Talsaclidine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Talsaclidine
- DrugBank Accession Number
- DB12287
- Background
Talsaclidine has been used in trials studying the treatment of Alzheimer Disease.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 165.236
Monoisotopic: 165.115364107 - Chemical Formula
- C10H15NO
- Synonyms
- Talsaclidine
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as quinuclidines. These are compounds containing a 1-azabicyclo[2.2.2]octane moiety.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinuclidines
- Sub Class
- Not Available
- Direct Parent
- Quinuclidines
- Alternative Parents
- Piperidines / Trialkylamines / Dialkyl ethers / Azacyclic compounds / Acetylides / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Acetylide / Aliphatic heteropolycyclic compound / Amine / Azacycle / Dialkyl ether / Ether / Hydrocarbon derivative / Organic nitrogen compound / Organic oxygen compound / Organonitrogen compound
- Molecular Framework
- Aliphatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1O8VSL798T
- CAS number
- 147025-53-4
- InChI Key
- XVFJONKUSLSKSW-JTQLQIEISA-N
- InChI
- InChI=1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1
- IUPAC Name
- (3R)-3-(prop-2-yn-1-yloxy)-1-azabicyclo[2.2.2]octane
- SMILES
- C#CCO[C@H]1CN2CCC1CC2
References
- General References
- Not Available
- External Links
- PubChem Compound
- 71792
- PubChem Substance
- 347828555
- ChemSpider
- 64819
- BindingDB
- 50119648
- ChEMBL
- CHEMBL2111051
- ZINC
- ZINC000001547638
- Wikipedia
- Talsaclidine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Alzheimer's Disease (AD) 1 2 Terminated Treatment Alzheimer's Disease (AD) 1 2, 3 Terminated Treatment Alzheimer's Disease (AD) 1 1 Completed Treatment Healthy Volunteers (HV) 4
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.666 mg/mL ALOGPS logP 1.02 ALOGPS logP 0.73 Chemaxon logS -2.4 ALOGPS pKa (Strongest Basic) 8.76 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 12.47 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 48.56 m3·mol-1 Chemaxon Polarizability 18.86 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-03di-5900000000-d44167244a04ec24bfc8 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-1b9156bd3eb4b48e1b5c Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-2900000000-cbe41b437c0262221d18 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0900000000-3cefb2e64f028afe9707 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0bt9-7900000000-4181166e91d6a35fd85e Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-08fr-0900000000-de2abdac214e2efbae0f Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-4900000000-f0f016b2b11b86a43f9e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 136.3889286 predictedDarkChem Lite v0.1.0 [M-H]- 133.54744 predictedDeepCCS 1.0 (2019) [M+H]+ 136.9231286 predictedDarkChem Lite v0.1.0 [M+H]+ 136.31847 predictedDeepCCS 1.0 (2019) [M+Na]+ 136.8241286 predictedDarkChem Lite v0.1.0 [M+Na]+ 145.14787 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 21:50 / Updated at February 21, 2021 18:53