Astodrimer

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Astodrimer
Accession Number
DB11854  (DB05658)
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Vivagel
External IDs
BRI-7013 / SPL-7013
Product Ingredients
IngredientUNIICASInChI Key
Astodrimer Sodium8Q3B8SV59LNot AvailableNot applicable
Categories
UNII
F8H3J9KSY9
CAS number
1379746-42-5

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action

Dendrimers such as astodrimer are polymers that contain a central core, interior branches, and terminal surface groups adapted to specific targets. Astodrimer has a polyanionic outer surface that provides for multiple target interactions. The active surface groups bind to gp120 proteins on HIV's surface, preventing CD4 receptor binding by healthy cells and thus blocking transmission of HIV to healthy cells.

TargetActionsOrganism
UEnvelope glycoprotein gp160Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Human Immunodeficiency Virus
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Gong E, Matthews B, McCarthy T, Chu J, Holan G, Raff J, Sacks S: Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses. Antiviral Res. 2005 Dec;68(3):139-46. Epub 2005 Sep 27. [PubMed:16219368]
  2. Jiang YH, Emau P, Cairns JS, Flanary L, Morton WR, McCarthy TD, Tsai CC: SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques. AIDS Res Hum Retroviruses. 2005 Mar;21(3):207-13. [PubMed:15795526]
  3. McCarthy TD, Karellas P, Henderson SA, Giannis M, O'Keefe DF, Heery G, Paull JR, Matthews BR, Holan G: Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention. Mol Pharm. 2005 Jul-Aug;2(4):312-8. [PubMed:16053334]
  4. Rosa Borges A, Schengrund CL: Dendrimers and antivirals: a review. Curr Drug Targets Infect Disord. 2005 Sep;5(3):247-54. [PubMed:16181143]
  5. Roth S, Monsour M, Dowland A, Guenthner PC, Hancock K, Ou CY, Dezzutti CS: Effect of topical microbicides on infectious human immunodeficiency virus type 1 binding to epithelial cells. Antimicrob Agents Chemother. 2007 Jun;51(6):1972-8. Epub 2007 Apr 2. [PubMed:17404008]
External Links
PubChem Substance
347911249

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionHealthy Volunteers1
1CompletedPreventionHuman Immunodeficiency Virus (HIV)1
1, 2CompletedTreatmentHSV-2 Genital Herpes / Human Immunodeficiency Virus (HIV) Infections1
2CompletedPreventionRecurrent Bacterial Vaginosis (BV)1
2CompletedTreatmentBacterial Vaginosis (BV)1
3CompletedPreventionBacterial Vaginosis (BV)2
3CompletedTreatmentBacterial Vaginosis (BV)2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Not Available
Pharmacological action
Unknown
General Function
Structural molecule activity
Specific Function
Envelope glycoprotein gp160: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The pre...
Gene Name
env
Uniprot ID
P35961
Uniprot Name
Envelope glycoprotein gp160
Molecular Weight
95647.42 Da

Drug created on October 20, 2016 14:54 / Updated on June 04, 2019 07:28