Osilodrostat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Osilodrostat
Accession Number
DB11837
Type
Small Molecule
Groups
Investigational
Description

Osilodrostat has been used in trials studying the treatment of AIMAH, PPNAD, Hypertension, Adrenal adenoma, and Renal Impairment, among others.

Structure
Thumb
Synonyms
Not Available
External IDs
LCI-699-NX / LCI699 / LCI699-NX
Product Ingredients
IngredientUNIICASInChI Key
Osilodrostat PhosphateY6581YAW9V1315449-72-9FMCPYRDGUZBOJZ-BTQNPOSSSA-N
Categories
UNII
5YL4IQ1078
CAS number
928134-65-0
Weight
Average: 227.242
Monoisotopic: 227.085875497
Chemical Formula
C13H10FN3
InChI Key
USUZGMWDZDXMDG-CYBMUJFWSA-N
InChI
InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
IUPAC Name
3-fluoro-4-[(5R)-5H,6H,7H-pyrrolo[1,2-c]imidazol-5-yl]benzonitrile
SMILES
FC1=C(C=CC(=C1)C#N)[C@H]1CCC2=CN=CN12

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
44139752
PubChem Substance
347828182
ChemSpider
29340911
BindingDB
50444549
ChEMBL
CHEMBL3099695
Wikipedia
Osilodrostat

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHepatic Impairment1
1CompletedTreatmentImpaired Renal Function1
2Active Not RecruitingTreatmentCushing's Disease1
2CompletedTreatmentAdrenal Adenoma / Adrenocortical Carcinoma / AIMAH / Cushing's Syndrome / Ectopic Corticotropin Syndrome / PPNAD1
2CompletedTreatmentHigh Blood Pressure (Hypertension)2
2CompletedTreatmentHypertension,Essential1
2CompletedTreatmentPrimary Hyperaldosteronism1
2Not Yet RecruitingTreatmentCushing's Disease1
2RecruitingTreatmentCushing's Syndrome1
3Active Not RecruitingTreatmentCushing's Disease2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.356 mg/mLALOGPS
logP2.18ALOGPS
logP2.11ChemAxon
logS-2.8ALOGPS
pKa (Strongest Basic)7.15ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area41.61 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity62.07 m3·mol-1ChemAxon
Polarizability22.53 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzonitriles. These are organic compounds containing a benzene bearing a nitrile substituent.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzonitriles
Direct Parent
Benzonitriles
Alternative Parents
Fluorobenzenes / N-substituted imidazoles / Aryl fluorides / Heteroaromatic compounds / Nitriles / Azacyclic compounds / Organofluorides / Hydrocarbon derivatives
Substituents
Benzonitrile / Fluorobenzene / Halobenzene / Aryl fluoride / Aryl halide / N-substituted imidazole / Azole / Heteroaromatic compound / Imidazole / Azacycle
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 14:52 / Updated on June 04, 2019 07:27