Aluminum chlorohydrate

Identification

Name
Aluminum chlorohydrate
Accession Number
DB11573
Type
Small Molecule
Groups
Approved
Description

Aluminum chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near the skin surface 1. It is also used as a coagulant in the water purification process.

Structure
Thumb
Synonyms
  • Aluminium chlorohydrate
  • Aluminum chlorohydrate
Active Moieties
NameKindUNIICASInChI Key
Aluminum cationionic3XHB1D032B22537-23-1REDXJYDRNCIFBQ-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2.25OZ EverDry Ultra Dry AntiperspirantStick20 g/100gTopicalAmerican Consumer Products Corp2019-09-17Not applicableUs
2.5OZ EverDry Antiperspirant InvisibleStick20 g/100gTopicalAmerican Consumer Products Corp2019-09-17Not applicableUs
5 DayLiquid0.25 g/1TopicalNumark Brands, Inc1937-04-10Not applicableUs
African OpiumLiquid200 mg/1mLTopicalN. N. IMPEX2020-05-28Not applicableUs
Alyssa Ashley Musk Creme DeS.A. Bille-20CreamTopicalHoubigant (1995) ltÉe.1996-06-271998-08-14Canada
Alyssa Ashley Musk Creme Desodor. A BilleCreamTopicalParfums Alyssa Ashley Inc.1975-12-311998-02-06Canada
Ambicious Antiperspirant Deodorant Roll On for WomenEmulsion200 mg/1gTopicalZermat Internacional S.A. de C.V.2016-08-292018-02-28Us
Amerfresh Roll-ON Antiperspirant DeodorantLiquid10 mg/1mLTopicalAmercare Products, Inc2010-07-06Not applicableUs
Angel - Caresse D'ange - Deodorant Roll-ON AntiperspirantSolutionTopicalThierry Mugler Parfums2003-03-202009-08-14Canada
Antartic Roll-ON Anti-perspirantLotionTopicalYves Rocher Inc.1998-08-172005-08-15Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Akileine Vaporisateur AntitranspirantAluminum chlorohydrate (50 mg) + Ethanol (600 mg)SprayTopicalLaboratoire Larima ltÉe1985-12-312007-07-31Canada
Anti-perspirant Roll-ON DeodAluminum chlorohydrate (20 %) + Aluminum chloride (2 %)LiquidTopicalEstee Lauder Dist1987-12-312002-07-31Canada
Arrid CreamAluminum chlorohydrate (21.2 %) + Aluminum chloride (1 %)CreamTopicalCarter Products, Division Of Carter Wallace Ns Inc.1939-12-311999-09-27Canada
Ban Ultra Antiperspirant Roll-ONAluminum chlorohydrate (12 %) + Aluminum zirconium tetrachlorohydrex gly (12 %)LiquidTopicalJergens Canada Inc.1999-12-302002-07-15Canada
Lactovit DEO ROLL ON LACTOUREA DEODORANT ANTIPERSPIRANTAluminum chlorohydrate (6.4 mg/1) + Aluminum sesquichlorohydrate (0.808 mg/1)LiquidTopicalLaboratorios Genesse Sl2016-11-192017-12-31Us
Lactovit DEO ROLL-ON LACTOUREA DEODORANT ANTIPERSPIRANTAluminum chlorohydrate (6.4 mg/1mL) + Aluminum sesquichlorohydrate (0.6464 mg/1mL)LiquidTopicalLaboratorios Genesse Sl2016-11-192017-12-31Us
Lactovit Mens Roll On Antiperspirant DeodorantAluminum chlorohydrate (9.6 mg/1) + Aluminum sesquichlorohydrate (0.9696 mg/1)LiquidTopicalLaboratorios Genesse Sl2016-11-192017-12-31Us
Lactovit Original Roll-On Antiperspirant DeodorantAluminum chlorohydrate (11.2 mg/1) + Aluminum sesquichlorohydrate (1.1312 mg/1)LiquidTopicalLaboratorios Genesse Sl2016-11-232017-12-31Us
Medrol Acne LotionAluminum chlorohydrate (100 mg) + Methylprednisolone acetate (2.5 mg) + Octasulfur (50 mg)LotionTopicalPfizer Canada Ulc1973-12-312014-04-04Canada
Mitchum Anti Perspirant Crm ScentedAluminum chlorohydrate (19 g) + Alcloxa (250 mg) + Aluminum chloride (4 g)CreamTopicalMitchum Thayer Ltd.1965-12-311996-09-09Canada
Categories
UNII
HPN8MZW13M
CAS number
12359-72-7
Weight
Average: 192.46
Monoisotopic: 191.9561926
Chemical Formula
Al2ClH7O6
InChI Key
ZLVPDILYQLCEJO-UHFFFAOYSA-H
InChI
InChI=1S/2Al.ClH.6H2O/h;;1H;6*1H2/q2*+3;;;;;;;/p-6
IUPAC Name
dialuminium(3+) ion hydrate chloride pentahydroxide
SMILES
O.[OH-].[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-]

Pharmacology

Indication

Indicated for use as an antiperspirant.

Pharmacodynamics

Aluminum chlorohydrate serves to reduce excessive sweating by directly blocking the sweat ducts 4.

Mechanism of action

Aluminum salts plug eccrine sweat pores and forms aggregates with swear proteins that bind to the wall of the sweat duct and form a tenuous membrane 4.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin 3. In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application 2. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period 2.

Volume of distribution

No pharmacokinetic information available.

Protein binding

No pharmacokinetic information available.

Metabolism

No pharmacokinetic information available.

Route of elimination

No pharmacokinetic information available.

Half life

No pharmacokinetic information available.

Clearance

No pharmacokinetic information available.

Toxicity

Dermal and oral LD50 in rat is > 2000 mg/kg MSDS.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

References

General References
  1. Quatrale RP, Coble DW, Stoner KL, Felger CB: The mechanism of antiperspirant action by aluminum salts. II. Histological observations of human eccrine sweat glands inhibited by aluminum chlorohydrate Journal of the Society of Cosmetic Chemists. 1981 Jan 1;32(3):107-136.
  2. Flarend R, Bin T, Elmore D, Hem SL: A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem Toxicol. 2001 Feb;39(2):163-8. [PubMed:11267710]
  3. Klotz K, Weistenhofer W, Neff F, Hartwig A, van Thriel C, Drexler H: The Health Effects of Aluminum Exposure. Dtsch Arztebl Int. 2017 Sep 29;114(39):653-659. doi: 10.3238/arztebl.2017.0653. [PubMed:29034866]
  4. Bretagne A, Cotot F, Arnaud-Roux M, Sztucki M, Cabane B, Galey JB: The mechanism of eccrine sweat pore plugging by aluminium salts using microfluidics combined with small angle X-ray scattering. Soft Matter. 2017 May 24;13(20):3812-3821. doi: 10.1039/c6sm02510b. [PubMed:28485735]
External Links
PubChem Compound
71586946
PubChem Substance
347827987
ChemSpider
32699791
RxNav
17610
Wikipedia
Aluminium_chlorohydrate
ATC Codes
D09AA08 — Aluminium chlorohydrateM05BX02 — Aluminium chlorohydrate
AHFS Codes
  • 84:12.00 — Astringents and Deodorants
MSDS
Download (333 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidTopical0.25 g/1
SprayTopical
LiquidTopical10 mg/1mL
SolutionTopical
LotionTopical
SolutionTopical10 mg/100mL
SprayTopical13 g/100mL
SprayTopical13 mg/100mL
SprayTopical130 mg/1mL
StickTopical52 mg/1g
StickTopical11.4 1/57g
StickTopical23 g/100g
LiquidTopical15 mL/100mL
LotionTopical250 mg/1mL
LiquidTopical12.3 g/100mL
Aerosol, sprayTopical23 g/100g
SwabTopical15 g/100g
LiquidTopical211 mg/1mL
LiquidTopical10 g/100mL
Aerosol, sprayTopical24.6 g/1g
Aerosol, sprayTopical0.246 g/1g
Aerosol, sprayTopical246 mg/1g
Aerosol, sprayTopical250 mg/1g
LiquidTopical16 1/100mL
LiquidTopical16 mL/100mL
LotionTopical25 g/100g
LotionTopical16 g/100g
LiquidTopical100 mg/1mL
Aerosol, sprayTopical23.3 g/100g
LiquidTopical18 g/100mL
LiquidTopical20 g/103mL
LiquidTopical250 mg/1mL
SprayTopical
AerosolTopical8.8 g/100g
GelTopical7.8 mL/100mL
StickTopical7.8 g/100g
StickTopical18 g/100g
LiquidTopical70 mL/100mL
GelTopical207 mg/1mL
SprayTopical12 g/125g
LiquidTopical25 mL/100mL
SprayTopical7.90 mL/100mL
GelTopical150 mg/1mL
GelTopical45 mg/1mL
LiquidTopical45 mg/1mL
LiquidTopical79 mg/1mL
LotionTopical45 mg/1mL
LotionTopical78 mg/1mL
SolutionTopical78 mg/100mL
StickTopical9.2 g/64g
StickCutaneous14.4 1/1
Aerosol, sprayTopical19.1 g/100g
Aerosol, sprayTopical8.8 g/100g
SuspensionTopical
StickTopical
LotionTopical155 mg/1mL
AerosolTopical
Aerosol, sprayTopical20.2 g/100g
LiquidTopical144 mg/1mL
CreamTopical200 mg/1g
GelTopical20 g/100g
LiquidTopical0.045 g/1mL
SprayTopical0.045 g/1mL
SprayTopical30 g/150mL
SprayTopical78 mg/1mL
LotionTopical160 mg/1mL
GelTopical7.25 mL/50mL
GelTopical13.5 g/60mL
EmulsionTopical150 mg/1mL
LiquidTopical15 g/100g
LiquidTopical0.25 g/1mL
StickTopical0.16 g/1g
ClothTopical0.2 mg/1mL
LiquidTopical100 g/100mL
LotionTopical11 g/50g
LiquidTopical78 mg/1mL
LiquidTopical0.18 g/1mL
GelTopical145 mg/1mL
StickTopical1 g/100g
LiquidTopical200 mg/1mL
LotionTopical12.3 g/100g
LiquidTopical160 mg/1mL
StickTopical15 g/75g
LotionTopical120 mg/1mL
StickTopical200 mg/1g
CreamTopical128 mg/1mL
ClothTopical0.15 g/1g
KitTopical140 mg/1mL
CreamTopical100 mg/1mL
CreamTopical63 mg/1mL
CreamTopical120 mg/1mL
LiquidTopical
LiquidTopical15 mg/100mL
CreamTopical140 mg/1mL
LiquidTopical150 mg/1mL
LiquidTopical10 mg/100mL
LiquidTopical10 mL/100mL
CreamTopical80 mg/1mL
Aerosol, sprayTopical0.24 g/1mL
SprayCutaneous3 mL/100mL
CreamTopical
LiquidTopical4.5 g/100mL
AerosolTopical0.25 g/1mL
CreamTopical
StickTopical0.23 g/1g
LotionTopical
LiquidTopical12.5 g/100mL
LiquidTopical180 mg/1mL
StickTopical15 g/100g
SolutionTopical15 g/100g
LiquidTopical15 g/100mL
LiquidTopical20 g/100mL
Aerosol, sprayTopical0.23 g/1g
SprayTopical24.1 g/100g
LiquidTopical14 g/100mL
GelTopical5.67 g/56.7g
SprayTopical20.2 g/100g
SprayTopical9.05 g/45g
EmulsionTopical200 mg/1g
SolutionTopical0.1 mg/1mL
SolutionTopical10 g/100mL
SolutionTopical14 mg/100mL
SolutionTopical14 g/100mL
CreamTopical200 mg/1mL
SolutionTopical200 mg/1mL
LiquidTopical
Aerosol, sprayTopical0.24 g/1g
SolutionTopical36 mL/65mL
Aerosol, sprayTopical23.5 g/100g
Aerosol, sprayTopical24.1 g/100g
CreamTopical160 mg/1g
AerosolTopical250 mg/1g
AerosolTopical200 mg/1g
Aerosol, sprayTopical200 mg/1g
CreamTopical11.4 g/57g
CreamTopical28 g/100g
EmulsionTopical280 mL/1000mL
LiquidTopical0.1128 g/1mL
StickTopical50 mL/50mL
LiquidTopical25 g/100mL
StickTopical25 g/100mL
LiquidTopical50 g/100mL
LiquidTopical25 g/50mL
StickTopical20 g/100g
LiquidTopical22 g/100mL
LiquidTopical22 mL/100mL
AerosolTopical12 g/100g
AerosolTopical10 g/100g
AerosolTopical
StickTopical0.22 g/1g
StickTopical220 mg/1g
StickTopical11.4 g/57g
LiquidTopical190 mg/1mL
Aerosol, sprayTopical0.194 g/1g
StickTopical12.3 g/12.3mL
CreamTopical11 g/57g
CreamTopical20 g/100g
LiquidTopical20 mL/100mL
LiquidTopical20 g/100g
LiquidTopical20 mg/100mL
LiquidTopical10 g/100g
LiquidTopical8 g/100g
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility451.0 mg/mLALOGPS
logP-0.32ALOGPS
logP-0.65ChemAxon
logS0.67ALOGPS
pKa (Strongest Acidic)15.7ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area25.3 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity3.7 m3·mol-1ChemAxon
Polarizability1.51 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as post-transition metal hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal hydroxides
Direct Parent
Post-transition metal hydroxides
Alternative Parents
Post-transition metal salts / Inorganic oxides / Inorganic hydrides / Inorganic chloride salts
Substituents
Post-transition metal hydroxide / Inorganic chloride salt / Inorganic post-transition metal salt / Inorganic hydride / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on April 06, 2016 16:31 / Updated on July 11, 2020 00:05

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