CUDC-907

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
CUDC-907
Accession Number
DB11891
Type
Small Molecule
Groups
Investigational
Description

CUDC-907 has been used in trials studying the treatment of Lymphoma, Solid Tumors, BREAST CANCER, Multiple Myeloma, and NUT Midline Carcinoma, among others.

Structure
Thumb
Synonyms
Not Available
External IDs
CUDC907
Categories
UNII
3S9RX35S5X
CAS number
1339928-25-4
Weight
Average: 508.56
Monoisotopic: 508.164122459
Chemical Formula
C23H24N8O4S
InChI Key
JOWXJLIFIIOYMS-UHFFFAOYSA-N
InChI
InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)
IUPAC Name
N-hydroxy-2-({[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl)amino)pyrimidine-5-carboxamide
SMILES
COC1=CC=C(C=N1)C1=NC(N2CCOCC2)=C2SC(CN(C)C3=NC=C(C=N3)C(=O)NO)=CC2=N1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with CUDC-907.Approved
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
54575456
PubChem Substance
347828226
ChemSpider
29314960
ChEMBL
CHEMBL3622533

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingTreatmentCancer, Breast / NUT Midline Carcinoma (NMC) / Tumors, Solid1
1RecruitingTreatmentMalignant Lymphomas / Multiple Myeloma (MM)1
1RecruitingTreatmentMalignant Lymphomas / Neoplasms, Brain / Neuroblastomas / Tumors, Solid1
2RecruitingTreatmentDifferentiated Thyroid Cancer (DTC) / Neoplasms, Thyroid / Poorly Differentiated and Undifferentiated Thyroid Cancer1
2RecruitingTreatmentRelapsed and/or Refractory Diffuse Large B-cell Lymphoma / Relapsed and/or Refractory Diffuse Large B-cell Lymphoma Including With Myc Alterations1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0153 mg/mLALOGPS
logP2.59ALOGPS
logP2.78ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)9.24ChemAxon
pKa (Strongest Basic)3.36ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area138.72 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity145.82 m3·mol-1ChemAxon
Polarizability53.01 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as pyridinylpyrimidines. These are compounds containing a pyridinylpyrimidine skeleton, which consists of a pyridine linked (not fused) to a pyrimidine by a bond.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazines
Sub Class
Pyrimidines and pyrimidine derivatives
Direct Parent
Pyridinylpyrimidines
Alternative Parents
Thienopyrimidines / Pyrimidinecarboxamides / 2,3,5-trisubstituted thiophenes / Dialkylarylamines / Alkyl aryl ethers / Aminopyrimidines and derivatives / Pyridines and derivatives / Morpholines / Imidolactams / Heteroaromatic compounds
show 6 more
Substituents
Pyridinylpyrimidine / Thienopyrimidine / Pyrimidine-5-carboxylic acid or derivatives / Pyrimidinecarboxamide / Dialkylarylamine / 2,3,5-trisubstituted thiophene / Alkyl aryl ether / Aminopyrimidine / Morpholine / Oxazinane
show 18 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 14:57 / Updated on December 01, 2017 16:25