. [Article]
  7. Ivey MC: Gas-liquid chromatographic determination of famphur and its oxygen analog in tissues of reindeer and cattle. J Assoc Off Anal Chem. 1976 Mar;59(2):261-3. [Article]
  8. Watson K, Black WD: Whole blood cholinesterase activity in calves after topical treatment with famphur. Can Vet J. 1981 Jun;22(6):179-81. [Article]
  9. White DH, Hayes LE, Bush PB: Case histories of wild birds killed intentionally with famphur in Georgia and West Virginia. J Wildl Dis. 1989 Apr;25(2):184-8. [Article]
  10. Felton CL, Brown PM, Fletcher MR, Stanley PI, Quick MP, Machin AF: Bird poisoning following the use of warble fly treatments containing famphur. Vet Rec. 1981 May 16;108(20):440. [Article]
KEGG Compound
C18658
ChemSpider
5650
ChEBI
38677
ChEMBL
CHEMBL1525287
ZINC
ZINC000002041376

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.229 mg/mLALOGPS
logP2.15ALOGPS
logP1.71Chemaxon
logS-3.2ALOGPS
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area65.07 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity77.82 m3·mol-1Chemaxon
Polarizability29.65 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-003r-0095000000-26c861413278b93a6dd7
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0029000000-fb13960bf727f63cb925
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0f7o-0090000000-6c1acd6054bcdd7905ce
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00e9-0069000000-c9a00616bb829b7d14b8
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0fk9-4911000000-c4132d92b2b2b9c60889
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a59-1910000000-b54298162c2af5d998fa
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-182.2644085
predicted
DarkChem Lite v0.1.0
[M-H]-182.9838085
predicted
DarkChem Lite v0.1.0
[M-H]-161.84453
predicted
DeepCCS 1.0 (2019)
[M+H]+164.20253
predicted
DeepCCS 1.0 (2019)
[M+Na]+170.53029
predicted
DeepCCS 1.0 (2019)

Drug created at February 25, 2016 18:28 / Updated at June 12, 2020 16:53