Neon

Identification

Name
Neon
Accession Number
DB11589
Type
Small Molecule
Groups
Approved, Investigational
Description

Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a reddish-orange light, and is commonly used in low-voltage neon glow lamps, high-voltage discharge tubes, and signs with fluorescent lighting. It is also used in vacuum tubes, high-voltage indicators, lightning arresters, wave meter tubes, television tubes, and helium–neon lasers. Neon may be used in the clinical setting as a diagnostic tracer gas in a gas analyzer for a lung diffusion test. Other clinical applications of neon, such as a radiotherapy in various cancers [1], have been studied.

Structure
Thumb
Synonyms
  • Ne
  • neón
  • néon
  • Neon
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Co-NE-O2-N2 MixtureNeon (0.5 %) + Carbon monoxide (0.3 %) + Nitrogen (78.2 %) + Oxygen (21.0 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Lung Diffusion Test Mix No Ne CoNeon (0.5 %) + Carbon monoxide (0.3 %) + Nitrogen (78.2 %) + Oxygen (21 %)GasRespiratory (inhalation)Praxair, Inc.1968-12-31Not applicableCanada
Categories
UNII
4VB4Y46AHD
CAS number
7440-01-9
Weight
Average: 20.1797
Monoisotopic: 19.99244018
Chemical Formula
Ne
InChI Key
GKAOGPIIYCISHV-UHFFFAOYSA-N
InChI
InChI=1S/Ne
IUPAC Name
neon
SMILES
[Ne]

Pharmacology

Indication

Indicated for use as a diagnostic tracer gas in pulmonary function tests.

Structured Indications
Not Available
Pharmacodynamics

A study demonstrated that neon beam radiotherapy improved the 5-year actuarial disease-specific survival rate and local control in patients with paranasal sinus tumours, macroscopic salivary gland tumours, bile duct carcinomas, macroscopic soft tissue and bone sarcomas, and advanced prostate carcinomas [1].

Mechanism of action

In a pulmonary diffusion capacity test, the diffusing capacity for carbon monoxide (Dlco) assesses the rate at which oxygen is transferred from the lung to the pulmonary capillary bed. In a neon gas analyzer, the mixture of carbon monoxide, neon gas, oxygen, and the balance nitrogen is inhaled by the individual and is eventually exhaled after being held at near full inspiration for brief seconds. The concentrations and ratio of carbon monoxide and neon is measured in the alveolar fraction of the expired gas. The change in the concentration of the tracer gas reflects the mean alveolar carbon monoxide concentration at the start of the breath hold and provides a measure of alveolar volume by gas dilution [2].

Neon ion radiotherapy has high linear energy transfer thus produces biological behaviour similar to neutron beams [1]. The rays are associated with a reduction in the oxygen enhancement ratio, which allows for more specificity for hypoxic cells, less variation in cell-cycle related radio sensitivity, and less capability for repair of radiation injury [1].

Absorption

No pharmacokinetic data available.

Volume of distribution

No pharmacokinetic data available.

Protein binding

No pharmacokinetic data available.

Metabolism

No pharmacokinetic data available.

Route of elimination

No pharmacokinetic data available.

Half life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Toxicity

In high concentrations, neon gas may act as a simple asphyxiant by displacing oxygen from the atmosphere leading to decreased alveolar partial oxygen pressure and hypoxemia [3].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Linstadt DE, Castro JR, Phillips TL: Neon ion radiotherapy: results of the phase I/II clinical trial. Int J Radiat Oncol Biol Phys. 1991 Apr;20(4):761-9. [PubMed:2004953]
  2. Castile RG, Davis SD (2012). 12. In Kendig & Chernick's Disorders of the Respiratory Tract in Children (8th ed., pp. 211). Elsevier Saunders. [ISBN:978-1-4377-1984-0]
  3. Neon, Elemental - National Library of Medicine HSDB Database - Toxnet [Link]
  4. FDA Code of Federal Regulations (CFR) Title 21 Sec. 868.1670 Neon gas analyzer [Link]
External Links
PubChem Compound
23935
PubChem Substance
347827996
ChemSpider
22377
ChEBI
33310
Wikipedia
Neon
MSDS
Download (145 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingOtherHigh Blood Pressure (Hypertension) / Insulin Resistance1
1WithdrawnTreatmentBacterial Infections1
Not AvailableActive Not RecruitingNot AvailableDiabetes Mellitus (DM)1
Not AvailableActive Not RecruitingNot AvailableHigh Blood Pressure (Hypertension)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)
Prices
Not Available
Patents
Not Available

Properties

State
Gas
Experimental Properties
PropertyValueSource
melting point (°C)-248.7MSDS
boiling point (°C)-246.1MSDS
water solubilityNegligibleMSDS
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous noble gases
Sub Class
Not Available
Direct Parent
Homogeneous noble gases
Alternative Parents
Not Available
Substituents
Homogeneous noble gas
Molecular Framework
Not Available
External Descriptors
monoatomic neon (CHEBI:49993)

Drug created on April 28, 2016 13:07 / Updated on May 02, 2018 00:08