Acridine Carboxamide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Acridine Carboxamide
Accession Number
DB11880
Type
Small Molecule
Groups
Investigational
Description

Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.

Structure
Thumb
Synonyms
  • DACA
External IDs
NSC 601316 / NSC-601316
Categories
UNII
0N3V8R4E13
CAS number
89459-25-6
Weight
Average: 293.37
Monoisotopic: 293.152812244
Chemical Formula
C18H19N3O
InChI Key
XBGNERSKEKDZDS-UHFFFAOYSA-N
InChI
InChI=1S/C18H19N3O/c1-21(2)11-10-19-18(22)15-8-5-7-14-12-13-6-3-4-9-16(13)20-17(14)15/h3-9,12H,10-11H2,1-2H3,(H,19,22)
IUPAC Name
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
SMILES
CN(C)CCNC(=O)C1=C2N=C3C=CC=CC3=CC2=CC=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Acridine Carboxamide.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
BevacizumabBevacizumab may increase the cardiotoxic activities of Acridine Carboxamide.Approved, Investigational
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Acridine Carboxamide.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Acridine Carboxamide.Approved, Investigational
CymarinCymarin may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
DeslanosideDeslanoside may decrease the cardiotoxic activities of Acridine Carboxamide.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Acridine Carboxamide.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Acridine Carboxamide.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Acridine Carboxamide.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Acridine Carboxamide.Approved, Investigational
GitoformateGitoformate may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
OleandrinOleandrin may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental, Investigational
OuabainOuabain may decrease the cardiotoxic activities of Acridine Carboxamide.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Acridine Carboxamide.Approved, Vet Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Acridine Carboxamide.Experimental
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Acridine Carboxamide.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
107805
PubChem Substance
347828217
ChemSpider
96954
ChEMBL
CHEMBL9940

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentBrain and Central Nervous System Tumors1
2CompletedTreatmentLung Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0376 mg/mLALOGPS
logP2.75ALOGPS
logP2.6ChemAxon
logS-3.9ALOGPS
pKa (Strongest Acidic)14.76ChemAxon
pKa (Strongest Basic)8.51ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area45.23 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity88.05 m3·mol-1ChemAxon
Polarizability33.51 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Quinolines and derivatives
Sub Class
Benzoquinolines
Direct Parent
Acridines
Alternative Parents
Quinoline carboxamides / Pyridines and derivatives / Benzenoids / Heteroaromatic compounds / Trialkylamines / Secondary carboxylic acid amides / Amino acids and derivatives / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds
show 2 more
Substituents
Acridine / Quinoline-8-carboxamide / Pyridine / Benzenoid / Heteroaromatic compound / Amino acid or derivatives / Carboxamide group / Secondary carboxylic acid amide / Tertiary amine / Tertiary aliphatic amine
show 11 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 14:57 / Updated on November 09, 2017 04:58