Showing BioInteractions for Lorlatinib (DB12130)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Lorlatinib is a ALK tyrosine kinase receptor inhibitor
1ALK tyrosine kinase receptor inhibitorsAlectinib, Brigatinib, Crizotinib, Fostamatinib, Gilteritinib
2ALK tyrosine kinase receptor antagonistsCeritinib
Interacting GroupInteracting Drugs
Lorlatinib is a Cytochrome P450 3A Subfamily substrate
1Cytochrome P450 3A Subfamily inhibitorsCrizotinib, Diacerein, Fluvoxamine, Glecaprevir, Istradefylline, Lemborexant, Lonafarnib, Lopinavir, Midostaurin, Nefazodone, Olanzapine, Phenelzine, Pibrentasvir, Remoxipride, Rhein, Risdiplam, Selpercatinib
2Cytochrome P450 3A Subfamily substratesAcalabrutinib, Ambroxol acefyllinate, Budesonide, Dolutegravir, Elagolix, Ethosuximide, Foretinib, Glecaprevir, Lonafarnib, Loxoprofen, Mebendazole, Methylprednisolone, Midostaurin, Mirodenafil, Moxisylyte, Naldemedine, Omega-3-carboxylic acids, Relugolix, Tazemetostat, Thiopental, Tucatinib, Zanubrutinib
3Cytochrome P450 3A Subfamily inducersBrigatinib, Budesonide, Lemborexant, Methylprednisolone, Midostaurin, Myrrh, Prednisolone phosphate, Prednisone, Relugolix, Rifapentine
Interacting GroupInteracting Drugs
Lorlatinib is a Cytochrome P450 3A Subfamily inhibitor
1Cytochrome P450 3A Subfamily inhibitorsCrizotinib, Diacerein, Fluvoxamine, Glecaprevir, Istradefylline, Lemborexant, Lonafarnib, Lopinavir, Midostaurin, Nefazodone, Olanzapine, Phenelzine, Pibrentasvir, Remoxipride, Rhein, Risdiplam, Selpercatinib
2Cytochrome P450 3A Subfamily substratesAcalabrutinib, Ambroxol acefyllinate, Budesonide, Dolutegravir, Elagolix, Ethosuximide, Foretinib, Glecaprevir, Lonafarnib, Loxoprofen, Mebendazole, Methylprednisolone, Midostaurin, Mirodenafil, Moxisylyte, Naldemedine, Omega-3-carboxylic acids, Relugolix, Tazemetostat, Thiopental, Tucatinib, Zanubrutinib
3Cytochrome P450 3A Subfamily inducersBrigatinib, Budesonide, Lemborexant, Methylprednisolone, Midostaurin, Myrrh, Prednisolone phosphate, Prednisone, Relugolix, Rifapentine
Interacting GroupInteracting Drugs
Lorlatinib is a Cytochrome P450 3A5 substrate
1Cytochrome P450 3A5 substratesAlfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apomorphine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Azimilide, Benidipine, Bimatoprost, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Cannabidiol, Carbamazepine, Cenobamate, Cerivastatin, Cethromycin, Chloroquine, Chlorpheniramine, Cilostazol, Cisapride, Clarithromycin, Clindamycin, Clonidine, Clopidogrel, Cobicistat, Copanlisib, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexloxiglumide, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Doravirine, Dronedarone, Dutasteride, Elbasvir, Elexacaftor, Enzalutamide, Eplerenone, Erlotinib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Ethinylestradiol, Etoposide, Felodipine, Fenfluramine, Finasteride, Fluoxetine, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gefitinib, Glyburide, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Istradefylline, Ivacaftor, Lapatinib, Lemborexant, Lercanidipine, Levonorgestrel, Lidocaine, Lonafarnib, Loratadine, Metronidazole, Midazolam, Mifepristone, Mycophenolate mofetil, Nabiximols, Nateglinide, Nevirapine, Nifedipine, Nisoldipine, Nitrendipine, Nortriptyline, Olaparib, Ondansetron, Oxybutynin, Oxycodone, Paclitaxel, Paliperidone, Paritaprevir, Pentamidine, Perampanel, Phenytoin, Pimozide, Ponatinib, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Selumetinib, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Tegafur, Temsirolimus, Tenapanor, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Udenafil, Umifenovir, Valbenazine, Valproic acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Vortioxetine, Zaleplon, Zonisamide
2Cytochrome P450 3A5 inhibitorsAcalabrutinib, Amlodipine, Boceprevir, Cannabidiol, Cenobamate, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Clofazimine, Cobicistat, Crizotinib, Curcumin sulfate, Delavirdine, Diltiazem, Ditiocarb, Dronedarone, Elbasvir, Erythromycin, Fluconazole, Fluticasone, Fluticasone furoate, Fluticasone propionate, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Ketoconazole, Letermovir, Lonafarnib, Medical Cannabis, Methylene blue, Mibefradil, Modafinil, Nabiximols, Nelfinavir, Nicardipine, Osilodrostat, Oxcarbazepine, Oxymetholone, Phenelzine, Pralsetinib, Ritonavir, Rucaparib, Safinamide, Saquinavir, Seproxetine, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
3Cytochrome P450 3A5 inducersAmcinonide, Armodafinil, Asunaprevir, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Budesonide, Carbamazepine, Clobetasol, Clobetasol propionate, Clocortolone acetate, Cloprednol, Cortisone, Cortisone acetate, Cortivazol, Daunorubicin, Deflazacort, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Difluocortolone, Efavirenz, Enzalutamide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Halometasone, Icotinib, Medrysone, Melengestrol acetate, Meprednisone, Methylprednisolone hemisuccinate, Midostaurin, Modafinil, Mometasone, Mometasone furoate, Oxcarbazepine, Paramethasone, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Reserpine, Rifampicin, Rimexolone, Thalidomide, Triamcinolone
Interacting GroupInteracting Drugs
Lorlatinib is a Cytochrome P450 2B6 inducer
1Cytochrome P450 2B6 substratesAmitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Fenfluramine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2Cytochrome P450 2B6 inducersArmodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Relugolix, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3Cytochrome P450 2B6 inhibitorsAbametapir, Abemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clascoterone, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Pexidartinib, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Tirbanibulin, Triclabendazole, Voriconazole
4Cytochrome P450 2B6 activatorsVerapamil
Interacting GroupInteracting Drugs
Lorlatinib is a Cytochrome P450 2C8 substrate
1Cytochrome P450 2C8 substrates(R)-warfarin, (S)-Warfarin, Almotriptan, Aminophenazone, Amiodarone, Amitriptyline, Amodiaquine, Anastrozole, Antipyrine, Apalutamide, Apixaban, Apomorphine, Atorvastatin, Azelastine, Balaglitazone, Benzyl alcohol, Beraprost, Bioallethrin, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Capravirine, Carbamazepine, Celecoxib, Cerivastatin, Chloroquine, Ciglitazone, Cisapride, Clozapine, Cyclophosphamide, Dabrafenib, Dapsone, Dasabuvir, Dexibuprofen, Diazepam, Diclofenac, Diethylstilbestrol, Diltiazem, Domperidone, Elagolix, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Eszopiclone, Ethinylestradiol, Fluorouracil, Fluvastatin, Glasdegib, Halofantrine, Hydroxychloroquine, Ibuprofen, Ifosfamide, Imatinib, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketorolac, Lansoprazole, Lapatinib, Levomilnacipran, Licofelone, Lidocaine, Lobeglitazone, Lonafarnib, Loperamide, Loratadine, Lovastatin, Meloxicam, Mephenytoin, Mestranol, Methadone, Montelukast, Morphine, Muraglitazar, Mycophenolate mofetil, Naproxen, Netoglitazone, Nicardipine, Nicotine, Odanacatib, Olodaterol, Ombitasvir, Omeprazole, Ozanimod, Paclitaxel, Paramethadione, Pazopanib, Perospirone, Perphenazine, Phenprocoumon, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Ponatinib, Propofol, Quinine, Relugolix, Remdesivir, Repaglinide, Riociguat, Rivoglitazone, Rosiglitazone, Selegiline, Selexipag, Selumetinib, Seratrodast, Simvastatin, Sitagliptin, Sorafenib, Sulfadiazine, Tazarotene, Tegafur, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tirbanibulin, Tolbutamide, Torasemide, Tretinoin, Trifarotene, Trimethadione, Trimethoprim, Troglitazone, Tucatinib, Velpatasvir, Verapamil, Vortioxetine, Voxilaprevir, Warfarin, Zopiclone
2Cytochrome P450 2C8 inducersAvatrombopag, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cyclophosphamide, Dexamethasone, Dexamethasone acetate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Ifosfamide, Isavuconazole, Ivosidenib, Lumacaftor, Methylprednisolone, Midostaurin, Nilotinib, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Probenecid, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
3Cytochrome P450 2C8 inhibitorsAbemaciclib, Abiraterone, Alpelisib, Amitriptyline, Amlodipine, Amoxicillin, Anastrozole, Atazanavir, Atorvastatin, Balaglitazone, Belinostat, Bexarotene, Bezafibrate, Bosutinib, Cabozantinib, Candesartan, Candesartan cilexetil, Cerivastatin, Cholecalciferol, Ciglitazone, Cimetidine, Clascoterone, Clofazimine, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Dabrafenib, Deferasirox, Diethylstilbestrol, Efavirenz, Elexacaftor, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Ethinylestradiol, Ezetimibe, Favipiravir, Felodipine, Fenofibrate, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gemfibrozil, Genistein, Idelalisib, Irbesartan, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lapatinib, Lenvatinib, Letermovir, Levothyroxine, Licofelone, Liotrix, Lobeglitazone, Lonafarnib, Loratadine, Losartan, Lumacaftor, Lumasiran, Medroxyprogesterone acetate, Mefenamic acid, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Mometasone, Mometasone furoate, Montelukast, Nabilone, Netoglitazone, Nicardipine, Nifedipine, Nilotinib, Nilvadipine, Opicapone, Oxybutynin, Pazopanib, Phenelzine, Pioglitazone, Ponatinib, Pralsetinib, Pyrimethamine, Quercetin, Quinidine, Quinine, Rabeprazole, Raloxifene, Regorafenib, Rifamycin, Ripretinib, Ritonavir, Rivoglitazone, Rofecoxib, Rosiglitazone, Rucaparib, Salmeterol, Saquinavir, Selpercatinib, Simvastatin, Sorafenib, Spironolactone, Sulfaphenazole, Sulfinpyrazone, Tamoxifen, Tegaserod, Terfenadine, Teriflunomide, Ticlopidine, Tirbanibulin, Tolbutamide, Topiroxostat, Trametinib, Triazolam, Triclabendazole, Trimethoprim, Troglitazone, Troleandomycin, Ubrogepant, Vemurafenib, Verapamil, Vismodegib, Warfarin, Zafirlukast
Interacting GroupInteracting Drugs
Lorlatinib is a Cytochrome P450 2C19 substrate
1Cytochrome P450 2C19 substrates(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Fenfluramine, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lonafarnib, Loratadine, Lorcaserin, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methohexital, Methsuximide, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Oliceridine, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Pirfenidone, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Valproic acid, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2Cytochrome P450 2C19 inhibitorsAbiraterone, Alpelisib, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clascoterone, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Letrozole, Lobeglitazone, Lonafarnib, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Mephenytoin, Methimazole, Methsuximide, Methylene blue, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Osilodrostat, Oxcarbazepine, Pantoprazole, Paroxetine, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Sitaxentan, Somapacitan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tirbanibulin, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Valproic acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Betamethasone, Budesonide, Carbamazepine, Dexamethasone, Dexamethasone acetate, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort
Interacting GroupInteracting Drugs
Lorlatinib is a UDP-glucuronosyltransferase 1-3 substrate
1UDP-glucuronosyltransferase 1-3 substratesAmbrisentan, Anastrozole, Atorvastatin, Baloxavir marboxil, Candesartan, Candesartan cilexetil, Cyproheptadine, Delafloxacin, Dexibuprofen, Diclofenac, Dolutegravir, Eltrombopag, Empagliflozin, Enasidenib, Etodolac, Ezetimibe, Ezogabine, Flurbiprofen, Fluvastatin, Gavestinel, Gemfibrozil, Hydromorphone, Ibuprofen, Irbesartan, Letermovir, Licofelone, Losartan, Lovastatin, Mitiglinide, Morphine, Muraglitazar, Naldemedine, Nalmefene, Naproxen, Pitavastatin, Simvastatin, Telmisartan, Troglitazone, Valproic acid
2UDP-glucuronosyltransferase 1-3 inhibitorsDeferasirox, Dovitinib, Flunitrazepam, Gemfibrozil