Identification

Name
Artenimol
Accession Number
DB11638
Type
Small Molecule
Groups
Approved, Investigational
Description

Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated Plasmodium falciparum infections [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2011 in combination with Piperaquine as the product Eurartesim. Artemisinin combination therapy is highly effective against malaria and stongly recommended by the World Health Organization [12].

Structure
Thumb
Synonyms
  • beta-Dihydroartemisinin
  • Dihydroartemisinin
External IDs
GNF-PF-5634
Categories
UNII
6A9O50735X
CAS number
71939-50-9
Weight
Average: 284.352
Monoisotopic: 284.162373873
Chemical Formula
C15H24O5
InChI Key
BJDCWCLMFKKGEE-HVDUHBCDSA-N
InChI
InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1
IUPAC Name
(1R,4S,5R,8S,9R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-ol
SMILES
[H][C@@]1(C)CC[C@@]2([H])[C@@]([H])(C)C([H])(O)O[C@]3([H])O[C@@]4(C)CC[C@]1([H])[C@@]23OO4

Pharmacology

Indication

For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with Piperaquine.

Pharmacodynamics

Artenimol is thought to form a reactive carbon radical intermediate which kills P. falciparum through alkylation of a wide array of proteins.

Mechanism of action

Artemisinins, including Artenimol which is a major active metabolite of many artemisinins, are thought to act via a common mechanism [4]. While the exact mechanism of action is not certain, theories exist as to how artemisinins produce their antimalarial effect.

Artemisinins are believed to bind to haem within the P. falciparum parasite [1, 3]. The source of this haem varies with the life stage of the parasite. When the parasite is in the early ring stage artemisinins are believed to bind haem produced by the parasite's haem biosynthesis pathway. In later stages artemisinins likely bind to haem released by haemoglobin digestion. Once bound to haem, artemisinins are thought to undergo activation involving ferrous iron via reductive scission which splits the endoperoxide bridge to produce a reactive oxygen [2, 9]. This reactive oxygen is thought to undergo a subsequent intramolecular hydrogen abstraction to produce a reactive carbon radical [9]. The carbon radical is believed to be the source of the drugs potent activity against P. falciparum by alkylating a wide array of protein targets [5, 1, 9]. The nature and magnitude of the effect on specific protein function as a result of this alkylation is unknown.

One target which has been the focus of research is the sarco/endoplasmic reticulum Ca2+ ATPase pump of P. falciparum [7]. Artemisinins have been found to irreversably bind to and inhibit this protein at a binding site similar to that of Thapsigargin. The mechanism is likely the same as for other proteins, namely alkylation via the carbon radical intermediate.

Artemisinins appear to preferentially collect in infected erythrocytes, concentrating the drug by several hundred-fold compared to uninfected cells [10]. This may play a role in why little alkylation is seen in uninfected erythrocytes [8].

TargetActionsOrganism
UActin, cytoplasmic 2
ligand
Human
UAlpha-aminoadipic semialdehyde dehydrogenase
ligand
Human
UAnnexin A2
ligand
Human
UATP synthase subunit alpha, mitochondrial
ligand
Human
UATP synthase subunit g, mitochondrial
ligand
Human
UATP synthase subunit O, mitochondrial
ligand
Human
UCalpastatin
ligand
Human
UT-complex protein 1 subunit gamma
ligand
Human
UCofilin-1
ligand
Human
UChloride intracellular channel protein 1
ligand
Human
UCysteine and glycine-rich protein 1
ligand
Human
UDihydropyrimidinase-related protein 2
ligand
Human
UDesmoplakin
ligand
Human
UElongation factor 1-alpha 1
ligand
Human
UAlpha-enolase
ligand
Human
UFilamin-A
ligand
Human
UAlpha-ketoglutarate-dependent dioxygenase FTO
ligand
Human
UGlucose-6-phosphate 1-dehydrogenase
ligand
Human
UGlyceraldehyde-3-phosphate dehydrogenase, testis-specific
ligand
Human
UGlucose-6-phosphate isomerase
ligand
Human
UHeterogeneous nuclear ribonucleoproteins A2/B1
ligand
Human
UHeterogeneous nuclear ribonucleoprotein D0
ligand
Human
UHeterogeneous nuclear ribonucleoprotein K
ligand
Human
UHeterochromatin protein 1-binding protein 3
ligand
Human
UHeat shock protein beta-1
ligand
Human
URas GTPase-activating-like protein IQGAP1
ligand
Human
UFar upstream element-binding protein 2
ligand
Human
UL-lactate dehydrogenase A chain
ligand
Human
UL-lactate dehydrogenase B chain
ligand
Human
UGalectin-1
ligand
Human
UMicrotubule-associated protein 4
ligand
Human
UMalate dehydrogenase, cytoplasmic
ligand
Human
UPuromycin-sensitive aminopeptidase
ligand
Human
UProfilin-1
ligand
Human
UPhosphoglycerate kinase 1
ligand
Human
UPyruvate kinase PKM
ligand
Human
UPeptidyl-prolyl cis-trans isomerase A
ligand
Human
UPeroxiredoxin-1
ligand
Human
U60S ribosomal protein L10
ligand
Human
U60S ribosomal protein L14
ligand
Human
U60S ribosomal protein L18
ligand
Human
U60S ribosomal protein L23a
ligand
Human
U60S ribosomal protein L35
ligand
Human
U60S ribosomal protein L4
ligand
Human
U40S ribosomal protein S13
ligand
Human
U40S ribosomal protein S17
ligand
Human
U40S ribosomal protein S18
ligand
Human
U40S ribosomal protein S19
ligand
Human
U40S ribosomal protein S28
ligand
Human
U40S ribosomal protein S5
ligand
Human
U40S ribosomal protein S6
ligand
Human
U40S ribosomal protein S8
ligand
Human
U40S ribosomal protein S9
ligand
Human
USplicing factor 1
ligand
Human
USplicing factor, proline- and glutamine-rich
ligand
Human
USmall nuclear ribonucleoprotein Sm D2
ligand
Human
USignal recognition particle 14 kDa protein
ligand
Human
USerine/arginine-rich splicing factor 4
ligand
Human
UTransgelin
ligand
Human
UTransgelin-2
ligand
Human
UTriosephosphate isomerase
ligand
Human
UTropomyosin alpha-1 chain
ligand
Human
UTubulin alpha-1A chain
ligand
Human
UVimentin
ligand
Human
UZyxin
ligand
Human
UHeat shock cognate 71 kDa protein
ligand
Human
UTubulin beta-6 chain
ligand
Human
UTubulin beta-4A chain
ligand
Human
UTubulin beta chain
ligand
Human
UFructose-bisphosphate aldolase A
ligand
Human
UGlyceraldehyde-3-phosphate dehydrogenase
ligand
Human
UCytochrome c
ligand
Human
UPhosphoglycerate mutase 1
ligand
Human
UMyosin-9
ligand
Human
UProtein disulfide-isomerase
ligand
Human
UProbable ATP-dependent RNA helicase DDX5
ligand
Human
USerine hydroxymethyltransferase, mitochondrial
ligand
Human
USpliceosome RNA helicase DDX39B
ligand
Human
UTemporary name for P06748
ligand
UTranslationally-controlled tumor protein homolog
ligand
Plasmodium falciparum (isolate 3D7)
UP-type Ca2+-transporting ATPase
antagonist
Plasmodium falciparum
UOrnithine aminotransferase
ligand
Plasmodium falciparum (isolate 3D7)
UElongation factor 1-alpha
ligand
Plasmodium falciparum (isolate K1 / Thailand)
UMultidrug resistance protein
ligand
Plasmodium falciparum (isolate FC27 / Papua New Guinea)
UElongation factor 2
ligand
Plasmodium falciparum (isolate 3D7)
UActin-1
ligand
Plasmodium falciparum (isolate HB3)
UGlyceraldehyde-3-phosphate dehydrogenase
ligand
Plasmodium falciparum (isolate 3D7)
UFructose-bisphosphate aldolase
ligand
Plasmodium falciparum
UCell division cycle protein 48 homologue,putative
ligand
Plasmodium falciparum (isolate 3D7)
UHeat shock protein 90
ligand
Plasmodium falciparum (isolate 3D7)
UEukaryotic initiation factor 4A
ligand
Plasmodium falciparum (isolate 3D7)
UPyruvate kinase
ligand
Plasmodium falciparum (isolate 3D7)
UL-lactate dehydrogenase
ligand
Plasmodium falciparum (isolate CDC / Honduras)
UProtein disulfide-isomerase
ligand
Plasmodium falciparum (isolate 3D7)
UThioredoxin-related protein, putative
ligand
Plasmodium falciparum (isolate 3D7)
USpermidine synthase
ligand
Plasmodium falciparum (isolate 3D7)
UProbable ATP-dependent 6-phosphofructokinase
ligand
Plasmodium falciparum (isolate 3D7)
UGlutamate dehydrogenase
ligand
Plasmodium falciparum (isolate 3D7)
UEndoplasmin homolog, putative
ligand
Plasmodium falciparum (isolate 3D7)
UHypoxanthine-guanine-xanthine phosphoribosyltransferase
ligand
Plasmodium falciparum (isolate FCR-3 / Gambia)
UEnolase
ligand
Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S3
ligand
Plasmodium falciparum (isolate 3D7)
UNon-SERCA-type Ca2+-transporting P-ATPase
ligand
Plasmodium falciparum (isolate 3D7)
UTubulin alpha chain
ligand
Plasmodium falciparum (isolate K1 / Thailand)
UKnob-associated histidine-rich protein
ligand
Plasmodium falciparum
US-adenosylmethionine synthase
ligand
Plasmodium falciparum (isolate 3D7)
UV-type H(+)-translocating pyrophosphatase, putative
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L4
ligand
Plasmodium falciparum (isolate 3D7)
UPhosphoethanolamine N-methyltransferase
ligand
Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S3a
ligand
Plasmodium falciparum (isolate 3D7)
UConserved Plasmodium membrane protein
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L3
ligand
Plasmodium falciparum (isolate 3D7)
UHigh molecular weight rhoptry protein 2
ligand
Plasmodium falciparum (isolate 3D7)
USerine repeat antigen 5
ligand
Plasmodium falciparum
U40S ribosomal protein S19
ligand
Plasmodium falciparum (isolate 3D7)
UGlycophorin-binding protein
ligand
Plasmodium falciparum (isolate 3D7)
UCalcium-transporting ATPase
ligand
Plasmodium falciparum (isolate K1 / Thailand)
UV-type proton ATPase catalytic subunit A
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L2
ligand
Plasmodium falciparum (isolate 3D7)
UAcyl-CoA synthetase
ligand
Plasmodium falciparum (isolate 3D7)
UPlasmepsin IV
ligand
Plasmodium falciparum (isolate 3D7)
UPlasmepsin-1
ligand
Plasmodium falciparum (isolate 3D7)
UChloroquine resistance transporter
ligand
Plasmodium falciparum
U14-3-3 protein
ligand
Plasmodium falciparum (isolate 3D7)
UIsoleucine--tRNA ligase, putative
ligand
Plasmodium falciparum (isolate 3D7)
UPlasmodium exported protein
ligand
Plasmodium falciparum (isolate 3D7)
UTubulin beta chain
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L27
ligand
Plasmodium falciparum (isolate 3D7)
USec62, putative
ligand
Plasmodium falciparum (isolate 3D7)
UAutophagy-related protein 18, putative
ligand
Plasmodium falciparum (isolate 3D7)
UMature parasite-infected erythrocyte surface antigen
ligand
Plasmodium falciparum (isolate 3D7)
UImportin-7, putative
ligand
Plasmodium falciparum (isolate 3D7)
UKaryopherin alpha
ligand
Plasmodium falciparum
UPeptidyl-prolyl cis-trans isomerase
ligand
Plasmodium falciparum (isolate 3D7)
UDnaJ protein, putative
ligand
Plasmodium falciparum (isolate 3D7)
UMerozoite surface protein 1
ligand
Plasmodium falciparum (isolate CDC / Honduras)
UGlutamate--tRNA ligase
ligand
Plasmodium falciparum (isolate 3D7)
UT-complex protein 1 subunit eta
ligand
Plasmodium falciparum (isolate 3D7)
UPlasmepsin-2
ligand
Plasmodium falciparum
UChaperone, putative
ligand
Plasmodium falciparum (isolate 3D7)
URhoptry neck protein 3
ligand
Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S5, putative
ligand
Plasmodium falciparum (isolate 3D7)
USkeleton-binding protein 1
ligand
Plasmodium falciparum (isolate 3D7)
UPurine nucleotide phosphorylase, putative
ligand
Plasmodium falciparum (isolate 3D7)
UAdenosylhomocysteinase
ligand
Plasmodium falciparum (isolate 3D7)
UAdenosine deaminase
ligand
Plasmodium falciparum (isolate 3D7)
UMethionine--tRNA ligase
ligand
Plasmodium falciparum (isolate 3D7)
UCarbamoyl phosphate synthetase
ligand
Plasmodium falciparum (isolate 3D7)
UAspartate carbamoyltransferase
ligand
Plasmodium falciparum (isolate 3D7)
USignal recognition particle receptor, beta subunit
ligand
Plasmodium falciparum (isolate 3D7)
UParasite-infected erythrocyte surface protein
ligand
Plasmodium falciparum (isolate 3D7)
UCoatomer alpha subunit, putative
ligand
Plasmodium falciparum (isolate 3D7)
UHexokinase
ligand
Plasmodium falciparum
UProteasome subunit alpha type
ligand
Plasmodium falciparum (isolate 3D7)
UHaloacid dehalogenase-like hydrolase
ligand
Plasmodium falciparum (isolate 3D7)
UInsulinase, putative
ligand
Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S21
ligand
Plasmodium falciparum (isolate 3D7)
UUbiquitin-conjugating enzyme E2
ligand
Plasmodium falciparum (isolate 3D7)
UEukaryotic translation initiation factor 3 subunit C
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L24, putative
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L23
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L17, putative
ligand
Plasmodium falciparum (isolate 3D7)
UNADP-specific glutamate dehydrogenase
ligand
Plasmodium falciparum
UHAP protein
ligand
Plasmodium falciparum (isolate 3D7)
UHeat shock protein 110, putative
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L10, putative
ligand
Plasmodium falciparum (isolate 3D7)
ULysophospholipase, putative
ligand
Plasmodium falciparum (isolate 3D7)
UPolyadenylate-binding protein
ligand
Plasmodium falciparum (isolate 3D7)
UUbiquitin-60S ribosomal protein L40
ligand
Plasmodium falciparum (isolate 3D7)
UPhosphoribosylpyrophosphate synthetase
ligand
Plasmodium falciparum
UThioredoxin peroxidase 1
ligand
Plasmodium falciparum (isolate 3D7)
UProtein transport protein SEC31
ligand
Plasmodium falciparum (isolate 3D7)
UDipeptidyl aminopeptidase 1
ligand
Plasmodium falciparum (isolate 3D7)
URing-infected erythrocyte surface antigen
ligand
Plasmodium falciparum (isolate FC27 / Papua New Guinea)
UATP-dependent RNA helicase UAP56
ligand
Plasmodium falciparum (isolate 3D7)
UCalcium-dependent protein kinase 4
ligand
Plasmodium falciparum (isolate 3D7)
UGTP-binding nuclear protein Ran
ligand
Plasmodium falciparum
UNucleoside transporter 2
ligand
Plasmodium falciparum (isolate 3D7)
UAnamorsin homolog
ligand
Plasmodium falciparum (isolate 3D7)
UGlutamine synthetase, putative
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L30e, putative
ligand
Plasmodium falciparum (isolate 3D7)
UCasein kinase 2, alpha subunit
ligand
Plasmodium falciparum (isolate 3D7)
UThreonine--tRNA ligase
ligand
Plasmodium falciparum (isolate 3D7)
UcAMP-dependent protein kinase regulatory subunit
ligand
Plasmodium falciparum (isolate 3D7)
UElongation factor 1-gamma, putative
ligand
Plasmodium falciparum (isolate 3D7)
UThioredoxin-like protein
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L21
ligand
Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L14, putative
ligand
Plasmodium falciparum (isolate 3D7)
UInner membrane complex sub-compartment protein 3
ligand
Plasmodium falciparum (isolate 3D7)
UHSP40, subfamily A, putative
ligand
Plasmodium falciparum (isolate 3D7)
UPyridoxal 5'-phosphate synthase subunit Pdx1
ligand
Plasmodium falciparum (isolate 3D7)
USerum albumin
ligand
Human
Absorption

The reported oral bioavailability of Artenimol was reported to be 45% in healthy adults [11]. The observed Tmax was 1-2 h This is known to increase in malaria infected patients which could be attributed to reduced metabolism by the liver or the drug's collection in infected erythrocytes. Artenimol was obeserved to have flip-flop kinetics with an overall absorption half-life of 1.04 h. When administered with food the AUC for Artenimol increases by 144%. Cmax was observed to increase by 129% but was not found to be statistically significant. Food was observed to delay Tmax by 1 h.

Volume of distribution

Artenimol was observed to have a mean apparent volume of distribution of 0.801 L/kg in adult patients and 0.705 L/kg in pediatric patients wit P. falciparum malaria [11].

Protein binding

Artenimol has been reported to be 44-93% bound to plasma proteins [FDA Label]. The identity of these proteins has not been reported.

Metabolism

The primary metabolite of Artenimol is the glucuronide conjugate, α-artenimol-β-glucuronide [FDA Label]. It is largely metabolized by UGT1A9 with some contribution by UGT2B7 [11].

Route of elimination

Artenimol is eliminated via metabolism to glucuronide conjugates [FDA Label]. There is little data on elimination of Artenimol but elimination of unchanged artemisinin compounds in feces and urine has been reported to be negligible.

Half life

Artenimol was reported to have a half life of elimination of approximately 1 h [FDA Label].

Clearance

Artenimol was observed to have a mean apparent clearance of 1.340 L/h/kg in adult patients and 1.450 L/h/kg in pediatric patients with P. falciparum malaria [11].

Toxicity

In single dose studies in CD-1 male mice, Artenimol did not show signs of toxicity up to 1200 mg/kg [11].

In repeated dose studies in CD-1 mice, the NOAEL for Artenimol was determined to be 200 mg/kg/day [11]. This value was determined to be 90 mg/kg/day in beagle dogs. The maximum tolerable dose in rats was observed to be 270 mg/kg/day. Doses of 540 mg/kg/day resulted in acute toxicity progressing to lethal effects. Toxicity was characterized by infiltration of macrophages and intracytoplasmic deposition of basophilic granular materials in macrophages consistent with phospholipidosis. Toxicity at high doses were accompanied by decreases in reticulocytes, and increases in AST and ALT.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcepromazineThe serum concentration of Acepromazine can be increased when it is combined with Artenimol.Approved, Vet Approved
AceprometazineThe serum concentration of Aceprometazine can be increased when it is combined with Artenimol.Approved
AlimemazineThe serum concentration of Alimemazine can be increased when it is combined with Artenimol.Approved, Vet Approved
ArtemetherThe risk or severity of QTc prolongation can be increased when Artenimol is combined with Artemether.Approved
BL-1020The serum concentration of BL-1020 can be increased when it is combined with Artenimol.Investigational
ChlorproethazineThe serum concentration of Chlorproethazine can be increased when it is combined with Artenimol.Experimental
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Artenimol.Approved, Investigational, Vet Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Artenimol.Approved, Investigational
DapsoneThe risk or severity of adverse effects can be increased when Artenimol is combined with Dapsone.Approved, Investigational
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Artenimol.Approved
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Artenimol.Approved
LumefantrineThe risk or severity of QTc prolongation can be increased when Artenimol is combined with Lumefantrine.Approved
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Artenimol.Approved, Investigational
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Artenimol.Approved, Investigational
Methylene blueThe serum concentration of Methylene blue can be increased when it is combined with Artenimol.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Artenimol.Approved, Investigational
MoricizineThe serum concentration of Moricizine can be increased when it is combined with Artenimol.Approved, Investigational, Withdrawn
PerazineThe serum concentration of Perazine can be increased when it is combined with Artenimol.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Artenimol.Approved
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Artenimol.Approved, Investigational
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Artenimol.Approved, Vet Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Artenimol.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Artenimol.Approved, Investigational
PropericiazineThe serum concentration of Propericiazine can be increased when it is combined with Artenimol.Approved, Investigational
PropiopromazineThe serum concentration of Propiopromazine can be increased when it is combined with Artenimol.Vet Approved
ThiazinamThe serum concentration of Thiazinam can be increased when it is combined with Artenimol.Experimental
ThiethylperazineThe serum concentration of Thiethylperazine can be increased when it is combined with Artenimol.Withdrawn
ThioproperazineThe serum concentration of Thioproperazine can be increased when it is combined with Artenimol.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Artenimol.Approved, Withdrawn
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Artenimol.Approved, Investigational
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Artenimol.Approved, Investigational
TriflupromazineThe serum concentration of Triflupromazine can be increased when it is combined with Artenimol.Approved, Vet Approved
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Artenimol.Approved
Food Interactions
Not Available

References

General References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
  2. Haynes RK and Vonwiller SC: The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III) Tetrahedron Lett.
  3. Paitayatat S, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y: Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. J Med Chem. 1997 Feb 28;40(5):633-8. doi: 10.1021/jm960767v. [PubMed:9057849]
  4. White NJ: Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans R Soc Trop Med Hyg. 1994 Jun;88 Suppl 1:S41-3. [PubMed:8053024]
  5. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
  6. Asawamahasakda W, Ittarat I, Pu YM, Ziffer H, Meshnick SR: Reaction of antimalarial endoperoxides with specific parasite proteins. Antimicrob Agents Chemother. 1994 Aug;38(8):1854-8. [PubMed:7986020]
  7. Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S: Artemisinins target the SERCA of Plasmodium falciparum. Nature. 2003 Aug 21;424(6951):957-61. doi: 10.1038/nature01813. [PubMed:12931192]
  8. Bhisutthibhan J, Pan XQ, Hossler PA, Walker DJ, Yowell CA, Carlton J, Dame JB, Meshnick SR: The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J Biol Chem. 1998 Jun 26;273(26):16192-8. [PubMed:9632675]
  9. Olliaro PL, Haynes RK, Meunier B, Yuthavong Y: Possible modes of action of the artemisinin-type compounds. Trends Parasitol. 2001 Mar;17(3):122-6. [PubMed:11286794]
  10. Gu HM, Warhurst DC, Peters W: Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg. 1984;78(2):265-70. [PubMed:6380017]
  11. EMA: Eurartesim Assessment Report [Link]
  12. WHO: Guidelines for the Treatment of Malaria 3rd Edition [Link]
External Links
ChemSpider
5293680
ChEBI
207229
ChEMBL
CHEMBL25164
Wikipedia
Dihydroartemisinin
ATC Codes
P01BE05 — ArtenimolP01BF05 — Artenimol and piperaquine
FDA label
Download (904 KB)
MSDS
Download (246 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentMalaria caused by Plasmodium falciparum1
2Not Yet RecruitingTreatmentSystemic Lupus Erythematosus (SLE) / Systemic Lupus Erythematosus Cerebritis1
2TerminatedTreatmentMalaria caused by plasmodium vivax1
3CompletedTreatmentMalaria caused by plasmodium vivax1
3CompletedTreatmentMalaria caused by plasmodium vivax / Uncomplicated Falciparum Malaria1
4CompletedTreatmentPlasmodium Vivax Malaria1
4Unknown StatusNot AvailablePlasmodium Infections1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)164-165MSDS
Predicted Properties
PropertyValueSource
Water Solubility3.16 mg/mLALOGPS
logP2.25ALOGPS
logP2.84ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)12.11ChemAxon
pKa (Strongest Basic)-4.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area57.15 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity69.91 m3·mol-1ChemAxon
Polarizability30.2 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Ubiquitin protein ligase binding
Specific Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Gene Name
ACTG1
Uniprot ID
P63261
Uniprot Name
Actin, cytoplasmic 2
Molecular Weight
41792.48 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
L-aminoadipate-semialdehyde dehydrogenase activity
Specific Function
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by meta...
Gene Name
ALDH7A1
Uniprot ID
P49419
Uniprot Name
Alpha-aminoadipic semialdehyde dehydrogenase
Molecular Weight
58486.74 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
S100 protein binding
Specific Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress resp...
Gene Name
ANXA2
Uniprot ID
P07355
Uniprot Name
Annexin A2
Molecular Weight
38603.63 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Transmembrane transporter activity
Specific Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport comp...
Gene Name
ATP5A1
Uniprot ID
P25705
Uniprot Name
ATP synthase subunit alpha, mitochondrial
Molecular Weight
59750.06 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Specific Function
Hydrogen ion transmembrane transporter activity
Gene Name
ATP5L
Uniprot ID
O75964
Uniprot Name
ATP synthase subunit g, mitochondrial
Molecular Weight
11428.4 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Specific Function
Atpase activity
Gene Name
ATP5O
Uniprot ID
P48047
Uniprot Name
ATP synthase subunit O, mitochondrial
Molecular Weight
23277.12 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Poly(a) rna binding
Specific Function
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in liv...
Gene Name
CAST
Uniprot ID
P20810
Uniprot Name
Calpastatin
Molecular Weight
76572.035 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Unfolded protein binding
Specific Function
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating tra...
Gene Name
CCT3
Uniprot ID
P49368
Uniprot Name
T-complex protein 1 subunit gamma
Molecular Weight
60533.34 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role...
Gene Name
CFL1
Uniprot ID
P23528
Uniprot Name
Cofilin-1
Molecular Weight
18502.315 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Voltage-gated ion channel activity
Specific Function
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved ...
Gene Name
CLIC1
Uniprot ID
O00299
Uniprot Name
Chloride intracellular channel protein 1
Molecular Weight
26922.47 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Could play a role in neuronal development.
Specific Function
Rna binding
Gene Name
CSRP1
Uniprot ID
P21291
Uniprot Name
Cysteine and glycine-rich protein 1
Molecular Weight
20567.32 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Dihydropyrimidinase activity
Specific Function
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subse...
Gene Name
DPYSL2
Uniprot ID
Q16555
Uniprot Name
Dihydropyrimidinase-related protein 2
Molecular Weight
62293.135 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Specific Function
Cell adhesion molecule binding
Gene Name
DSP
Uniprot ID
P15924
Uniprot Name
Desmoplakin
Molecular Weight
331771.16 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Trna binding
Specific Function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-sp...
Gene Name
EEF1A1
Uniprot ID
P68104
Uniprot Name
Elongation factor 1-alpha 1
Molecular Weight
50140.565 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Transcription factor activity, sequence-specific dna binding
Specific Function
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravas...
Gene Name
ENO1
Uniprot ID
P06733
Uniprot Name
Alpha-enolase
Molecular Weight
47168.555 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity).
Specific Function
Actin filament binding
Gene Name
FLNA
Uniprot ID
P21333
Uniprot Name
Filamin-A
Molecular Weight
280737.58 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Oxidative rna demethylase activity
Specific Function
Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-m...
Gene Name
FTO
Uniprot ID
Q9C0B1
Uniprot Name
Alpha-ketoglutarate-dependent dioxygenase FTO
Molecular Weight
58281.53 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Protein homodimerization activity
Specific Function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is ...
Gene Name
G6PD
Uniprot ID
P11413
Uniprot Name
Glucose-6-phosphate 1-dehydrogenase
Molecular Weight
59256.31 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Nadp binding
Specific Function
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (B...
Gene Name
GAPDHS
Uniprot ID
O14556
Uniprot Name
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Molecular Weight
44500.835 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Ubiquitin protein ligase binding
Specific Function
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophi...
Gene Name
GPI
Uniprot ID
P06744
Uniprot Name
Glucose-6-phosphate isomerase
Molecular Weight
63146.745 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
Specific Function
G-rich strand telomeric dna binding
Gene Name
HNRNPA2B1
Uniprot ID
P22626
Uniprot Name
Heterogeneous nuclear ribonucleoproteins A2/B1
Molecular Weight
37429.71 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Specific Function
At dna binding
Gene Name
HNRNPD
Uniprot ID
Q14103
Uniprot Name
Heterogeneous nuclear ribonucleoprotein D0
Molecular Weight
38434.09 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Specific Function
Cadherin binding
Gene Name
HNRNPK
Uniprot ID
P61978
Uniprot Name
Heterogeneous nuclear ribonucleoprotein K
Molecular Weight
50975.81 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Specific Function
Dna binding
Gene Name
HP1BP3
Uniprot ID
Q5SSJ5
Uniprot Name
Heterochromatin protein 1-binding protein 3
Molecular Weight
61206.5 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Ubiquitin binding
Specific Function
Involved in stress resistance and actin organization.
Gene Name
HSPB1
Uniprot ID
P04792
Uniprot Name
Heat shock protein beta-1
Molecular Weight
22782.3 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Specific Function
Cadherin binding
Gene Name
IQGAP1
Uniprot ID
P46940
Uniprot Name
Ras GTPase-activating-like protein IQGAP1
Molecular Weight
189250.43 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Specific Function
Dna binding
Gene Name
KHSRP
Uniprot ID
Q92945
Uniprot Name
Far upstream element-binding protein 2
Molecular Weight
73115.16 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Nad binding
Specific Function
Not Available
Gene Name
LDHA
Uniprot ID
P00338
Uniprot Name
L-lactate dehydrogenase A chain
Molecular Weight
36688.465 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Nad binding
Specific Function
Not Available
Gene Name
LDHB
Uniprot ID
P07195
Uniprot Name
L-lactate dehydrogenase B chain
Molecular Weight
36638.225 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Signal transducer activity
Specific Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase ac...
Gene Name
LGALS1
Uniprot ID
P09382
Uniprot Name
Galectin-1
Molecular Weight
14715.57 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Structural molecule activity
Specific Function
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Gene Name
MAP4
Uniprot ID
P27816
Uniprot Name
Microtubule-associated protein 4
Molecular Weight
121003.805 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Nad binding
Specific Function
Not Available
Gene Name
MDH1
Uniprot ID
P40925
Uniprot Name
Malate dehydrogenase, cytoplasmic
Molecular Weight
36425.795 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Zinc ion binding
Specific Function
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a ...
Gene Name
NPEPPS
Uniprot ID
P55786
Uniprot Name
Puromycin-sensitive aminopeptidase
Molecular Weight
103275.36 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Proline-rich region binding
Specific Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2...
Gene Name
PFN1
Uniprot ID
P07737
Uniprot Name
Profilin-1
Molecular Weight
15054.145 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Phosphoglycerate kinase activity
Specific Function
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
Gene Name
PGK1
Uniprot ID
P00558
Uniprot Name
Phosphoglycerate kinase 1
Molecular Weight
44614.36 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Pyruvate kinase activity
Specific Function
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general rol...
Gene Name
PKM
Uniprot ID
P14618
Uniprot Name
Pyruvate kinase PKM
Molecular Weight
57936.38 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Virion binding
Specific Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Gene Name
PPIA
Uniprot ID
P62937
Uniprot Name
Peptidyl-prolyl cis-trans isomerase A
Molecular Weight
18012.42 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Thioredoxin peroxidase activity
Specific Function
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating pe...
Gene Name
PRDX1
Uniprot ID
Q06830
Uniprot Name
Peroxiredoxin-1
Molecular Weight
22110.19 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of the large ribosomal subunit.
Specific Function
Rna binding
Gene Name
RPL10
Uniprot ID
P27635
Uniprot Name
60S ribosomal protein L10
Molecular Weight
24603.705 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of the large ribosomal subunit.
Specific Function
Cadherin binding
Gene Name
RPL14
Uniprot ID
P50914
Uniprot Name
60S ribosomal protein L14
Molecular Weight
23431.68 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of the large ribosomal subunit.
Specific Function
Rna binding
Gene Name
RPL18
Uniprot ID
Q07020
Uniprot Name
60S ribosomal protein L18
Molecular Weight
21634.315 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Structural constituent of ribosome
Specific Function
This protein binds to a specific region on the 26S rRNA.
Gene Name
RPL23A
Uniprot ID
P62750
Uniprot Name
60S ribosomal protein L23a
Molecular Weight
17694.885 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of the large ribosomal subunit.
Specific Function
Mrna binding
Gene Name
RPL35
Uniprot ID
P42766
Uniprot Name
60S ribosomal protein L35
Molecular Weight
14551.37 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
RPL4
Uniprot ID
P36578
Uniprot Name
60S ribosomal protein L4
Molecular Weight
47696.95 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
5.8s rrna binding
Gene Name
RPS13
Uniprot ID
P62277
Uniprot Name
40S ribosomal protein S13
Molecular Weight
17222.13 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
RPS17
Uniprot ID
P08708
Uniprot Name
40S ribosomal protein S17
Molecular Weight
15550.02 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
Specific Function
Protein kinase binding
Gene Name
RPS18
Uniprot ID
P62269
Uniprot Name
40S ribosomal protein S18
Molecular Weight
17718.565 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
Specific Function
Fibroblast growth factor binding
Gene Name
RPS19
Uniprot ID
P39019
Uniprot Name
40S ribosomal protein S19
Molecular Weight
16060.44 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
RPS28
Uniprot ID
P62857
Uniprot Name
40S ribosomal protein S28
Molecular Weight
7840.97 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Mrna binding
Gene Name
RPS5
Uniprot ID
P46782
Uniprot Name
40S ribosomal protein S5
Molecular Weight
22876.165 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Specific Function
Protein kinase binding
Gene Name
RPS6
Uniprot ID
P62753
Uniprot Name
40S ribosomal protein S6
Molecular Weight
28680.42 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
RPS8
Uniprot ID
P62241
Uniprot Name
40S ribosomal protein S8
Molecular Weight
24205.015 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
RPS9
Uniprot ID
P46781
Uniprot Name
40S ribosomal protein S9
Molecular Weight
22591.235 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Specific Function
Identical protein binding
Gene Name
SF1
Uniprot ID
Q15637
Uniprot Name
Splicing factor 1
Molecular Weight
68329.55 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647).
Specific Function
Chromatin binding
Gene Name
SFPQ
Uniprot ID
P23246
Uniprot Name
Splicing factor, proline- and glutamine-rich
Molecular Weight
76149.15 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
Specific Function
Rna binding
Gene Name
SNRPD2
Uniprot ID
P62316
Uniprot Name
Small nuclear ribonucleoprotein Sm D2
Molecular Weight
13526.815 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Rna binding
Specific Function
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, con...
Gene Name
SRP14
Uniprot ID
P37108
Uniprot Name
Signal recognition particle 14 kDa protein
Molecular Weight
14569.775 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
Specific Function
Rna binding
Gene Name
SRSF4
Uniprot ID
Q08170
Uniprot Name
Serine/arginine-rich splicing factor 4
Molecular Weight
56677.745 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
59. Transgelin
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Cadherin binding
Gene Name
TAGLN2
Uniprot ID
P37802
Uniprot Name
Transgelin-2
Molecular Weight
22391.36 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Ubiquitin protein ligase binding
Specific Function
Not Available
Gene Name
TPI1
Uniprot ID
P60174
Uniprot Name
Triosephosphate isomerase
Molecular Weight
30790.785 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Specific Function
Actin binding
Gene Name
TPM1
Uniprot ID
P09493
Uniprot Name
Tropomyosin alpha-1 chain
Molecular Weight
32708.175 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function
Gtp binding
Gene Name
TUBA1A
Uniprot ID
Q71U36
Uniprot Name
Tubulin alpha-1A chain
Molecular Weight
50135.25 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Structural constituent of eye lens
Specific Function
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, eit...
Gene Name
VIM
Uniprot ID
P08670
Uniprot Name
Vimentin
Molecular Weight
53651.165 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Specific Function
Rna binding
Gene Name
ZYX
Uniprot ID
Q15942
Uniprot Name
Zyxin
Molecular Weight
61276.885 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Unfolded protein binding
Specific Function
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that f...
Gene Name
HSPA8
Uniprot ID
P11142
Uniprot Name
Heat shock cognate 71 kDa protein
Molecular Weight
70897.565 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name
TUBB6
Uniprot ID
Q9BUF5
Uniprot Name
Tubulin beta-6 chain
Molecular Weight
49856.785 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name
TUBB4A
Uniprot ID
P04350
Uniprot Name
Tubulin beta-4A chain
Molecular Weight
49585.475 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Ubiquitin protein ligase binding
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name
TUBB
Uniprot ID
P07437
Uniprot Name
Tubulin beta chain
Molecular Weight
49670.515 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Tubulin binding
Specific Function
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Gene Name
ALDOA
Uniprot ID
P04075
Uniprot Name
Fructose-bisphosphate aldolase A
Molecular Weight
39419.675 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Peptidyl-cysteine s-nitrosylase activity
Specific Function
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including tran...
Gene Name
GAPDH
Uniprot ID
P04406
Uniprot Name
Glyceraldehyde-3-phosphate dehydrogenase
Molecular Weight
36053.0 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Metal ion binding
Specific Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfe...
Gene Name
CYCS
Uniprot ID
P99999
Uniprot Name
Cytochrome c
Molecular Weight
11748.69 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Specific Function
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Gene Name
PGAM1
Uniprot ID
P18669
Uniprot Name
Phosphoglycerate mutase 1
Molecular Weight
28803.675 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.
Specific Function
Actin binding
Gene Name
MYH9
Uniprot ID
P35579
Uniprot Name
Myosin-9
Molecular Weight
226530.505 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Protein heterodimerization activity
Specific Function
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attach...
Gene Name
P4HB
Uniprot ID
P07237
Uniprot Name
Protein disulfide-isomerase
Molecular Weight
57115.795 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Specific Function
Androgen receptor binding
Gene Name
DDX5
Uniprot ID
P17844
Uniprot Name
Probable ATP-dependent RNA helicase DDX5
Molecular Weight
69147.585 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Pyridoxal phosphate binding
Specific Function
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.
Gene Name
SHMT2
Uniprot ID
P34897
Uniprot Name
Serine hydroxymethyltransferase, mitochondrial
Molecular Weight
55992.385 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
U6 snrna binding
Specific Function
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically ass...
Gene Name
DDX39B
Uniprot ID
Q13838
Uniprot Name
Spliceosome RNA helicase DDX39B
Molecular Weight
48990.945 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Not Available
Pharmacological action
Unknown
Actions
Ligand
General Function
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
Specific Function
Activating transcription factor binding
Gene Name
NPM1
Uniprot ID
P06748
Uniprot Name
Nucleophosmin
Molecular Weight
32574.765 Da
References
  1. Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [PubMed:26340163]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Involved in calcium binding and microtubule stabilization.
Specific Function
Calcium ion binding
Gene Name
TCTP
Uniprot ID
Q8I3Z5
Uniprot Name
Translationally-controlled tumor protein homolog
Molecular Weight
19979.25 Da
References
  1. Bhisutthibhan J, Pan XQ, Hossler PA, Walker DJ, Yowell CA, Carlton J, Dame JB, Meshnick SR: The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J Biol Chem. 1998 Jun 26;273(26):16192-8. [PubMed:9632675]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Antagonist
General Function
Not Available
Specific Function
Atp binding
Gene Name
serca
Uniprot ID
Q5R2K6
Uniprot Name
P-type Ca2+-transporting ATPase
Molecular Weight
139413.605 Da
References
  1. Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S: Artemisinins target the SERCA of Plasmodium falciparum. Nature. 2003 Aug 21;424(6951):957-61. doi: 10.1038/nature01813. [PubMed:12931192]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and of glutamate-5-semialdehyde with glutamate and alanine.
Specific Function
Identical protein binding
Gene Name
OAT
Uniprot ID
Q6LFH8
Uniprot Name
Ornithine aminotransferase
Molecular Weight
46054.755 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate K1 / Thailand)
Pharmacological action
Unknown
Actions
Ligand
General Function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Specific Function
Gtp binding
Gene Name
MEF-1
Uniprot ID
Q00080
Uniprot Name
Elongation factor 1-alpha
Molecular Weight
49040.52 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Pharmacological action
Unknown
Actions
Ligand
General Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Specific Function
Atp binding
Gene Name
MDR1
Uniprot ID
P13568
Uniprot Name
Multidrug resistance protein
Molecular Weight
162250.55 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Gtp binding
Gene Name
Not Available
Uniprot ID
Q8IKW5
Uniprot Name
Elongation factor 2
Molecular Weight
93521.915 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate HB3)
Pharmacological action
Unknown
Actions
Ligand
General Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
P86287
Uniprot Name
Actin-1
Molecular Weight
41870.305 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (phosphorylating) activity
Gene Name
GAPDH
Uniprot ID
Q8IKK7
Uniprot Name
Glyceraldehyde-3-phosphate dehydrogenase
Molecular Weight
36634.97 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Fructose-bisphosphate aldolase activity
Gene Name
Not Available
Uniprot ID
P14223
Uniprot Name
Fructose-bisphosphate aldolase
Molecular Weight
40104.68 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
C6KT34
Uniprot Name
Cell division cycle protein 48 homologue,putative
Molecular Weight
92386.055 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8IC05
Uniprot Name
Heat shock protein 90
Molecular Weight
86165.63 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
3'-5' dna/rna helicase activity
Gene Name
H45
Uniprot ID
Q8IKF0
Uniprot Name
Eukaryotic initiation factor 4A
Molecular Weight
45309.745 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Kinase activity
Gene Name
Not Available
Uniprot ID
C6KTA4
Uniprot Name
Pyruvate kinase
Molecular Weight
55660.3 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate CDC / Honduras)
Pharmacological action
Unknown
Actions
Ligand
General Function
L-lactate dehydrogenase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q27743
Uniprot Name
L-lactate dehydrogenase
Molecular Weight
34107.505 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Protein disulfide isomerase activity
Gene Name
Not Available
Uniprot ID
C0H4Y6
Uniprot Name
Protein disulfide-isomerase
Molecular Weight
55513.84 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Protein disulfide isomerase activity
Gene Name
Not Available
Uniprot ID
Q8IDH5
Uniprot Name
Thioredoxin-related protein, putative
Molecular Weight
23987.805 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Spermidine synthase activity
Gene Name
Not Available
Uniprot ID
Q8II73
Uniprot Name
Spermidine synthase
Molecular Weight
36595.23 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Specific Function
6-phosphofructokinase activity
Gene Name
Not Available
Uniprot ID
Q8I2Z8
Uniprot Name
Probable ATP-dependent 6-phosphofructokinase
Molecular Weight
159450.815 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Glutamate dehydrogenase (nadp+) activity
Gene Name
Not Available
Uniprot ID
Q8ILF7
Uniprot Name
Glutamate dehydrogenase
Molecular Weight
57342.635 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8I0V4
Uniprot Name
Endoplasmin homolog, putative
Molecular Weight
95017.4 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate FCR-3 / Gambia)
Pharmacological action
Unknown
Actions
Ligand
General Function
Xanthine phosphoribosyltransferase activity
Specific Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, ...
Gene Name
LACZ
Uniprot ID
P20035
Uniprot Name
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Molecular Weight
26348.18 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Magnesium ion binding
Gene Name
ENO
Uniprot ID
Q8IJN7
Uniprot Name
Enolase
Molecular Weight
48677.255 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Damaged dna binding
Gene Name
Not Available
Uniprot ID
Q8IKH8
Uniprot Name
40S ribosomal protein S3
Molecular Weight
24667.57 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
A0A143ZZK9
Uniprot Name
Non-SERCA-type Ca2+-transporting P-ATPase
Molecular Weight
140260.855 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate K1 / Thailand)
Pharmacological action
Unknown
Actions
Ligand
General Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function
Gtp binding
Gene Name
Not Available
Uniprot ID
P14642
Uniprot Name
Tubulin alpha chain
Molecular Weight
50296.57 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
KAHRP might mimick human histidine-rich glycoproteins to anchor host thrombospondin or a parasite analog in a binding complex with the endothelial cell receptor.
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P13817
Uniprot Name
Knob-associated histidine-rich protein
Molecular Weight
53191.4 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q7K6A4
Uniprot Name
S-adenosylmethionine synthase
Molecular Weight
44843.535 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Hydrogen ion transmembrane transporter activity
Gene Name
Not Available
Uniprot ID
Q8IKR1
Uniprot Name
V-type H(+)-translocating pyrophosphatase, putative
Molecular Weight
76415.56 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8I431
Uniprot Name
60S ribosomal protein L4
Molecular Weight
46211.16 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Phosphoethanolamine n-methyltransferase activity
Gene Name
Not Available
Uniprot ID
Q8IDQ9
Uniprot Name
Phosphoethanolamine N-methyltransferase
Molecular Weight
31042.865 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Structural constituent of ribosome
Gene Name
Not Available
Uniprot ID
O97313
Uniprot Name
40S ribosomal protein S3a
Molecular Weight
30047.235 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q8IJT2
Uniprot Name
Conserved Plasmodium membrane protein
Molecular Weight
78005.095 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8IJC6
Uniprot Name
60S ribosomal protein L3
Molecular Weight
44220.715 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
C0H571
Uniprot Name
High molecular weight rhoptry protein 2
Molecular Weight
162663.655 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Cysteine-type peptidase activity
Gene Name
SERA5
Uniprot ID
T1RTG8
Uniprot Name
Serine repeat antigen 5
Molecular Weight
39765.935 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
C0H5C2
Uniprot Name
40S ribosomal protein S19
Molecular Weight
16763.56 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Involved in erythrocyte invasion.
Specific Function
Not Available
Gene Name
GBP
Uniprot ID
Q8I6U8
Uniprot Name
Glycophorin-binding protein
Molecular Weight
95843.285 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate K1 / Thailand)
Pharmacological action
Unknown
Actions
Ligand
General Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Specific Function
Atp binding
Gene Name
ATP6
Uniprot ID
Q08853
Uniprot Name
Calcium-transporting ATPase
Molecular Weight
139413.605 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Specific Function
Atp binding
Gene Name
vapA
Uniprot ID
Q76NM6
Uniprot Name
V-type proton ATPase catalytic subunit A
Molecular Weight
68575.81 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8I3T9
Uniprot Name
60S ribosomal protein L2
Molecular Weight
27999.655 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Ankyrin binding
Gene Name
ACS3
Uniprot ID
Q8I0X2
Uniprot Name
Acyl-CoA synthetase
Molecular Weight
93865.435 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Aspartic-type endopeptidase activity
Gene Name
Not Available
Uniprot ID
Q8IM16
Uniprot Name
Plasmepsin IV
Molecular Weight
51045.89 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation (By similarity).
Specific Function
Aspartic-type endopeptidase activity
Gene Name
Not Available
Uniprot ID
Q7KQM4
Uniprot Name
Plasmepsin-1
Molecular Weight
51460.555 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
May regulate endogenous transporter.
Specific Function
Drug transmembrane transporter activity
Gene Name
CRT
Uniprot ID
Q9N623
Uniprot Name
Chloroquine resistance transporter
Molecular Weight
48674.705 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Histone binding
Gene Name
Not Available
Uniprot ID
C0H4V6
Uniprot Name
14-3-3 protein
Molecular Weight
30192.435 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Aminoacyl-trna editing activity
Gene Name
Not Available
Uniprot ID
Q8I5G6
Uniprot Name
Isoleucine--tRNA ligase, putative
Molecular Weight
204244.265 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
C6S3C7
Uniprot Name
Plasmodium exported protein
Molecular Weight
36265.665 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function
Gtp binding
Gene Name
Not Available
Uniprot ID
Q7KQL5
Uniprot Name
Tubulin beta chain
Molecular Weight
49750.65 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Structural constituent of ribosome
Gene Name
Not Available
Uniprot ID
Q8IKM5
Uniprot Name
60S ribosomal protein L27
Molecular Weight
16744.955 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Protein transporter activity
Gene Name
Not Available
Uniprot ID
Q8IL86
Uniprot Name
Sec62, putative
Molecular Weight
43936.8 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Phosphatidylinositol-3,5-bisphosphate binding
Gene Name
Not Available
Uniprot ID
Q8IJR6
Uniprot Name
Autophagy-related protein 18, putative
Molecular Weight
43519.065 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q8I492
Uniprot Name
Mature parasite-infected erythrocyte surface antigen
Molecular Weight
168286.965 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Protein transporter activity
Gene Name
Not Available
Uniprot ID
C0H4L1
Uniprot Name
Importin-7, putative
Molecular Weight
145507.21 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
133. Karyopherin alpha
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Specific Function
Cyclosporin a binding
Gene Name
Not Available
Uniprot ID
Q76NN7
Uniprot Name
Peptidyl-prolyl cis-trans isomerase
Molecular Weight
18952.44 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Dna-directed dna polymerase activity
Gene Name
Not Available
Uniprot ID
Q8IB72
Uniprot Name
DnaJ protein, putative
Molecular Weight
76681.32 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate CDC / Honduras)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
MSP-1
Uniprot ID
P13827
Uniprot Name
Merozoite surface protein 1
Molecular Weight
26050.51 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8IDD3
Uniprot Name
Glutamate--tRNA ligase
Molecular Weight
68366.905 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
Curator comments
Drug reported as binding to entire complex. Subunit is listed as a representative as no specific binding site was reported.
General Function
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
O77323
Uniprot Name
T-complex protein 1 subunit eta
Molecular Weight
59576.67 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
Aspartic-type endopeptidase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P46925
Uniprot Name
Plasmepsin-2
Molecular Weight
51489.41 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atpase activator activity
Gene Name
Not Available
Uniprot ID
C0H546
Uniprot Name
Chaperone, putative
Molecular Weight
29803.79 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Host cell surface binding
Gene Name
Not Available
Uniprot ID
Q8I4R5
Uniprot Name
Rhoptry neck protein 3
Molecular Weight
263153.05 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Mrna binding
Gene Name
Not Available
Uniprot ID
Q8IBN5
Uniprot Name
40S ribosomal protein S5, putative
Molecular Weight
21863.19 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q8I487
Uniprot Name
Skeleton-binding protein 1
Molecular Weight
36298.62 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Uridine phosphorylase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q8I3X4
Uniprot Name
Purine nucleotide phosphorylase, putative
Molecular Weight
26857.88 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Specific Function
Adenosylhomocysteinase activity
Gene Name
Not Available
Uniprot ID
P50250
Uniprot Name
Adenosylhomocysteinase
Molecular Weight
53838.54 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Adenosine deaminase activity
Gene Name
Not Available
Uniprot ID
Q8IJA9
Uniprot Name
Adenosine deaminase
Molecular Weight
42465.51 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8IJ60
Uniprot Name
Methionine--tRNA ligase
Molecular Weight
104167.4 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8IEN3
Uniprot Name
Carbamoyl phosphate synthetase
Molecular Weight
273435.35 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Amino acid binding
Gene Name
Not Available
Uniprot ID
Q8IDP8
Uniprot Name
Aspartate carbamoyltransferase
Molecular Weight
43251.38 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Gtp binding
Gene Name
Not Available
Uniprot ID
Q8I4W4
Uniprot Name
Signal recognition particle receptor, beta subunit
Molecular Weight
30623.99 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Transferase activity, transferring glycosyl groups
Gene Name
Not Available
Uniprot ID
O77361
Uniprot Name
Parasite-infected erythrocyte surface protein
Molecular Weight
154087.705 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Structural molecule activity
Gene Name
Not Available
Uniprot ID
C6KSR5
Uniprot Name
Coatomer alpha subunit, putative
Molecular Weight
176944.825 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
HK
Uniprot ID
Q02155
Uniprot Name
Hexokinase
Molecular Weight
55345.73 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Endopeptidase activity
Gene Name
Not Available
Uniprot ID
Q8IBI3
Uniprot Name
Proteasome subunit alpha type
Molecular Weight
28388.035 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Metal ion binding
Gene Name
Not Available
Uniprot ID
Q8IJ74
Uniprot Name
Haloacid dehalogenase-like hydrolase
Molecular Weight
32841.285 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Hydrolase activity
Gene Name
Not Available
Uniprot ID
Q8III5
Uniprot Name
Insulinase, putative
Molecular Weight
173623.945 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Structural constituent of ribosome
Gene Name
Not Available
Uniprot ID
Q8IHS5
Uniprot Name
40S ribosomal protein S21
Molecular Weight
9145.425 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atpase activity
Gene Name
Not Available
Uniprot ID
Q8IDP1
Uniprot Name
Ubiquitin-conjugating enzyme E2
Molecular Weight
32787.585 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Specific Function
Translation initiation factor activity
Gene Name
Not Available
Uniprot ID
Q8I5Y3
Uniprot Name
Eukaryotic translation initiation factor 3 subunit C
Molecular Weight
116012.945 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8IEM3
Uniprot Name
60S ribosomal protein L24, putative
Molecular Weight
19244.665 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8IE82
Uniprot Name
60S ribosomal protein L23
Molecular Weight
22092.425 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Structural constituent of ribosome
Gene Name
Not Available
Uniprot ID
Q8IDI5
Uniprot Name
60S ribosomal protein L17, putative
Molecular Weight
23414.59 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
163. NADP-specific glutamate dehydrogenase
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Aspartic-type endopeptidase activity
Gene Name
Not Available
Uniprot ID
Q8IM15
Uniprot Name
HAP protein
Molecular Weight
51692.85 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
C0H5H0
Uniprot Name
Heat shock protein 110, putative
Molecular Weight
108184.515 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8ILV2
Uniprot Name
60S ribosomal protein L10, putative
Molecular Weight
25216.14 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Hydrolase activity
Gene Name
Not Available
Uniprot ID
Q8IM74
Uniprot Name
Lysophospholipase, putative
Molecular Weight
43737.01 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Binds the poly(A) tail of mRNA.
Specific Function
Mrna binding
Gene Name
Not Available
Uniprot ID
Q8I5H4
Uniprot Name
Polyadenylate-binding protein
Molecular Weight
97229.36 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Metal ion binding
Gene Name
Not Available
Uniprot ID
Q8ID50
Uniprot Name
Ubiquitin-60S ribosomal protein L40
Molecular Weight
14616.985 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
170. Phosphoribosylpyrophosphate synthetase
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Antioxidant activity
Gene Name
TPx1
Uniprot ID
Q8IL80
Uniprot Name
Thioredoxin peroxidase 1
Molecular Weight
21806.91 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Sec31p
Uniprot ID
O96221
Uniprot Name
Protein transport protein SEC31
Molecular Weight
166708.21 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Aminopeptidase activity
Gene Name
Not Available
Uniprot ID
A0A144A2G5
Uniprot Name
Dipeptidyl aminopeptidase 1
Molecular Weight
80411.405 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Pharmacological action
Unknown
Actions
Ligand
General Function
May disrupt the normal intermolecular interactions of the cytoplasmic domain of band 3 and thereby facilitate the invagination of the red cell membrane which is necessary for the formation of the parasitophorous vacuole.
Specific Function
Not Available
Gene Name
RESA
Uniprot ID
P13830
Uniprot Name
Ring-infected erythrocyte surface antigen
Molecular Weight
124906.19 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
UAP56
Uniprot ID
Q9TY94
Uniprot Name
ATP-dependent RNA helicase UAP56
Molecular Weight
52223.26 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
Specific Function
Atp binding
Gene Name
CPK4
Uniprot ID
Q8IBS5
Uniprot Name
Calcium-dependent protein kinase 4
Molecular Weight
60779.205 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
Actions
Ligand
General Function
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
Specific Function
Gtp binding
Gene Name
Not Available
Uniprot ID
P38545
Uniprot Name
GTP-binding nuclear protein Ran
Molecular Weight
24875.185 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Nucleoside transmembrane transporter activity
Gene Name
Not Available
Uniprot ID
Q8IB78
Uniprot Name
Nucleoside transporter 2
Molecular Weight
67641.47 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Has anti-apoptotic effects in the cell.
Specific Function
2 iron, 2 sulfur cluster binding
Gene Name
Not Available
Uniprot ID
C0H4X5
Uniprot Name
Anamorsin homolog
Molecular Weight
30837.715 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Glutamate-ammonia ligase activity
Gene Name
Not Available
Uniprot ID
C0H551
Uniprot Name
Glutamine synthetase, putative
Molecular Weight
63230.14 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8IJK8
Uniprot Name
60S ribosomal protein L30e, putative
Molecular Weight
11774.605 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8IIR9
Uniprot Name
Casein kinase 2, alpha subunit
Molecular Weight
39889.96 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Atp binding
Gene Name
Not Available
Uniprot ID
Q8IIA4
Uniprot Name
Threonine--tRNA ligase
Molecular Weight
119544.87 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Camp binding
Gene Name
PKAr
Uniprot ID
Q7KQK0
Uniprot Name
cAMP-dependent protein kinase regulatory subunit
Molecular Weight
50832.44 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Glutathione transferase activity
Gene Name
Not Available
Uniprot ID
Q8IDV0
Uniprot Name
Elongation factor 1-gamma, putative
Molecular Weight
47776.84 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Nucleoside diphosphate kinase activity
Gene Name
tlp1
Uniprot ID
Q8IKL4
Uniprot Name
Thioredoxin-like protein
Molecular Weight
14423.54 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Structural constituent of ribosome
Gene Name
Not Available
Uniprot ID
Q8ILK3
Uniprot Name
60S ribosomal protein L21
Molecular Weight
18795.0 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Rna binding
Gene Name
Not Available
Uniprot ID
Q8ILE8
Uniprot Name
60S ribosomal protein L14, putative
Molecular Weight
19297.13 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q8IKM6
Uniprot Name
Inner membrane complex sub-compartment protein 3
Molecular Weight
17117.295 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Not Available
Specific Function
Heat shock protein binding
Gene Name
Not Available
Uniprot ID
Q8IL88
Uniprot Name
HSP40, subfamily A, putative
Molecular Weight
48468.875 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Plasmodium falciparum (isolate 3D7)
Pharmacological action
Unknown
Actions
Ligand
General Function
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Specific Function
Catalytic activity
Gene Name
pdx1
Uniprot ID
C6KT50
Uniprot Name
Pyridoxal 5'-phosphate synthase subunit Pdx1
Molecular Weight
33013.16 Da
References
  1. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [PubMed:26694030]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Ligand
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Yang YZ, Asawamahasakda W, Meshnick SR: Alkylation of human albumin by the antimalarial artemisinin. Biochem Pharmacol. 1993 Jul 20;46(2):336-9. [PubMed:8347159]
  2. Veerappan A, Eichhorn T, Zeino M, Efferth T, Schneider D: Differential interactions of the broad spectrum drugs artemisinin, dihydroartemisinin and artesunate with serum albumin. Phytomedicine. 2013 Aug 15;20(11):969-74. doi: 10.1016/j.phymed.2013.04.003. Epub 2013 May 16. [PubMed:23684544]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Retinoic acid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks trans...
Gene Name
UGT1A9
Uniprot ID
O60656
Uniprot Name
UDP-glucuronosyltransferase 1-9
Molecular Weight
59940.495 Da
References
  1. EMA: Eurartesim Assessment Report [Link]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Glucuronosyltransferase activity
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su...
Gene Name
UGT2B7
Uniprot ID
P16662
Uniprot Name
UDP-glucuronosyltransferase 2B7
Molecular Weight
60694.12 Da
References
  1. EMA: Eurartesim Assessment Report [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. EMA: Eurartesim Assessment Report [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Curator comments
Drug inhibits CYP2D6 but not strongly enough to be considered clinically relevant (<1.25 fold change in AUC)
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. EMA: Eurartesim Assessment Report [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Ericsson T, Sundell J, Torkelsson A, Hoffmann KJ, Ashton M: Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies. Xenobiotica. 2014 Jul;44(7):615-26. doi: 10.3109/00498254.2013.878815. Epub 2014 Jan 8. [PubMed:24400699]
  2. EMA: Eurartesim Assessment Report [Link]

Drug created on October 17, 2016 15:29 / Updated on June 07, 2018 05:22