Identification
- Summary
Neon is a diagnostic tracer gas used in pulmonary function tests.
- Generic Name
- Neon
- DrugBank Accession Number
- DB11589
- Background
Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a reddish-orange light, and is commonly used in low-voltage neon glow lamps, high-voltage discharge tubes, and signs with fluorescent lighting. It is also used in vacuum tubes, high-voltage indicators, lightning arresters, wave meter tubes, television tubes, and helium–neon lasers. Neon may be used in the clinical setting as a diagnostic tracer gas in a gas analyzer for a lung diffusion test. Other clinical applications of neon, such as a radiotherapy in various cancers 1, have been studied.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Neon (DB11589)
- Weight
- Average: 20.1797
Monoisotopic: 19.99244018 - Chemical Formula
- Ne
- Synonyms
- Ne
- neón
- néon
- Neon
Pharmacology
- Indication
Indicated for use as a diagnostic tracer gas in pulmonary function tests.
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A study demonstrated that neon beam radiotherapy improved the 5-year actuarial disease-specific survival rate and local control in patients with paranasal sinus tumours, macroscopic salivary gland tumours, bile duct carcinomas, macroscopic soft tissue and bone sarcomas, and advanced prostate carcinomas 1.
- Mechanism of action
In a pulmonary diffusion capacity test, the diffusing capacity for carbon monoxide (Dlco) assesses the rate at which oxygen is transferred from the lung to the pulmonary capillary bed. In a neon gas analyzer, the mixture of carbon monoxide, neon gas, oxygen, and the balance nitrogen is inhaled by the individual and is eventually exhaled after being held at near full inspiration for brief seconds. The concentrations and ratio of carbon monoxide and neon is measured in the alveolar fraction of the expired gas. The change in the concentration of the tracer gas reflects the mean alveolar carbon monoxide concentration at the start of the breath hold and provides a measure of alveolar volume by gas dilution 2.
Neon ion radiotherapy has high linear energy transfer thus produces biological behaviour similar to neutron beams 1. The rays are associated with a reduction in the oxygen enhancement ratio, which allows for more specificity for hypoxic cells, less variation in cell-cycle related radio sensitivity, and less capability for repair of radiation injury 1.
- Absorption
No pharmacokinetic data available.
- Volume of distribution
No pharmacokinetic data available.
- Protein binding
No pharmacokinetic data available.
- Metabolism
No pharmacokinetic data available.
- Route of elimination
No pharmacokinetic data available.
- Half-life
No pharmacokinetic data available.
- Clearance
No pharmacokinetic data available.
- Adverse Effects
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In high concentrations, neon gas may act as a simple asphyxiant by displacing oxygen from the atmosphere leading to decreased alveolar partial oxygen pressure and hypoxemia 3.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
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Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Co-NE-O2-N2 Mixture Neon (0.5 % v/v) + Carbon monoxide (0.3 % v/v) + Nitrogen (78.2 % v/v) + Oxygen (21 % v/v) Gas Respiratory (inhalation) Messer Canada Inc. 1995-12-31 Not applicable Canada 
Lung Diffusion Test Mix No Ne Co Neon (0.5 %) + Carbon monoxide (0.3 %) + Nitrogen (78.2 %) + Oxygen (21 %) Gas Respiratory (inhalation) Praxair, Inc. 1968-12-31 Not applicable Canada Lung Diffusion Test Mixture Neon (1 %) + Acetylene (.6 %) + Carbon monoxide (1.5 %) + Nitrogen (81.7 %) + Oxygen (23 %) Gas Respiratory (inhalation) Matheson Gas Products Canada Inc. 1982-12-31 1997-12-24 Canada Lung Diffusion Test Mixture Neon (.5 %) + Acetylene (.5 %) + Carbon dioxide (.4 %) + Medical air (98.6 %) Gas Respiratory (inhalation) Matheson Gas Products Canada Inc. 1961-12-31 1997-12-24 Canada
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Homogeneous noble gases
- Sub Class
- Not Available
- Direct Parent
- Homogeneous noble gases
- Alternative Parents
- Not Available
- Substituents
- Homogeneous noble gas
- Molecular Framework
- Not Available
- External Descriptors
- monoatomic neon (CHEBI:49993)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4VB4Y46AHD
- CAS number
- 7440-01-9
- InChI Key
- GKAOGPIIYCISHV-UHFFFAOYSA-N
- InChI
- InChI=1S/Ne
- IUPAC Name
- neon
- SMILES
- [Ne]
References
- General References
- Linstadt DE, Castro JR, Phillips TL: Neon ion radiotherapy: results of the phase I/II clinical trial. Int J Radiat Oncol Biol Phys. 1991 Apr;20(4):761-9. [Article]
- Castile RG, Davis SD (2012). 12. In Kendig & Chernick's Disorders of the Respiratory Tract in Children (8th ed., pp. 211). Elsevier Saunders. [ISBN:978-1-4377-1984-0]
- Neon, Elemental - National Library of Medicine HSDB Database - Toxnet [Link]
- FDA Code of Federal Regulations (CFR) Title 21 Sec. 868.1670 Neon gas analyzer [Link]
- External Links
- MSDS
- Download (145 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 0 Unknown Status Diagnostic Vasoplegia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gas Respiratory (inhalation) - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Gas
- Experimental Properties
Property Value Source melting point (°C) -248.7 MSDS boiling point (°C) -246.1 MSDS water solubility Negligible MSDS - Predicted Properties
Property Value Source logP 0 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at April 28, 2016 19:07 / Updated at October 01, 2021 23:55