NAV

Carisbamate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Carisbamate
DrugBank Accession Number
DB12338
Background

Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 215.63
Monoisotopic: 215.0349209
Chemical Formula
C9H10ClNO3
Synonyms
  • Carisbamate
External IDs
  • JNJ-10234094
  • RWJ-333369-000
  • YKP-509
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when Carisbamate is combined with 1,2-Benzodiazepine.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Carisbamate.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Carisbamate.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Carisbamate.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Carisbamate.
Food Interactions
Not Available

Categories

ATC Codes
N03AX19 — Carisbamate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Halobenzenes
Direct Parent
Chlorobenzenes
Alternative Parents
Aryl chlorides / Carbamate esters / Secondary alcohols / Organonitrogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds / Aromatic alcohols
Substituents
Alcohol / Aromatic alcohol / Aromatic homomonocyclic compound / Aryl chloride / Aryl halide / Carbamic acid ester / Carbonyl group / Chlorobenzene / Hydrocarbon derivative / Organic nitrogen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
P7725I9V3Z
CAS number
194085-75-1
InChI Key
OLBWFRRUHYQABZ-MRVPVSSYSA-N
InChI
InChI=1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1
IUPAC Name
(2S)-2-(2-chlorophenyl)-2-hydroxyethyl carbamate
SMILES
NC(=O)OC[C@@H](O)C1=CC=CC=C1Cl

References

General References
Not Available
PubChem Compound
6918474
PubChem Substance
347828597
ChemSpider
5293671
ChEBI
135966
ChEMBL
CHEMBL2087003
ZINC
ZINC000030691363
Wikipedia
Carisbamate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentComplex Partial Seizure Disorder / Epilepsy / Focal Impaired Awareness Seizures / Partial Epilepsy1
3CompletedTreatmentEpilepsy, Partial, Motor / Focal Impaired Awareness Seizures / Partial Seizures, Simple2
3RecruitingTreatmentLennox-Gastaut Syndrome / Seizures1
3TerminatedTreatmentEpilepsy / Seizures1
2CompletedTreatmentDiabetic Mononeuropathy / Diabetic Polyneuropathy / Neuralgia, Diabetic / Painful Diabetic Neuropathy (PDN)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.15 mg/mLALOGPS
logP0.94ALOGPS
logP1.29Chemaxon
logS-2ALOGPS
pKa (Strongest Acidic)13.43Chemaxon
pKa (Strongest Basic)-3.5Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area72.55 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity51.47 m3·mol-1Chemaxon
Polarizability20.38 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0006-5900000000-5243dde1463d8e4c28cf
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-052o-0910000000-76c9c7986e84cf3bf5ec
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9300000000-1cecd4f706b544ddb7bf
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03dl-0900000000-b12906775364a5112537
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-9b301a5d281a74c1bc83
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-7cf6092e14287c9b9ac2
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-08j3-1900000000-546a271c83b3a7e66d9b
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-138.69902
predicted
DeepCCS 1.0 (2019)
[M+H]+141.09459
predicted
DeepCCS 1.0 (2019)
[M+Na]+147.0717
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 22:00 / Updated at February 21, 2021 18:53