Mirvetuximab Soravtansine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Mirvetuximab Soravtansine
Accession Number
DB12489
Type
Small Molecule
Groups
Investigational
Description

Mirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others.

Structure
Thumb
Synonyms
  • IMGN853
Categories
UNII
98DE7VN88D
CAS number
1453084-37-1
Weight
Average: 977.59
Monoisotopic: 976.3034939
Chemical Formula
C42H61ClN4O14S3
InChI Key
ZOHXWSHGANNQGO-GGEPYJLJSA-N
InChI
InChI=1S/C42H61ClN4O14S3/c1-23-12-11-13-31(58-10)42(53)22-29(59-39(52)45-42)24(2)36-41(6,61-36)32(21-34(49)47(8)27-19-26(18-23)20-28(57-9)35(27)43)60-38(51)25(3)46(7)33(48)14-16-40(4,5)63-62-17-15-30(37(44)50)64(54,55)56/h11-13,19-20,24-25,29-32,36,53H,14-18,21-22H2,1-10H3,(H2,44,50)(H,45,52)(H,54,55,56)/b13-11+,23-12-/t24-,25+,29+,30?,31-,32+,36+,41+,42+/m1/s1
IUPAC Name
1-carbamoyl-3-[(4-{[(2S)-1-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)carbamoyl}-2-methylbutan-2-yl)disulfanyl]propane-1-sulfonic acid
SMILES
CO[C@@H]1C=CC=C(C)CC2=CC(N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSCCC(C(N)=O)S(O)(=O)=O)[C@]3(C)O[C@H]3[C@H](C)[C@@H]3C[C@@]1(O)NC(=O)O3)=C(Cl)C(OC)=C2

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe serum concentration of (R)-warfarin can be increased when it is combined with Mirvetuximab Soravtansine.
(S)-WarfarinThe serum concentration of (S)-Warfarin can be increased when it is combined with Mirvetuximab Soravtansine.
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Mirvetuximab Soravtansine.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Mirvetuximab Soravtansine.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Mirvetuximab Soravtansine.
7-DeazaguanineThe metabolism of 7-Deazaguanine can be decreased when combined with Mirvetuximab Soravtansine.
7,9-DimethylguanineThe metabolism of 7,9-Dimethylguanine can be decreased when combined with Mirvetuximab Soravtansine.
8-azaguanineThe metabolism of 8-azaguanine can be decreased when combined with Mirvetuximab Soravtansine.
8-chlorotheophyllineThe metabolism of 8-chlorotheophylline can be decreased when combined with Mirvetuximab Soravtansine.
9-DeazaguanineThe metabolism of 9-Deazaguanine can be decreased when combined with Mirvetuximab Soravtansine.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
131704323
PubChem Substance
347828725
ChemSpider
64873336

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentFOLR-1 Positive Solid Tumors1
1RecruitingTreatmentBRCA1 Gene Mutation / Brca2 Gene Mutation / Folate Receptor Alpha Positive / Platinum Resistant Ovarian Cancer / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Recurrent Uterine Carcinosarcoma / Recurrent Uterine Corpus Carcinoma / Recurrent Uterine Serous Carcinoma1
1RecruitingTreatmentEstrogen Receptor Negative / Folate Receptor Alpha Positive / HER2/Neu Negative / Progesterone Receptor Negative / Recurrent Breast Carcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Recurrent Uterine Corpus Carcinoma / Triple-Negative Breast Carcinoma1
1WithdrawnTreatmentBreast Cancer Triple Negative1
1, 2RecruitingTreatmentEndometrial Cancers / Fallopian Tube Cancer / Ovarian Epithelial Cancer / Primary Peritoneal Cancer1
2Not Yet RecruitingTreatmentEndometrial Cancers1
2RecruitingTreatmentMalignant Neoplasm of Breast1
3Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Ovarian Epithelial Cancer / Primary Fallopian Tube Cancer / Primary Peritoneal Carcinoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00238 mg/mLALOGPS
logP2.88ALOGPS
logP2.54ChemAxon
logS-5.6ALOGPS
pKa (Strongest Acidic)-0.63ChemAxon
pKa (Strongest Basic)-1.3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area253.93 Å2ChemAxon
Rotatable Bond Count16ChemAxon
Refractivity242.59 m3·mol-1ChemAxon
Polarizability97.98 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Kuper JI, D'Aprile M: Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin Pharmacokinet. 2000 Sep;39(3):203-14. [PubMed:11020135]

Drug created on October 20, 2016 16:35 / Updated on June 04, 2019 07:39