Selurampanel

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Selurampanel
Accession Number
DB12367
Description

Selurampanel has been investigated in Adrenocortical Adenoma and Sarcoma, Endometrial Stromal.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 377.42
Monoisotopic: 377.115775286
Chemical Formula
C16H19N5O4S
Synonyms
Not Available
External IDs
  • BGG-492
  • BGG492

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazanaphthalenes
Sub Class
Benzodiazines
Direct Parent
Quinazolines
Alternative Parents
Cumenes / Pyrimidones / Sulfonohydrazides / Hydrazinosulfonyl compounds / Vinylogous amides / Pyrazoles / Heteroaromatic compounds / Lactams / Azacyclic compounds / Organooxygen compounds
show 3 more
Substituents
Aromatic heteropolycyclic compound / Azacycle / Azole / Benzenoid / Cumene / Heteroaromatic compound / Hydrazinosulfonyl compound / Hydrocarbon derivative / Lactam / Organic nitrogen compound
show 14 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
7WG1MR7DAR
CAS number
912574-69-7
InChI Key
MCECSFFXUPEPDB-UHFFFAOYSA-N
InChI
InChI=1S/C16H19N5O4S/c1-9(2)10-8-13-12(7-11(10)14-5-6-17-20(14)3)15(22)21(16(23)18-13)19-26(4,24)25/h5-9,19H,1-4H3,(H,18,23)
IUPAC Name
N-[6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-7-(propan-2-yl)-1,2,3,4-tetrahydroquinazolin-3-yl]methanesulfonamide
SMILES
CC(C)C1=C(C=C2C(NC(=O)N(NS(C)(=O)=O)C2=O)=C1)C1=CC=NN1C

References

General References
Not Available
PubChem Compound
45381907
PubChem Substance
347828618
ChemSpider
32698379
ChEMBL
CHEMBL3545042
ZINC
ZINC000116796247
Wikipedia
Selurampanel

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedNot AvailableAdrenocortical Adenoma / Sarcoma, Endometrial Stromal1
2CompletedTreatmentChronic Subjective Tinnitus1
2CompletedTreatmentEpilepsies / Seizures1
2CompletedTreatmentMigraine1
2CompletedTreatmentPartial-Onset Seizures2
2CompletedTreatmentPhotosensitive Epilepsy1
2WithdrawnTreatmentMuscle Spasticity Due to Multiple Sclerosis1
2WithdrawnTreatmentPartial-Onset Seizures1
2WithdrawnTreatmentPatients With Migraine Equal of /More Than 3 and Equal of/ Less Than 12 Migraine Attacks/4 Weeks for Each of the Last 6 Months Preceding the Screening1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.207 mg/mLALOGPS
logP1.69ALOGPS
logP1.54ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)8.3ChemAxon
pKa (Strongest Basic)2.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area113.4 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity108.35 m3·mol-1ChemAxon
Polarizability37.82 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on October 20, 2016 16:06 / Updated on June 12, 2020 10:53

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