Faropenem

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Faropenem
Accession Number
DB12190
Type
Small Molecule
Groups
Investigational
Description

Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Faropenem Sodium7O46G914RQ122547-49-3ICSAXRANXQSPQP-VUKDEKJYSA-M
Categories
UNII
F52Y83BGH3
CAS number
106560-14-9
Weight
Average: 285.316
Monoisotopic: 285.067093285
Chemical Formula
C12H15NO5S
InChI Key
HGGAKXAHAYOLDJ-FHZUQPTBSA-N
InChI
InChI=1S/C12H15NO5S/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6/h5-7,11,14H,2-4H2,1H3,(H,16,17)/t5-,6-,7+,11-/m1/s1
IUPAC Name
(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
SMILES
[H][C@]12SC([C@H]3CCCO3)=C(N1C(=O)[C@@H]2[C@@H](C)O)C(O)=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0041892
PubChem Compound
65894
PubChem Substance
347828475
ChemSpider
59303
ChEBI
51257
ChEMBL
CHEMBL556262
HET
FPM
Wikipedia
Faropenem
ATC Codes
J01DI03 — Faropenem
PDB Entries
3bff / 4hky

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentTuberculosis Infection1
2CompletedTreatmentPulmonary Tuberculosis (TB)1
2RecruitingTreatmentTuberculosis Infection1
3Unknown StatusTreatmentCommunity Acquired Pneumonia (CAP)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility14.7 mg/mLALOGPS
logP0.24ALOGPS
logP-0.75ChemAxon
logS-1.3ALOGPS
pKa (Strongest Acidic)4.16ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area87.07 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity69.26 m3·mol-1ChemAxon
Polarizability28.16 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acids and derivatives
Alternative Parents
Thiazolecarboxylic acids and derivatives / Penems / Vinylogous thioesters / Thiazolines / Tetrahydrofurans / Tertiary carboxylic acid amides / Azetidines / Thioenol ethers / Secondary alcohols / Azacyclic compounds
show 10 more
Substituents
Alpha-amino acid or derivatives / Penem / Thiazolecarboxylic acid or derivatives / Vinylogous thioester / Beta-lactam / Tertiary carboxylic acid amide / Tetrahydrofuran / Thiazole / Meta-thiazoline / Thioenolether
show 22 more
Molecular Framework
Aliphatic heteropolycyclic compounds
External Descriptors
faropenem (CHEBI:51257)

Drug created on October 20, 2016 15:34 / Updated on November 02, 2018 09:03