Identification Name Exatecan Accession Number DB12185 Type Small Molecule Groups Investigational Description
Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.
Structure Synonyms Not Available External IDs DX-8951 / DX-8951f Product Ingredients Products Not Available International Brands Not Available Brand mixtures Not Available Categories UNII OC71PP0F89 CAS number 171335-80-1 Weight Average: 435.455 Monoisotopic: 435.159434363 Chemical Formula C 24H 22FN 3O 4 InChI Key ZVYVPGLRVWUPMP-FYSMJZIKSA-N InChI
SMILES Pharmacology Indication Not Available Structured Indications Not Available Pharmacodynamics Not Available Mechanism of action Not Available Related Articles Absorption Not Available Volume of distribution Not Available Protein binding Not Available Metabolism Not Available Route of elimination Not Available Half life Not Available Clearance Not Available Toxicity Not Available Affected organisms Not Available Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Interactions Drug Interactions
Drug Interaction Drug group Acetyldigitoxin Acetyldigitoxin may decrease the cardiotoxic activities of Exatecan. Approved Bevacizumab Bevacizumab may increase the cardiotoxic activities of Exatecan. Approved, Investigational Cabazitaxel The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Exatecan. Approved Cyclophosphamide Cyclophosphamide may increase the cardiotoxic activities of Exatecan. Approved, Investigational Deslanoside Deslanoside may decrease the cardiotoxic activities of Exatecan. Approved Digitoxin Digitoxin may decrease the cardiotoxic activities of Exatecan. Approved Digoxin Digoxin may decrease the cardiotoxic activities of Exatecan. Approved Docetaxel The risk or severity of adverse effects can be increased when Docetaxel is combined with Exatecan. Approved, Investigational Oleandrin Anvirzel may decrease the cardiotoxic activities of Exatecan. Experimental Ouabain Ouabain may decrease the cardiotoxic activities of Exatecan. Approved Paclitaxel The risk or severity of adverse effects can be increased when Paclitaxel is combined with Exatecan. Approved, Vet Approved Trastuzumab Trastuzumab may increase the cardiotoxic activities of Exatecan. Approved, Investigational Food Interactions Not Available References Synthesis Reference Not Available General References Not Available External Links ATC Codes Not Available AHFS Codes Not Available PDB Entries Not Available FDA label Not Available MSDS Not Available Clinical Trials Clinical Trials Properties State Not Available Experimental Properties Not Available Predicted Properties Predicted ADMET features Not Available Spectra Mass Spec (NIST) Not Available Spectra Taxonomy Description This compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring). Kingdom Organic compounds Super Class Alkaloids and derivatives Class Camptothecins Sub Class Not Available Direct Parent Camptothecins Alternative Parents Haloquinolines / Pyranopyridines / Pyridinones / Aralkylamines / Aryl fluorides / Benzenoids / Tertiary alcohols / Heteroaromatic compounds / Amino acids and derivatives / Lactones / Lactams / Carboxylic acid esters / Oxacyclic compounds / Monocarboxylic acids and derivatives / Azacyclic compounds / Carbonyl compounds / Hydrocarbon derivatives / Monoalkylamines / Organic oxides / Organofluorides / Organopnictogen compounds show 11 more Substituents Camptothecin / Haloquinoline / Pyranopyridine / Quinoline / Aralkylamine / Pyridinone / Aryl fluoride / Aryl halide / Benzenoid / Pyridine / Heteroaromatic compound / Tertiary alcohol / Amino acid or derivatives / Carboxylic acid ester / Lactam / Lactone / Carboxylic acid derivative / Oxacycle / Azacycle / Monocarboxylic acid or derivatives / Organoheterocyclic compound / Organohalogen compound / Primary aliphatic amine / Organic nitrogen compound / Amine / Hydrocarbon derivative / Alcohol / Carbonyl group / Organic oxide / Organopnictogen compound / Organofluoride / Organonitrogen compound / Organooxygen compound / Primary amine / Organic oxygen compound / Aromatic heteropolycyclic compound show 26 more Molecular Framework Aromatic heteropolycyclic compounds External Descriptors Not Available