GDC-0623

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
GDC-0623
Accession Number
DB11982
Type
Small Molecule
Groups
Investigational
Description

GDC-0623 has been used in trials studying the treatment of Solid Cancers.

Structure
Thumb
Synonyms
Not Available
Categories
UNII
HW67545I4Q
CAS number
1168091-68-6
Weight
Average: 456.216
Monoisotopic: 456.00946
Chemical Formula
C16H14FIN4O3
InChI Key
RFWVETIZUQEJEF-UHFFFAOYSA-N
InChI
InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
IUPAC Name
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
SMILES
OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)N2C=NC=C2C=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
42642654
PubChem Substance
347828304
ChemSpider
30687718
BindingDB
50025226
ChEMBL
CHEMBL3330650
ZINC
ZINC000043206499
PDBe Ligand
LCJ
PDB Entries
6nyb / 6pp9 / 6q0j / 6q0t

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentSolid Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0427 mg/mLALOGPS
logP2.36ALOGPS
logP2.85ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)12.05ChemAxon
pKa (Strongest Basic)7.84ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area87.89 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity99.27 m3·mol-1ChemAxon
Polarizability37.82 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as imidazopyridines. These are organic polycyclic compounds containing an imidazole ring fused to a pyridine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Imidazopyridines
Sub Class
Not Available
Direct Parent
Imidazopyridines
Alternative Parents
Pyridinecarboxamides / Aniline and substituted anilines / Aminopyridines and derivatives / Fluorobenzenes / Iodobenzenes / Aryl fluorides / Aryl iodides / N-substituted imidazoles / Heteroaromatic compounds / Vinylogous amides
show 9 more
Substituents
Imidazopyridine / Pyridinecarboxamide / Pyridine carboxylic acid or derivatives / Aniline or substituted anilines / Aminopyridine / Fluorobenzene / Halobenzene / Iodobenzene / Aryl fluoride / Aryl halide
show 27 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 15:08 / Updated on March 01, 2020 21:03

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