NAV

Navarixin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Navarixin
DrugBank Accession Number
DB11711
Background

Navarixin has been investigated for the treatment of Asthma.

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 411.458
Monoisotopic: 411.179420917
Chemical Formula
C22H25N3O5
Synonyms
  • Navarixin
  • Navarixin anhydrous
External IDs
  • SCH-527123
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Navarixin monohydrate7V3BY6G538862464-58-2OVPWPDFETBKAQQ-UNTBIKODSA-N

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4GMU5HUX5I
CAS number
473727-83-2
InChI Key
FIABAPOOXILNJX-CQSZACIVSA-N
InChI
InChI=1S/C22H25N3O5/c1-5-7-14(16-11-10-12(2)30-16)23-17-18(21(28)20(17)27)24-15-9-6-8-13(19(15)26)22(29)25(3)4/h6,8-11,14,23-24,26H,5,7H2,1-4H3/t14-/m1/s1
IUPAC Name
2-hydroxy-N,N-dimethyl-3-[(2-{[(1R)-1-(5-methylfuran-2-yl)butyl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]benzamide
SMILES
CCC[C@@H](NC1=C(NC2=CC=CC(C(=O)N(C)C)=C2O)C(=O)C1=O)C1=CC=C(C)O1

References

General References
Not Available
PubChem Compound
71587743
PubChem Substance
347828076

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentAsthma1
2CompletedTreatmentCastration Resistant Prostate Cancer / Microsatellite Stable (MSS) Colorectal Cancer (CRC) / Non-Small Cell Lung Cancer (NSCLC) / Solid Tumors1
2CompletedTreatmentNeutrophilic Asthma1
2CompletedTreatmentPsoriasis1
2TerminatedTreatmentChronic Obstructive Pulmonary Disease (COPD)2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0665 mg/mLALOGPS
logP3.12ALOGPS
logP3.01Chemaxon
logS-3.8ALOGPS
pKa (Strongest Acidic)8.06Chemaxon
pKa (Strongest Basic)-1.5Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area111.88 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity115.77 m3·mol-1Chemaxon
Polarizability44.92 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-03xr-1039700000-85b64287cff7688084b7
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-03di-0024900000-27bdff86178c76ecdf35
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-01ox-2209200000-143e6d811d0b3951fafd
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-03fu-0129200000-030d6458c6a74e0b22ba
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00kf-3698000000-2978846a02503b388a38
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-2639000000-f4ccedb859df95be51b6
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 20, 2016 20:41 / Updated at January 16, 2023 09:34